Reposted
Honored to receive the 2026 DeLano Award from @asbmb.bsky.social. Warren wrote PyMOL which I spend several hours a day with -- a hero for open & accessible software. Helen Berman, another of my heroes, nominated me (with help from Ruth Nussinov & Janet Thornton), three women I admire tremendously.
September 5, 2025 at 10:35 PM
Honored to receive the 2026 DeLano Award from @asbmb.bsky.social. Warren wrote PyMOL which I spend several hours a day with -- a hero for open & accessible software. Helen Berman, another of my heroes, nominated me (with help from Ruth Nussinov & Janet Thornton), three women I admire tremendously.
Reposted
Keep advocating! “Kerry Kennedy, sister of Robert F. Kennedy Jr., has joined her nephew, former Massachusetts Rep. Joseph P. Kennedy III, calling on her brother to resign…
“Medical decisions belong in the hands of trained and licensed professionals, not incompetent and misguided leadership”
“Medical decisions belong in the hands of trained and licensed professionals, not incompetent and misguided leadership”
RFK Jr.’s sister, nephew call for him to resign from HHS
“Enough is enough”: RFK Jr.’s sister and other Kennedy family members are calling for the HHS secretary to step down.
www.statnews.com
September 6, 2025 at 11:34 AM
Keep advocating! “Kerry Kennedy, sister of Robert F. Kennedy Jr., has joined her nephew, former Massachusetts Rep. Joseph P. Kennedy III, calling on her brother to resign…
“Medical decisions belong in the hands of trained and licensed professionals, not incompetent and misguided leadership”
“Medical decisions belong in the hands of trained and licensed professionals, not incompetent and misguided leadership”
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A really good explanation of why relying on cherry-picked science to draw a Tylenol-autism link (as RFK seems poised to do) is really harmful, along with a reminder that Tylenol deserves a lot of scrutiny for other reasons.
open.substack.com/pub/insideme...
open.substack.com/pub/insideme...
Tylenol has entered the chat: RFK Jr. wants to link it to autism, even though the best evidence says otherwise.
It's not pseudoscience. But it's not settled either, nor is it "safe" to assume otherwise.
open.substack.com
September 6, 2025 at 11:58 AM
A really good explanation of why relying on cherry-picked science to draw a Tylenol-autism link (as RFK seems poised to do) is really harmful, along with a reminder that Tylenol deserves a lot of scrutiny for other reasons.
open.substack.com/pub/insideme...
open.substack.com/pub/insideme...
Reposted
My quote of the day
Nobody ever thanks you for saving them from the disease they didn't know they were going to get.
William Foege
Nobody ever thanks you for saving them from the disease they didn't know they were going to get.
William Foege
September 1, 2025 at 11:26 AM
My quote of the day
Nobody ever thanks you for saving them from the disease they didn't know they were going to get.
William Foege
Nobody ever thanks you for saving them from the disease they didn't know they were going to get.
William Foege
Reposted
9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American."
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...
Opinion | We Ran the C.D.C.: Kennedy Is Endangering Every American’s Health
www.nytimes.com
September 1, 2025 at 11:23 AM
9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American."
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...
Reposted
Good news. The House of Representatives stands behind the NIH budget with no cuts.
September 2, 2025 at 12:53 AM
Good news. The House of Representatives stands behind the NIH budget with no cuts.
Reposted
I stand with Joachim Frank. I would hope that others would have had a better understanding of history.
2/2
2/2
August 29, 2025 at 11:58 AM
I stand with Joachim Frank. I would hope that others would have had a better understanding of history.
2/2
2/2
Reposted
"Success for all", from his University's motto to a life that changed everyone else's... Today's #ECM35 starts with a lecture filled with emotions and anecdotes by Isabel Usón, remembering George Sheldrick #crystallography
August 26, 2025 at 7:03 AM
"Success for all", from his University's motto to a life that changed everyone else's... Today's #ECM35 starts with a lecture filled with emotions and anecdotes by Isabel Usón, remembering George Sheldrick #crystallography
Reposted
No matter how hard you try, you simply cannot guess the journal withe the highest “impact factor” in organic chemistry last year. Really. Nor will you guess many of the other “winners”:
Journal Impact Nonsense
www.science.org
August 14, 2025 at 6:32 PM
No matter how hard you try, you simply cannot guess the journal withe the highest “impact factor” in organic chemistry last year. Really. Nor will you guess many of the other “winners”:
Reposted
Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX.
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
August 20, 2025 at 9:01 PM
Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX.
