Lightnews — Scholar-powered news

Roychoudhuri Lab @roychoudhurilab.bsky.social · 2d

Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.

2 8

Reposted by Roychoudhuri Lab

Seth Thomas Scanlon @immunoeditor.bsky.social · 19d

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

Nuclear polarization to the immune synapse facilitates an early transcriptional burst

Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.

www.science.org

5 26

Roychoudhuri Lab @roychoudhurilab.bsky.social · 19d

The new #ALASCCA RCT shows that low-dose aspirin prevents metastatic recurrence by ~50% in patients with PI3K altered colorectal cancer #aspirin #metastasis #prevention

4

Roychoudhuri Lab @roychoudhurilab.bsky.social · 26d

A fantastic 2 days in Lille thinking T cell therapy at CAR T Day - the 9th international symposium on CAR T cells cartday.org. Thanks to Suman Mitra for the invitation to share our new data

CAR T Day

International Symposium on CAR T Cells

cartday.org

3

Roychoudhuri Lab @roychoudhurilab.bsky.social · Aug 14

Our total energy (electricity) bill for heating and the all other used was £1700 last year! We have described our experience with it here: sites.google.com/view/becomin...

Put in a heatpump this summer! You’ll not look back!

https://sites.google.com/view/becoming-sustainable/home…

1 1

Roychoudhuri Lab @roychoudhurilab.bsky.social · Aug 14

Cool to see so many #heatpumps being installed this year. We’ve had our heatpump at home now for 3 years and it’s been saving us money while providing more comfortable heating and reducing our estimated CO2e by 75-80%.

2 2 5

Roychoudhuri Lab @roychoudhurilab.bsky.social · Aug 7

Please sign: petition.parliament.uk/petitions/72...

Petition: Review all trade ties with Israel, suspend 2030 roadmap & impose trade sanctions

We call on the Government to review existing trade ties with Israel, suspend the 2030 Roadmap for UK-Israel bilateral relations and impose trade sanctions upon Israel.

petition.parliament.uk

3

Roychoudhuri Lab @roychoudhurilab.bsky.social · Aug 5

Please sign this Parliamentary petition calling for comprehensive trade sanctions on Israel - the limited sanctions on specific members of the Israeli Government by the UK do not go far enough: petition.parliament.uk/petitions/72...

Petition: Review all trade ties with Israel, suspend 2030 roadmap & impose trade sanctions

We call on the Government to review existing trade ties with Israel, suspend the 2030 Roadmap for UK-Israel bilateral relations and impose trade sanctions upon Israel.

petition.parliament.uk

4 6

Roychoudhuri Lab @roychoudhurilab.bsky.social · Jul 31

www.thelancet.com/journals/lan...

2

Roychoudhuri Lab @roychoudhurilab.bsky.social · May 21

The limited set of sanctions the UK has placed on specific individuals in Israel is not enough. Comprehensive sanctions needed to pressure the Israeli govt to reverse course in #Gaza. Please sign this petition to Parliament: #StopIsraelNow: chng.it/tsH8ZSJfRH via
@UKChange

Sign the Petition

#StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK

chng.it

1 2

Reposted by Roychoudhuri Lab

Roychoudhuri Lab @roychoudhurilab.bsky.social · May 20

Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via
@ukchange.bsky.social

Sign the Petition

#StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK

chng.it

2 5

Roychoudhuri Lab @roychoudhurilab.bsky.social · May 20

Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via
@ukchange.bsky.social

Sign the Petition

#StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK

chng.it

2 5

Reposted by Roychoudhuri Lab

Ezra Aksoy @aksoylab.bsky.social · Mar 25

Many wonders of aspirin 👍

Roychoudhuri Lab @roychoudhurilab.bsky.social · Mar 25

Research Highlight of our recent paper by @jieyang437.bsky.social on Aspirin and cancer metastasis in Nature Reviews Immunology. Thanks to Yvonne Bordon for a crystal clear account of the experimental findings www.nature.com/articles/s41...

