theaoti.bsky.social
@theaoti.bsky.social
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What’s amazing about this story is that they *reversed* it. It’s not just a treatment that can stave it off or delay it. It *cures* Alzheimer’s. I know lots of research initially seems hopeful in mice and then doesn’t go anywhere, but this could be momentous.
I cried.
I cried.
Wanna see real-life miracles? Fund scientific research.
A team of US scientists just cured Alzheimer’s in mice — and there is now hope that the disease can be reversed in humans.
futurism.com/health-medic...
A team of US scientists just cured Alzheimer’s in mice — and there is now hope that the disease can be reversed in humans.
futurism.com/health-medic...
Alzheimer's Fully Reversed in Mice, Scientists Say
A new compound has been shown to reverse late stage Alzheimer's disease in lab mice, which gives millions of sufferers new cause for hope.
futurism.com
December 31, 2025 at 2:45 AM
What’s amazing about this story is that they *reversed* it. It’s not just a treatment that can stave it off or delay it. It *cures* Alzheimer’s. I know lots of research initially seems hopeful in mice and then doesn’t go anywhere, but this could be momentous.
I cried.
I cried.
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This is a really nice analysis of the AI bubble, how we got here, and where we might be going. www.lrb.co.uk/the-paper/v4...
John Lanchester · King of Cannibal Island: Will the AI bubble burst?
Nvidia shares are the purest bet you can make on the impact of AI. The leading firms are lending money to one another in...
www.lrb.co.uk
December 27, 2025 at 12:16 PM
This is a really nice analysis of the AI bubble, how we got here, and where we might be going. www.lrb.co.uk/the-paper/v4...
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started / going
December 18, 2025 at 12:13 AM
started / going
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Absolutely right.
AI might be able to summarize (poorly) what we currently know, but a major goal of historical research is to find the hidden surprises out there.
Let me illustrate …
AI might be able to summarize (poorly) what we currently know, but a major goal of historical research is to find the hidden surprises out there.
Let me illustrate …
Not a historian but like to research. The AI might summarize what I'm looking for, but it doesn't find what I'm *not* looking for. The book on the shelf next to the one I wanted. The insight in chapter 6 based on the quote I needed from chapter 4.
December 21, 2025 at 4:09 PM
Absolutely right.
AI might be able to summarize (poorly) what we currently know, but a major goal of historical research is to find the hidden surprises out there.
Let me illustrate …
AI might be able to summarize (poorly) what we currently know, but a major goal of historical research is to find the hidden surprises out there.
Let me illustrate …
Just to clear up any controversy, yes, The Thin Man is a Christmas movie.
December 20, 2025 at 9:24 PM
Just to clear up any controversy, yes, The Thin Man is a Christmas movie.
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Sounds about right.
December 15, 2025 at 12:38 PM
Sounds about right.
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Important to repost this every time Lizza drops another substack
November 26, 2025 at 9:57 PM
Important to repost this every time Lizza drops another substack
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Eagles sports radio is gonna make the red wedding look like a romantic comedy
November 24, 2025 at 12:47 AM
Eagles sports radio is gonna make the red wedding look like a romantic comedy
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A friend who teaches theology shared with me a post about CS Lewis's Mere Christianity, which discusses foundational Christian logic across denominations. It reminded me of Dale's tweet below, and I wanted to share some thoughts here regarding modesty and respectability, which are often hot topics.
November 23, 2025 at 7:35 PM
A friend who teaches theology shared with me a post about CS Lewis's Mere Christianity, which discusses foundational Christian logic across denominations. It reminded me of Dale's tweet below, and I wanted to share some thoughts here regarding modesty and respectability, which are often hot topics.
Reposted by theaoti.bsky.social
Well, it works in theory...
Cryptology Group Held an Election, but Can’t Decrypt the Results
A global group of researchers was unable to read the vote tally, after an official lost one of three secret code keys needed to unlock a hyper-secure election system.
www.nytimes.com
November 22, 2025 at 10:31 PM
Well, it works in theory...
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This is a statement I received from a Epstein survivor who is a Jane Doe.
Share it widely.
Share it widely.
November 14, 2025 at 10:45 PM
This is a statement I received from a Epstein survivor who is a Jane Doe.
Share it widely.
Share it widely.
Love in sports when a guy screws up and he pats his chest as if to say, "Yeah, it's on me."
No need dude, we were watching. Trust me, we were already blaming you.
No need dude, we were watching. Trust me, we were already blaming you.
November 11, 2025 at 1:45 AM
Love in sports when a guy screws up and he pats his chest as if to say, "Yeah, it's on me."
No need dude, we were watching. Trust me, we were already blaming you.
No need dude, we were watching. Trust me, we were already blaming you.
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I'll get back to "party unity" as soon as the Senate Minority Leader tells us if he voted for the Democratic party nominee for mayor of his city.
I'm tired of party unity only ever running one way.
I'm tired of party unity only ever running one way.
