During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

Nature - Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining...

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...

Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the im...

APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.

Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

In 2019, scientists discovered Jo Cameron, a Scottish woman with a rare genetic mutation that prevents her from feeling pain, anxiety, or fear and allows her to heal without scarring. This condition...

NYU Langone researchers have helped an 8-year-old boy regain mobility using an experimental treatment.

Cancers use lipids to build a shield with vitamin E. Stripping that shield could lead to new treatments.

Uridine is a pyrimidine nucleoside composed of an uracil base and a ribose sugar. In cells, uridine is predominantly present in RNA (as uridine monophosphate, UMP). Uridine can be produced through de ...

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.

Zhang et al. identify a regulatory mechanism for how cells adapt to nutrient scarcity through widespread −1 ribosomal frameshifts, culminating in accelerated mRNA decay. This process, dependent on codon optimality and conserved across species, establishes direct feedback coupling the translation of new proteins with the stability of the mRNA that encodes for them.

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

Cuts and layoffs to the National Institutes of Health threaten medical research around the U.S., agency insiders warn.

In the 1970’s I was probably one of the last American high school students who was told that if you wanted to go to medical school, you should learn to speak German. This was because in the late 19th ...