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
Reposted
Neil deGrass Tyson: "How sad it must be believing that scientists, historians, scholars, economists, journalists devoted their entire lives to deceiving you, but a reality-TV star proven in court to be a lying felon is your beacon of truth & honesty"
August 23, 2025 at 4:26 PM
Neil deGrass Tyson: "How sad it must be believing that scientists, historians, scholars, economists, journalists devoted their entire lives to deceiving you, but a reality-TV star proven in court to be a lying felon is your beacon of truth & honesty"
Reposted
Want to see the economic impact of #NIH grant cuts in your community? Check out @joshuasweitz.bsky.social and colleagues' project here. Tell your friends and neighbors what is happening. scienceimpacts.org
SCIMaP - Impacts of Federal Cuts to Science and Medical Research
Developed by an interdisciplinary research team, this website shows how funding cuts reduce economic activity and employment nationwide
scienceimpacts.org
August 23, 2025 at 1:16 PM
Want to see the economic impact of #NIH grant cuts in your community? Check out @joshuasweitz.bsky.social and colleagues' project here. Tell your friends and neighbors what is happening. scienceimpacts.org
Reposted
And a further report on his use of made-up science to attack climate change policies. www.nature.com/articles/d41... 3/4
Outrage over Trump team’s climate report spurs researchers to fight back
The authors welcome ‘serious’ scientific rebuttals to report that some say misrepresents decades of climate science.
www.nature.com
August 24, 2025 at 12:29 PM
And a further report on his use of made-up science to attack climate change policies. www.nature.com/articles/d41... 3/4
Reposted
Three pieces in Nature this week on Trump’s assaults on science. An editorial on the cancellation of $500m funding for mRNA vaccine research www.nature.com/articles/d41... 1/4
Cancelling mRNA studies is the highest irresponsibility
The rest of the world is not following the US government’s dangerous path, and will stick with the technology that helped the world out of the COVID-19 pandemic.
www.nature.com
August 24, 2025 at 12:29 PM
Three pieces in Nature this week on Trump’s assaults on science. An editorial on the cancellation of $500m funding for mRNA vaccine research www.nature.com/articles/d41... 1/4
Reposted
Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination.
buff.ly/ofD02RD
buff.ly/ofD02RD
August 24, 2025 at 8:21 AM
Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination.
buff.ly/ofD02RD
buff.ly/ofD02RD
Reposted
5-Methyluridine is Ubiquitous in Pseudomonas aeruginosa tRNA and Modulates Antimicrobial Resistance and Virulence
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
5-Methyluridine is Ubiquitous in Pseudomonas aeruginosa tRNA and Modulates Antimicrobial Resistance and Virulence
Building on decades of work in characterizing the dozens of RNA modifications in the microbial epitranscriptome, recent advances in analytical technol…
www.sciencedirect.com
August 13, 2025 at 12:21 PM
5-Methyluridine is Ubiquitous in Pseudomonas aeruginosa tRNA and Modulates Antimicrobial Resistance and Virulence
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted
It’s certainly Not Good.
Federal funding for US science research has been disrupted dramatically in 2025. Other countries are enticing US students and scientists to move abroad, leaving the overall impact on chemistry and science uncertain. cen.acs.org/careers/US-s... #chemsky 🧪
US science research was gutted in 2025. How will it rebuild?
New strategies as diverse as venture capitalism and investments from abroad are emerging to sustain the field
cen.acs.org
August 13, 2025 at 12:55 PM
It’s certainly Not Good.
Reposted
Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳
How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps
Lövestam and Scheres present a cryo-EM structure of vault particles, found during
tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They
reveal a symmetry shift at the va...
www.cell.com
August 12, 2025 at 4:05 PM
Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳
How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
Reposted
What’s the next PDB? Maybe it’s …the PDB.
We just launched @diffuseproject.bsky.social a structural biology initiative exploring protein motion & rethinking how we generate and use experimental data. Quick 🧵👇
www.diffuse.science
We just launched @diffuseproject.bsky.social a structural biology initiative exploring protein motion & rethinking how we generate and use experimental data. Quick 🧵👇
www.diffuse.science
The Diffuse Project
The Diffuse Project
www.diffuse.science
August 12, 2025 at 4:16 PM
What’s the next PDB? Maybe it’s …the PDB.
We just launched @diffuseproject.bsky.social a structural biology initiative exploring protein motion & rethinking how we generate and use experimental data. Quick 🧵👇
www.diffuse.science
We just launched @diffuseproject.bsky.social a structural biology initiative exploring protein motion & rethinking how we generate and use experimental data. Quick 🧵👇
www.diffuse.science
Reposted
We are proud to announce our newest adventure!
