Lightnews — Scholar-powered news

Jaehyuk Choi @jaehyukchoimd.bsky.social · 19d

We have an active search for tenure-track faculty interested in #ImmuneEngineering #ProteinEngineering #GenomeEngineering & #CancerImmunology. Join the newly formed Center for Cellular Therapies and Cancer Immunology #CCTCI. Learn more at apply.interfolio.com/173562. #facultyjobs

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

1 3

Reposted by Jaehyuk Choi

Vijay G. Sankaran @bloodgenes.bsky.social · Jun 21

Wow!!! 👏👏👏 Amazing to see this develop over the years!

www.nytimes.com/2025/06/20/h...

People With Severe Diabetes Are Cured in Small Trial of New Drug

www.nytimes.com

3 9

Reposted by Jaehyuk Choi

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · Apr 17

☕Have you read this study from our journal (@naturecellbiology.bsky.social) yet?
Studies of endolysosomes and #proteostasis suggest a role for lysosomal quality control in #Alzheimers disease pathology.
bit.ly/4lSORPV

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease - Nature Cell Biology

Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role f...

bit.ly

7 16

Reposted by Jaehyuk Choi

Mark Cuban @mcuban.bsky.social · Apr 17

Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M ohiocapitaljournal.com/2025/04/17/o...

Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M • Ohio Capital Journal

The Ohio Department of Medicaid department in 2022 gave powerful prescription drug middlemen the boot and created a new system. The result: Fees paid to pharmacies were boosted more than 1,200% while ...

ohiocapitaljournal.com

320 2.5K 11K

Jaehyuk Choi @jaehyukchoimd.bsky.social · Apr 16

some GD T cell lymphomas are addicted to JAK-STAT signaling and relapse with new JAK-STAT mutations, much like melanomas to BRAF inhibitors. ? new approach ? to treating these aggressive diseases. cell of origin (GD cells) important but unclear why. stay tuned for more.
www.jci.org/articles/vie...

JCI - Addiction of primary cutaneous γδ T cell lymphomas to JAK/STAT signaling

www.jci.org

3 2

Reposted by Jaehyuk Choi

Ming Tommy Tang @tommytang.bsky.social · Mar 23

DNMT1 inhibition reprograms T cells to NK-like cells with potent antitumor activity www.science.org/doi/10.1126...

4 8

Reposted by Jaehyuk Choi

Waggoner Lab @labwaggoner.bsky.social · Mar 21

Review @jimmunol.bsky.social
Can autoimmune disease be cured by deep CD19+ cell depletion?
doi.org/10.1093/jimm...

1 5 12

Reposted by Jaehyuk Choi

Waggoner Lab @labwaggoner.bsky.social · Mar 21

Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering
www.nature.com/articles/s41...

3 11

Reposted by Jaehyuk Choi

Nick Vitanza @nickvitanza.bsky.social · Mar 20

Thanks to Dr. Syal & @nbcnews.com for visiting our #CARTcell program to highlight one of our courageous little patients with #DIPG #DMG. So much work left to do but thankful for the support of Seattle Children’s and our brave families. ❤️

www.nbcnews.com/now/video/ex...

Experimental brain tumor treatment shows promise for pediatric brain cancer

Gavin Nielsen, who was 2 years old when he was diagnosed with a rare brain cancer, met Dr. Nicholas Vitanza who is part of a growing group of researchers exploring CAR-T therapy. The treatment program...

www.nbcnews.com

6 21

Reposted by Jaehyuk Choi

Waggoner Lab @labwaggoner.bsky.social · Mar 19

AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity
www.cell.com/cell-reports...
@cp-cellreports.bsky.social

2 3

Reposted by Jaehyuk Choi

Science Magazine @science.org · Mar 19

New #ScienceImmunology research involving mice and human tissues demonstrates how different immune cell types modify expression of stimulator of interferon genes (STING) to support their normal development and function. scim.ag/4idx7wn

Dynamic STING repression orchestrates immune cell development and function

Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

scim.ag

8 55

Reposted by Jaehyuk Choi

Eric Topol @erictopol.bsky.social · Mar 19

How does sleep protect against neurodegenerative disease? A review, open-access
www.cell.com/neuron/fullt...

