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Thanh Nha Thai, MD @thaithanhnha.bsky.social · 1d

Congratulations to the scientists!

@nobelprize.bsky.social

#CardioSky #MedSky

www.nytimes.com/2025/10/06/h...

Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems

www.nytimes.com

Reposted by Thanh Nha Thai, MD

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Reposted by Thanh Nha Thai, MD

Megan Ranney MD MPH @meganranney.bsky.social · 2d

I know the news is tough right now.

So take a moment and soak in the gorgeousness & promise of the science that led to this year’s Nobel Prize in Medicine & Physiology.

WOW.

www.nytimes.com/2025/10/06/h...

Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems

www.nytimes.com

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Reposted by Thanh Nha Thai, MD

Nature Portfolio @natureportfolio.nature.com · 2d

This year’s Nobel Prize in Physiology or Medicine has been awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering a class of immune cells that help to prevent the body from attacking its own tissues. #medsky 🧪

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

go.nature.com

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Reposted by Thanh Nha Thai, MD

Harlan M. Krumholz @hmkyale.bsky.social · 2d

Physician certification should not be an ordeal; it is in vast need of improvement.
My @jaccjournals.bsky.social Journals Editor’s Page explores how we can modernize physician certification to be relevant, humane, and effective.
🔗 www.jacc.org/doi/10.1016/...

Rethinking Physician Certification: A Call for a Modern, Meaningful Standard

www.jacc.org

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Reposted by Thanh Nha Thai, MD

Thanh Nha Thai, MD @thaithanhnha.bsky.social · 6d

Targeting Calcium Regulation for Heart Failure and Arrhythmia Therapeutics: A Critical Review

www.ahajournals.org/doi/10.1161/...

@ahascience.bsky.social @ahajournals.bsky.social
#CardioSky #Circulation

Therapeutic targeting of calcium handling proteins for heart failure and arrhythmias. Shown is a schematic highlighting key proteins involved in Ca2+ cycling cardiomyocyte that have emerged as therapeutic targets. Investigational agents recently or currently in clinical trials, as well as US Food and Drug Administration–approved agents are shown in relation to their specific molecular targets. Created in BioRender. ACE indicates angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor/neprolysin inhibitor; AT2R, angiotensin 2 receptor; β-AR, β-adrenergic receptor; Cal2, calstabin 2; CaMKII, Ca2+/calmodulin-dependent kinase; LTCC, L-type Ca2+ channel; MR, mineralocorticoid receptor; MRA, mineralocorticoid receptor antagonist; NCX, sodium-calcium exchanger; PP1, protein phosphatase 1; PLN, phospholamban; RyR, ryanodine receptor; S100A1, S100 Ca2+ binding protein; and SR, sarcoplasmic reticulum. Figure 2 was created with BioRender.

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Thanh Nha Thai, MD @thaithanhnha.bsky.social · 6d

Targeting Calcium Regulation for Heart Failure and Arrhythmia Therapeutics: A Critical Review

www.ahajournals.org/doi/10.1161/...

@ahascience.bsky.social @ahajournals.bsky.social
#CardioSky #Circulation

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Reposted by Thanh Nha Thai, MD

European Society of Cardiology @escardio.bsky.social · 9d

Today is #WorldHeartDay ❤️ Every heartbeat matters.

At ESC, we work to reduce the global burden of cardiovascular disease through awareness, science & healthy hearts. 💪🫀

Take care of your heart & inspire others—together we can build a healthier future.

#DontMissABeat

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Reposted by Thanh Nha Thai, MD

Harlan M. Krumholz @hmkyale.bsky.social · 11d

This is an extraordinary report from @ihmeuw.bsky.social and published in @jaccjournals.bsky.social; it demonstrates that cardiovascular disease is a global scourge. And we are failing to leverage what we know to save lives. www.jacc.org/doi/10.1016/...

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Reposted by Thanh Nha Thai, MD

JAMA @jama.com · 12d

#Alzheimer disease is more common in women than men.

Often attributed to the fact that women tend to live longer, research shows the sex gap likely stems from a complex mix of biological and sociocultural factors.

ja.ma/4nMfLc1

Why Is Alzheimer Disease More Common in Women?

This Medical News article discusses the biological and sociocultural factors that may contribute to sex-based differences in Alzheimer disease prevalence and progression.

ja.ma

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Reposted by Thanh Nha Thai, MD

JACC Journals @jaccjournals.bsky.social · 13d

📢 New in #JACC: ACC/AHA methodology statements on:
🔹 Core Principles & Development
🔹 Cost/Value (update)
🔹 FDA Processes

Together with Circulation, they provide the framework to keep guidelines rigorous, transparent & responsive.

🔗 Explore the statements: https://bit.ly/3IE4EDc #CardioSky #MedSky

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Thanh Nha Thai, MD @thaithanhnha.bsky.social · 13d

Trump, Tylenol and the Plaintiffs Bar from @wsj.com

www.wsj.com/opinion/tyle...

#MedSky #CardioSky #Tylenol #Acetaminophen

Opinion | Trump, Tylenol and the Plaintiffs Bar

The acetaminophen link to autism is based on weak evidence pushed by RFK Jr. and his legal allies.

www.wsj.com

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Reposted by Thanh Nha Thai, MD

Dimitri Drekonja, MD, MS @dimitridrekonja.bsky.social · 15d

I remember when the press was on a weeks-long feeding frenzy because of concerns over the (former) president’s mental state. That concern seems gone 🙄🙄🙄

Aaron Rupar @atrupar.com · 15d

Kimmel's show put together a montage of Trump insisting dozens of times yesterday to "DON'T TAKE TYLENOL." Complete insanity.

