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Xinnan Wang Lab @xinnanwanglab.bsky.social · 13d

Our new review is out! Likely once an independent organism, mitochondria have retained a striking degree of autonomy. We discuss their capacity to sense within—a process we refer to as mitochondrial inside-out signaling. Written by talented @furkanoflaz.bsky.social @signscaztl.bsky.social

Waggoner Lab @labwaggoner.bsky.social · 13d

Review @cp-cellchembiol.bsky.social @xinnanwanglab.bsky.social @stanforduniversity.bsky.social
Sensing within: Mitochondrial inside-out signal transduction
www.cell.com/cell-chemica...

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Xinnan Wang Lab @xinnanwanglab.bsky.social · 16d

Congratulations Andy on this beautiful study! Thanks for including us!

C. Andrew Frank @candrewfrank.bsky.social · 16d

We have an uncorrected proof published for Bhagaban Mallik's study on Mitochondrial Complex I and how it regulates synapse function. You can find it in @plosbiology.org. I am so proud!

H/T collaborators: Drs. Sajad Bhat and Xinnan Wang @xinnanwanglab.bsky.social

journals.plos.org/plosbiology/...

Mitochondrial Complex I and ROS control neuromuscular function through opposing pre- and postsynaptic mechanisms

How do neurons adapt to mitochondrial dysfunction in different tissues? This study shows that Mitochondrial Complex I depletion triggers ROS-driven compensatory signaling in motor neurons that preserv...

journals.plos.org

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Xinnan Wang Lab @xinnanwanglab.bsky.social · 23d

Our previous papers: www.cell.com/cell-stem-ce...; www.cell.com/cell-metabol...; www.nature.com/articles/s42...; www.cell.com/cell-reports...

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

Using iPSC-derived neurons and other models, Hsieh et al. uncover a defect in clearance of damaged mitochondria in Parkinson’s disease. They show that in mutant cells, the mitochondrial outer membrane...

www.cell.com

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Xinnan Wang Lab @xinnanwanglab.bsky.social · 23d

doi.org/10.1038/s415...

Methodological validation of Miro1 retention as a candidate Parkinson’s disease biomarker - npj Parkinson's Disease

npj Parkinson's Disease - Methodological validation of Miro1 retention as a candidate Parkinson’s disease biomarker

doi.org

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Xinnan Wang Lab @xinnanwanglab.bsky.social · 23d

Happy to see our previous studies showing Miro1 resistance to mitochondrial depolarization in PD and the efficacy of Miro1-binding compounds are fully validated in independent cohorts by Julia Fitzgerald's group: doi: 10.1038/s41531-025-01115-8

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Xinnan Wang Lab @xinnanwanglab.bsky.social · Aug 29

We had so much fun presenting 5 posters at Stanford Bio-X Symposium!

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Reposted by Xinnan Wang Lab

Anupam Patgiri @apatgiri.bsky.social · Aug 28

Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress www.science.org/doi/10.1126/...

Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress

Drugs targeting mitochondrial removal show unexpected mechanisms with implications for Parkinson’s therapeutics.

www.science.org

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Xinnan Wang Lab @xinnanwanglab.bsky.social · Aug 23

Mitochondrial pearling and zipping 🤔! So cool! Inspiring talk from @sulianamanley.bsky.social

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Reposted by Xinnan Wang Lab

Alex Whitworth lab @labwhitworth.bsky.social · Jul 16

Delighted to share our latest work looking at the role of the RNA-binding proteins Clu1 (yeast)/Clu (flies) in regulating the translation of #mitochondria proteins. Really interesting regulator of mito biology.

Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...

Clu1/Clu form mitochondria-associated granules upon metabolic transitions and regulate mitochondrial protein translation via ribosome interactions

Author summary Mitochondria are essential cellular organelles that perform many important roles in regulating metabolism. They are dynamic in form, function and composition which is crucial to maintai...

dx.plos.org

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Reposted by Xinnan Wang Lab

Molly Schumer @mollyschumer.bsky.social · Jun 16

Please share! We are accepting applications for the Biology Preview Program, which aims to make the PhD application process accessible and work with students to strenghten applications. Participants will receive a fee waiver, work 1:1 w/ a mentor, and meet w/faculty. Link: forms.gle/1xBShmvot5Vr...