8 91 280

Jaehyuk Choi @jaehyukchoimd.bsky.social · Mar 19

Congratulations! Great talk at keystone

1 1

Reposted by Jaehyuk Choi

Waggoner Lab @labwaggoner.bsky.social · Mar 19

Regulatory T cells with engineered specificity for HLA-DQ2.5–restricted deamidated gluten peptides exert bystander suppression in vivo
www.science.org/doi/10.1126/...

6 16

Reposted by Jaehyuk Choi

Ivan Zanoni @lozanzi.bsky.social · Mar 19

⁦‪#InterferonPower! Hongbo Chi‬⁩ &co @stjude.bsky.social @stjuderesearch.bsky.social show ⁦‪@nature.com‬⁩ that VDAC2 deficiency facilitates tumor destruction by T cell-driven IFNgamma by causing mitochondrial (mt) damage & mtDNA sensing by cGAS–STING, which drives type I IFNs & tumor death!

VDAC2 loss elicits tumour destruction and inflammation for cancer therapy - Nature

VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy.

www.nature.com

1 3 29

Reposted by Jaehyuk Choi

Nature Metabolism @natmetabolism.nature.com · Mar 17

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research

Nature Metabolism, Published online: 17 March 2025; doi:10.1038/s42255-025-01237-6This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological,…

bit.ly

9 12

Jaehyuk Choi @jaehyukchoimd.bsky.social · Mar 13

Congratulations!

Roychoudhuri Lab @roychoudhurilab.bsky.social · Mar 5

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

1

Reposted by Jaehyuk Choi

Dr. Patrick Hwu @patrickhwumd.bsky.social · Mar 1

#ScienceSaturday 🧵

❓ Are B cells important to eliminate cancers? T cells, capable of directly killing cancers, have been widely studied in tumor immunology.

1 1 4

Reposted by Jaehyuk Choi

Sinai Immuno @sinaiimmuno.bsky.social · Feb 13

🎉 Congratulations 🥳 to our Director, @miriammerad.bsky.social, on winning this year’s Sjöberg Prize! Check out the video announcement below 🔽

The Royal Swedish Academy of Sciences @scienceacademyswe.bsky.social · Feb 13

🌟Sjöberg Laureate Miriam Merad has studied how cells in the innate immune system affect the body’s ability to fight tumours. Her discoveries have hugely contributed to making these cells a promising target for the development of new cancer therapies.
www.kva.se/en/news/sjob...
#Science #Academicsky

Sjöberg Prize 2025

Miriam Merad is awarded the Sjöberg Prize 2025 for discovering new targets for cancer therapies in the immune system.

www.kva.se

2 2 15

Reposted by Jaehyuk Choi

Waggoner Lab @labwaggoner.bsky.social · Feb 12

Review @nature.com @quintanalab.bsky.social
The neuroimmune connectome in health and disease
www.nature.com/articles/s41...

4 16

Reposted by Jaehyuk Choi

Waggoner Lab @labwaggoner.bsky.social · Feb 12

Repair Drive enables in vivo expansion of gene-targeted hepatocytes in adult mice
www.science.org/doi/10.1126/...

1 1

Reposted by Jaehyuk Choi

Waggoner Lab @labwaggoner.bsky.social · Feb 12

PD-L1 from tumor extracellular vesicles induces T cell senescence through lipid metabolism
www.science.org/doi/10.1126/...

7 15

Reposted by Jaehyuk Choi

Ross Levine MD @rosslevinemd.bsky.social · Feb 1

In chaotic times, it is important to emphasize how much i appreciate my fellow scientists and the science they do. Inspired countless times each day by my colleagues in the field.

1 1 39

Reposted by Jaehyuk Choi

Ross Levine MD @rosslevinemd.bsky.social · Feb 6

The best part of science for me is when someone in the lab or a former lab member has awesome new data and rushes to share it. everything else pales in comparison.

3 1 25

Reposted by Jaehyuk Choi

Ross Levine MD @rosslevinemd.bsky.social · Feb 6

Going post new things here and not on X. Will be focused on science/career development and drug development, with the occasional sports (Mets, Knicks, hockey) tweet..

2 2 29