Olive Laprévote
@pestofasta.bsky.social
Protein Design enthusiast
He/She/They
He/She/They
Reposted by Olive Laprévote
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
December 2, 2025 at 9:02 PM
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
Reposted by Olive Laprévote
Been excited about this one for a while! What would you do with a new alphabet and the wealth of protein sequence bioinformatics at your disposal? We're also around at #EMBOComp3D Heidelberg and MLSB Copenhagen this week to discuss
Fresh from bioRxiv our latest work introducing The Embedded Alphabet (TEA), a powerful new representation for protein sequences obtained by discretising ESM2 embeddings into 20 characters.
Pre-print: www.biorxiv.org/content/10.1...
🧵👇(1/n)
Pre-print: www.biorxiv.org/content/10.1...
🧵👇(1/n)
Rewriting protein alphabets with language models
Detecting remote homology with speed and sensitivity is crucial for tasks like function annotation and structure prediction. We introduce a novel approach using contrastive learning to convert protein...
www.biorxiv.org
December 1, 2025 at 10:58 AM
Been excited about this one for a while! What would you do with a new alphabet and the wealth of protein sequence bioinformatics at your disposal? We're also around at #EMBOComp3D Heidelberg and MLSB Copenhagen this week to discuss
Reposted by Olive Laprévote
New 🧬✂️ pre-print! We show that paired prime editing can efficiently generate large deletions — even >1 Mb — with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome.
🔗 biorxiv.org/content/10.1...
A short thread (by Juliane Weller)👇
🔗 biorxiv.org/content/10.1...
A short thread (by Juliane Weller)👇
Generating long deletions across the genome with pooled paired prime editing screens
Engineered deletions are a powerful probe for studying genome architecture, function, and regulation. Yet, the lack of effective methods to create them in large numbers and at multi-kilobase scale has...
biorxiv.org
November 5, 2025 at 2:17 PM
New 🧬✂️ pre-print! We show that paired prime editing can efficiently generate large deletions — even >1 Mb — with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome.
🔗 biorxiv.org/content/10.1...
A short thread (by Juliane Weller)👇
🔗 biorxiv.org/content/10.1...
A short thread (by Juliane Weller)👇
Reposted by Olive Laprévote
📣New CRC 1357 Publication: The Key to Enzymatic Degradation of Polybutylene Terephthalate (PBT): Influence of Semicrystalline Properties on Degradation
doi.org/10.1002/cssc...
doi.org/10.1002/cssc...
The Key to Enzymatic Degradation of Polybutylene Terephthalate (PBT): Influence of Semicrystalline Properties on Degradation
This study demonstrates that enzymatic degradation of polybutylene terephthalate (PBT) can be achieved by tuning PBT's semicrystalline properties and incubation conditions. Polymers with a high conte....
doi.org
November 3, 2025 at 4:29 PM
📣New CRC 1357 Publication: The Key to Enzymatic Degradation of Polybutylene Terephthalate (PBT): Influence of Semicrystalline Properties on Degradation
doi.org/10.1002/cssc...
doi.org/10.1002/cssc...
Reposted by Olive Laprévote
📣New CRC 1357 Publication: Congrats to Onur Turak, Protein Design @birtehoecker.bsky.social, & co-authors and their new article: A third type of PETase from the marine Halopseudomonas lineage
Structure & sequence features of type III PETases reported!
onlinelibrary.wiley.com/doi/10.1002/...
Structure & sequence features of type III PETases reported!
onlinelibrary.wiley.com/doi/10.1002/...
A third type of PETase from the marine Halopseudomonas lineage
The enzymatic degradation of polyethylene terephthalate (PET) offers a sustainable solution for PET recycling. Over the past two decades, more than 100 PETases have been characterized, primarily exhi...
onlinelibrary.wiley.com
September 30, 2025 at 11:54 AM
📣New CRC 1357 Publication: Congrats to Onur Turak, Protein Design @birtehoecker.bsky.social, & co-authors and their new article: A third type of PETase from the marine Halopseudomonas lineage
Structure & sequence features of type III PETases reported!
onlinelibrary.wiley.com/doi/10.1002/...
Structure & sequence features of type III PETases reported!
