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morwan.me
Morwan Osman
@morwan.me
520 followers 320 following 29 posts
Mycobacteriologist and Postdoctoral Fellow in the York Bioenergetics Lab, University Of York (@jnb-lab.bsky.social). Formerly: @pembroke1347.bsky.social & @mrclmb.bsky.social. @mcbseattle.bsky.social PhD.
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morwan.me
Morwan Osman @morwan.me · Dec 6
Our first TB preprint with @jnb-lab.bsky.social is out! Using spectroscopic techniques from our lab, we resolve the exact mode of action of everyone's favourite TB drug, bedaquiline. I'd like to add a few comments about the microbiology part of the picture! #TBsky #MicroSky (1/7)
jnb-lab.bsky.social
Jamie Blaza @jnb-lab.bsky.social · Dec 5
Finally we are able to share our story on the molecular mechanism of the transformative anti-tuberculosis drug bedaquiline within living cells

www.biorxiv.org/content/10.1...

A (hopefully) broadly-accessible tutorial below ⬇️ (it ended up being really long!)
bioRxiv Manuscript Processing System
Manuscript Processing System for bioRxiv.
submit.biorxiv.org
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Reposted by Morwan Osman
labliston.bsky.social
Adrian Liston @labliston.bsky.social · 2d
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
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Reposted by Morwan Osman
eachanjohnson.bsky.social
Eachan Johnson @eachanjohnson.bsky.social · 2d
📢 PhD Opportunity @crick.ac.uk

Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.

We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.

November deadlines. More details ⬇️🧵
PhD students
Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.
www.crick.ac.uk
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Reposted by Morwan Osman
immunoah.bsky.social
ImmuNoah's Ark (Noe Rodriguez) @immunoah.bsky.social · 7d
📣📣We're seeking a postdoc to join us at the @mrclmb.bsky.social to investigate neuroimmune interactomes in tumour & viral immunity.
If you find fascinating & want to learn about #neuroscience & #immunology, tracing neurons, molecular biology & #flowcytometry, apply!
🧠🫁👀🩸🔬
mrc.tal.net/vx/mobile-0/...
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Reposted by Morwan Osman
mycolates.bsky.social
Louis Ates @mycolates.bsky.social · 8d
Very happy to see this work accepted, congrats! It really elegantly confirms how evolution of Mtb virulence and transmission is largely driven by expression of secreted proteins. Very important impact on correlate of protection studies for vaccines as well.
cp-cell.bsky.social
Cell - a Cell Press journal @cp-cell.bsky.social · 8d
Now online! Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Mycobacterium tuberculosis isolates have a complex phylogenetic structure and vary in clinical phenotypes. Combining high-throughput RNA-seq and global population genomics reveals gene expression as an axis of variation in host interaction. Underscoring this, variants in a regulator of a key virulence pathway are associated with increased transmission and drug resistance.
dlvr.it
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pierresantucci.bsky.social
Pierre Santucci @pierresantucci.bsky.social · 9d
Extremely happy to share the fruit of a beautiful collaborative research study.

France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺

Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇

doi.org/10.1101/2025...
Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification
Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...
doi.org
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Reposted by Morwan Osman
turnbulldugarte.com
Stuart Turnbull-Dugarte @turnbulldugarte.com · Sep 5
The takeaway:

👉 Accommodating the radical right on immigration doesn’t win back voters.
👉 It alienates the progressive base.
👉 And it raises the salience of the very issue the radical right owns.
In short: it’s electoral self-harm.
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Reposted by Morwan Osman
loyteam.bsky.social
Alex Loy @loyteam.bsky.social · Aug 27
📢 New paper in @nature.com

Microbes rock 🎸🤘 with sulfide and iron minerals

I am very excited to share our recent study, which describes a previously unknown microbial energy metabolism ⚡⚡⚡🦠🧫⚡⚡⚡

🆕 Microbial iron oxide respiration coupled to sulfide oxidation - MISO

www.nature.com/articles/s41...
Microbial iron oxide respiration coupled to sulfide oxidation - Nature
Genomic and biochemical analyses of prokaryotic sulfur metabolism identify diverse microorganisms with the capacity to oxidize sulfide using iron(iii).
www.nature.com
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Reposted by Morwan Osman
rockefeller.edu
The Rockefeller University @rockefeller.edu · Aug 20
Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.

