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Reposted by Daniel E. Weeks

Paysages Mathématiques @paysmaths.bsky.social · 15h

"My whole life, my ambition as a mathematician, or rather my joy and my passion, have always been to discover the obvious things." – Alexandre Grothendieck (1928-2014)
#quote #mathematics #math #maths

Photographic portrait of Alexandre Grothendieck, and a quote : "My whole life, my ambition as a mathematician, or rather my joy and my passion, have always been to discover the obvious things."

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Paul Pharoah @paulpharoah.bsky.social · 13h

The Bayesian Priors: a group of monks singing Gregorian chants.

Dichotomania: a punk rock band relying on their ability to play no more than two notes.

Factor Analysis: A progressive rock band

Jason Moore @moorejh.bsky.social · 15h

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Andrea Ganna @andganna.bsky.social · 11h

💥 New preprint & our first RCT! 💥

Does an extremely high or low BMI polygenic score influence weight loss after a diet intervention?

GENEROOS is a 6-month randomized diet vs. control trial testing if genetic predisposition to higher BMI affects weight loss in overweight adults

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Matthew Neville @mattneville.bsky.social · 16h

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Sperm sequencing reveals extensive positive selection in the male germline - Nature

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

www.nature.com

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Hanbin Lee @epigenci.bsky.social · 6h

Our paper (Brieuc Lehmann is the first author) is now online in Genetics.

academic.oup.com/genetics/adv...

On ARGs, pedigrees, and genetic relatedness matrices

Abstract. Genetic relatedness is a central concept in genetics, underpinning studies of population and quantitative genetics in human, animal, and plant se

academic.oup.com

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Pragati Kore @pragskore.bsky.social · 2d

📃 We’re excited to share our latest work, now published in Nature Communications — a major update to the Genome Aggregation Database (gnomAD) that improves allele frequency resolution for two gnomAD-defined genetic ancestry groups using local ancestry inference (LAI).

Improved allele frequencies in gnomAD through local ancestry inference - Nature Communications

This study incorporates local ancestry into the Genome Aggregation Database (gnomAD) to improve allele frequency estimates for admixed populations, enhancing variant interpretation and enabling more accurate and equitable genomic research and clinical care.

www.nature.com

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Max Planck Institute for Molecular Genetics @molgen.mpg.de · 18h

🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences.
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...

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Ben Strober @bennystrobes.bsky.social · 1d

Exciting updates!!
(1) I just opened my lab at Boston Children’s Hospital (Harvard-affiliated)
(2) I’m hiring a postdoc focused on integrating GWAS and functional genomic data. Reach out if you’re interested or connect at ASHG next week!
(3) Learn more at stroberlab.com

Strober Lab

The Strober lab is a computational group at Boston Children's Hospital (a Harvard Medical School affiliated hospital) focused on developing statistical and machine learning tools applied to human gene...

stroberlab.com

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bioRxivpreprint @biorxivpreprint.bsky.social · 1d

Long-read sequencing reveals telomere inheritance patterns from human trios https://www.biorxiv.org/content/10.1101/2025.10.07.680721v1

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Michael Friendly @datavisfriendly.bsky.social · 2d

A nice, simple analogy and explanation

I Love Science! @ilovescience.bsky.social · 4d

The importance of uncertainty in measurement #statistics #reality #truth

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Andrew Heiss @andrew.heiss.phd · 5d

If you've ever wanted to learn how to make beautiful websites with #QuartoPub and #rstats , check out this workshop I'm giving in a couple weeks! It'll be a blast (and we're covering Quarto's brand new _brand dot yaml system!)

Statistical Horizons @stathorizons.bsky.social · 20d

Learn to create and publish a professional, data-focused website in “Create an Online Presence with Quarto Websites” on October 16-17, with @andrew.heiss.phd‬! Discover how to use #Quarto to build a variety of websites like personal portfolios, research compendiums, and interactive dashboards.

Quarto Websites | Online Seminar | Code Horizons

This online course taught by Andrew Heiss, Ph.D., teaches you how to use Quarto to build a variety of data-focused websites.

codehorizons.com

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Matt Holt @holtjma.bsky.social · 2d

I'm excited to share our pre-print about a new variant benchmarking tool we've been working on for the past few months!

Aardvark: Sifting through differences in a mound of variants
GitHub: github.com/PacificBiosc...

Some highlights in this thread:
1/N

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Jonathan Pritchard @jkpritch.bsky.social · 2d

I want to try something again at #ASHG25 this year: I'll block some time on Thursday and Friday afternoons to meet with trainees who would be interested to chat on any topic.

I did this last year and it was great to meet a whole bunch of new people, at all career stages!

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Dr Elsje van Bergen @drelsje.bsky.social · 2d

🧩Learning to talk & read isn’t just about effort or teaching—it’s shaped by biology, experience & context

🧠Our new review links genetics, neuroscience, psychology & education to show why some children find language or reading easier.

📖 doi.org/10.31234/osf...

🖼️genes→brain→cognition→behaviour 🧵👇

Figure 2 in the review: Levels of analysis from genes and brain systems to cognition and behaviour.
The child both influences and is influenced by parents through genetically shaped interactions, and by the wider school and social environment.
Figure design by Neil Usher.
Figure from this review paper: https://doi.org/10.31234/osf.io/w23yz_v1

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Aki Vehtari @avehtari.bsky.social · 2d

I'm looking for a doctoral student with Bayesian background to work on Bayesian workflow and cross-validation (see my publication list users.aalto.fi/~ave/publica... for my recent work) at Aalto University.