2025 Stanford Biology Preview Program Application

The Stanford Biology Preview Program (BPP) aims to support scholars through the PhD application process. The Stanford BPP offers virtual workshops to provide insight into the Stanford Biology PhD Prog...

forms.gle

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Reposted by Xinnan Wang Lab

A. Phillip West @westlabmito.bsky.social · Jun 1

Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease - Nature Communications

Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...

www.nature.com

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Reposted by Xinnan Wang Lab

Yasemin Sancak @yasesancak.bsky.social · May 31

Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...

Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma

Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.

www.science.org

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Reposted by Xinnan Wang Lab

Science Magazine @science.org · May 23

Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d

Silencing mitochondrial gene expression in living cells

Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...

scim.ag

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Xinnan Wang Lab @xinnanwanglab.bsky.social · May 12

Congratulations Furkan!

furkanoflaz.bsky.social @furkanoflaz.bsky.social · May 12

I’m happy to share that my latest PhD work is published in
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. www.embopress.org/doi/full/10....

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Reposted by Xinnan Wang Lab

Flora Rutaganira @frutag33.bsky.social · Apr 21

Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)

Flyer for the 2025 Next Generation Faculty Symposium (including QR code in top right corner). This symposium highlights the work of exceptional early-career scientists in the broad field of quantitative biological and biomedical sciences, with a track record of excellence in research, leadership, mentorship, and community engagement. These early career scientists are preparing to launch a faculty search. Applications are due May 30th, 2025.

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Xinnan Wang Lab @xinnanwanglab.bsky.social · Apr 10

ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution | Science Advances www.science.org/doi/10.1126/...

ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution

ARMC1 partitions between distinct outer mitochondrial membrane complexes and the cytosol to control mitochondrial distribution.

www.science.org

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Reposted by Xinnan Wang Lab

Mito@GU @mito-at-gu.bsky.social · Apr 9

New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...

Small molecules restore mutant mitochondrial DNA polymerase activity - Nature

An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

www.nature.com

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Reposted by Xinnan Wang Lab

Nature Metabolism @natmetabolism.nature.com · Apr 8

TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux

Nature Metabolism, Published online: 08 April 2025; doi:10.1038/s42255-025-01250-9Garbincius et al. show that the mitochondrial protein TMEM65 is required to mediate NCLX-dependent mitochondrial calcium efflux, thus fine-tuning mitochondrial function and cellular homeostasis

bit.ly

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Reposted by Xinnan Wang Lab

Tatjana Kleele @tatjanakleele.bsky.social · Apr 4

Thrilled to announce that the registration for the EMBO workshop „Mitochondria in the Nervous System“ is now open.
Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland!
meetings.embo.org/event/25-mit...

Mitochondria in the Nervous System

The brain is a high energy-demanding tissue with an heterogenous cellular composition. Most of the energy consumed is used for maintenance of neuronal synaptic transmission, and neurons almost exclus…

meetings.embo.org

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Xinnan Wang Lab @xinnanwanglab.bsky.social · Jan 28

Beautiful paper on mitochondrial DNA (mtDNA) stress sensing, from our postdoc Alva Sainz @signscaztl.bsky.social of her Ph.D work in the Shadel lab!

Journal of Cell Biology @jcb.org · Jan 27

New: Sainz, Shadel et al. @salkinstitute.bsky.social investigate mitochondrial respiration-independent signaling induced by acute mtDNA depletion and uncover a role for FAM43A in a CHK2-dependent mitochondrial stress signaling pathway. https://buff.ly/40MBmIW
#mitochondria

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Xinnan Wang Lab @xinnanwanglab.bsky.social · Nov 30

Impressive #MitoSky 🦋 in Japan! #MBSJ2024

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Xinnan Wang Lab @xinnanwanglab.bsky.social · Nov 22

We had a nice lab visit from Gordon Freedman, the mastermind of MitoWorld - seems a great initiative: mitoworld.org

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Xinnan Wang Lab @xinnanwanglab.bsky.social · Nov 20

Hi everyone, really enjoy the fresh air here and meeting new people! Thanks to @colemanlab.bsky.social for the nudge! We study everything related to mitochondria. Hope to form more connections and conversations! Some blue sky pics from a fantastic nature conference on mito and immunity in September.

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Reposted by Xinnan Wang Lab

Coleman Lab @colemanlab.bsky.social · Nov 10

Welcome to @xinnanwanglab.bsky.social - a star of mitochondrial dynamics in neurons!😀

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Xinnan Wang Lab @xinnanwanglab.bsky.social · Nov 11

Thank you so much Michael 😊, and for the introduction!

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