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Reposted by Thanh Nha Thai, MD

Eric Topol @erictopol.bsky.social · 15d

To be clear, there are no data that provide a link between short-term use of Tylenol during pregnancy and autism. In fact, one of the best prospective studies w/ sibling controls, if anything, pointed to a protective effect for use less than 7 days
acamh.onlinelibrary.wiley.com/doi/10.1002/...

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Reposted by Thanh Nha Thai, MD

JACC Journals @jaccjournals.bsky.social · 14d

A new report in #JACC, published to coincide with a #UNGA80 event, highlights the urgent need to prioritize heart health. #CVD causes 1 in 3 deaths worldwide, driven by population growth, aging, obesity & diabetes.

Read the report: www.jacc.org/doi/10.1016/...

#GBDStudy #CardioSky #MedSky

Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023:

Download article citation: If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

www.jacc.org

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Reposted by Thanh Nha Thai, MD

JAMA @jama.com · 19d

What you need to know about this year’s #ESCCongress: from the latest on #GLP1 drugs and β-blockers to the potential #cardiovascular benefits of the #shingles vaccine and the risks of poor mental health.

#MedSky #CardioSky

Clinical Highlights From ESC 2025—GLP-1 Drugs in Heart Failure and More

This Medical News article is an interview with Felix Mahfoud, MD, chair of the Department of Cardiology at University Hospital Basel, about clinical highlights from the European Society of Cardiology ...

jamanetwork.com

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Thanh Nha Thai, MD @thaithanhnha.bsky.social · 21d

Monarez told senators she was fired for “holding the line on scientific integrity” and pushing back on demands from Health and Human Services Secretary Robert F. Kennedy Jr. to preapprove vaccine recommendations from his advisers who have criticized vaccines.

@washingtonpost.com

wapo.st/48hzE6o

Live updates: CDC director ousted by RFK Jr. appears before Senate

Susan Monarez, the fired CDC director, and Debra Houry, one of three top agency leaders who resigned in protest, are testifying before the Senate health committee.

wapo.st

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Reposted by Thanh Nha Thai, MD

Eric Topol @erictopol.bsky.social · 21d

Senate hearing today, Dr. Monarez testified:
Kennedy directed her to commit to approving every recommendation "regardless of the scientific evidence" and also directed her to "dismiss career officials responsible for vaccine policy, w/o cause"
"He said if I was unwilling to do both, I should resign"

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Reposted by Thanh Nha Thai, MD

Harlan M. Krumholz @hmkyale.bsky.social · 22d

New @JACCJournals: Guiding the AI Revolution in CV Medicine
I lay out 5 operational principles—from rigorous validation to bias reduction—to make AI safe, equitable & impactful in cardiology.
➡️ www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @yalemed.bsky.social @yaleschoolofmed.bsky.social

Guiding the AI Revolution in Cardiovascular Medicine:

www.jacc.org

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Thanh Nha Thai, MD @thaithanhnha.bsky.social · 21d

Echocardiography guided management of atrial fibrillation.

link.springer.com/article/10.1...

@esicm.bsky.social @intenscaremed.bsky.social

#CardioSky #AF #Echocardiography

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Reposted by Thanh Nha Thai, MD

Cristina Popa @nephroseeker.medsky.social · 22d

Came across this. Their conclusion: ACEi might be associated with ⬆️mortality (vs ARBs). Even if better quality, target emulation trials=observational+ association isn’t causation (more pts are on ACEi🤷‍♀️) #nephjc
cc @hswapnil.medsky.social @jordybc.bsky.social

www.ahajournals.org/doi/10.1161/...

American Heart Association Journals

www.ahajournals.org

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Thanh Nha Thai, MD @thaithanhnha.bsky.social · 24d

Cardiometabolic and renal benefits of sodium–glucose cotransporter 2 inhibitors.

www.nature.com/articles/s41...

@natrevendo.nature.com

#CardioSky #EndoSky #NephroSky #SGLT2i #Flozin

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Reposted by Thanh Nha Thai, MD

Eric Topol @erictopol.bsky.social · 25d

We know GLP-1 drugs reduce brain inflammation. But I didn't anticipate bipolar disorder as a possible indication in the future
www.nature.com/articles/s41...

Glucagon-like Peptide-1 receptor agonists as emerging therapeutics in bipolar disorder: a narrative review of preclinical and clinical evidence - Molecular Psychiatry

Molecular Psychiatry - Glucagon-like Peptide-1 receptor agonists as emerging therapeutics in bipolar disorder: a narrative review of preclinical and clinical evidence

www.nature.com

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Thanh Nha Thai, MD @thaithanhnha.bsky.social · 25d

Hyperacute T Waves are specific for Occlusion Myocardial Infarction, even without diagnostic ST elevation.

www.jacc.org/doi/10.1016/...

@accintouch.bsky.social @jaccjournals.bsky.social

#CardioSky #JACCAdvances #JACC #JACCJournals

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Reposted by Thanh Nha Thai, MD

Nature Reviews Cardiology @natrevcardiol.nature.com · 26d

New online! The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative #CardioSky

The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative

Nature Reviews Cardiology, Published online: 12 September 2025; doi:10.1038/s41569-025-01209-zIn this Review, Khoury and colleagues examine the growing body of evidence demonstrating the benefits of screening for cardiovascular risk factors, including dyslipidaemia and high blood pressure, starting in childhood to reduce the lifetime burden of cardiovascular disease.

bit.ly

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