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Reposted by @MorieLAB

Caro Goujon @carogoujon.bsky.social · 1d

After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...

Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS

Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza A virus (IAV) transcription/replication process. Herein,...

www.pnas.org

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@MorieLAB @morielab.bsky.social · 5d

Big congratulations! MicroPublication is a so valuable initiative to inform the community of accomplished work that will save time and effort to other researchers! I am superhappy to see you joined this initiative! Congratulations to Louison! 🎉

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@MorieLAB @morielab.bsky.social · 5d

Massive congratulations, Felipe! This work is a gigantic endeavour! And a fantastic resource! Mechanistically, is the absence of Homologous Recombination intrinsic to the pathways dictated by using Cas9 to create the cut? In S. cerevisiae Cas9 cuts very efficiently engage HR. Felicidades de nuevo! 😍

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Yale Cell Biology @yalecellbiology.bsky.social · 19d

Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction.

www.nature.com/articles/s41...

Nuclear mechanics as a determinant of nuclear pore complex plasticity - Nature Cell Biology

In this Review, Lusk et al. discuss emerging insights into nuclear pore complex variability with regard to composition and dilation state, and propose nuclear mechanics as a key determinant of driving...

www.nature.com

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Smolka Lab @smolka-lab.bsky.social · 21d

A significant conceptual advance in the field of DNA recombination… great work by the labs of @brookscrickard1.bsky.social
and Michelle Wang

brookscrickard1.bsky.social @brookscrickard1.bsky.social · 21d

Just throwing this out there as a significant conceptual advance in the field

www.biorxiv.org/content/10.1...

The Eukaryotic homology search complex distorts donor DNA structure to probe for homology

Homologous recombination (HR) is a DNA double-strand break repair pathway that facilitates genetic exchange and protects damaged replication forks during DNA synthesis. As a template-based repair proc...

www.biorxiv.org

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@MorieLAB @morielab.bsky.social · Sep 7

I would like to read what @marcofumasoni.bsky.social has to say about these data…!

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@MorieLAB @morielab.bsky.social · Sep 7

Coincident with loss of Rev1, however… 🤔

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@MorieLAB @morielab.bsky.social · Sep 7

Thanks so much, this is very interesting, so do you think (or can know) if they co-lost the fatty acid synthase and the DNA polymerase delta??? I now wonder if there might exist a functional association if this is the case…

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@MorieLAB @morielab.bsky.social · Sep 6

Cool… can you provide me with the original work about fatty acid synthase dependency? We study the control that lipids exert onto genome (in)stability… thus not sure the two events you name are unrelated…!!! 🧐

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@MorieLAB @morielab.bsky.social · Sep 6

Hi, super nice story! Just to mention that in S. cerevisiae it has been shown that DNA synthesis can be replicated (at least for initiation) by DNA polymerase delta!, both basally and, most importantly with respect to your findings, in the absence of Pol ε! doi.org/10.1038/s414...

Evidence that DNA polymerase δ contributes to initiating leading strand DNA replication in Saccharomyces cerevisiae - Nature Communications

DNA polymerases δ and ε (Pols δ and ε) are thought to be responsible for lagging and leading strand synthesis, respectively. Here the authors present evidence that Pol δ contributes to the initiation ...

doi.org

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@MorieLAB @morielab.bsky.social · Sep 5

Huge congratulations, Milena! This is fantastic! You are going to make awesome things

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Alexander Bartelt @barteltlab.bsky.social · Aug 28

Our PhD students @albamena.bsky.social & @annasjung.bsky.social wrote a thing on our ongoing efforts for understanding adipocytes & metabolism @erc.europa.eu
👇
www.europeandissemination.eu/article/fat-...

Fat, stress, and survival: exploring the secret life of adipocytes

Physical activity and exercise have beneficial effects on overall fitness and health. However, exercise-induced increases in metabolism require specific molecular adaptation of the muscle cells. This ...

www.europeandissemination.eu

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Julia Vorhauser @juliavorhauser.bsky.social · Aug 26

I am very happy to share that my PhD work in the Mansfeld lab (www.mansfeldlab.com) was published yesterday! 🎉 In this study, we characterized a novel redox switch on p21 that regulates proliferation: www.cell.com/molecular-ce...
Huge thanks to everyone involved for making this possible 🙏@icr.ac.uk

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision

ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase contro...

www.cell.com

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Andrei Goga @andreigoga.bsky.social · Aug 20

New work from stellar scientists Jeremy Williams and Roman Camarda. Many contributors including the amazing Zena Werb and Atul Butte

Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social

Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis

Nature Communications - Breast cancer cells interact with neighbouring adipocytes, but the mechanisms are not fully understood. Here, the authors show that triple-negative breast cancer (TNBC)...

www.nature.com

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IGBMC @igbmc.bsky.social · Aug 21

Ne manquez pas le 20e GERLI International Lipid Meeting, Strasbourg, 3-5 nov 2025

Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !

Plus d'info : : www.gerli.com/congres/welc...

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Journal of Cell Science @jcellsci.bsky.social · Aug 18

Ryosuke Seino, Kai Nishikubo and Hisanori Fukunaga interrogate cell cycle- and dose-dependent effects on mitochondrial DNA copy number variation following irradiation.
#OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...

Cartoon showing that G1 phase-synchronized cells showed dose-dependence in the relative mtDNAcn increase at 48 h after X-ray exposure, G2 cells at 24 h, and S phase cells at 24 and 48 h.

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The Interactive Fly @interactivefly.bsky.social · Aug 12

Boumard, B., Le Meur, G., Aboutine, L., Stefanutti, M., Maalouf, T., El-Hajj, M., Choi, B. J., Bauer, R., Bardin, A. J. (2025). Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in #Drosophila. Dev Cell, www.sciencedirect.com/science/arti...

Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila

Cell proliferation, which underlies tissue growth and homeostasis, requires high levels of metabolites such as deoxynucleotides (dNTPs). The dNTP pool…

www.sciencedirect.com

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@MorieLAB @morielab.bsky.social · Jul 9

@morielab.bsky.social proudly presents a tool to induce, in S. cerevisiae, DNA double strand breaks in a site-specific AND in a dose-dependent manner, in a very simple way: just transform two plasmids!!! It allows you to assess many aspects of DNA damage signaling & repair!
doi.org/10.1111/febs...

FEBS Press

Using CRISPR-Cas9, we engineered a genetic system allowing the dose-dependent induction of a controllable number of DNA double-strand breaks in Saccharomyces cerevisiae. The tool was used to study th....

doi.org

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@MorieLAB @morielab.bsky.social · Aug 5

Tardigrades tardigrades tardigrades

@MorieLAB @morielab.bsky.social · Jul 25

New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)

www.biorxiv.org/cgi/content/...

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@MorieLAB @morielab.bsky.social · Aug 3

Reminiscent to how mitochondria can selectively extrude damaged mtDNA, locally, along with mitochondrial membranes (or through them) towards the cytoplasm… DNA-lipids interactions at play!!

Debnath Ghosal @debnathghosal.bsky.social · Aug 2

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬

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Itai Yanai @itaiyanai.bsky.social · Jul 29

🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!

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Erika Girardi @alphaerika.bsky.social · Jul 18

I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism
www.biorxiv.org/cgi/content/...

Fatty Acid Synthase binds endogenous dsRNAs and dampens the innate immune response to exogenous dsRNAs by limiting their accumulation.

In mammalian cells, the presence of double-stranded RNA (dsRNA) in the cytoplasm is a danger signal indicative of viral infection. Cells establish and maintain an antiviral state via the production of...

www.biorxiv.org

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@MorieLAB @morielab.bsky.social · Jul 25

New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)

www.biorxiv.org/cgi/content/...

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@MorieLAB @morielab.bsky.social · Jul 25

New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)

www.biorxiv.org/cgi/content/...

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Biology Open @biologyopen.bsky.social · Jul 22

Phase II of our Fast & Fair peer review experiment is testing scalability. Results so far are promising. Read more at bit.ly/41N31tO.

#FastandFairPeerReview #PeerReview #ScientificPublishing

Two scatter plots compare the time to first decision with reviews (in working days) for "Fast & Fair" and "Conventional" peer review methods. The left plot, titled "July-Dec 2024 peer reviewed only," and the right plot, titled "Jan-Jun 2025 peer reviewed only," both show that "Fast & Fair" has significantly lower decision times than "Conventional." Each plot has a Y-axis ranging from 0 to 100 working days and X-axis categories for the two review methods. Data points cluster lower for "Fast & Fair" and higher for "Conventional," with blue lines indicating lower mean times for "Fast & Fair." Asterisks (****) above both plots indicate statistical significance. A caption notes that the blue line represents the mean.

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