Sanjana
@sanj12.bsky.social
K99 fellow with Bieker Lab @IcahnMountSinai. Interested in 3D chromatin organisation and red cell biology
Reposted by Sanjana
Prof. Laura Dassama (Stanford Chem) is developing a small-molecule therapy for sickle cell disease that removes BCL11A, restoring fetal hemoglobin without gene editing. Her goal is a simpler, more affordable sickle cell therapy. brnw.ch/21wXP8k
November 26, 2025 at 9:10 PM
Prof. Laura Dassama (Stanford Chem) is developing a small-molecule therapy for sickle cell disease that removes BCL11A, restoring fetal hemoglobin without gene editing. Her goal is a simpler, more affordable sickle cell therapy. brnw.ch/21wXP8k
Reposted by Sanjana
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
c.org
November 24, 2025 at 3:53 PM
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Reposted by Sanjana
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Sanjana
Very interesting new @wbickmor.bsky.social commentary on the mechanistic mystery that is very distal enhancer-promoter interactions www.nature.com/articles/s41...
Is enhancer-driven gene regulation all wrapped up? - Nature Reviews Genetics
In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.
www.nature.com
September 17, 2025 at 12:41 PM
Very interesting new @wbickmor.bsky.social commentary on the mechanistic mystery that is very distal enhancer-promoter interactions www.nature.com/articles/s41...
Reposted by Sanjana
Congratulations to Masahiro Nagano on his new paper on STAG3-cohesin.
STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation.
www.nature.com/articles/s41...
STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation.
www.nature.com/articles/s41...
August 26, 2025 at 4:18 PM
Congratulations to Masahiro Nagano on his new paper on STAG3-cohesin.
STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation.
www.nature.com/articles/s41...
STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation.
www.nature.com/articles/s41...
Reposted by Sanjana
Pleased to see this study out, combining experimental work from our lab at the @cbitoulouse.bsky.social, in particular by @nathaliebastie.bsky.social and @beckof.bsky.social, and from Laura Chaptal and @alengronne.bsky.social at IGH Montpellier
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!
RNA Pol II-based regulations of chromosome folding
How transcription and cohesin complexes interact to regulate 3D genome organization
remains unclear. Chapard et al. dissect their respective contributions and their interplay
in shaping the genome arc...
www.cell.com
August 9, 2025 at 10:47 AM
Pleased to see this study out, combining experimental work from our lab at the @cbitoulouse.bsky.social, in particular by @nathaliebastie.bsky.social and @beckof.bsky.social, and from Laura Chaptal and @alengronne.bsky.social at IGH Montpellier
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!
Reposted by Sanjana
EpiSci - 🧬 - 🧪 - The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 23, 2025 at 1:53 PM
EpiSci - 🧬 - 🧪 - The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sanjana
(1/n) Excited to present the latest work from the de Wit lab, where we identify and characterise loop extrusion-mediated fountains in mammalian genomes using acute depletion of 3D genome regulators: doi.org/10.1093/nar/.... A Bluetorial🧵:
Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers
Abstract. Interphase chromosomes are mainly shaped by loop extrusion and compartmentalisation mechanisms. However, their temporal component and cause-effec
doi.org
July 1, 2025 at 6:34 AM
(1/n) Excited to present the latest work from the de Wit lab, where we identify and characterise loop extrusion-mediated fountains in mammalian genomes using acute depletion of 3D genome regulators: doi.org/10.1093/nar/.... A Bluetorial🧵:
Reposted by Sanjana
From MBoC
Dr. Robert Krauss, Professor of Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai, wants to bring clarity to a classic biology term: “master regulator.” What should it really mean? ➡️ www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
Dr. Robert Krauss, Professor of Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai, wants to bring clarity to a classic biology term: “master regulator.” What should it really mean? ➡️ www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
May 15, 2025 at 9:48 AM
From MBoC
Dr. Robert Krauss, Professor of Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai, wants to bring clarity to a classic biology term: “master regulator.” What should it really mean? ➡️ www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
Dr. Robert Krauss, Professor of Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai, wants to bring clarity to a classic biology term: “master regulator.” What should it really mean? ➡️ www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
Reposted by Sanjana
🚨The formation of 3D chromatin hubs is a poorly understood
phenomenon.
I wrote a N&V about the excellent work Karpinska, Zhu and colleagues, from @mariekeoudelaar.bsky.social lab, who shed new light on the formation and function of these structures.
rdcu.be/elPt3
phenomenon.
I wrote a N&V about the excellent work Karpinska, Zhu and colleagues, from @mariekeoudelaar.bsky.social lab, who shed new light on the formation and function of these structures.
rdcu.be/elPt3
Decoupling chromatin hubs from gene control
Nature Structural & Molecular Biology - Chromatin hubs, which are formed during cell differentiation, are characterized by simultaneous interactions between multiple regulatory elements and...
www.nature.com
May 13, 2025 at 10:13 AM
🚨The formation of 3D chromatin hubs is a poorly understood
phenomenon.