Learn more below:
Faculty recruitment - Our Scientists
Applications for faculty positions are currently being accepted. Application deadline is October 6, 2025.
www.rockefeller.edu
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Reposted by Morwan Osman
natureportfolio.nature.com
Nature Portfolio @natureportfolio.nature.com · Aug 17
A study in Nature Medicine uses a supervised deep neural network to explain the network of concurrent molecular and macroscopic patterns related to insurgence and course of myalgic encephalomyelitis/chronic fatigue syndrome. go.nature.com/4mhoLpp #medsky 🧪
This is figure 3, which shows that BioMapAI identifies both disease- and symptom-specific biomarkers.
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Reposted by Morwan Osman
Kat Coyte @coytelab.bsky.social · Aug 12
A new 4 year PostDoc position in our lab! Modeling + experiments to explore dynamics of carbon fixing hot-spring microbiomes. Part of an exciting multidisciplinary team with Sophie Nixon, @brockhurstlab.bsky.social & others

Please share & get in touch if interested!

tinyurl.com/e7j7bha3
Research Associate in Microbiome Ecology:Oxford Road
www.jobs.manchester.ac.uk
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Reposted by Morwan Osman
atomicvirology.bsky.social
Stephen Graham's Lab @atomicvirology.bsky.social · Aug 11
Now published in @embomolmed.org 🥳🎉
Protein-based tools for detection and characterisation of #Oropouche virus infection...
See the final paper at doi.org/10.1038/s443... and read the bluetorial 👇
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Reposted by Morwan Osman
greening.bsky.social
Chris Greening @greening.bsky.social · Aug 8
1/3 Electricity from air! In the top journal Nano Energy today, we report the first fuel cell that makes power from air alone. We achieved this by using the enzyme Huc to oxidize ambient hydrogen. This results in a continuous low-level power from air and higher outputs with industrial waste gases.
Nanoengineered bioanode with oxygen-insensitive hydrogenase for sustainable energy harvesting from atmospheric hydrogen and waste gases
Enzymatic biofuel cells (EBFCs) utilizing hydrogenases to oxidize hydrogen offer a sustainable approach to energy conservation. However, the oxygen se…
www.sciencedirect.com
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Reposted by Morwan Osman
charliejpyle.bsky.social
charliejpyle.bsky.social @charliejpyle.bsky.social · Aug 7
Proud to present our latest work!
@tobinlab.bsky.social
@wallacewly.bsky.social
@gregorylab.bskyverified.social

Human TB granuloma transcriptional blueprints show they are dominated by SPP1 macrophages. spp1 is essential for granuloma formation in zebrafish.

journals.asm.org/doi/10.1128/...
Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation | mBio
Tuberculosis is the world’s most deadly single-pathogen infection. Its causative bacterium, Mycobacterium tuberculosis, sickens over 10 million people annually. Mycobacterial granulomas are the pathol...
journals.asm.org
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Reposted by Morwan Osman
bsacandjac.bsky.social
The British Society for Antimicrobial Chemotherapy @bsacandjac.bsky.social · Aug 4
Applications close 10 August for our paid Parliamentary Internship Programme. If you're a UK-based PhD student passionate about #AMR and infectious disease policy, this is a unique chance to gain first-hand experience in UK Parliament. Find out more and apply: bsac.org.uk/call-for-app...
Call for applications: The BSAC Parliamentary Internship Programme 2025 - The British Society for Antimicrobial Chemotherapy
bsac.org.uk
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Reposted by Morwan Osman
alanmcn1.bsky.social
Alan McNally @alanmcn1.bsky.social · Aug 4
Feels about right