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Olive Laprévote
Explore PDB-themed #Inktober #SciArt images from structural biologist Irina Bezsonova from (2023 and 2022)
PDB101: Irina Bezsonova Gallery
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb101.rcsb.org
September 30, 2025 at 4:55 PM
Reposted by Olive Laprévote
This database aggregates over 1 millisecond of unbiased MD simulations across >700 systems, including mAbs and protein-ligand complexes dynarepo.inria.fr However...
DynaRepo: The repository of macromolecular conformational dynamics
Proteins, RNA, and DNA are central to virtually all cellular processes, often assembling into macromolecular complexes to perform their functions. While these molecules are inherently dynamic, most me...
www.biorxiv.org
August 21, 2025 at 1:41 PM
This database aggregates over 1 millisecond of unbiased MD simulations across >700 systems, including mAbs and protein-ligand complexes dynarepo.inria.fr However...
Reposted by Olive Laprévote
Nobody is commenting on this little nugget from Fig 1?
July 18, 2025 at 2:55 PM
Nobody is commenting on this little nugget from Fig 1?
Reposted by Olive Laprévote
Exclusive: Famed protein structure competition nears end as NIH grant money runs out | Science | AAAS www.science.org/content/arti... 🧪
Exclusive: Famed protein structure competition nears end as NIH grant money runs out
Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold
www.science.org
July 3, 2025 at 9:18 PM
Exclusive: Famed protein structure competition nears end as NIH grant money runs out | Science | AAAS www.science.org/content/arti... 🧪
Reposted by Olive Laprévote
Physics-based design of efficient Kemp eliminases
@lynnkamerlin.bsky.social
www.nature.com/articles/s41...
@lynnkamerlin.bsky.social
www.nature.com/articles/s41...
June 19, 2025 at 9:18 PM
Physics-based design of efficient Kemp eliminases
@lynnkamerlin.bsky.social
www.nature.com/articles/s41...
@lynnkamerlin.bsky.social
www.nature.com/articles/s41...
Reposted by Olive Laprévote
🚧Open PhD position!🚧
Do you think protein machines are super cool 🤖? Would you like to design them using Nobel prize-winning methods? ➡️ Apply and choose topic 12.
www.ki.si/en/news/tend...
Position is fully funded for four years. One week left to apply.
Do you think protein machines are super cool 🤖? Would you like to design them using Nobel prize-winning methods? ➡️ Apply and choose topic 12.
www.ki.si/en/news/tend...
Position is fully funded for four years. One week left to apply.
www.ki.si
June 9, 2025 at 3:53 PM
🚧Open PhD position!🚧
Do you think protein machines are super cool 🤖? Would you like to design them using Nobel prize-winning methods? ➡️ Apply and choose topic 12.
www.ki.si/en/news/tend...
Position is fully funded for four years. One week left to apply.
Do you think protein machines are super cool 🤖? Would you like to design them using Nobel prize-winning methods? ➡️ Apply and choose topic 12.
www.ki.si/en/news/tend...
Position is fully funded for four years. One week left to apply.
