Rhys Allan
@rhyscienceallan.bsky.social
Scientist at WEHI research, fascinated by the DNA circuitry of the immune system https://www.wehi.edu.au/researcher/rhys-allan/
Pinned
The long non-coding RNA Dreg1 is required for optimal ILC2 development
Gata3 is an essential transcription factor for the development of several distinct immune cell lineages such as T cells, natural killer (NK) cells and innate lymphoid cells (ILC). As such, the levels ...
www.biorxiv.org
I am excited to share our latest study by Sara Quon in collaboration with @ajithvasanthan.bsky.social entitled “The lncRNA Dreg1 is required for optimal ILC2 development” www.biorxiv.org/content/10.1...
Reposted by Rhys Allan
HAP2 is an ancient fusogen and used by malaria parasites for gamete fusion during fertilisation 🦟
Please check out our preprint on Plasmodium falciparum HAP2 - crystal structure of domain 3 and nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚
www.biorxiv.org/content/10.6...
Please check out our preprint on Plasmodium falciparum HAP2 - crystal structure of domain 3 and nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚
www.biorxiv.org/content/10.6...
Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium falciparum HAP2
Malaria parasites are transmitted to humans through a bite from an infected female Anopheles mosquito. Within the mosquito midgut, malaria parasite gametes are activated and undergo fertilisation. If ...
www.biorxiv.org
December 3, 2025 at 11:27 AM
HAP2 is an ancient fusogen and used by malaria parasites for gamete fusion during fertilisation 🦟
Please check out our preprint on Plasmodium falciparum HAP2 - crystal structure of domain 3 and nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚
www.biorxiv.org/content/10.6...
Please check out our preprint on Plasmodium falciparum HAP2 - crystal structure of domain 3 and nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚
www.biorxiv.org/content/10.6...
Reposted by Rhys Allan
Thank you for submitting your abstracts for Lorne Genome 2026!
We're excited to feature presentations selected from your submissions alongside talks from our invited speakers, including Prof Jose Polo, a leading expert in cellular reprogramming and epigenetics: www.lornegenome.org/jose-polo
We're excited to feature presentations selected from your submissions alongside talks from our invited speakers, including Prof Jose Polo, a leading expert in cellular reprogramming and epigenetics: www.lornegenome.org/jose-polo
December 3, 2025 at 3:04 AM
Thank you for submitting your abstracts for Lorne Genome 2026!
We're excited to feature presentations selected from your submissions alongside talks from our invited speakers, including Prof Jose Polo, a leading expert in cellular reprogramming and epigenetics: www.lornegenome.org/jose-polo
We're excited to feature presentations selected from your submissions alongside talks from our invited speakers, including Prof Jose Polo, a leading expert in cellular reprogramming and epigenetics: www.lornegenome.org/jose-polo
Reposted by Rhys Allan
New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase".
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase - Nature Communications
Telomerase recruitment to telomeres is a tightly regulated process which is stimulated by replication stress. Here, the authors identify that nuclear filamentous actin is important for interaction bet...
www.nature.com
December 3, 2025 at 12:19 AM
New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase".
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
Happy our lab could play a small part.
Congrats Tracy, Ash Harman, Noa Lamm and the whole team.
www.nature.com/articles/s41...
Reposted by Rhys Allan
A little late to this, but very happy to see this nice paper from @nilskrietenstein.bsky.social and co out now at @natcomms.nature.com 🍻 www.nature.com/articles/s41...
Deciphering histone mark-specific fine-scale chromatin organization at high resolution with Micro-C-ChIP - Nature Communications
Here, the authors introduce Micro-C-ChIP, a strategy combining Micro-C with chromatin immunoprecipitation to map 3D genome organization at nucleosome resolution for defined histone modifications.
www.nature.com
December 2, 2025 at 2:44 PM
A little late to this, but very happy to see this nice paper from @nilskrietenstein.bsky.social and co out now at @natcomms.nature.com 🍻 www.nature.com/articles/s41...
Reposted by Rhys Allan
Beyond excited to share the collaborative work with @faryabi.bsky.social led by stars Yeqiao Zhou and @atishayjay.bsky.social; Walking along thousands of chromosomes has shown us just how essential it is to measure chromatin fiber geometry to truly understand enhancer biology. tinyurl.com/2st3afwf
Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology
Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...
www.nature.com
December 2, 2025 at 3:57 PM
Beyond excited to share the collaborative work with @faryabi.bsky.social led by stars Yeqiao Zhou and @atishayjay.bsky.social; Walking along thousands of chromosomes has shown us just how essential it is to measure chromatin fiber geometry to truly understand enhancer biology. tinyurl.com/2st3afwf
Reposted by Rhys Allan
www.embopress.org/doi/full/10....
