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Reposted by Pedro Ortega

Nature Cell Biology @natcellbio.nature.com · Jun 13

💫NEW: Saur, Lesage et al. report that RNA:DNA hybrids arise at double-strand breaks in transcribed genes, independently of de novo recruitment of RNA polymerase II/III, as a result of DSB-induced transcriptional repression.
@lablegube.bsky.social
@cbitoulouse.bsky.social
bit.ly/4kFWGr1

Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks - Nature Cell Biology

Saur, Lesage et al. report that RNA:DNA hybrids arise at double-strand breaks in transcribed genes, independently of de novo recruitment of RNA polymerase II/III, as a result of DSB-induced transcript...

bit.ly

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Reposted by Pedro Ortega

Andrew Blackford @andrewblackford.bsky.social · 28d

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis

DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

www.biorxiv.org

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Reposted by Pedro Ortega

Daniel Durocher @durocher1.bsky.social · 28d

New work from the lab! 🔬

We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n

www.biorxiv.org/content/10.1...

Mitotic single-stranded DNA suppression by DDIAS

Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...

www.biorxiv.org

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Reposted by Pedro Ortega

Cantorlab @cantorlab.bsky.social · 28d

Happy to share new work from my lab by co-authors Peng and Lee-when BRCA1 is absent, RAD51 is busy authors.elsevier.com/sd/article/S...

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Reposted by Pedro Ortega

Sarah Moser @sarahmoser.bsky.social · Aug 13

Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...

We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

www.nature.com

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Reposted by Pedro Ortega

Tony Cesare @thecesarelab.bsky.social · Aug 4

New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...

DNA-repair-driven cell death compels us to rethink cancer therapies - Nature Reviews Molecular Cell Biology

Emerging evidence suggests that, following genotoxic therapy, it is the repair of DNA double-strand breaks, rather than the damage itself, that frequently drives cancer cell death.

www.nature.com

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Reposted by Pedro Ortega

Iván Núñez Martín @ivannm97.bsky.social · Jul 31

Excited to share my first PhD paper published in @narjournal.bsky.social! This project was led by amazing supervisor Belén Gómez González in @aguilerloop.bsky.social lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it!
Now online here 👇🏼 academic.oup.com/nar/article/...

S-phase checkpoint protects from aberrant replication fork processing and degradation

Abstract. Replication stress, a hallmark of cancer cells, is detected by checkpoint mechanisms that trigger a range of cellular responses. Among these, the

academic.oup.com

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Reposted by Pedro Ortega

Arinjay Banerjee @banerjeelab.ca · Jul 1

🚨Our new study out today in Nature Communications. Bats can asymptomatically host multiple viruses while remaining apparently healthy. Here we identify how interferon-mediated responses protect bats and identify molecular adaptations in GBP1. #LZCI
Link: www.nature.com/articles/s41...

Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity - Nature Communications

Bats harbor diverse viruses but it’s less clear how they tolerate infection. Here, by characterizing innate immune responses in bat cells the authors show that IFN-beta signaling resists antagonistic ...

www.nature.com

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Reposted by Pedro Ortega

Pedro Leão @pedroleao.bsky.social · Jun 16

"In a competitive academic world, building bridges instead of walls may be our most powerful tool to accelerate discovery and rebuild public trust in science."

I'm very happy with this article piece! 🥳

www.the-scientist.com/science-thri...

Science Thrives on Trust: Why Collaboration Is Our Greatest Strength

In a competitive academic world, building bridges instead of walls may be our most powerful tool to accelerate discovery and rebuild public trust in science.

www.the-scientist.com

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Reposted by Pedro Ortega

Dr. Thomas Martínez @thomasmartinez.bsky.social · Jun 12

These tiny proteins are super cool! 😊

www.science.org/doi/10.1126/...

www.nytimes.com/2025/06/12/s...

Shining a Light on the World of Tiny Proteins

www.nytimes.com

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Reposted by Pedro Ortega

Environmental Mutagenesis and Genomics Society @emgsus.bsky.social · Jun 3

Join us NEXT WEEK for the #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," featuring a workshop lead by Drs. Laurie Sanders and Tobias Dansen, a keynote talk by Dr. Karlene Cimprich, and more!

Register Today: emgs-us.org/event/OxiDNA...

