Susanne Fleig
@sfleig.bsky.social
250 followers 300 following 21 posts
Nephrologist / Clinical Scientist at RWTH Aachen University Hospital. Vascular biology, tertiary lymphoid structures; outpatient clinic for CKD and hypertension; ultrasound instructor DEGUM2, renal nutrition
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sfleig.bsky.social
Good coffee, good science!
sfleig.bsky.social
would the original star wars movies count?
„a long time ago in a galaxy far, far away….“ - not spoken though, written intro.
Reposted by Susanne Fleig
asnpublications.bsky.social
Kidney dysfunction was diagnosed at 5-months postpartum in 12% of patients who had gestational diabetes mellitus. Read more in #ASNCJASN kidney.pub/CJASN0802
Reposted by Susanne Fleig
asnpublications.bsky.social
New in #ASNJASN and at #Hypertension25: In a randomized, double-blind, placebo-controlled trial, Baxdrostat reduced systolic blood pressure in patients with CKD and uncontrolled hypertension. Read more about its safety and efficacy in patients with CKD here: kidney.pub/JASN0849
Reposted by Susanne Fleig
hswapnil.medsky.social
If you are a nephrology or kidney disease or renal professional or interested in the field - make sure you have liked/followed/pinned the nephrology feed

bsky.app/profile/did:...

Thanks again to @richardferro.xyz for creating & updating this! It’s a one-stop shop for nephrology needs

#NephSky
sfleig.bsky.social
Should you, too, feel like your brain is shrinking during the winter: here is why! 👇
(now, how closely related are we really to shrews!)
joannabagniewska.com
❄️ Common shrews shrink their brains in winter.

🧠 The process is reversible and occurs because brain cells shrink, rather than die off. As a result, neuronal numbers stay constant and preserve brain function.

I can defo relate to seasonal brain shrinkage.

🧪🦊🌍
Paper: www.cell.com/current-biol...
Image of a shrew in summer (left) and winter (right), with brain cells containing more (L) and less (R) water. Young common shrews, photo WWalas from Wikimedia Commons
Reposted by Susanne Fleig
hjanders.bsky.social
Now open access in @ndt-era.bsky.social

Anti-nephrin, anti-podocin and anti-Kirrel1 antibodies: Biological challenges and clinical implications

🧐 Clinical implementation of anti-slit diaphragm antibody testing = precision dx and tx in podocytopathies

▶️ academic.oup.com/ndt/article/...
Reposted by Susanne Fleig
hellmutaugustin.bsky.social
Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...
Reposted by Susanne Fleig
ibidicells.bsky.social
We also congratulate Dr. Laetitia Préau from Karlsruhe Institute of Technology (KIT) and Dr.Tore Bleckwehl from Uniklinik RWTH Aachen for their outstanding presentations

@cpi-exstra.bsky.social @sfb1531.bsky.social @sfleig.bsky.social

#PCVB2025
Reposted by Susanne Fleig
ibidicells.bsky.social
🔬 Congrats to the 2025 #GfMVB Award Winners! 🏆

Proudly #sponsored by ibidi at “Perspectives in Cardiovascular Biology” Conference🫀

🏅Emerging Scientist: Dr. Haaglim Cho from
@mpi-hlr.bsky.social

🏅Young Investigator: Dr. Julian Wagner from Universitätsmedizin Frankfurt

🔗https://zurl.co/IAJmC
Reposted by Susanne Fleig
arvindcanchi.bsky.social
Resolution of steatohepatitis without worsening of fibrosis occurred in 62.9% in the semaglutide group & in 34.3% in the placebo group.
Reduction in liver fibrosis without worsening of steatohepatitis was reported in 36.8% in the semaglutide group & in 22.4% in the placebo group
tinyurl.com/338u24b2
Reposted by Susanne Fleig
Reposted by Susanne Fleig
kidneyint.bsky.social
B cell-derived exosomal miR-483-5p and its potential role in promoting kidney function loss in IgA nephropathy

doi.org/10.1016/j.kint.2025.03.019

#OpenAccess #MedSky #NephSky #SkyNeph #IgAN #IgAnephropathy
Reposted by Susanne Fleig
academiceurope.bsky.social
Job - Alert 🚑