Introducing the Diffuse Project, a community-driven effort to predict protein dynamics using the subtle diffuse scattering signal from protein crystals. This collaboration marks a new era for the Ando lab!
as.cornell.edu/news/philant...
🧪
🧬🧶
💫
Introducing the Diffuse Project, a community-driven effort to predict protein dynamics using the subtle diffuse scattering signal from protein crystals. This collaboration marks a new era for the Ando lab!
as.cornell.edu/news/philant...
🧪
🧬🧶
💫
Philanthropic support accelerates infrastructure for the future of structural biology
A new $5 million initiative, funded by the Astera Institute with experimental work conducted at the Cornell High Energy Synchrotron Source, aims to make diffuse scattering accessible to the public and...
as.cornell.edu
August 13, 2025 at 12:06 AM
We are proud to announce our newest adventure!
Introducing the Diffuse Project, a community-driven effort to predict protein dynamics using the subtle diffuse scattering signal from protein crystals. This collaboration marks a new era for the Ando lab!
as.cornell.edu/news/philant...
🧪
🧬🧶
💫
Introducing the Diffuse Project, a community-driven effort to predict protein dynamics using the subtle diffuse scattering signal from protein crystals. This collaboration marks a new era for the Ando lab!
as.cornell.edu/news/philant...
🧪
🧬🧶
💫
Reposted
"meaningful and innovative health research has never flourished amid constraints on language and free exchange of ideas"
Article in Nature from a former NIH employee and Bethesda Declaration signer...
www.nature.com/articles/d41...
www.nature.com/articles/d41...
‘A whole body of health-equity research is being disappeared’ — why I resigned from the NIH
As federal support vanishes for research addressing the root causes of health disparities in the United States, we are left with a dangerous void and an urgent need to rethink science funding.
www.nature.com
August 13, 2025 at 4:51 AM
"meaningful and innovative health research has never flourished amid constraints on language and free exchange of ideas"
Reposted
The mRNA vaccines were miraculous. It lost public trust because there was a calculated campaign to undermine it. Jay Bhattacharya, RFK & Vinay Prasad were all accomplices in destroying trust in vaccines & science in general. More people will die as a result. www.washingtonpost.com/opinions/202...
Opinion | Jay Bhattacharya: Why the NIH is pivoting away from mRNA vaccines
As a vaccine for broad public use, mRNA technology has failed to earn the public’s trust.
www.washingtonpost.com
August 12, 2025 at 8:42 PM
The mRNA vaccines were miraculous. It lost public trust because there was a calculated campaign to undermine it. Jay Bhattacharya, RFK & Vinay Prasad were all accomplices in destroying trust in vaccines & science in general. More people will die as a result. www.washingtonpost.com/opinions/202...
Reposted
Our new research was just published in Nature Communications! Graduate student Evy Kimbrough, Ha An Nguyen and Jacob Mattingly contributed to this work, Our results directly answer a long-standing and fundamental question in biology of how tRNA modifications influence mRNA reading frame maintenance.
August 12, 2025 at 11:11 AM
Our new research was just published in Nature Communications! Graduate student Evy Kimbrough, Ha An Nguyen and Jacob Mattingly contributed to this work, Our results directly answer a long-standing and fundamental question in biology of how tRNA modifications influence mRNA reading frame maintenance.
Reposted
Bacterial cell wall & periplasm paradigm shift - important read #MicroSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 29, 2025 at 4:01 PM
Bacterial cell wall & periplasm paradigm shift - important read #MicroSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Carol Robinson on Desert Island Discs - have a listen friends: www.bbc.co.uk/sounds/play/...
An inspirational scientist & friend. An example of combining scientific excellence, courage, hard work and really importantly; kindness. (Yes I’m biased, but it’s true nevertheless)
@kavlioxford.bsky.social
An inspirational scientist & friend. An example of combining scientific excellence, courage, hard work and really importantly; kindness. (Yes I’m biased, but it’s true nevertheless)
@kavlioxford.bsky.social
Desert Island Discs - Professor Dame Carol Robinson, scientist - BBC Sounds
Dame Carol Robinson, scientist, shares the soundtrack of her life with Lauren Laverne.
www.bbc.co.uk
August 10, 2025 at 10:40 AM
Carol Robinson on Desert Island Discs - have a listen friends: www.bbc.co.uk/sounds/play/...
An inspirational scientist & friend. An example of combining scientific excellence, courage, hard work and really importantly; kindness. (Yes I’m biased, but it’s true nevertheless)
@kavlioxford.bsky.social
An inspirational scientist & friend. An example of combining scientific excellence, courage, hard work and really importantly; kindness. (Yes I’m biased, but it’s true nevertheless)
@kavlioxford.bsky.social