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Reposted by Raquel Garza

David Landeira @davidlandeira.bsky.social · 28d

Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.

https://nature.com/articles/s41467-025-63778-4💥

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Raquel Garza @raquelgarza.bsky.social · Sep 8

💥 New preprint! 💥
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠

What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org

#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs

Johan Jakobsson @jakobssonlab.bsky.social · Sep 7

New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.

www.biorxiv.org/content/10.1...

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease

Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...

www.biorxiv.org

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Raquel Garza @raquelgarza.bsky.social · Aug 31

Cheers @anitaada.bsky.social for some more awesome science together 🍾🌟

Check out our latest work on L1 retrotransposons and their cis acting effect in early brain development 🧠 www.cell.com/cell-genomic...

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Raquel Garza @raquelgarza.bsky.social · Aug 24

Excited to share our latest work!! 🌟🌟

Thank you for all the amazing work and congratulations to @anitaada.bsky.social and all the coauthors! 🍾

Johan Jakobsson @jakobssonlab.bsky.social · Aug 23

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.

Funded by @asapresearch.parkinsonsroadmap.org

www.cell.com/cell-genomic...

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development

Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of L1s...

www.cell.com

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Reposted by Raquel Garza

Johan Jakobsson @jakobssonlab.bsky.social · Aug 23

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.

Funded by @asapresearch.parkinsonsroadmap.org

www.cell.com/cell-genomic...

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development

Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of L1s...

www.cell.com

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Reposted by Raquel Garza

Rebecca Berrens @rberrens.bsky.social · Jul 16

Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...

Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols

Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...

doi.org

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Reposted by Raquel Garza

EMBL Events @events.embl.org · Jun 18

⏰ Abstract deadline for 'The mobile genome' is 29 July!

👉 https://s.embl.org/mge25-01-bl

Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍

⭐🧑🏼‍🔬 24 talks + 15 flash talks from posters – don't miss out!

#EMBOMobileGenome

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Raquel Garza @raquelgarza.bsky.social · Jul 9

These past 2 months as a visiting scholar at KU Leuven flew by! It has been so enriching to work side by side with #TeamVoet on @jakobssonasap.bsky.social research into Transposable Elements & Parkinson’s Disease 🧠🧬 Excited for what’s next!

#ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements

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Reposted by Raquel Garza

Johan Jakobsson @jakobssonlab.bsky.social · Mar 29

New preprint from our lab! Why is not everyone working on Transposons?

Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons

www.biorxiv.org/content/10.1...

Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons

Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and associated with the histone mark H3K9me3. Heterochromatin erosion is a hallmark of human ageing and H3K9me3 ...

www.biorxiv.org

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Reposted by Raquel Garza

ASAP Team Jakobsson @jakobssonasap.bsky.social · Mar 18

Last week, some of us from Team Jakobsson had a great time in Arizona at the 2025 CRN Collaborative Meeting! Plenty of insightful talks and networking. Shoutout to @kirkebylab.bsky.social for a fantastic talk on PSC-based therapies and models of PD 🌟🧬🏜️ #CRNPhoenix2025 @asapresearch.bsky.social

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Raquel Garza @raquelgarza.bsky.social · Mar 12

Popcorn worthy research at #CRNPhoenix2025 with
@jakobssonasap.bsky.social 🍿

#ParkinsonsDisease #PD #TEsky

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Reposted by Raquel Garza

Molly Gale (Gale-Hammell Lab) @mollygale.bsky.social · Mar 10

Super happy to announce the latest work from my lab together with Hemali Phatnani @nygenome.org & NYGC ALS Consortium!

We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes

#NIHfundedResearch
www.cell.com/cell-reports...

ALS molecular subtypes are a combination of cellular and pathological features learned by deep multiomics classifiers

O’Neill et al. present a deep exploration of molecular subtypes in ALS postmortem tissues from the NYGC ALS Consortium. Matched bulk and single-cell profiles demonstrate that ALS subtypes are a combin...

www.cell.com

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Reposted by Raquel Garza

Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · Feb 26

In this paper, CRN Team @jacksonlab.bsky.social found that LINE-1 transposable elements contribute to the complexity of the transcriptome in human pluripotent stem cells by acting as alternative promoters for approximately 100 genes.

Check out the full #preprint: shorturl.at/TJ9BK

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Raquel Garza @raquelgarza.bsky.social · Jan 23

Congrats @marliesoomen.bsky.social! 🧬🍾 Had been looking forward to see this paper since I heard of it in CSHL 🍂 Having it for JC next week 🤓

Marlies Oomen @marliesoomen.bsky.social · Jan 20

Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex...
A short thread to highlight some of our findings 🧵

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Reposted by Raquel Garza

ASAP Team Jakobsson @jakobssonasap.bsky.social · Jan 20

🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social

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Raquel Garza @raquelgarza.bsky.social · Jan 18

We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾

#TEsky #CRISPR #L1 #development #epigenetics

ASAP Team Jakobsson @jakobssonasap.bsky.social · Jan 18

🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development.

This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.

www.biorxiv.org/content/10.1...

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...

www.biorxiv.org

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Reposted by Raquel Garza

Miguel Branco @brancolab.bsky.social · Jan 9

CSH Asia is organising its first transposon meeting. Don't miss out on some great science and a fantastic trip. Abstract deadline fast approaching.
www.csh-asia.org?content/2544

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Raquel Garza @raquelgarza.bsky.social · Dec 13

Secret santa @jakobssonlab.bsky.social 🧬🎄

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Reposted by Raquel Garza

Molly Gale (Gale-Hammell Lab) @mollygale.bsky.social · Nov 18

Tracking transposable element (TE) activity in genomics data can be a pain, but there are solutions! Our lab built TEtranscripts -- which we've updated to work for small RNAs (TEsmall), bulk RNA at the locus level (TElocal), and in single-cell data (TEsingle). Check it out!

www.mghlab.org/software

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Raquel Garza @raquelgarza.bsky.social · Dec 6

Thank you Geoff!! 🌟

Raquel Garza @raquelgarza.bsky.social · Dec 5

💥🦊 So proud of being part of this team!

ASAP Team Jakobsson @jakobssonasap.bsky.social · Dec 5

We're thrilled to announce that our project has been funded by @asapresearch.bsky.social in partnership with the Michael J. Fox Foundation! 🚀 Excited to continue exploring the role of transposable elements in Parkinson’s disease. Learn more here:
www.lunduniversity.lu.se/article/52-m...

52 Million SEK towards uncovering genetic drivers of Parkinson’s Disease

Lund University. Jumping genes, or transposable elements, make up nearly half of the human genome. These mobile sequences can shift within the genome and are known to influence various biological proc...

www.lunduniversity.lu.se

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Raquel Garza @raquelgarza.bsky.social · Nov 30

Nice! Could you add me please?

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Raquel Garza @raquelgarza.bsky.social · Nov 27

🧬 🧠 Excited to see it printed! We bring key insights on the epigenetic regulation of SVAs, including SVA-XDP: a polymorphic SVA driving a rare neurodegenerative disorder

@jakobssonlab.bsky.social @vivienhorvath.bsky.social
#TEworldwide #Transposons #XDP #NSMB
+ the volume has the cutest cover 🦔

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Raquel Garza @raquelgarza.bsky.social · Apr 24

Gorgeous. Plain gorgeous jumping genes 💜👾🧬

#TEsky

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Raquel Garza @raquelgarza.bsky.social · Mar 22

Today we are showing high school students how cool things we can do using #nanopore sequencing at the #unistemday at the Lund Stem Cell Center 🧬👩‍🔬🦠🧪

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