Our latest now online at EMBO Journal. Read if you are interested in how epimutations mediate antifungal resistance & how this might result in heteroresistance in human & cereal crop fungal pathogens. Big Thx & congrats to Andreas Fellas, Pin Tong & Alison Pidoux
Our latest now online at EMBO Journal. Read if you are interested in how epimutations mediate antifungal resistance & how this might result in heteroresistance in human & cereal crop fungal pathogens. Big Thx & congrats to Andreas Fellas, Pin Tong & Alison Pidoux
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance | The EMBO Journal
imageimageHeterochromatin-island epimutations can provide resistance to caffeine and antifungal
drugs in the fission yeast Schizosaccharomyces pombe. This study reveals that some epimutations cause re...
www.embopress.org
December 1, 2025 at 3:44 PM
www.embopress.org/doi/full/10....
Our latest now online at EMBO Journal. Read if you are interested in how epimutations mediate antifungal resistance & how this might result in heteroresistance in human & cereal crop fungal pathogens. Big Thx & congrats to Andreas Fellas, Pin Tong & Alison Pidoux
Our latest now online at EMBO Journal. Read if you are interested in how epimutations mediate antifungal resistance & how this might result in heteroresistance in human & cereal crop fungal pathogens. Big Thx & congrats to Andreas Fellas, Pin Tong & Alison Pidoux
Reposted by Rhys Allan
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
www.science.org
November 28, 2025 at 5:22 PM
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Reposted by Rhys Allan
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
November 27, 2025 at 9:59 PM
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Reposted by Rhys Allan
Bah, who needs cohesin if you're at the right place (near). Grover once taught us the difference between near and far (my favourite Sesame Street piece), and now amazing work from @elphegenoralab.bsky.social led by @karissalhansen.bsky.social shows us how: www.science.org/doi/10.1126/...
Synergy between regulatory elements can render cohesin dispensable for distal enhancer function
Enhancers are critical genetic elements controlling transcription from promoters, yet how they convey regulatory information across large genomic distances remains unclear. Here, we engineer pluripote...
www.science.org
November 27, 2025 at 7:10 PM
Bah, who needs cohesin if you're at the right place (near). Grover once taught us the difference between near and far (my favourite Sesame Street piece), and now amazing work from @elphegenoralab.bsky.social led by @karissalhansen.bsky.social shows us how: www.science.org/doi/10.1126/...
Reposted by Rhys Allan
I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in
@sciimmunology.bsky.social scim.ag/4o12TOZ
@sciimmunology.bsky.social scim.ag/4o12TOZ
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.
scim.ag
November 26, 2025 at 6:55 PM
I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in
@sciimmunology.bsky.social scim.ag/4o12TOZ
@sciimmunology.bsky.social scim.ag/4o12TOZ
Reposted by Rhys Allan
Interested in #3DGenomics #4Dnucleome? Like #Barcelona? Would like to enjoy doing #science and to have fun during your #PhD?
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Doctoral INPhINIT fellowships - Incoming Call 2026
We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.
lacaixafoundation.org
November 26, 2025 at 8:56 AM
Interested in #3DGenomics #4Dnucleome? Like #Barcelona? Would like to enjoy doing #science and to have fun during your #PhD?
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Reposted by Rhys Allan
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D @sciimmunology.bsky.social @vahedilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 21, 2025 at 7:41 PM
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D @sciimmunology.bsky.social @vahedilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Rhys Allan
Only 𝟏𝟐𝐡𝐫 𝐥𝐞𝐟𝐭 to submit your abstract and secure earlybird registration rates! The deadline is 𝐦𝐢𝐝𝐧𝐢𝐠𝐡𝐭 𝐅𝐫𝐢𝐝𝐚𝐲 𝟐𝟏 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫. Don't forget to apply for awards if you're eligible! www.lornegenome.org/registrations
Registrations — Lorne Genome
Registrations are now open! Secure your ticket to attend Lorne Genome 2022!
