Swiss Myeloid League (SMyLe)
@smyle-ch.bsky.social
Swiss Myeloid League (SMyLe) is a network uniting researchers studying myeloid cells in health and disease across Switzerland.
Building community, collaboration, and global connections.
🔗 www.myeloid.ch
Building community, collaboration, and global connections.
🔗 www.myeloid.ch
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Home - Swiss Myeloid League
Advancing Myeloid Research Together Join us! Discover SMyLe Connecting Switzerland’s Myeloid Researchers SMyLe unites scientists studying myeloid cells acros...
myeloid.ch
We’re excited to announce the launch of the Swiss Myeloid League (SMyLe), a new network uniting myeloid cell researchers across Switzerland. 🇨🇭
Our mission: foster collaboration and strengthen the Swiss myeloid community, locally and globally.
👉 Join our growing network: myeloid.ch
Our mission: foster collaboration and strengthen the Swiss myeloid community, locally and globally.
👉 Join our growing network: myeloid.ch
Reposted by Swiss Myeloid League (SMyLe)
Microglia are not required for normal postnatal brain development and cognitive function in the rat. https://www.biorxiv.org/content/10.64898/2025.12.22.694658v1
December 24, 2025 at 6:16 PM
Microglia are not required for normal postnatal brain development and cognitive function in the rat. https://www.biorxiv.org/content/10.64898/2025.12.22.694658v1
Reposted by Swiss Myeloid League (SMyLe)
#NewResearch
IL-17 signaling restricts C. albicans pathogenicity in the colonized oral cavity.
#MicroSky 🦠🍄
@lableibundgut.bsky.social @frois-martins.bsky.social
www.nature.com/articles/s41...
IL-17 signaling restricts C. albicans pathogenicity in the colonized oral cavity.
#MicroSky 🦠🍄
@lableibundgut.bsky.social @frois-martins.bsky.social
www.nature.com/articles/s41...
IL-17-mediated antifungal immunity restricts Candida albicans pathogenicity in the oral cavity - Nature Microbiology
IL-17 signalling restricts C. albicans pathogenicity in the colonized oral cavity. Lack of IL-17 is associated with overt filamentation due to impaired zinc nutritional immunity and over time leads to...
www.nature.com
December 18, 2025 at 3:03 PM
#NewResearch
IL-17 signaling restricts C. albicans pathogenicity in the colonized oral cavity.
#MicroSky 🦠🍄
@lableibundgut.bsky.social @frois-martins.bsky.social
www.nature.com/articles/s41...
IL-17 signaling restricts C. albicans pathogenicity in the colonized oral cavity.
#MicroSky 🦠🍄
@lableibundgut.bsky.social @frois-martins.bsky.social
www.nature.com/articles/s41...
Reposted by Swiss Myeloid League (SMyLe)
Dendritic cells regulate the innate-adaptive balance in lymph nodes for optimal host defense @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @uwapress.uw.edu @michael-gerner.bsky.social @jehuang6.bsky.social
www.cell.com/cell/fulltex... @uwapress.uw.edu @michael-gerner.bsky.social @jehuang6.bsky.social
December 21, 2025 at 5:00 PM
Dendritic cells regulate the innate-adaptive balance in lymph nodes for optimal host defense @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @uwapress.uw.edu @michael-gerner.bsky.social @jehuang6.bsky.social
www.cell.com/cell/fulltex... @uwapress.uw.edu @michael-gerner.bsky.social @jehuang6.bsky.social
Reposted by Swiss Myeloid League (SMyLe)
Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity @cp-immunity.bsky.social @beatricezitti.bsky.social @biology-unige.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
December 21, 2025 at 5:24 PM
Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity @cp-immunity.bsky.social @beatricezitti.bsky.social @biology-unige.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Swiss Myeloid League (SMyLe)
F4/80, the Plasma Membrane Antigen of Mouse Macrophages, an historic journey
academic.oup.com/jleukbio/adv...
academic.oup.com/jleukbio/adv...