🩺 Full Professorship for Nephrology

Deadline: 2025-05-03

Location: Switzerland, Bern

www.academiceurope.com/job/?id=7332

#hiring #Nephrology #medicine #biomedicine #Leadership #professor #director
Academic Europe - Full Professorship for Nephrology
www.academiceurope.com
Reposted by Susanne Fleig
sfb1531.bsky.social
Congrats to Maria Dekrolia, Nivethitha Manickam, Leah Vanicek, and Sofia de la Puente Secades for receiving the Aletta Jacobs Award at the PCVB Meeting 2025 in Frankfurt! A well-deserved recognition of their outstanding contributions to science. #PCVB2025 #AlettaJacobsAward
sfleig.bsky.social
Tore Bleckwehl from Aachen presenting as a finalist in the GfMVB Emerging Scientist Award session at #PCVB2025 in Frankfurt!
Reposted by Susanne Fleig
rainerkaiser.bsky.social
Excited to share the most recent work from our lab and results from two exciting cooperations:

In this week's issue of @bloodjournal.bsky.social (ashpublications.org/blood/issue), Afra Anjum presents her cover story on how aging platelets gain inflammatory functions in the circulation. 1/4
Reposted by Susanne Fleig
nejm.org
NEJM.org @nejm.org · Mar 30
Presented at #ACC25:

Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels. Full ALPACA trial results: nej.md/4kWjJyn

#MedSky @accintouch.bsky.social
A graph showing the least-squares mean percent change in the lipoprotein(a) concentration from baseline through 540 days in the efficacy analysis set, which included data from participants who received at least one dose of lepodisiran or placebo, with the exclusion of data collected from participants after discontinuation of lepodisiran or placebo or initiation of medications known to affect lipoprotein(a).
Reposted by Susanne Fleig
immunoboys.bsky.social
During inflammation, CCL21 is down-regulated in the lymph node. Enzymes for production of oxysterols are induced and recruitment of naive/central memory cells relies more in oxysterols interacting with GPR183 (+ CCL19). in 🐭

Chen et al @cellpress.bsky.social 2025
pubmed.ncbi.nlm.nih.gov/39708807/
Reposted by Susanne Fleig
kidneyboy.bsky.social
Finally!

(Psst it was never the fluid, it was always the sodium)
nephroseeker.medsky.social
FRESH-UP Trial #ACC25 #medsky

RCT comparing liberal vs restricted fluid intake (≤1500 ml/d) in 504 pts with stable chronic HF

🌊No difference in status health quantified by Kansas City Cardiomyopathy Questionnaire at 3 mths
🌊 More thirst distress with restriction

www.nature.com/articles/s41...
Reposted by Susanne Fleig
brendonneuen.bsky.social
Cardiovascular, Kidney & Mortality Outcomes With Long-Acting Injectable & Oral GLP1-RA in T2 Diabetes

An updated meta-analysis of >70,000 patients after the SOUL trial

⬇️ 14% MACE
⬇️ 14% heart failure
⬇️ 17% CKD progression
⬇️ 12% all-cause mortality

diabetesjournals.org/care/article...
Reposted by Susanne Fleig
cifarelliv.bsky.social
Our latest publication investigating the role of #palmitoylation in #lymphatic endothelial integrity.

Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏

www.sciencedirect.com/science/arti...
Insulin regulates lymphatic endothelial integrity via palmitoylation
Lipid metabolism plays a critical role in lymphatic endothelial cell (LEC) development and vessel maintenance. Altered lipid metabolism is associated …
www.sciencedirect.com