Lightnews — Scholar-powered news

Marc van Oostrum @marcvoo.bsky.social · 2d

Reposted by Marc van Oostrum

Jakob Meier-Credo @meiercredo.bsky.social · 19d

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

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Reposted by Marc van Oostrum

Max Planck Institute for Brain Research @mpibrain.bsky.social · Jul 10

🎉 Huge congratulations to @MpiBrain director Erin Schuman @erin-schuman.bsky.social on receiving the 2026 Nakasone Award for her groundbreaking work on the function and plasticity of neuronal synapses! 🧠 @hfspo.bsky.social ‬#neuroscience #HFSP #NakasoneAward 👉 bit.ly/4m6g40P

Erin M. Schuman Wins 2026 Nakasone Award

bit.ly

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Reposted by Marc van Oostrum

Maria Leptin @marialep.bsky.social · Jun 17

Congratulations! The new Advanced Grant winners are great news.
But yet again, many scientists - around 260 - with ground-breaking ideas were rated as excellent, but remained unfunded due to a lack of funds at the ERC. Hope that more funding will be available in the future!

European Research Council (ERC) @erc.europa.eu · Jun 17

📣 Good news: 281 top researchers have just won ERC Advanced Grants!

The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme.

Find out more 👉 europa.eu/!JYKxkD

#ERCAdG #FrontierResearch @ec.europa.eu

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Reposted by Marc van Oostrum

Ilaria Piazza lab @iplab.bsky.social · Jun 17

We are accepting applications for a PhD opportunity at @scilifelab.se

this is part of a MSCA Doctoral Network on the topic of metabolic regulation of genome function and cell identity.

A EU funded generous fellowship is offered with possibility of industry experience. Apply here:

PhD project in METABOLIC REGULATION OF GENOME FUNCTION AND CELL IDENTITY – Ilaria Piazza Laboratory

thewittysquare.eu

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Reposted by Marc van Oostrum

Zeynep Okur @zeynepokur.bsky.social · Jun 11

@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...

Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation

Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…

www.sciencedirect.com

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Marc van Oostrum @marcvoo.bsky.social · May 26

We are using Synaptophysin in vivo and in vitro, mostly because we had good experiences with the Ai34D mouse line- you can get the AAVs from the repository at vvf.ethz.ch. For minimal effects I‘d consider the Synaptotagmin intrabody but haven‘t tried it.

Viral Vector Facility (VVF)

The VVF of the ZNZ - a joint competence center of ETH Zurich and University of Zurich - offers professional production of viral vectors and associated services (e.g. cloning)

vvf.ethz.ch

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Reposted by Marc van Oostrum

Julia Kuhl @somedonkey.bsky.social · May 23

"Exploring brain circuits, one cell type - or more - at a time" www.cell.com/neuron/fullt...
This one is for all the #ChandelierNeuron fans out there
#sciArt #sciComm #neuroscience #neuroskyence

Cover of journal Neuron shows a female scientists turning lamp-like neurons on and off

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Reposted by Marc van Oostrum

Proteomes MDPI @proteomesmdpi.bsky.social · May 22

🎉 Big congrats to @marcvoo.bsky.social for winning the Best Talk Prize sponsored by Proteomes at the Annual Swiss Proteomics Meeting 2025!

🎉Congratulations to all other prize winners！

👏 Warm congratulations to the organizers on the successful completion of the event!

#proteomes #proteomics

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Reposted by Marc van Oostrum

Joris de Wit @synapse-lab.bsky.social · May 20

Glad to see our new paper finally out! We show how the GPR158 receptor controls synapse maturation and function by silencing an intrinsic inhibitory mechanism.
authors.elsevier.com/a/1l7HS5Sx5g...
Work from Ben Verpoort and colleagues, with special thanks to our collaborators.

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Reposted by Marc van Oostrum

Zampieri Lab @zampierilab.bsky.social · May 13

We are happy to share our new work on glutamine addiction in cancer cells. By characterizing the exchange rate and dynamic metabolite response to extracellular glutamine deprivation, we shed light on long standing questions about glutamine addiction.

www.biorxiv.org/content/10.1...

The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility.

Cancer cells develop unique addictions to nutrients offering attractive opportunities for clinical intervention. However, how cancer cells orchestrate and benefit from metabolic rewiring remain fundam...

www.biorxiv.org

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Reposted by Marc van Oostrum

Nature Biotechnology @natbiotech.nature.com · May 2

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - @pedrobeltrao.bsky.social @imsb-eth.bsky.social @opentargets.org go.nature.com/3Z1q0PM

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology

Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.

go.nature.com

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Reposted by Marc van Oostrum

ETH Zurich @ethz.ch · May 12

Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing the map. ethz.ch/en/news-and-...