www.lornegenome.org
November 21, 2025 at 12:54 AM
Only 𝟏𝟐𝐡𝐫 𝐥𝐞𝐟𝐭 to submit your abstract and secure earlybird registration rates! The deadline is 𝐦𝐢𝐝𝐧𝐢𝐠𝐡𝐭 𝐅𝐫𝐢𝐝𝐚𝐲 𝟐𝟏 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫. Don't forget to apply for awards if you're eligible! www.lornegenome.org/registrations
Reposted by Rhys Allan
We are excited to welcome 𝐀/𝐏𝐫𝐨𝐟 𝐉𝐞𝐧𝐧 𝐁𝐫𝐨𝐩𝐡𝐲 as an invited speaker at Lorne Genome 2026, whose lab uses genetic engineering of plants and their microbiomes to uncover stress resilience mechanisms and advance agricultural innovation https://www.lornegenome.org/jenn-brophy
November 20, 2025 at 7:26 AM
We are excited to welcome 𝐀/𝐏𝐫𝐨𝐟 𝐉𝐞𝐧𝐧 𝐁𝐫𝐨𝐩𝐡𝐲 as an invited speaker at Lorne Genome 2026, whose lab uses genetic engineering of plants and their microbiomes to uncover stress resilience mechanisms and advance agricultural innovation https://www.lornegenome.org/jenn-brophy
Reposted by Rhys Allan
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Reposted by Rhys Allan
The Medical Research Future Fund (MRFF) funds medical research in Australia. Only half the funds have been released. If you're an Australian and able to vote please use the form below to email your local MP to release the full amount of the MRFF
aamri.org.au/mrff/
aamri.org.au/mrff/
Half the Funding. Half the Future. - AAMRI
The Medical Research Future Fund (MRFF) was designed to deliver $1 billion each year in new, lifesaving funding for medical research. We know through financial modelling that the full amount can be re...
aamri.org.au
November 16, 2025 at 9:14 PM
The Medical Research Future Fund (MRFF) funds medical research in Australia. Only half the funds have been released. If you're an Australian and able to vote please use the form below to email your local MP to release the full amount of the MRFF
aamri.org.au/mrff/
aamri.org.au/mrff/
Reposted by Rhys Allan
Excited to share matchbox. It’s super fast and versatile to search for patterns in reads, I’m curious to see all the uses it will find!
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...
November 18, 2025 at 1:26 AM
Excited to share matchbox. It’s super fast and versatile to search for patterns in reads, I’m curious to see all the uses it will find!
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...
Reposted by Rhys Allan
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
November 15, 2025 at 9:53 AM
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Proud to contribute to this important supplement! The burden of asthma is too high. We need to stretch for a CURE!!!
The CURE Asthma initiative is an unprecedented opportunity for accelerating the translation of research findings and bringing curative therapies within reach.
Available now as a supplement in the MJA
buff.ly/BK7aPac
Available now as a supplement in the MJA
buff.ly/BK7aPac
November 17, 2025 at 9:17 AM
Proud to contribute to this important supplement! The burden of asthma is too high. We need to stretch for a CURE!!!
Reposted by Rhys Allan
Wonderful to see the beautiful preprint from Sabate et al now published - TADs are also dynamic structures in human cells, with remarkably similar parameters between mESCs and HCT116 cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 15, 2025 at 5:24 PM
Wonderful to see the beautiful preprint from Sabate et al now published - TADs are also dynamic structures in human cells, with remarkably similar parameters between mESCs and HCT116 cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Rhys Allan
In this episode we talked with @andersshansen.bsky.social from MIT about his work on the impact of 3D genome structures on gene expression and advanced techniques like Region Capture Micro-C for mapping genome organisation. #podcast #epigenetics
Listen here: activemotif.com/podcasts-and...
Listen here: activemotif.com/podcasts-and...
November 14, 2025 at 8:01 AM
In this episode we talked with @andersshansen.bsky.social from MIT about his work on the impact of 3D genome structures on gene expression and advanced techniques like Region Capture Micro-C for mapping genome organisation. #podcast #epigenetics
Listen here: activemotif.com/podcasts-and...
Listen here: activemotif.com/podcasts-and...
Reposted by Rhys Allan
New WEHI research shows caspase-8 is a driver of severe COVID-19 through modulation of inflammation, but not through induction of apoptosis.
The landmark study is the first to clarify the protein's role in COVID disease in vivo.
Published in Nature Communications.
rdcu.be/ePJoA
🧵1/2
The landmark study is the first to clarify the protein's role in COVID disease in vivo.
Published in Nature Communications.
rdcu.be/ePJoA
🧵1/2
November 14, 2025 at 1:00 AM
New WEHI research shows caspase-8 is a driver of severe COVID-19 through modulation of inflammation, but not through induction of apoptosis.
The landmark study is the first to clarify the protein's role in COVID disease in vivo.
Published in Nature Communications.
rdcu.be/ePJoA
🧵1/2
The landmark study is the first to clarify the protein's role in COVID disease in vivo.
Published in Nature Communications.
rdcu.be/ePJoA
🧵1/2
Reposted by Rhys Allan
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Rhys Allan
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Rhys Allan
Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program @cp-immunity.bsky.social @monashuniversity.bsky.social www.cell.com/immunity/ful...
November 4, 2025 at 5:46 PM
Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program @cp-immunity.bsky.social @monashuniversity.bsky.social www.cell.com/immunity/ful...