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Reposted by Boris D Heifets

Scott Thompson, PhD @sthom003.bsky.social · 8d

Interested in bridging the translatability gap between mice and humans, specifically with regard to psychedelics? Have I got an opportunity for you! Join us for an interactive and stimulating pre-meeting before #SfN2025. @theborislab.bsky.social @bita37.bsky.social @fredbarrettphd.bsky.social

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Boris D Heifets @theborislab.bsky.social · 9d

They would be bashed

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Reposted by Boris D Heifets

Scott Thompson, PhD @sthom003.bsky.social · 9d

Interested in bridging the translatability gap between mice and humans, specifically with regard to psychedelics? Have I got an opportunity for you! Join us for an interactive and stimulating pre-meeting before #SfN2025. @theborislab.bsky.social @bita37.bsky.social @fredbarrett.bsky.social

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Boris D Heifets @theborislab.bsky.social · 9d

Amazing lineup! And I promise we won’t just bash forced swim tests

Nate Heller @nate-h-heller.bsky.social · Aug 26

🚨 Limited spots!

👉 🌈🧠 SfN Psychedelic Research Event 🌈🧠

Join us before #SfN2025 (Friday, Nov 14) for a deep dive into cross-species psychedelic neuroscience.

Register + speaker profiles: 👉 hopkinspsychedelic.org/sfn2025

Posters, 🎤 panels, 🔑 keynotes,🍸 cocktails + 🥟 bites.
#psychedelicresearch

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Tyler Ekins @tylerekins.bsky.social · 22d

Excited to share our latest publication -- psychedelic drugs can enhance synaptic connectivity of neurons not expressing 5-HT2ARs (but requiring 5-HT2AR expression in the input neurons -- lots in the supplementals too!)

www.nature.com/articles/s41...

Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors - Molecular Psychiatry

Molecular Psychiatry - Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors

www.nature.com

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Reposted by Boris D Heifets

Allen Institute @alleninstitute.org · Aug 11

Meet one of the winning teams of our MapMySections challenge! 🧠📈

Daniel Rijsketic, Austen Casey, and @theborislab.bsky.social developed UNRAVEL, a tool that precisely maps fluorescent labels across the mouse brain.

Join us on 8/27 for a webinar and live demo: alleninstitute.org/events/mapmy...

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Reposted by Boris D Heifets

Allen Institute @alleninstitute.org · Aug 4

🎯 Algorithm Accuracy Award 🎯

Daniel Ryskamp Rijsketic, Austen Casey, and @theborislab.bsky.social (StanfordMedicine.bsky.social) created UNRAVEL, a Python library for whole-brain fluorescent label mapping: b-heifets.github.io/UNRAVEL/

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Boris D Heifets @theborislab.bsky.social · Aug 2

Thought this would be a useful baseline measure, perhaps predicting elements of the narratives people use to explain their experience, or possible predicting therapeutic outcome. Judging by what I see on other SM, many of these mythical statements are alive and well…

Boris D Heifets @theborislab.bsky.social · Jul 31

One reason this looks the way it does is we envisioned this survey as one of the (many) measures used in a research study- accurate info about possible risks and benefits would be in the consent form. Good idea re white space for other sourced claims

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Boris D Heifets @theborislab.bsky.social · Jul 30

Yes, observation is rarely a passive process- I’m not sure what the answer is besides not asking,this seems low risk to me

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Ted Price @tedpricethepainguy.bsky.social · Jul 24

Hope this paper gets some recognition.
www.biorxiv.org/content/10.1...
Basic pharmacological principles are kinda important for experimental design.

Off-target effects of PLX5622 revealed: mixing microglial function in anesthesia and addiction withdrawal

Microglia have gained increasing attention as important regulators in the brain. Acute microglial depletion using the colony-stimulating factor 1 receptor (CSF1R) inhibitor, PLX5622, has become a popu...

www.biorxiv.org

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Sam Woodburn @samcwoodburn.bsky.social · Jul 19

#GRCPsychedelics - What a blast! It was great to talk science with so many incredible people in the field. Can't wait to do it all over again!

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Melissa Herman @melissaherman.bsky.social · Jul 18

So happy the first #GRCPsychedelics was such a success. It was great to see everyone and share all the amazing science and community. Thank you to all the speakers and congratulations to the travel awardees!!

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Melissa Herman @melissaherman.bsky.social · Jul 18

So grateful to @alexkwan.bsky.social and @vyazovskiy.bsky.social for such a great program. Excited to plan for 2027 with @viditavaidya.bsky.social and new vice chairs @theborislab.bsky.social and @mikaelpalner.bsky.social

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Alaina Jaster, PhD @jasteralaina.bsky.social · Jul 17

I’ve been really feeling down recently, feeling a lot of stress around my job situation + coming to terms with identity shift.