www.researchprofessionalnews.com/rr-news-uk-r...
UKRI award rate halves in seven years as grant applications double - Research Professional News
Trends across research councils prompt warning that system is “overstretched or broken”
www.researchprofessionalnews.com
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Reposted by Morwan Osman
prisonculture.bsky.social
Prisonculture @prisonculture.bsky.social · Aug 3
I don't think people need to sit around wringing their hands or scrolling. We can act and do the things we want.
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Reposted by Morwan Osman
biorxiv-biophys.bsky.social
bioRxiv Biophysics @biorxiv-biophys.bsky.social · Aug 1
Assessing cellular metabolic dynamics with NAD(P)H fluorescence polarization imaging https://www.biorxiv.org/content/10.1101/2025.07.28.667273v1
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uwmadisonrna.bsky.social
Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · Jul 30
This has a neat mechanism of inhibition:
www.nature.com/articles/s41...
SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature
A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a pro...
www.nature.com
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Reposted by Morwan Osman
rocklabtb.bsky.social
Rock Lab @rocklabtb.bsky.social · Jul 29
Thanks for your leadership on this @asm.org. asm.org/articles/pol...
ASM Leads Letter on Federal Biosecurity & Biosafety Policy | ASM.org
The American Society for Microbiology leads a stakeholder letter expressing concerns on the implementation of EO 14292.
asm.org
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Reposted by Morwan Osman
kateduncan.bsky.social
Dr Katherine Duncan @kateduncan.bsky.social · Jul 22
*JOB AD*: interested in doing a postdoc in microbial metabolomics? Passionate about natural products mass spec?

Come join the group! Informal enquires welcome!

Closing Date: 19 August 2025

jobs.ncl.ac.uk/job/Newcastl...
Research Associate - Microbial Metabolomic
Research Associate - Microbial Metabolomic
jobs.ncl.ac.uk
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greening.bsky.social
Chris Greening @greening.bsky.social · Jul 25
Our article showing energy production from air alone is in PNAS today. This paper provides an ultimate biochemical proof that microbes can survive simply by 'making' energy from air (making two ATP per molecule atmospheric H2 consumed) and has biotech applications. www.pnas.org/doi/10.1073/...
ATP synthesis driven by atmospheric hydrogen concentrations | PNAS
All cells require a continuous supply of the universal energy currency, adenosine triphosphate (ATP), to drive countless cellular reactions. The un...
www.pnas.org
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Reposted by Morwan Osman
chillzaa.bsky.social
Chris H. Hill @chillzaa.bsky.social · Jul 19
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨

www.biorxiv.org/content/10.1...
A new protein-dependent riboswitch activates ribosomal frameshifting
Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...
www.biorxiv.org
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Reposted by Morwan Osman
blackinmicro.bsky.social
Black Microbiologists Assoc (Black In Micro) @blackinmicro.bsky.social · Jun 10
In a year filled with uncertainty for the future of science, we’re choosing to lead with HARMONY.💛🧫 We believe in the power of community, in raising our voices, and in caring deeply for one another. This October, join us as we create a space rooted in hope. #BlackInMicroWeek #BiM2025
The Black in Micro Week 2025 schedule announcement with a black and yellow microbe background. The flyer reads "Black Microbiologists Association presents Black in Micro Week 2025, October 14-16. Events: Mon 14, Pathways for Change; Tues 15, Careers & Research; Weds 16, Community. The Conference theme is Harmony: Hope, Alliance, Resilience, Mutual Support, Optimism, Nurturing and Yielding Progress. Registration opens soon.
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immunoah.bsky.social
ImmuNoah's Ark (Noe Rodriguez) @immunoah.bsky.social · Jul 9
I'll soon be recruiting a postdoc fellow to join us @mrclmb.bsky.social to continue developing our programme to understand neuroimmune modulation🧠🔬🧬🩸🫁
If you're interested in joining us check also @erc.europa.eu MSCA actions, @wellcometrust.bsky.social & www2.mrc-lmb.cam.ac.uk/recruitment/...
DM'me
Rising Talent Fellowship - MRC Laboratory of Molecular Biology
RISING TALENT FELLOWSHIP In 2024 the MRC Laboratory of Molecular Biology (LMB) launched the first round of their three-year fully funded fellowship for
www2.mrc-lmb.cam.ac.uk
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