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Rosado lab @rosadolab.bsky.social · 3d

Congrats Felipe! I hope this is one of just many more to come!!

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Europa Press @europapress.es · 7d

#ÚLTIMAHORA | Muere a los 91 años la etóloga británica Jane Goodall

Muere a los 91 años la etóloga británica Jane Goodall

La etóloga británica Jane Goodall ha fallecido a los 91 años de edad en la ciudad estadounidense de...

www.europapress.es

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Rosado lab @rosadolab.bsky.social · 16d

Great work David! Congratulations to you and your team!

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David Landeira @davidlandeira.bsky.social · 16d

Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...

A new study suggests that aging begins in the early stages of embryo development, and not only in adulthood - Canal UGR

This work by the University of Granada, published in Nature Communications, opens up a new paradigm in biomedicine by examining the role of the BMAL1 protein in aging and the… Seguir Leyendo A new stu...

canal.ugr.es

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eric lai @lucksmith.bsky.social · 21d

congratulations to our DB colleague Maria Jasin, recognized by the Greengard Prize! when she started her lab @mskcancercenter.bsky.social, she was the first to insert DNA into a defined location of a mammalian genome! her work underlies today's CRISPR-mediated HDR. here in convo with Rick Lifton.🧬

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Rosado lab @rosadolab.bsky.social · Sep 2

Si quieres hacer una tesis doctoral en tumorogenesis asociada a la inestabilidad genética, contáctanos!!
Please RT!!

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Duxin lab @duxinlab.bsky.social · Aug 22

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

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Rosado lab @rosadolab.bsky.social · Aug 16

Totally left!!!

Rosado lab @rosadolab.bsky.social · Aug 1

Congratulations!!

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Iván Núñez Martín @ivannm97.bsky.social · Jul 31

Excited to share my first PhD paper published in @narjournal.bsky.social! This project was led by amazing supervisor Belén Gómez González in @aguilerloop.bsky.social lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it!
Now online here 👇🏼 academic.oup.com/nar/article/...

S-phase checkpoint protects from aberrant replication fork processing and degradation

Abstract. Replication stress, a hallmark of cancer cells, is detected by checkpoint mechanisms that trigger a range of cellular responses. Among these, the

academic.oup.com

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Titia Sixma @titiasixma.bsky.social · Jul 31

Happy to see this out, great work from Niels, combining kinetic analysis, cryoEM and an unexpected gain-of-function mutant, nice work from master students Jan and Nina, from Kaustav and from Alex for the kinetics
‪@oncodeinstitute.bsky.social‬,
‪@nkinl.bsky.social‬

Niels Keijzer @nkeijzer.bsky.social · Jul 31

I'm very proud that our paper, and with that the main project of my PhD, has just been published by @natcomms.nature.com! 🎉
Here, we reveal the unique, molecular mechanism by which USP1/UAF1 cleaves ubiquitin chains on PCNA, which may direct DNA damage tolerance.

doi.org/10.1038/s414...

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA - Nature Communications

DNA damage tolerance is regulated by ubiquitination of PCNA. Here, the authors present kinetic and structural studies showing that USP1/UAF1 prefers trimming K63- and K48-ubiquitin chains down over cl...

doi.org

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Nature Portfolio @natureportfolio.nature.com · Jul 31

A study in Nature shows that respiratory viruses trigger metastatic breast cancer cells to proliferate in lungs in mouse models of breast cancer. These findings are supported by human observational data. go.nature.com/4l7NZ8l #medsky 🧪

This is figure 2, which shows influenza A virus infection promotes dormant DCC proliferation and phenotypic change.

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Mathieu Lupien @matlupien.bsky.social · Jul 31

One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all.
Regardless, the paper is a must-read:

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures

Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensi…

www.sciencedirect.com

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Rosado lab @rosadolab.bsky.social · Jul 29

My grant application to follow up my research line has preliminary been accepted. Thanks to those involved in peer reviewing and to @CienciaGob for this great news! Let's keep science moving!!!

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Cassie Clarke @cassiejclarke.bsky.social · Jul 23

🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇

Cassie Clarke @cassiejclarke.bsky.social · Jul 23

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

www.embopress.org

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Julian Stingele @jstingele.bsky.social · Jul 21

Now peer reviewed and in its final form @natcomms.nature.com

www.nature.com/articles/s41...

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Jacob Corn @jcornlab.bsky.social · Feb 12

New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage.
doi.org/10.1101/2025...

doi.org

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FJI-PRECARIAS @fjiprecarios.bsky.social · Jul 8

🔴La convocatoria “Consolidación Investigadora” de este año vuelve a sufrir un recorte
📉Es un 50% menos que 2024, que a su vez ya fue recortada otro 50% respecto a 2023
👉¿Consecuencia? Aún más problemas para la estabilización @cienciagob.bsky.social @ageinves.bsky.social @dianamorantr.bsky.social
🧵

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Andrew Deans @genomestability.bsky.social · Jun 15

Really cool new cryoEM structure of RAD51 caught in the act of recombination initiation at a D-loop. elifesciences.org/reviewed-pre...

Structural mechanism of strand exchange by the RAD51 filament

elifesciences.org

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Andrew Blackford @andrewblackford.bsky.social · May 29

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

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Rosado lab @rosadolab.bsky.social · May 31

This is the reason why voting for right-hand parties must never be a choice! You 'll never know what they are capable of...

Dr. Sven-Eric Jordt #TobRegSky @sejordt.bsky.social · May 31

NIH stops development of HIV vaccine, terminates grants to consortia, including at Duke University.

www.science.org/content/arti...

‘Devasting.’ NIH cancels future funding plans for HIV vaccine consortia

Researchers decry agency’s decision just as new leads reinvigorate search for long-sought vaccine

www.science.org

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Hao Yin @haoyin.bsky.social · May 31

What is the E3 ligase/Deubiquinating enzyme for your protein?😁👇

UbiBrowser 2.0: a proteome-wide known & predicted E3/DUB-substrate interactions (~4k/1k & 1900k/300k) database in 39 eukaryotic species

ubibrowser.bio-it.cn/ubibrowser_v...

#NucAcisRes 2022
academic.oup.com/nar/article/...

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Elisabeth Bik - Perpetrator 5, a fraudulent microbiologist @elisabethbik.bsky.social · May 16

What a great day to be at @childrensphila.bsky.social and @pennmedicine.bsky.social

Published today:

www.nejm.org/doi/full/10....

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Rosado lab @rosadolab.bsky.social · May 15

Investigadores sevillanos descubren un mecanismo que causa fragilidad cromosómica en la anemia de Fanconi www.diariodesevilla.es/sevilla/inve...

Investigadores sevillanos descubren un mecanismo que causa fragilidad cromosómica en la anemia de Fanconi

El hallazgo ha sido liderado por el departamento de Genética de la Universidad de Sevilla y el Instituto Cabimer

www.diariodesevilla.es

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Andrew Deans @genomestability.bsky.social · May 15

I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org

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