F4/80, the Plasma Membrane Antigen of Mouse Macrophages, an historic journey
The F4/80 antigen is a plasma membrane pan-marker for resident and recruited mouse tissue macrophages.
academic.oup.com
September 4, 2025 at 1:42 AM
F4/80, the Plasma Membrane Antigen of Mouse Macrophages, an historic journey
academic.oup.com/jleukbio/adv...
academic.oup.com/jleukbio/adv...
Reposted by Swiss Myeloid League (SMyLe)
Today’s #JEMjc @jem.org highlights the work of Alan Saltiel & colleagues @nature.com reporting the role of neutrophil-derived IL-1β in preserving lipid stores during metabolic stress.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neutrophils preserve energy storage in sympathetically activated adipocytes - Nature
Neutrophil-derived IL-1β has a role in preserving lipid stores during metabolic stress.
www.nature.com
December 21, 2025 at 6:10 PM
Today’s #JEMjc @jem.org highlights the work of Alan Saltiel & colleagues @nature.com reporting the role of neutrophil-derived IL-1β in preserving lipid stores during metabolic stress.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Swiss Myeloid League (SMyLe)
@biorxivpreprint.bsky.social Eosinophil-derived COX-2 protects against experimental colitis through the PGE2-IL-22 axis www.biorxiv.org/content/10.6...
December 23, 2025 at 3:23 AM
@biorxivpreprint.bsky.social Eosinophil-derived COX-2 protects against experimental colitis through the PGE2-IL-22 axis www.biorxiv.org/content/10.6...
Reposted by Swiss Myeloid League (SMyLe)
Research Spotlight 💡
New study shows #astrocyte reactivity in #Alzheimers depends on activated #microglia. PET imaging & biomarkers reveal microglia drive Aβ-linked astrocyte reactivity, tau pathology, and cognitive decline.
🔗 https://www.nature.com/articles/s41593-025-02103-0
New study shows #astrocyte reactivity in #Alzheimers depends on activated #microglia. PET imaging & biomarkers reveal microglia drive Aβ-linked astrocyte reactivity, tau pathology, and cognitive decline.
🔗 https://www.nature.com/articles/s41593-025-02103-0
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience
Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphorylation and aggregation.
www.nature.com
December 23, 2025 at 9:11 AM
Research Spotlight 💡
New study shows #astrocyte reactivity in #Alzheimers depends on activated #microglia. PET imaging & biomarkers reveal microglia drive Aβ-linked astrocyte reactivity, tau pathology, and cognitive decline.
🔗 https://www.nature.com/articles/s41593-025-02103-0
New study shows #astrocyte reactivity in #Alzheimers depends on activated #microglia. PET imaging & biomarkers reveal microglia drive Aβ-linked astrocyte reactivity, tau pathology, and cognitive decline.
🔗 https://www.nature.com/articles/s41593-025-02103-0
Reposted by Swiss Myeloid League (SMyLe)
Myeloid cells contribute to bystander CD8 T cell accumulation in metabolic-associated steatohepatitis and are sufficient for fibrosis https://www.biorxiv.org/content/10.64898/2025.12.17.694415v1
December 20, 2025 at 4:18 AM
Myeloid cells contribute to bystander CD8 T cell accumulation in metabolic-associated steatohepatitis and are sufficient for fibrosis https://www.biorxiv.org/content/10.64898/2025.12.17.694415v1
Reposted by Swiss Myeloid League (SMyLe)
Wishing you a very happy holiday season, from our lab to yours!! 🎄❄️⛄🌟
Grateful for everything we were able to celebrate together this year - and looking forward for new discoveries and adventures in 2026 💫
Grateful for everything we were able to celebrate together this year - and looking forward for new discoveries and adventures in 2026 💫
December 19, 2025 at 2:56 PM
Wishing you a very happy holiday season, from our lab to yours!! 🎄❄️⛄🌟
Grateful for everything we were able to celebrate together this year - and looking forward for new discoveries and adventures in 2026 💫
Grateful for everything we were able to celebrate together this year - and looking forward for new discoveries and adventures in 2026 💫
Reposted by Swiss Myeloid League (SMyLe)
Corneal sensory neuron production of CCL2 initiates anti-viral immunity of monocytes, neutrophils and NK cells at the cornea and trigeminal ganglion @cp-cellreports.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 18, 2025 at 4:21 PM
Corneal sensory neuron production of CCL2 initiates anti-viral immunity of monocytes, neutrophils and NK cells at the cornea and trigeminal ganglion @cp-cellreports.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Swiss Myeloid League (SMyLe)
📣 We’re searching for the top immunology publication of 2025!