I wrote a N&V about the excellent work Karpinska, Zhu and colleagues, from @mariekeoudelaar.bsky.social lab, who shed new light on the formation and function of these structures.
rdcu.be/elPt3
phenomenon.
I wrote a N&V about the excellent work Karpinska, Zhu and colleagues, from @mariekeoudelaar.bsky.social lab, who shed new light on the formation and function of these structures.
rdcu.be/elPt3
Reposted by Sanjana
New preprint from our lab!
TORC1-driven translation of Nucleoporin 44A promotes chromatin remodeling and germ cell-to-maternal transition in Drosophila https://www.biorxiv.org/content/10.1101/2025.03.14.643309v1
March 17, 2025 at 9:30 PM
New preprint from our lab!
Reposted by Sanjana
To the top of the "to-read" list. Looks like a heroic amount of work from the Hahn lab (large-scale ChEC-seq compendium!) www.nature.com/articles/s41...
Low overlap of transcription factor DNA binding and regulatory targets - Nature
A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between t...
www.nature.com
April 16, 2025 at 4:04 PM
To the top of the "to-read" list. Looks like a heroic amount of work from the Hahn lab (large-scale ChEC-seq compendium!) www.nature.com/articles/s41...
Reposted by Sanjana
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...
www.training.nih.gov
April 10, 2025 at 1:22 AM
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...
Reposted by Sanjana
At NIH, new fudging opportunities (NOFO) will need to be approved by DOGE. That should be a NOGO.
www.science.org/content/arti...
www.science.org/content/arti...
Trump officials will screen NIH funding opportunities
Staff at biomedical agency worry about political interference in setting priorities
www.science.org
March 27, 2025 at 6:35 PM
At NIH, new fudging opportunities (NOFO) will need to be approved by DOGE. That should be a NOGO.
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Sanjana
I received one of the 232 NIH grant "terminations" sent to scientists at Columbia last night. My research focuses on improving maternal and child health in the US. Also affected: ongoing clinical trials, research training programs, and research centers that aim to improve the health of Americans.
Hundreds of research grants at Columbia canceled following Trump edict, administrator says
The National Institutes of Health is terminating 232 grants for scientific research at Columbia University Irving Medical Center, according to an email an administrator sent to faculty.
gothamist.com
March 11, 2025 at 9:05 PM
I received one of the 232 NIH grant "terminations" sent to scientists at Columbia last night. My research focuses on improving maternal and child health in the US. Also affected: ongoing clinical trials, research training programs, and research centers that aim to improve the health of Americans.
Reposted by Sanjana
Here is the careful look at efficiency DOGE is taking: a recent law school graduate with no science training is deciding what areas are worthy of scientific study 🧪
March 9, 2025 at 12:57 PM
Here is the careful look at efficiency DOGE is taking: a recent law school graduate with no science training is deciding what areas are worthy of scientific study 🧪
Reposted by Sanjana
Here is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development.
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Deletion of a single CTCF motif at the boundary of a chromatin domain with three FGF genes disrupts gene expression and embryonic development
Chromatin domains delimited by CTCF can restrict the range of enhancer action. However, disruption of some domain boundaries results in mild gene dysr…
www.sciencedirect.com
February 26, 2025 at 9:22 PM
Here is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development.
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Reposted by Sanjana
Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
February 21, 2025 at 3:50 PM
Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Reposted by Sanjana
For decades, the US government has painstakingly kept American science #1 globally—and every facet of American life has improved because of it. The internet? Flu shot? Ozempic? All grew out of federally-funded research. Now all that's being dismantled. 1/ www.technologyreview.com/2025/02/21/1...
The foundations of America’s prosperity are being dismantled
Federal scientists warn that Americans could feel the effects of the new administration's devastating cuts for decades to come
www.technologyreview.com
February 21, 2025 at 1:01 PM
For decades, the US government has painstakingly kept American science #1 globally—and every facet of American life has improved because of it. The internet? Flu shot? Ozempic? All grew out of federally-funded research. Now all that's being dismantled. 1/ www.technologyreview.com/2025/02/21/1...
Reposted by Sanjana
Genome architecture folks, this perspective is really worth your time www.cell.com/molecular-ce...
Cohesin as an essential disruptor of chromosome organization
Chromosomes are long strings of DNA carrying multiple genes. A chromosomal factor
called cohesin creates loops of DNA proposed to be functional units of the genome.
By contrast, it is proposed here th...
www.cell.com
February 6, 2025 at 11:31 AM
Genome architecture folks, this perspective is really worth your time www.cell.com/molecular-ce...