Reposted by Olive Laprévote
Coot Release 1.1.16
o FEATURE: Local B-factor display
o FEATURE: Built-in logging (started) - view it by clicking the "Log" button
o FEATURE: Anisotropic probability radius scaling
o CHANGE: Boron atoms are now pinky-beige (like Jmol)
#coot
o FEATURE: Local B-factor display
o FEATURE: Built-in logging (started) - view it by clicking the "Log" button
o FEATURE: Anisotropic probability radius scaling
o CHANGE: Boron atoms are now pinky-beige (like Jmol)
#coot
June 5, 2025 at 9:11 AM
Coot Release 1.1.16
o FEATURE: Local B-factor display
o FEATURE: Built-in logging (started) - view it by clicking the "Log" button
o FEATURE: Anisotropic probability radius scaling
o CHANGE: Boron atoms are now pinky-beige (like Jmol)
#coot
o FEATURE: Local B-factor display
o FEATURE: Built-in logging (started) - view it by clicking the "Log" button
o FEATURE: Anisotropic probability radius scaling
o CHANGE: Boron atoms are now pinky-beige (like Jmol)
#coot
Reposted by Olive Laprévote
We (@sacquin-mo.bsky.social, Chantal Prevost and I) teamed up with @etiennereboul.bsky.social and @ataly.bsky.social to design a parallelized MDAKit implementation of the Proteic Menger Curvatures. Local protein dynamics and backbone flexibility have never been easier and faster to compute 😁
Menger_Curvature : a MDAKit implementation to decipher the dynamics, curvatures and flexibilities of polymeric backbones at the residue level https://www.biorxiv.org/content/10.1101/2025.04.04.647214v1
April 11, 2025 at 11:46 AM
We (@sacquin-mo.bsky.social, Chantal Prevost and I) teamed up with @etiennereboul.bsky.social and @ataly.bsky.social to design a parallelized MDAKit implementation of the Proteic Menger Curvatures. Local protein dynamics and backbone flexibility have never been easier and faster to compute 😁
Reposted by Olive Laprévote
Great talks & discussions at the 76th Mosbacher Kolloquium last week - in particular fantastic Lynen Lecture by Tanja Kortemme @kortemmelab.bsky.social and Eduard-Buchner award lecture by Dorothee Kern! And great to see so many old and new friends. @gbmev.bsky.social
March 24, 2025 at 9:55 PM
Great talks & discussions at the 76th Mosbacher Kolloquium last week - in particular fantastic Lynen Lecture by Tanja Kortemme @kortemmelab.bsky.social and Eduard-Buchner award lecture by Dorothee Kern! And great to see so many old and new friends. @gbmev.bsky.social
Reposted by Olive Laprévote
Birte Höcker opens the 76. Mosbacher Kolloquium. We look forward to learning a lot about AI and the (r)evolution of protein folding in the next three days!
March 20, 2025 at 7:59 AM
Birte Höcker opens the 76. Mosbacher Kolloquium. We look forward to learning a lot about AI and the (r)evolution of protein folding in the next three days!
Reposted by Olive Laprévote
Feodor-Lynen-Lecture delivered by Tanja Kortemme (UCSF) at the Mosbacher Kolloquium. Congratulations!
March 20, 2025 at 6:44 PM
Feodor-Lynen-Lecture delivered by Tanja Kortemme (UCSF) at the Mosbacher Kolloquium. Congratulations!
Reposted by Olive Laprévote
Had a great time at the Mosbacher Colloquium 2025—fantastic science, engaging discussions, and lots of inspiration. Shoutout to Anna and Hubert for taking the stage and board with their work!!!
March 22, 2025 at 10:01 AM
Had a great time at the Mosbacher Colloquium 2025—fantastic science, engaging discussions, and lots of inspiration. Shoutout to Anna and Hubert for taking the stage and board with their work!!!
GIMP 3.0 is released!!!! LET’S GOOOOO! ❤️🔥
Version 3.0 of the GNU Image Manipulation Program (GIMP) is released!
www.gimp.org/news/2025/03...
Congratulations and thank you to all who helped in any way to make this real!
www.gimp.org/news/2025/03...
Congratulations and thank you to all who helped in any way to make this real!
GIMP - GIMP 3.0 Released
Release notes for GIMP 3.0
www.gimp.org
March 18, 2025 at 9:23 AM
GIMP 3.0 is released!!!! LET’S GOOOOO! ❤️🔥
Reposted by Olive Laprévote
From octopuses to snails, the complicated molluscan family tree has now been mapped in unprecedented detail, researchers report in Science.
This includes sequences for 13 new complete genomes from across the phylum. scim.ag/3DrGAkg
This includes sequences for 13 new complete genomes from across the phylum. scim.ag/3DrGAkg
A genome-based phylogeny for Mollusca is concordant with fossils and morphology
Extreme morphological disparity within Mollusca has long confounded efforts to reconstruct a stable backbone phylogeny for the phylum. Familiar molluscan groups—gastropods, bivalves, and cephalopods—e...
scim.ag
March 5, 2025 at 4:11 PM
From octopuses to snails, the complicated molluscan family tree has now been mapped in unprecedented detail, researchers report in Science.
This includes sequences for 13 new complete genomes from across the phylum. scim.ag/3DrGAkg
This includes sequences for 13 new complete genomes from across the phylum. scim.ag/3DrGAkg
Reposted by Olive Laprévote
How do distal mutations contribute to enzyme catalysis?
