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Reposted by Vincent Tse

Emilia Favuzzi @emiliafavuzzi.bsky.social · 5d

WTI Postdoctoral Fellowship applications are open! Unique opportunity for those pivoting fields or working across disciplines. I’d be happy to support candidates with a background in immunology and/or in vivo 2-photon imaging, including collaborations with other WTI labs wti.yale.edu/initiatives/...

Postdoctoral Fellowships | Wu Tsai Institute

wti.yale.edu

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Reposted by Vincent Tse

PLOS Biology @plosbiology.org · 5d

What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap

Top: Example confocal micrograph showing astrocyte expression of S100β (green), Cre-RFP (magenta), and H1R mRNA (cyan). Left: summed z-projection of all three confocal channels. Middle: RNAscope detected H1R mRNA with white and yellow arrows indicating example WT (S100β+/RFP−/H1R+) and cKO (RFP+/H1R−) soma regions of interest (ROIs), respectively. Right: Cre-RFP expression (top, magenta) and S100β expression (bottom, green). Scale bars = 10 μm. Bottom: Example confocal micrograph showing astrocytic Cre-RFP (magenta), neuronal NeuN (green), and nuclear marker DAPI (blue). Left: summed z-projection of all three confocal channels. Middle: astrocytic Cre-RFP signal with astrocyte soma ROIs overlaid. Right: NeuN signal with astrocyte soma ROIs overlaid. Scale bars = 50 μm.

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Vincent Tse @vincenttse.bsky.social · 6d

Really excited to see this work from my postgrad days come out of its "slumber" 💤 If you are interested in how astrocytes interact with neuromodulatory systems to regulate cortical states, this is for you!

Kira Poskanzer @kiraposkanzer.bsky.social · 6d

Congrats to Charlotte Taylor and team for dissecting how astrocyte networks integrate histamine to modulate adenosine over sleep and wake in unexpected ways:

dx.plos.org/10.1371/jour...

@vincenttse.bsky.social @maxine.science @trishavv.bsky.social

Cortical astrocyte histamine-1-receptors regulate intracellular calcium and extracellular adenosine dynamics across sleep and wake

While histamine-1-receptor (H1R) signaling in neurons regulates arousal, these receptors are also abundant on cortical astrocytes. This study shows that astrocytic H1R signaling modulates calcium acti...

dx.plos.org

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Reposted by Vincent Tse

Kira Poskanzer @kiraposkanzer.bsky.social · 6d

Congrats to Charlotte Taylor and team for dissecting how astrocyte networks integrate histamine to modulate adenosine over sleep and wake in unexpected ways:

dx.plos.org/10.1371/jour...

@vincenttse.bsky.social @maxine.science @trishavv.bsky.social

Cortical astrocyte histamine-1-receptors regulate intracellular calcium and extracellular adenosine dynamics across sleep and wake

While histamine-1-receptor (H1R) signaling in neurons regulates arousal, these receptors are also abundant on cortical astrocytes. This study shows that astrocytic H1R signaling modulates calcium acti...

dx.plos.org

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Reposted by Vincent Tse

Misha Ahrens @mishaahrens.bsky.social · Sep 8

Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...

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Vincent Tse @vincenttse.bsky.social · Aug 28

Cool work @lester-rodriguez.bsky.social ! Congrats 🎉

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Reposted by Vincent Tse

Sreeganga Chandra Lab at Yale @schandralab.bsky.social · Aug 8

Postdocs: Apply now for the SYNAPSES series @kavliatyale.bsky.social @yaleneuro.bsky.social! Deadline to apply is September 7th

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Reposted by Vincent Tse

Dementia Researcher @dementiaresearcher.bsky.social · Aug 5

Yale School of Medicine seeks a tenure track faculty member to research neuroinflammation in Alzheimer’s, bridging disciplines within a vibrant, collaborative community. Closing date: 31st October

www.dementiaresearcher.nihr.ac.uk/job/associat...

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Reposted by Vincent Tse

Gan Lab @liganlab.bsky.social · Jul 28

The Sirota & Huang labs identified a novel letrozole–irinotecan combination therapy that improves memory and reduces pathology in Alzheimer's disease models—showcasing a transformative drug discovery approach rooted in human transcriptomics and real-world clinical data www.cell.com/cell/fulltex...

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease

A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...

www.cell.com

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Reposted by Vincent Tse

Wu Tsai Institute | Yale University @wutsaiyale.bsky.social · Jul 28

In collaboration with @pebyale.bsky.social, WTI presents the 2025 Undergraduate Poster Symposium. Join us at 100 College Street on Wednesday, July 30, from 2-4 pm.