🧬 Nominate your favourite work for the 2025 SYIS Publication Award below.
⏳ Deadline: 31 December 2025
Submit your nomination here 👉🏻 docs.google.com/forms/d/e/1F...
🧬 Nominate your favourite work for the 2025 SYIS Publication Award below.
⏳ Deadline: 31 December 2025
Submit your nomination here 👉🏻 docs.google.com/forms/d/e/1F...
docs.google.com
December 10, 2025 at 10:27 PM
📣 We’re searching for the top immunology publication of 2025!
🧬 Nominate your favourite work for the 2025 SYIS Publication Award below.
⏳ Deadline: 31 December 2025
Submit your nomination here 👉🏻 docs.google.com/forms/d/e/1F...
🧬 Nominate your favourite work for the 2025 SYIS Publication Award below.
⏳ Deadline: 31 December 2025
Submit your nomination here 👉🏻 docs.google.com/forms/d/e/1F...
Reposted by Swiss Myeloid League (SMyLe)
New findings from Sebastian Stifter, Melanie Greter et al. (University of Zurich) reveal that XPR1 is required for the development, identity, and function of #macrophages involved in #erythropoiesis. rupress.org/jem/article/...
#InnateImmunity #inflammation
#InnateImmunity #inflammation
December 18, 2025 at 5:24 PM
New findings from Sebastian Stifter, Melanie Greter et al. (University of Zurich) reveal that XPR1 is required for the development, identity, and function of #macrophages involved in #erythropoiesis. rupress.org/jem/article/...
#InnateImmunity #inflammation
#InnateImmunity #inflammation
Reposted by Swiss Myeloid League (SMyLe)
A proinflammatory vascular niche of macrophage-fibroblast signaling in treatment-naïve diffuse cutaneous systemic sclerosis @insight.jci.org
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
December 18, 2025 at 9:25 PM
A proinflammatory vascular niche of macrophage-fibroblast signaling in treatment-naïve diffuse cutaneous systemic sclerosis @insight.jci.org
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Reposted by Swiss Myeloid League (SMyLe)
Our recent review on #microglia and brain #organoids is getting a good reception! 🧠🧪
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
December 19, 2025 at 9:21 AM
Our recent review on #microglia and brain #organoids is getting a good reception! 🧠🧪
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by Swiss Myeloid League (SMyLe)
Engineered dendritic cells called iCAR-DCs integrate tumor-antigen uptake with programmable cell activation in mouse cancer models
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 17, 2025 at 9:59 PM
Engineered dendritic cells called iCAR-DCs integrate tumor-antigen uptake with programmable cell activation in mouse cancer models
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Swiss Myeloid League (SMyLe)
Very pleased to share our new review "The Evolving Landscape of Brain Metastasis" in @cp-trendscancer.bsky.social 🧠🔬🧪
Grateful to an outstanding team of co-authors, all pioneers in the #brain #metastasis field and to @valientelab.bsky.social for co-leading this 🙏🏻
Link: www.cell.com/trends/cance...
Grateful to an outstanding team of co-authors, all pioneers in the #brain #metastasis field and to @valientelab.bsky.social for co-leading this 🙏🏻
Link: www.cell.com/trends/cance...