Apply through the ELLIS PhD program (dl October 31) ellis.eu/news/ellis-p...

ELLIS PhD Program: Call for Applications 2025

The ELLIS mission is to create a diverse European network that promotes research excellence and advances breakthroughs in AI, as well as a pan-European PhD program to educate the next generation of AI...

ellis.eu

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Dr. Arun Sethuraman @arunsethuraman.bsky.social · Aug 8

Excited for this to finally see the light of day - new preprint from my lab, where we present a fast, accurate maximum likelihood tool to estimate population structure, called MULTICLUST. We extend the model of Alexander et al 2009 (ADMIXTURE) to multiallelic data. www.biorxiv.org/content/10.1...

MULTICLUST - Fast multinomial clustering of multiallelic genotypes to infer genetic population structure

Identifying population structure from multilocus genotype data is key to downstream population genetic analyses in a variety of fields, including conservation, evolutionary genetics, Genome-Wide Assoc...

www.biorxiv.org

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Aida Andres @aidaandres.bsky.social · 28d

Jasmin Rees PhD chapter as a paper just out at the AJHG @ajhgnews.bsky.social, with Sergi Castellano, who first envisioned the study. Jas investigated signatures of human local genetic adaptation in hundreds of micronutrient-associated genes.

The American Journal of Human Genetics @ajhgnews.bsky.social · 28d

📣New from @aidaandres.bsky.social & co
📄Global impact of micronutrients in modern human evolution

Global impact of micronutrients in modern human evolution

In this study, Rees et al. evaluate the role of dietary micronutrients in driving local genetic adaptation and population differentiation in humans. The authors find evidence that micronutrient-associ...

www.cell.com

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Andrea Ganna @andganna.bsky.social · 8d

🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much.

Our new study in Nature Genetics including 9 disease and 7 biobanks shows:

• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better

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Almost Sure @almostsure.bsky.social · 3d

Helter skelter

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Mike Inouye @mikeinouye.bsky.social · 3d

ICYMI 👉 Quantifying the fairness of polygenic risk scores: our modelling and analysis for CVD risk prediction www.medrxiv.org/content/10.1...

Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)

h\t @iamslambert.bsky.social @clairecoffey.bsky.social

Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction

Background Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critical...

www.medrxiv.org

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Adria LeBoeuf @adriatica.bsky.social · 3d

These are hilarious.

profserious @profserious.bsky.social · 3d

Here are your 10 -essential- AI prompts for academics ... make your life easy with help from @profserious.bsky.social profserious.substack.com/p/10-ai-prom...

10 AI Prompts for Academics

making those hard jobs a little easier ...

profserious.substack.com

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Daniel E. Weeks @statgendan.bsky.social · 4d

Wonderful thread!

I was wondering where Cecilia is now, and I found this:

daphnejackson.org/2025/03/retu...

Returning to the research career you love with the Daphne Jackson Trust and the Royal Society - Daphne Jackson Trust

How one fellow is returning to a research career she loves with the Daphne Jackson Trust and the Royal Society

daphnejackson.org

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Simon Fisher @profsimonfisher.bsky.social · 4d

Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350....
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪

Image shows the first two printed pages of the paper “A forkhead-domain gene is mutated in a severe speech and language disorder” by Cecilia Lai and colleagues, published in Nature in 2001 (volume 413, pages 519-523). The abstract reads as follows:
Individuals affected with developmental disorders of speech and language have substantial difficulty acquiring expressive and/or receptive language in the absence of any profound sensory or neurological impairment and despite adequate intelligence and opportunity. Although studies of twins consistently indicate that a significant genetic component is involved, most families segregating speech and language deficits show complex patterns of inheritance, and a gene that predisposes individuals to such disorders has not been identified. We have studied a unique three-generation pedigree, KE, in which a severe speech and language disorder is transmitted as an autosomal-dominant monogenic trait. Our previous work mapped the locus responsible, SPCH1, to a 5.6-cM interval of region 7q31 on chromosome 7. We also identified an unrelated individual, CS, in whom speech and language impairment is associated with a chromosomal translocation involving the SPCH1 interval. Here we show that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, is directly disrupted by the translocation breakpoint in CS. In addition, we identify a point mutation in affected members of the KE family that alters an invariant amino-acid residue in the forkhead domain. Our findings suggest that FOXP2 is involved in the developmental process that culminates in speech and language.

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Daniel E. Weeks @statgendan.bsky.social · 5d

I’m afraid the only solution is to keep birding … more! 😄

My eBird counts in Pennsylvania over the last ten years.

Pennsylvania
Your Species by Year

Year
2025
2024
2023
2022
2021
2020
2019
2018
2017
2016
2015

Count as of 3 Oct
124
113
121
125
119
135
145
139
121
136
146

Count as of 31 Dec

116
126
135
120
147
147
142
123
146
149
…

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Cameron Patrick @cameronpat.bsky.social · 5d

This is how I integrate Quarto and Zotero with minimal suffering (long rambling post, scroll down to the section on bibliography or search for Zotero): cameronpatrick.com/post/2023/07...

Cameron Patrick - Some Quarto PDF formatting tips, with particular reference to thesis writing

I’ve just spent most of a day faffing around trying to get Quarto to produce a nice PDF file that I like the look of and which meets my university’s formatting requirements for a PhD thesis. Maybe my ...

cameronpatrick.com

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