Our new study, in collaboration with @thompson-lab.bsky.social, Marc Garcia-Borràs, and @ferranfeixas.bsky.social, reveals how they optimize structural dynamics & local electric fields to drive the catalytic cycle. 🧵👇
Our new study, in collaboration with @thompson-lab.bsky.social, Marc Garcia-Borràs, and @ferranfeixas.bsky.social, reveals how they optimize structural dynamics & local electric fields to drive the catalytic cycle. 🧵👇
February 27, 2025 at 9:16 PM
How do distal mutations contribute to enzyme catalysis?
Our new study, in collaboration with @thompson-lab.bsky.social, Marc Garcia-Borràs, and @ferranfeixas.bsky.social, reveals how they optimize structural dynamics & local electric fields to drive the catalytic cycle. 🧵👇
Our new study, in collaboration with @thompson-lab.bsky.social, Marc Garcia-Borràs, and @ferranfeixas.bsky.social, reveals how they optimize structural dynamics & local electric fields to drive the catalytic cycle. 🧵👇
Pro Tip: this is the day you can ask your significant other "Will you be my Sam?"
February 26, 2025 at 8:28 PM
Pro Tip: this is the day you can ask your significant other "Will you be my Sam?"
Reposted by Olive Laprévote
petitions.senat.fr/initiatives/...
⚠️ Hésitez pas à signer la pétition demandant le retrait de la réforme sur le TVA qui risque de décimer l'activité des freelances et micro-entreprises. 🙏
⚠️ Hésitez pas à signer la pétition demandant le retrait de la réforme sur le TVA qui risque de décimer l'activité des freelances et micro-entreprises. 🙏
Pétition demandant la suppression de la baisse de la franchise en base de TVA à 25 000 € - Pétition demandant la suppression de la baisse de la franchise en base de TVA à 25 000 € - e-pétitions du Sén...
La Loi de Finances 2025 validée le 03 février 2025 par l’utilisation de l’article 49.3 de la constitution par le gouvernement inclut un amendement visant à modifier l'article 293b du Code Général des ...
petitions.senat.fr
February 21, 2025 at 11:05 PM
petitions.senat.fr/initiatives/...
⚠️ Hésitez pas à signer la pétition demandant le retrait de la réforme sur le TVA qui risque de décimer l'activité des freelances et micro-entreprises. 🙏
⚠️ Hésitez pas à signer la pétition demandant le retrait de la réforme sur le TVA qui risque de décimer l'activité des freelances et micro-entreprises. 🙏
I reviewed this work for my lab when it was still a preprint! So happy to see it published now! 🤩
(Also happy to see my good taste confirmed by this being published in Science. Which journal it’s published in shouldn’t matter buuuut… 😬🤷♀️)
Anyways, 100% worth reading. It’s a bundle of good ideas!
(Also happy to see my good taste confirmed by this being published in Science. Which journal it’s published in shouldn’t matter buuuut… 😬🤷♀️)
Anyways, 100% worth reading. It’s a bundle of good ideas!
Curious about how ensembles have shaped our fundamental understanding of enzyme mechanisms? Check out this amazing work led by Siyuan Du, now published! Congrats all!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
February 18, 2025 at 8:26 PM
I reviewed this work for my lab when it was still a preprint! So happy to see it published now! 🤩
(Also happy to see my good taste confirmed by this being published in Science. Which journal it’s published in shouldn’t matter buuuut… 😬🤷♀️)
Anyways, 100% worth reading. It’s a bundle of good ideas!
(Also happy to see my good taste confirmed by this being published in Science. Which journal it’s published in shouldn’t matter buuuut… 😬🤷♀️)
Anyways, 100% worth reading. It’s a bundle of good ideas!
GUYS THERE’S VMD 2.0 !!! FINALLY !!!!!! 🤤
🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization
www.ks.uiuc.edu/Research/vmd...
www.ks.uiuc.edu/Research/vmd...
February 17, 2025 at 2:38 PM
GUYS THERE’S VMD 2.0 !!! FINALLY !!!!!! 🤤
Ooooh gotta read this! 👀
Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 16, 2025 at 3:35 PM
Ooooh gotta read this! 👀