Faculty, students + trainees are encouraged to attend! Learn more: wti.yale.edu/event/2025-0...

#KnowTogether

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Reposted by Vincent Tse

Melissa Cooper, PhD @melcooperphd.bsky.social · Jul 22

Now on bioRxiv! Astrocytes in one brain region (cyan) communicate in expansive networks (magenta). Through tool development, tissue clearing, and many hours on our @zeiss-microscopy.bsky.social Z1, we now know these networks are repeatable across mice, plastic, and specific.
doi.org/10.1101/2025...

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Matt Girgenti @mattgirgenti.bsky.social · Jun 18

Very proud of our new #SingleCell work on #PTSD and #MDD out in @nature.com today.
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...

Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD - Nature

A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.

www.nature.com

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Reposted by Vincent Tse

Emilia Favuzzi @emiliafavuzzi.bsky.social · May 22

I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!

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Vincent Tse @vincenttse.bsky.social · May 16

Really cool work -- congrats to all the authors!

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Reposted by Vincent Tse

Konrad Kording @kordinglab.bsky.social · May 15

I have seen folks waste so much time by not properly planning research. Missed literature, missing controls, ignored hypotheses, etc. Lack of planning also produces bad science (e.g. analysis until significant). So I am writing an app. Looking for feedback. scientific-paper-planner-test.vercel.app

Scientific Paper Planner

Scientific Paper Planner Application

scientific-paper-planner-test.vercel.app

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Vincent Tse @vincenttse.bsky.social · Apr 25

Lovely image, Andrew! Would you mind sharing the antibody you are using to stain phospho-tau? Thanks in advance.

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Reposted by Vincent Tse

Irene Serra Hueto @ireneserrahu.bsky.social · Feb 3

Extremely proud to finally be able to present this work in the open🍾✨ We identify and manipulate astrocytic calcium-dependent ensembles in the NAc ✨✨ It gathers new tools, intense experiments and results that blowed our minds in the process at Navarrete's lab 🤯 Check it out! rdcu.be/d8qJi

Astrocyte ensembles manipulated with AstroLight tune cue-motivated behavior

Nature Neuroscience - Using the AstroLight system, the authors reveal that astrocytic ensembles in the nucleus accumbens regulate cue-motivated reward behavior, demonstrating that selective...

rdcu.be

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Reposted by Vincent Tse

Andrew Octavian Sasmita @aosasmita.bsky.social · Jan 20

Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.

Thread below: (1/11)

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease

The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying cerebral plaque burden depending on the parental source of the transgene. Mice inheriting the transgene paternally...

www.cell.com

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Reposted by Vincent Tse

Jaime Grutzendler @jgrutzendler.bsky.social · Jan 8

Our lab at Yale U/Wu Tsai Institute has a postdoctoral position on neurodegeneration, neuro-glial-vascular biology using 2photon, calcium/voltage imaging, gene editing,transcriptome/proteome, 3D EM, translational neurosci/chemistry. Email me if interested. Forward to those interested pls

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Reposted by Vincent Tse

Shanae Aerts @shanaeaerts.bsky.social · Dec 16

Adding @tamarajafar.bsky.social
@schandralab.bsky.social
@toddc.bsky.social
@vincenttse.bsky.social

If you’re interested in understanding cognition and Neuroscience at Yale follow our starter pack .

If there are others that should be added let me know !

go.bsky.app/CqNL4be

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Vincent Tse @vincenttse.bsky.social · Dec 16

I would like to join! Thank you so much

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Dr. Nathan A Smith @drnathanasmith.bsky.social · Nov 18

I would appreciate it if you could share this invitation and respond if you would like to join this group.

go.bsky.app/DXdNa8k

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Monica Carson @brainimmunity.bsky.social · Nov 17

some great starter packs for the #glia, #astrocyte, #oligodendrocyte, #microglia, #neuro researcher: gliasky, astrocytesky, microglia
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?

go.bsky.app/MHtJzeC

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Vincent Tse @vincenttse.bsky.social · Dec 16

I would love to be added! Thank you so much

Reposted by Vincent Tse

Shane Liddelow @liddelowsa.bsky.social · Nov 17

There are lots of us missing, but so many joining so quickly

Please do share, and comment below to be added

go.bsky.app/5f2V6L6

(microglia starter pack also here by @mancusorenzo.bsky.social - bsky.app/starter-pack...)

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