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Reposted by Ricardo Leon-Sampedro

Manuel Ares-Arroyo @aresarroyom.bsky.social · Apr 4

Do restriction-modification systems shape plasmid sequence composition? A group of plasmid-aficionados, led by Liam Shaw, started to explore this during the 2023 @embo.org Workshop on Plasmids in Trieste. Happy to have contributed to this work and be part of such a great team!

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Apr 4

The leading region of many conjugative plasmids is depleted in restriction-modification targets https://www.biorxiv.org/content/10.1101/2025.04.03.647016v1

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Reposted by Ricardo Leon-Sampedro

Jerónimo Rodríguez-Beltrán @jerorb.bsky.social · Apr 2

Really looking forward to this!!

👇

Ricardo Leon-Sampedro @rleonsampedro.bsky.social · Apr 2

🚨 Seminar at ETH this Thursday! 🚨

Join Dr. Jerónimo Rodríguez-Beltrán (@jerorb.bsky.social) for a talk on how plasmids shape antibiotic resistance.

Plasmid evolution: a (copy) numbers game

🗓 April 3rd | 🕙 10:00–11:00
📍 CHN F42, ETH Zurich

evodynamicslab.com

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Ricardo Leon-Sampedro @rleonsampedro.bsky.social · Apr 2

🚨 Seminar at ETH this Thursday! 🚨

Join Dr. Jerónimo Rodríguez-Beltrán (@jerorb.bsky.social) for a talk on how plasmids shape antibiotic resistance.

Plasmid evolution: a (copy) numbers game

🗓 April 3rd | 🕙 10:00–11:00
📍 CHN F42, ETH Zurich

evodynamicslab.com

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Reposted by Ricardo Leon-Sampedro

Csaba Pal Laboratory @csabapallab.bsky.social · Jan 13

🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is published in @naturemicrobiol.bsky.social. For details, see the 🧵below and read the paper here: www.nature.com/articles/s41...

ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology

An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...

www.nature.com

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Reposted by Ricardo Leon-Sampedro

Csaba Pal Laboratory @csabapallab.bsky.social · Feb 24

🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...

Exploring the principles behind antibiotics with limited resistance - Nature Communications

This study shows that only those dual-targeting antibiotics limit resistance in Gram-negative pathogens that also target the membrane of the bacteria. This mechanism provides a basis for designing fut...

www.nature.com

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Ricardo Leon-Sampedro @rleonsampedro.bsky.social · Feb 28

We kicked off this semester's #SMEE with two great talks by @dnasaur.bsky.social and @phagemuffin.bsky.social. @usyseth.bsky.social

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Reposted by Ricardo Leon-Sampedro

Olaya Rendueles @olayarendueles.bsky.social · Dec 19

Really glad I could contribute to this work exploring biofilm formation, mucoidy and tip adhesin diversity in #klebsiella.
For those in #KLEBS2024, I provided a sneak peak of the potential relation between K3 serotype & HMV
This is also my first publication since I joined @cbitoulouse.bsky.social !

Fleeman Lab @fleemanlab.bsky.social · Dec 19

Check out our latest publication aligning the MRSN panel biofilm and mucoid phenotypes to the genotypes in npj Biofilms and Microbiomes!

Special thanks to my collaborators on this work
@olayarendueles.bsky.social and Taj Azarian!

www.nature.com/articles/s41...

Diverse polysaccharide production and biofilm formation abilities of clinical Klebsiella pneumoniae - npj Biofilms and Microbiomes

npj Biofilms and Microbiomes - Diverse polysaccharide production and biofilm formation abilities of clinical Klebsiella pneumoniae

www.nature.com

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Reposted by Ricardo Leon-Sampedro

Aswin Krishna @krishnaaswin77.bsky.social · Dec 19

Really happy to see this paper out. Extra special for me because it marks my first research publication. Aswin has officially entered the academic world! 📈🦠🧑‍💻

Noelle Held @proteocean.bsky.social · Dec 18

What does it really mean to be in nutrient colimitation? We demonstrate a distinct growth phenotype and that (co)limitation can (and should!) be quantified. The result of many late afternoon chats with @michaelmanhart.bsky.social. Let us know what you think! www.pnas.org/doi/10.1073/pnas.2400304121

www.pnas.org

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Ricardo Leon-Sampedro @rleonsampedro.bsky.social · Dec 18

New paper from our group in @pnas.org!! 🚀
Malte Mütter used our amazing liquid-handling robot to test different treatment strategies and found that combination therapy is the most effective to prevent the emergence of plasmid-mediated double resistance www.pnas.org/doi/10.1073/...

The impact of treatment strategies on the epidemiological dynamics of plasmid-conferred antibiotic resistance | PNAS

The issue of antibiotic resistance is a critical concern for public health, prompting numerous investigations into the impact of treatment strategi...

www.pnas.org

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Reposted by Ricardo Leon-Sampedro

Simona Huwiler @simonahuwiler.bsky.social · Nov 11

Can E.coli 🦠 escape from predation by ‘living antibiotic’ 💊B.bacteriovorus, a predatory bacterium ?
A first preprint from my lab for people interested in: #MicroSky, #Evolution and new ways to treat #AMR and #Bdellovibrio

www.biorxiv.org/content/10.1...

Some findings in the following thread:

Outer membrane changes enable evolutionary escape from bacterial predation

To combat antimicrobial resistant pathogens, natural predatory bacteria, like Bdellovibrio bacteriovorus , represent potential alternatives. B. bacteriovorus could be particularly potent as it kills a...

www.biorxiv.org

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Reposted by Ricardo Leon-Sampedro

Jana Huisman @jhuisman.bsky.social · Oct 22

Should I stay or should I go? 🎵

In a new opinion piece, Claudia Igler, Andrina Bernhard and I discuss how conjugative plasmids and temperate bacteriophages balance vertical and horizontal transmission: ecoevorxiv.org/repository/v...