December 17, 2025 at 4:49 PM
Very pleased to share our new review "The Evolving Landscape of Brain Metastasis" in @cp-trendscancer.bsky.social 🧠🔬🧪
Grateful to an outstanding team of co-authors, all pioneers in the #brain #metastasis field and to @valientelab.bsky.social for co-leading this 🙏🏻
Link: www.cell.com/trends/cance...
Grateful to an outstanding team of co-authors, all pioneers in the #brain #metastasis field and to @valientelab.bsky.social for co-leading this 🙏🏻
Link: www.cell.com/trends/cance...
Reposted by Swiss Myeloid League (SMyLe)
@biorxivpreprint.bsky.social The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages
www.biorxiv.org/content/10.6... @harvard.edu @hhmi-science.bsky.social
www.biorxiv.org/content/10.6... @harvard.edu @hhmi-science.bsky.social
December 16, 2025 at 10:17 PM
@biorxivpreprint.bsky.social The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages
www.biorxiv.org/content/10.6... @harvard.edu @hhmi-science.bsky.social
www.biorxiv.org/content/10.6... @harvard.edu @hhmi-science.bsky.social
Reposted by Swiss Myeloid League (SMyLe)
Excited to share our work at @natcomms.nature.com
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
December 15, 2025 at 8:09 PM
Excited to share our work at @natcomms.nature.com
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
Reposted by Swiss Myeloid League (SMyLe)
I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca
December 12, 2025 at 4:40 PM
I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca
Reposted by Swiss Myeloid League (SMyLe)
Single-cell transcriptomics resolves mononuclear phagocyte diversity in the human intestine in health and inflammatory bowel disease @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Heterogeneity of the intestinal mononuclear phagocyte compartment in health and inflammatory bowel disease
Single-cell transcriptomics resolves mononuclear phagocyte diversity in the human intestine in health and inflammatory bowel disease.
www.science.org
December 12, 2025 at 8:24 PM
Single-cell transcriptomics resolves mononuclear phagocyte diversity in the human intestine in health and inflammatory bowel disease @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Swiss Myeloid League (SMyLe)
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
rdcu.be
October 28, 2025 at 11:24 AM
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
Reposted by Swiss Myeloid League (SMyLe)
What are #Neutrophils? why are there so many? how are they shaped by disease? how is it that they maintain memory despite their short lifespan?
Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇
authors.elsevier.com/a/1mFj9L7PXu...
Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇
authors.elsevier.com/a/1mFj9L7PXu...
authors.elsevier.com
December 11, 2025 at 8:39 PM
What are #Neutrophils? why are there so many? how are they shaped by disease? how is it that they maintain memory despite their short lifespan?
Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇
authors.elsevier.com/a/1mFj9L7PXu...
Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇
authors.elsevier.com/a/1mFj9L7PXu...
Reposted by Swiss Myeloid League (SMyLe)
ILC2 trigger an inflammatory switch in alveolar macrophages @cp-immunity.bsky.social
www.cell.com/immunity/ful... @stijnverwaerde.bsky.social @martinguilliams.bsky.social @viblifesciences.bsky.social
www.cell.com/immunity/ful... @stijnverwaerde.bsky.social @martinguilliams.bsky.social @viblifesciences.bsky.social
December 12, 2025 at 3:59 AM
ILC2 trigger an inflammatory switch in alveolar macrophages @cp-immunity.bsky.social
www.cell.com/immunity/ful... @stijnverwaerde.bsky.social @martinguilliams.bsky.social @viblifesciences.bsky.social
www.cell.com/immunity/ful... @stijnverwaerde.bsky.social @martinguilliams.bsky.social @viblifesciences.bsky.social
Reposted by Swiss Myeloid League (SMyLe)
Erythropoietin receptor on cDC1s dictates immune tolerance @nature.com @stanforduniversity.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 10, 2025 at 8:45 PM
Erythropoietin receptor on cDC1s dictates immune tolerance @nature.com @stanforduniversity.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...