Intrahepatic immune responses are often insufficient to control hepatitis virus infections. A recent study by Venzin and colleagues demonstrates a detailed mechanism by which an intrahepatic tricellular network and the cytokine IL-27 can augment virus-specific immunity.

Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and be...

Mini placentas can be grown in the lab to study pregnancy and complications like preeclampsia. Using 3D printing technology, we have bioprinted the first placental organoids and studied the impact of their environment on cell behaviour.

Podcast Episode · The Immunology Podcast · 08/21/2025 · 25m

The transfer of microbiota and pathogens from wild mice to genetically tractable laboratory mice has been shown to enhance modeling of human immune responses in preclinical studies. However, the long-term stability of the transferred complex microbiota and the induced immune phenotype in a standard laboratory mouse colony are not known. Oh et al. demonstrate that microbiota from wild mice maintain their composition and biodiversity over multiple years in a laboratory mouse colony, with increased myeloid cell numbers and immune cell function across organs. This phenotype can be transferred to adult lab mice, creating a sharable resource for preclinical research.

Dr. Johnathan Canton is an Assistant Professor at the University of Calgary, where his lab uses advanced microscopy techniques to study dendritic cells, macrophages, and innate immunity. He talks abou...

Effector CD4⁺ T cells restore antiviral CD8⁺ T cell function in the liver by licensing Kupffer cells via CD40–CD40L interactions. This triggers IL-27 production and reprograms the hepatic immune envir...

RNA-targeting therapies hold promise for contributing to HBV cure regimens, but challenges remain before that promise can be realized.