November 10, 2025 at 11:14 PM
I'll get back to "party unity" as soon as the Senate Minority Leader tells us if he voted for the Democratic party nominee for mayor of his city.
I'm tired of party unity only ever running one way.
I'm tired of party unity only ever running one way.
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There really should be a coordinated effort to force Schumer out as Minority Leader as a result of his failure here.
The coordinated nature of this—none are facing voters in 2026—means that either Schumer approved it or failed in his job as Senate Majority Leader to stop it.
Dems voting "no" get zero credit until they demand a change in leadership. Schumer out as Leader, Durbin out as Whip.
Dems voting "no" get zero credit until they demand a change in leadership. Schumer out as Leader, Durbin out as Whip.
so currently defectors are:
Kaine (2030)
Shaheen (Retiring)
Hasan (2028)
Fetterman (2028)
Durbin (Retiring)
CCM (2028)
Rosen (2030)
King (2030)
Kaine (2030)
Shaheen (Retiring)
Hasan (2028)
Fetterman (2028)
Durbin (Retiring)
CCM (2028)
Rosen (2030)
King (2030)
November 10, 2025 at 3:05 AM
There really should be a coordinated effort to force Schumer out as Minority Leader as a result of his failure here.
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Dear Democratic Senators: if you vote for this selling out of the ACA it will be the end of your careers. Depend upon it. You are there to defend this country against Trump and the fascists, not collude with them. If you become Quislings, you will forever REMAIN Quislings
November 9, 2025 at 8:26 PM
Dear Democratic Senators: if you vote for this selling out of the ACA it will be the end of your careers. Depend upon it. You are there to defend this country against Trump and the fascists, not collude with them. If you become Quislings, you will forever REMAIN Quislings
Imagine how quickly you would have been laughed out of a pitch meeting in the late 80s or 1990 when you said something like...
You: I feel like we need a TV cop show and I think if I had a choice, I'd grab Donnie Wahlberg....
Network exec: From New Kids on the Block?
You: Yep and maybe Ice-T
You: I feel like we need a TV cop show and I think if I had a choice, I'd grab Donnie Wahlberg....
Network exec: From New Kids on the Block?
You: Yep and maybe Ice-T
November 8, 2025 at 7:58 PM
Imagine how quickly you would have been laughed out of a pitch meeting in the late 80s or 1990 when you said something like...
You: I feel like we need a TV cop show and I think if I had a choice, I'd grab Donnie Wahlberg....
Network exec: From New Kids on the Block?
You: Yep and maybe Ice-T
You: I feel like we need a TV cop show and I think if I had a choice, I'd grab Donnie Wahlberg....
Network exec: From New Kids on the Block?
You: Yep and maybe Ice-T
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This is the perfect distillation of why baseball is great.
Did not expect one of the best paragraphs I’d read about baseball would come from an Irish newspaper
www.irishexaminer.com/sport-column...
www.irishexaminer.com/sport-column...
November 2, 2025 at 4:37 PM
This is the perfect distillation of why baseball is great.
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stellan skarsgård seems like a good dude
October 27, 2025 at 11:48 PM
stellan skarsgård seems like a good dude
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every sports team is a Ship of Theseus
October 25, 2025 at 9:16 PM
every sports team is a Ship of Theseus
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Since Barack Obama, Democratic presidential candidates and "dark money" groups have raised more money than Republicans--often doubling them.
So much of the Dem money is wasted. Publishing a piece on this Sunday explaining these graphs and much more. I need your help to make the piece viral. Thanks!
So much of the Dem money is wasted. Publishing a piece on this Sunday explaining these graphs and much more. I need your help to make the piece viral. Thanks!
October 23, 2025 at 7:04 PM
Since Barack Obama, Democratic presidential candidates and "dark money" groups have raised more money than Republicans--often doubling them.
So much of the Dem money is wasted. Publishing a piece on this Sunday explaining these graphs and much more. I need your help to make the piece viral. Thanks!
So much of the Dem money is wasted. Publishing a piece on this Sunday explaining these graphs and much more. I need your help to make the piece viral. Thanks!
Turns out norms are constructed mostly of paper mache and fairy dust.
October 22, 2025 at 7:47 PM
Turns out norms are constructed mostly of paper mache and fairy dust.
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That’s incomplete, he only got 2 of his 3 feet down inbounds
Roger Goodell says the NFL is looking into how AI can help officiating in the future.
October 22, 2025 at 5:15 PM
That’s incomplete, he only got 2 of his 3 feet down inbounds
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Consciousness of guilt
The Treasury Department instructed employees not to share to share photos of the demolition of parts of the White House’s East Wing
Exclusive | Treasury Tells Employees Not to Share Photos of White House Ballroom Construction
Images of the demolition of parts of the East Wing went viral on Monday, and Treasury’s headquarters next door to the White House has a front-row seat.
www.wsj.com
October 21, 2025 at 2:50 AM
Consciousness of guilt