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Reposted by Pedro Ortega

Ed Boyden @eboyden3.bsky.social · May 30

Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...

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Pedro Ortega @pedroorteg.bsky.social · May 28

Congrats! 🙌

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Pedro Ortega @pedroorteg.bsky.social · May 21

Beautiful work!

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Reposted by Pedro Ortega

altmeyerlab @altmeyerlab.bsky.social · May 21

Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...

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Reposted by Pedro Ortega

Zha Lab @zhalab.bsky.social · May 16

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...

Ku limits RNA-induced innate immunity to allow Alu-expansion in primates - Nature

Nature - Ku limits RNA-induced innate immunity to allow Alu-expansion in primates

www.nature.com

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Reposted by Pedro Ortega

Bou-Nader lab @bounaderlab.bsky.social · May 14

Happy to share yet another story back from my days as a postdoc 👇 we uncovered how the J2 antibody specifically recognizes #dsRNA. J2 is a quintessential tool used to discover #RNA, QC #RNA therapeutics and much more

Jinwei Zhang Lab @jinweizhang.bsky.social · May 12

Where and how to find fantastic new #RNAs? The J2 antibody is the gold standard to detect, map & enrich dsRNAs. Co-led by @bounaderlab.bsky.social, Kevin Juma, Ankur Bothra & Steve Leppla’s lab, we visualize how J2 recognizes dsRNA and define its epitope, specificity & bias. doi.org/10.1101/2025...

Specificity and mechanism of the double-stranded RNA-specific J2 monoclonal antibody

Double-stranded (ds) RNAs are major structural components of the transcriptome, hallmarks of viral infection, and primary triggers of innate immune responses. The J2 monoclonal antibody is the gold-st...

doi.org

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Pedro Ortega @pedroorteg.bsky.social · Apr 29

We describe how to perform Oligo-seq, a new method to map DNA motifs targeted by base editors. Validated with APOBEC3A and APOBEC3B, but adaptable to AID, CRISPR-Cas9, and more.

🧬 Full protocol 👉 www.sciencedirect.com/science/arti...

Thanks to @buissonlab.bsky.social at @ucirvine.bsky.social!

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Pedro Ortega @pedroorteg.bsky.social · Apr 17

Thanks Nibal!

Pedro Ortega @pedroorteg.bsky.social · Apr 16

Our latest study from my postdoctoral work has just been published in Science Advances!

Grateful to my mentor and collaborators who made it possible! @buissonlab.bsky.social @ucirvine.bsky.social

🔗 www.science.org/doi/10.1126/...

Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe

Upon ATR inhibition, APOBEC3B targets unprotected single-stranded DNA at replication forks, leading to fork breakage.

www.science.org

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Reposted by Pedro Ortega

Debbie Caswell @caswelldrm.bsky.social · Apr 7

I am excited to announce that my laboratory @ucl.ac.uk is now open!

We are hiring so please contact us if you are interested.

www.caswelllaboratory.com

Lung Cancer Prevention Laboratory

Pioneering research in lung cancer to improve diagnosis, treatment and prevention

www.caswelllaboratory.com

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Pedro Ortega @pedroorteg.bsky.social · Apr 7

Glad to see our PACT preprint published in @naturecomms.bsky.social!

"Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA"

Another step forward in understanding innate immunity. @buissonlab.bsky.social

🔗 www.nature.com/articles/s41...

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Reposted by Pedro Ortega

Rosado lab @rosadolab.bsky.social · Mar 27

Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells

HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.

www.science.org

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Reposted by Pedro Ortega

Isabelle @seppai99.bsky.social · Mar 26

Really excited to share my co-first author paper with @cejkalab.bsky.social looking at how/which nucleases are involved in resecting ssDNA gaps generated by PARPi!

Can’t wait to talk about our work at the DNA Replication Gaps, Cancer and Disease meeting in South Korea next month!

Vindigni Lab @vindignilab.bsky.social · Mar 26

Check out our new paper led by @seppai99.bsky.social from the Vindigni Lab in collaboration with @cejkalab.bsky.social delving into the role of nucleases resecting ssDNA gaps generated by PARPi. You can read more here: genesdev.cshlp.org/content/earl...

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Reposted by Pedro Ortega

DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · Mar 15

1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social
www.science.org/doi/10.1126/...

Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.

www.science.org

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