Being at the GRC has filled me with such love, such a sense of community and reminded me of my hard work and that I can continue to inspire people.

Thank you ❤️

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Jibran Khokhar @drjkhokhar.bsky.social · Jul 9

We’ve got some with psilocybin and nicotine withdrawal that we really should publish!

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Boris D Heifets @theborislab.bsky.social · Jul 9

Oh, we have sooooo many to report. Sometimes I do wonder if we’re doing science completely wrong….

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Boris D Heifets @theborislab.bsky.social · Jul 9

The survey:

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Boris D Heifets @theborislab.bsky.social · Jul 9

www.medrxiv.org/content/10.1...

The Psychedelic Media Exposure Questionnaire: The development and validation of a new scale assessing psychedelic-related media exposure

Rationale: A reliable and valid instrument is needed to measure exposure to psychedelic-related media to examine the impact of media and expectations on outcomes in psychedelic clinical trials. Object...

www.medrxiv.org

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Boris D Heifets @theborislab.bsky.social · Jul 9

How much is the psychedelic experience influenced by what we see, hear and read? We made a way to measure it: The Psychedelic Media Exposure Questionnaire - developed by Audrey Evers, Chris Kelly, @shaylalove.bsky.social , @tehseennoorani.bsky.social, validated on >600 respondents. Link below:

The Psychedelic Media Exposure Questionnaire: The development and validation of a new scale assessing psychedelic-related media exposure

Rationale: A reliable and valid instrument is needed to measure exposure to psychedelic-related media to examine the impact of media and expectations on outcomes in psychedelic clinical trials. Object...

www.medrxiv.org

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Boris D Heifets @theborislab.bsky.social · Jul 9

Preprint online! www.biorxiv.org/content/10.1...

Psilocybin has no immediate or persistent analgesic effect in acute and chronic mouse pain models

The psychedelic psilocybin may have lasting therapeutic effects for patients with chronic pain syndromes. Some clinical and preclinical data suggest these putative benefits derive from direct analgesi...

www.biorxiv.org

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Max Wolff @trpwolff.bsky.social · Jun 30

This seems relevant to psychedelic research, where expectancy is still often viewed only as a baseline variable. We should also consider its dynamic changes, how (psychedelic & other) treatment experiences influence them, and their impact on outcomes.

@psybalazs.bsky.social
@theborislab.bsky.social

Liron Rozenkrantz @lironrozenkrantz.bsky.social · Jun 29

In psychotherapy, treatment expectations matter. But even more powerful? ➡️ How they change over time. Our new paper shows that updating expectations during psychotherapy for MDD predicts depression outcomes. 🔗 www.tandfonline.com/eprint/WRBWU...
#depression #psychotherapy #beliefupdating

Dynamic expectancies: The independent role of within-person change in outcome expectancy in predicting overall treatment outcomes in psychotherapy for depression

Dynamic changes in patients’ outcome expectancy have been increasingly recognized as important for psychotherapy success. However, whether expectancy change predicts treatment outcomes independentl...

www.tandfonline.com

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Alex Kwan @alexkwan.bsky.social · Jun 26

Great lineup of speakers from preclinical to clinical, drug discovery to plasticity, and animals to human research. 🔥
@argelaguilarvalles.bsky.social @rcbagot.bsky.social @fredbarrettphd.bsky.social @theborislab.bsky.social @kepecslab.bsky.social @nuro-science.bsky.social @amykooz.bsky.social ...

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Psychedelic Brain Science @psychedbrainsci.bsky.social · May 5

The final episode of Season 4 of Psychedelic Brain Science discusses a recent preprint that gets at the heart of reproducibility in science.

This body of work titled "A multi-institutional investigation of psilocybin's effects on mouse behavior" can be found on BioRxiv!

bioRxiv

www.biorxiv.org

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Boris D Heifets @theborislab.bsky.social · May 5

Does ketamine reset the placebo response? Some interesting links emerging between opioids, placebo antidepressant responses, and maybe a ketamine mechanism to links them. Thx PsyPost for the writeup, lead author Theresa Lii. PsyPost write up here:

Unexpected results from a ketamine study might reshape depression research

A new study suggests chronic opioid use may interfere with the brain’s natural ability to respond to placebo antidepressants. Surprisingly, ketamine’s antidepressant effects remained intact—raising in...

www.psypost.org

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