Our framework sheds light on many aspects of MGE biology (1/7)

Should I stay or should I go: Transmission trade-offs in mobile genetic elements

ecoevorxiv.org

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Reposted by Ricardo Leon-Sampedro

Olaya Rendueles @olayarendueles.bsky.social · Dec 12

Next in my To Read list!
Surely great & thorough work from Alex Hall, led by @rleonsampedro.bsky.social Read his thread here 👇🏻👇🏻

Ricardo Leon-Sampedro @rleonsampedro.bsky.social · Dec 11

🚨 New preprint!! How can antibiotic-resistant bacteria increase in abundance in the human gut microbiome, even without antibiotics? 🧐 We show that strain-specific ecological interactions are key to understanding resistance dynamics in microbial communities. 🧵👇 1/5
www.biorxiv.org/content/10.1...

www.biorxiv.org

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Reposted by Ricardo Leon-Sampedro

Mike Bottery @mbottery.bsky.social · Dec 16

New in Nature Comms, we show that azole-resistant Aspergillus fumigatus are more likely to evolve resistance to new antifungals due to variants in their DNA mismatch repair system rdcu.be/d3Iyc @natureportfolio.bsky.social #microsky #fungi #amr

Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance

Nature Communications - Here, Bottery et al show that resistance to next generation antifungals is more likely to occur within azole resistant Aspergillus fumigatus due to the close linkage between...

rdcu.be

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Reposted by Ricardo Leon-Sampedro

Alvaro Sanchez @asanchezlab.bsky.social · Dec 16

Nora finished her paper with a sentence I like a lot "Our results show that even under extremely restrictive, competitive conditions, the simplest biological entities on Earth can still find paths to coexistence." There is a curious dichotomy in her experiments... 1/3
www.science.org/doi/10.1126/...

Diverse phage communities are maintained stably on a clonal bacterial host

Bacteriophages are the most abundant and phylogenetically diverse biological entities on Earth, yet the ecological mechanisms that sustain this extraordinary diversity remain unclear. In this study, w...

www.science.org

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Reposted by Ricardo Leon-Sampedro

Gleb Ebert @gl-eb.me · Dec 16

New preprint by the group I am doing my PhD in: “Chromosomal plasticity can drive rapid adaptation in bacteria”.

This is the first chapter of Ever Vega-Cabrera's thesis and has been in the works for a long time.

https://doi.org/10.1101/2024.12.11.627208 […]

Original post on mstdn.science

mstdn.science

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Reposted by Ricardo Leon-Sampedro

Célia Souque @celiasouque.bsky.social · Nov 22

Very glad to see this properly out and open access from my time with @baym.lol We've learnt so much about antibiotic resistance evolution already, and yet so many outstanding and fascinating questions remain, at all levels of selection.
www.annualreviews.org/content/jour...

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Alan McNally @alanmcn1.bsky.social · Dec 12

Possible explains our displacement papers

www.sciencedirect.com/science/arti...

journals.plos.org/plosbiology/...

Ricardo Leon-Sampedro @rleonsampedro.bsky.social · Dec 11

🚨 New preprint!! How can antibiotic-resistant bacteria increase in abundance in the human gut microbiome, even without antibiotics? 🧐 We show that strain-specific ecological interactions are key to understanding resistance dynamics in microbial communities. 🧵👇 1/5
www.biorxiv.org/content/10.1...

www.biorxiv.org

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Ricardo Leon-Sampedro @rleonsampedro.bsky.social · Dec 12

Thanks for sharing, Alan. Your findings on displacement dynamics align well with what we see: strain-specific competition shapes community composition and resistance dynamics.

Reposted by Ricardo Leon-Sampedro

Tatiana Dimitriu @tatianadimitriu.bsky.social · Dec 11

PhD opportunity in St Andrews on plasmids, antibiotics and defence systems, in collaboration with Helen Alexander in Edinburgh. Funding via BBSRC EastBio, please share & pass on to anyone interested! #microsky🦠🧫🧬
www.findaphd.com/phds/project...

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Ricardo Leon-Sampedro @rleonsampedro.bsky.social · Dec 11

Thanks Rachel!!

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Reposted by Ricardo Leon-Sampedro

Typas Lab @typaslab.bsky.social · Dec 2

Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics - Nature Microbiology

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. This study presents an approach to systematically discover and ...

www.nature.com

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Reposted by Ricardo Leon-Sampedro

Elisabetta Cacace @elisca.bsky.social · Dec 2

Interested in antibiotic cross-resistance/sensitivity? Tired of experimental evolution? Then check our new story led by brilliant @nazgulsakenova.bsky.social, now out on Nature Microbiology @naturemicrobiol.bsky.social !

Typas Lab @typaslab.bsky.social · Dec 2

Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics - Nature Microbiology

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. This study presents an approach to systematically discover and ...

www.nature.com

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Ricardo Leon-Sampedro @rleonsampedro.bsky.social · Dec 11

Why it matters: Understanding these interactions can inform strategies to identify and manage high-risk clones in clinical and community settings. 5/5

Ricardo Leon-Sampedro @rleonsampedro.bsky.social · Dec 11

Resistant strains also reshaped the microbiota, driving distinct changes in bacterial community composition. These strain-specific effects reveal how ecological interactions shape resistance dynamics and community structure. 4/5

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