Aspirin helps T cells to stop cancer spread - Nature Reviews Immunology

Drugs like aspirin can enhance the anti-metastatic activity of T cells by blocking a platelet-mediated pathway of suppression.

www.nature.com

1 3

Reposted by Roychoudhuri Lab

Waggoner Lab @labwaggoner.bsky.social · Apr 3

T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses
www.embopress.org/doi/full/10....
@iannaconelab.bsky.social

9 19

Reposted by Roychoudhuri Lab

Roychoudhuri Lab @roychoudhurilab.bsky.social · Apr 2

Really enjoyed discussing our recent findings and thoughts on cancer immunity with Nick Jikomes of the Mind and Matter podcast mindandmatter.substack.com/p/can-aspiri...
@campathology.bsky.social @crukcamcentre.bsky.social

Can Aspirin Prevent Cancer Metastasis? | Rahul Roychoudhuri | 216

Download, watch, read, or listen to this podcast conversation.

mindandmatter.substack.com

2 8

Roychoudhuri Lab @roychoudhurilab.bsky.social · Apr 2

Really enjoyed discussing our recent findings and thoughts on cancer immunity with Nick Jikomes of the Mind and Matter podcast mindandmatter.substack.com/p/can-aspiri...
@campathology.bsky.social @crukcamcentre.bsky.social

Can Aspirin Prevent Cancer Metastasis? | Rahul Roychoudhuri | 216

Download, watch, read, or listen to this podcast conversation.

mindandmatter.substack.com

2 8

Reposted by Roychoudhuri Lab

Waggoner Lab @labwaggoner.bsky.social · Apr 2

Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity @cp-immunity.bsky.social
www.cell.com/immunity/ful...

2 15

Roychoudhuri Lab @roychoudhurilab.bsky.social · Mar 25

Research Highlight of our recent paper by @jieyang437.bsky.social on Aspirin and cancer metastasis in Nature Reviews Immunology. Thanks to Yvonne Bordon for a crystal clear account of the experimental findings www.nature.com/articles/s41...

Aspirin helps T cells to stop cancer spread - Nature Reviews Immunology

Drugs like aspirin can enhance the anti-metastatic activity of T cells by blocking a platelet-mediated pathway of suppression.

www.nature.com

5 18

Roychoudhuri Lab @roychoudhurilab.bsky.social · Mar 25

New results from the ALASCCA prospective randomised controlled trial showing daily #aspirin reduces colorectal cancer recurrence by ~50% in patients with PIK3CA or related mutations. Findings extend benefits of aspirin beyond Lynch syndrome cancers to nearly 40% of CRCs ascopubs.org/doi/10.1200/...

Low-dose aspirin to reduce recurrence rate in colorectal cancer patients with PI3K pathway alterations: 3-year results from a randomized placebo-controlled trial.

LBA125Background: Colorectal cancer (CRC) affects 1.9 million individuals globally each year. Among patients with stage II-III CRC, 20-40% develop metastatic disease. Aspirin lowers the incidence of a...

ascopubs.org

1 5

Reposted by Roychoudhuri Lab

Waggoner Lab @labwaggoner.bsky.social · Mar 18

Reactivation of CTLA4-expressing T cells Accelerates Resolution of Lung Fibrosis in a Humanized Mouse Model @jclinical-invest.bsky.social
www.jci.org/articles/vie...

1 9

Roychoudhuri Lab @roychoudhurilab.bsky.social · Mar 19

Imagine if all those who are silent about the terrible evil being committed in Gaza spoke up

www.theguardian.com/commentisfre...

Imagine if all those who are silent about the terrible evil being committed in Gaza spoke up | Owen Jones

No crime in history has been so well documented by its victims. And yet inaction and censorship reign, says Guardian columnist Owen Jones

www.theguardian.com

3

Roychoudhuri Lab @roychoudhurilab.bsky.social · Mar 13

Thank you Jae!

Jaehyuk Choi @jaehyukchoimd.bsky.social · Mar 13

Congratulations!

Roychoudhuri Lab @roychoudhurilab.bsky.social · Mar 5

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

Reposted by Roychoudhuri Lab

Dipsikha Biswas @itsmedipsikha.bsky.social · Mar 7

Huge study in @nature.com by the @roychoudhurilab.bsky.social group
#Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature

Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

www.nature.com

2 6

Roychoudhuri Lab @roychoudhurilab.bsky.social · Mar 6

Thanks for all your ideas and support with this work Klaus!

Klaus Okkenhaug @klausokken.bsky.social · Mar 5

Brilliant new paper from Jie Yang @jieyang437.bsky.social and Rahul Roychoudhuri @roychoudhurilab.bsky.social linking aspirin to immune-mediated prevention of cancer metastasis.
www.nature.com/articles/s41...

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature

Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

www.nature.com

1

Reposted by Roychoudhuri Lab

Waggoner Lab @labwaggoner.bsky.social · Mar 5

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity @nature.com @roychoudhurilab.bsky.social
www.nature.com/articles/s41...

2 7