Understanding which proteins work together

Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing...

ethz.ch

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Reposted by Marc van Oostrum

Pedro Beltrao @pedrobeltrao.bsky.social · May 2

Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology

Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.

www.nature.com

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Reposted by Marc van Oostrum

Mara Mueller @muellermara.bsky.social · Apr 28

New Preprint out !

The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...

Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more

Short thread below 🧵1/4

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Marc van Oostrum @marcvoo.bsky.social · Apr 28

50% of all proteins localize to multiple locations - but check this out, a proteasome maturation factor that acts as nexus linking protein turnover with RNA biogenesis! Congrats Stef & @erin-schuman.bsky.social from @mpibrain.bsky.social !
www.biorxiv.org/content/10.1...

The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator

Proteostasis - the maintenance of proteins at proper concentrations, conformations, and subcellular locations - is essential for cellular function and is governed by tightly regulated protein synthesi...

www.biorxiv.org

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Reposted by Marc van Oostrum

Pedro Beltrao @pedrobeltrao.bsky.social · Apr 18

On the value of exploration of nature and "fishing" expeditions. Hypothesis driven research is important but so is simply observing, measuring and looking for cool new unexpected things.

Luis Javier Galindo @luisjagago.bsky.social · Apr 18

First study from the lab is out! We describe ApuRs, a new family of microbial rhodopsins unique from apusomonads. ApuRs represent the first anion-conducting rhodopsin channels that can be controlled by UV light, offering potential as new optogenetic tools. #protistsonsky
doi.org/10.1101/2025...
👇

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Marc van Oostrum @marcvoo.bsky.social · Apr 17

Exciting paper - lots of things to discover in the data and the approach!

Nature @nature.com · Apr 11

Nature research paper: Multimodal cell maps as a foundation for structural and functional genomics

https://go.nature.com/3YpvALv

Multimodal cell maps as a foundation for structural and functional genomics - Nature

A global map of human subcellular architecture yields protein complex structures, reveals protein functions, identifies assemblies with multiple localizations or cell-type specificity and decodes paediatric cancer genomes.

go.nature.com

Reposted by Marc van Oostrum

Swiss National Science Foundation (SNSF) @snsf.ch · Apr 11

❗Serious consequences for the Swiss economy and society – the SNSF urges the abandonment of the proposed cuts to research funding in "Relief Package 27," as they threaten the country's innovative capacity and competitiveness.

➡️

The SNSF urges against cuts

In its statement on "Relief Package 27", the SNSF speaks out against the proposed annual cuts of 10 percent.

buff.ly

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Reposted by Marc van Oostrum

Schweizerischer Nationalfonds - Fonds National Suisse @snf-fns.ch · Apr 11

❗Gravierende Folgen für die Schweizer Wirtschaft und Gesellschaft: Der SNF fordert den Verzicht auf die im «Entlastungspaket 27» vorgesehenen Kürzungen bei der Forschungsförderung. Diese würden die Innovationskraft und Wettbewerbsfähigkeit des Landes gefährden.

➡️https://buff.ly/eorZPvl

www.snf.ch

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Reposted by Marc van Oostrum

Joris de Wit @synapse-lab.bsky.social · Apr 8

Postdoc opportunity in the heart of Europe! Check out the flyer below.
Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.

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Reposted by Marc van Oostrum

Hovy Wong @hovywong.bsky.social · Feb 4

My lab at CUHK (QS: 36th) is hiring!
We are looking for motivated Research Assistants, PhD students (urgent🚨) and Postdocs who love solving problems. To understand the mysterious brain, we use a range of fun techniques. Please spread the word and get in touch if you are interested!

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Reposted by Marc van Oostrum

JesperOlsenLab @jesperolsenlab.bsky.social · Mar 31

🚀 Excited to share our latest article in #singlecell proteomics published in Cell!
We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution!

www.cell.com/cell/fulltex...

Global analysis of protein turnover dynamics in single cells

The SC-pSILAC method enables single-cell measurement of both protein abundance and turnover, providing notable advances in the depth and versatility of proteomic technologies.

eur02.safelinks.protection.outlook.com

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Reposted by Marc van Oostrum

Biozentrum, University of Basel @biozentrum.unibas.ch · Mar 7

Flow Cytometry Operator/Specialist at the FACS Core Facility (FCF) of the Biozentrum, University of Basel (60-80%)
www.biozentrum.unibas.ch/open-positio...

@biozentrum @unibas.ch #Biozentrum #Basel #research #science #joboffer #hiring #cytometry #operator

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