A GLP1 side effect that I never paid much attention to was Allodynia and I didn’t pay attention to it because after almost 2 years I had never experienced it… Until now! This is no joke! Has anyone else experienced this and if so, what do you do to soothe it?
February 3, 2026 at 6:16 PM
A GLP1 side effect that I never paid much attention to was Allodynia and I didn’t pay attention to it because after almost 2 years I had never experienced it… Until now! This is no joke! Has anyone else experienced this and if so, what do you do to soothe it?
transcriptomic, biochemical, and functional approaches.
RESULT: Repeated inflammatory stimulation markedly increased CXCL13 and CXCR5 expression and ERK phosphorylation in the Sp5C, accompanied by mechanical allodynia, thermal hyperalgesia, glial activation, and elevated IL-6 (🧵 3/9)
RESULT: Repeated inflammatory stimulation markedly increased CXCL13 and CXCR5 expression and ERK phosphorylation in the Sp5C, accompanied by mechanical allodynia, thermal hyperalgesia, glial activation, and elevated IL-6 (🧵 3/9)
February 3, 2026 at 12:51 PM
transcriptomic, biochemical, and functional approaches.
RESULT: Repeated inflammatory stimulation markedly increased CXCL13 and CXCR5 expression and ERK phosphorylation in the Sp5C, accompanied by mechanical allodynia, thermal hyperalgesia, glial activation, and elevated IL-6 (🧵 3/9)
RESULT: Repeated inflammatory stimulation markedly increased CXCL13 and CXCR5 expression and ERK phosphorylation in the Sp5C, accompanied by mechanical allodynia, thermal hyperalgesia, glial activation, and elevated IL-6 (🧵 3/9)
Does anyone else have allodynia? I get it all over my body during a flare up and it's so bad in my one hand today. For those who don't know, allodynia is a nerve issue that causes areas of your skin to be extremely painful to touch or temperature changes. 😓 Mines both a lot of the time.
February 2, 2026 at 4:18 PM
Does anyone else have allodynia? I get it all over my body during a flare up and it's so bad in my one hand today. For those who don't know, allodynia is a nerve issue that causes areas of your skin to be extremely painful to touch or temperature changes. 😓 Mines both a lot of the time.
I have allodynia, and anyway I lost my bp machine 🙁
February 2, 2026 at 7:39 AM
I have allodynia, and anyway I lost my bp machine 🙁
I never heard of it before but he inferred that it is used for diabetic neuropathy and may help as the allodynia is right where my bra touches my back and shoulders. Botox only helps for 8-10 weeks.
February 2, 2026 at 2:42 AM
I never heard of it before but he inferred that it is used for diabetic neuropathy and may help as the allodynia is right where my bra touches my back and shoulders. Botox only helps for 8-10 weeks.
I've never used ketamine typically but have had intranasal. I was prescribed a super low dose, though, so found it ineffective. I don't know much about topical k.
Lowering your attacks in general should help the allodynia so a preventive is still a good idea. But sound like a topical is smart, too.
Lowering your attacks in general should help the allodynia so a preventive is still a good idea. But sound like a topical is smart, too.
February 2, 2026 at 2:21 AM
I've never used ketamine typically but have had intranasal. I was prescribed a super low dose, though, so found it ineffective. I don't know much about topical k.
Lowering your attacks in general should help the allodynia so a preventive is still a good idea. But sound like a topical is smart, too.
Lowering your attacks in general should help the allodynia so a preventive is still a good idea. But sound like a topical is smart, too.
I haven’t tried any. I have had allodynia so bad the days I don’t have migraine pain that I need to do something. Anything that helps break the cycle because I’m so light sensitive driving is an issue. My pharmacist offered ketamine cream and said to ask the people who really know.
February 2, 2026 at 2:14 AM
I haven’t tried any. I have had allodynia so bad the days I don’t have migraine pain that I need to do something. Anything that helps break the cycle because I’m so light sensitive driving is an issue. My pharmacist offered ketamine cream and said to ask the people who really know.
Allodynia is one of the worst fibro symptoms and so hard to explain to people. Ice is smart for that. I started logging what triggers those flares using the CareClinic app and found a pattern with weather and stress. Might help you spot yours too. Hope the ice gives you some relief tonight.
January 28, 2026 at 8:14 PM
Allodynia is one of the worst fibro symptoms and so hard to explain to people. Ice is smart for that. I started logging what triggers those flares using the CareClinic app and found a pattern with weather and stress. Might help you spot yours too. Hope the ice gives you some relief tonight.
#ChronicPain #CRPS #Allodynia #Arthritis #SpinalStenosis #BrokeBackL1 #Lupus #Sjogrens #Dystonia #COPD #DEPRESSION ...and #RELEASE the #EpsteinFiles
January 27, 2026 at 7:32 PM
I am ABSOLUTELY RAGING, pals. When I had my stroke the medical team knew a) I had fibro b) I’m hypermobile.
Did anyone bother to mention I was at risk of increased allodynia because of (a) and potential claw toe because of (b).
No, no they did not.
ABSOLUTE FUCKERS - having issues with both 🤨😒😡
Did anyone bother to mention I was at risk of increased allodynia because of (a) and potential claw toe because of (b).
No, no they did not.
ABSOLUTE FUCKERS - having issues with both 🤨😒😡
January 26, 2026 at 9:40 AM
I am ABSOLUTELY RAGING, pals. When I had my stroke the medical team knew a) I had fibro b) I’m hypermobile.
Did anyone bother to mention I was at risk of increased allodynia because of (a) and potential claw toe because of (b).
No, no they did not.
ABSOLUTE FUCKERS - having issues with both 🤨😒😡
Did anyone bother to mention I was at risk of increased allodynia because of (a) and potential claw toe because of (b).
No, no they did not.
ABSOLUTE FUCKERS - having issues with both 🤨😒😡
My foot recently joined the pain party and started hurting to put weight on my heel.
My excess skin makes it hard to find clothes, but not as hard as my allodynia from my fibromyalgia. Touch can hurt, and I have far more skin than I need or want. Less skin, less pain. That’s what I need. 🧵
My excess skin makes it hard to find clothes, but not as hard as my allodynia from my fibromyalgia. Touch can hurt, and I have far more skin than I need or want. Less skin, less pain. That’s what I need. 🧵
January 24, 2026 at 10:15 PM
My foot recently joined the pain party and started hurting to put weight on my heel.
My excess skin makes it hard to find clothes, but not as hard as my allodynia from my fibromyalgia. Touch can hurt, and I have far more skin than I need or want. Less skin, less pain. That’s what I need. 🧵
My excess skin makes it hard to find clothes, but not as hard as my allodynia from my fibromyalgia. Touch can hurt, and I have far more skin than I need or want. Less skin, less pain. That’s what I need. 🧵
Managing #Autoimmune condition has been an increased challenge the last few weeks with added stress of what is happening in #Minneapolis. Its like a game of whack-a-mole with symptom flares from hypnotic jerks to allodynia & paresthesia to severe bursitis & more. Just trying to get through.
January 23, 2026 at 5:13 PM
Managing #Autoimmune condition has been an increased challenge the last few weeks with added stress of what is happening in #Minneapolis. Its like a game of whack-a-mole with symptom flares from hypnotic jerks to allodynia & paresthesia to severe bursitis & more. Just trying to get through.
Allodynia is pain with light touch. Something I assumed was normal my entire life until recently 🧍
January 23, 2026 at 7:02 AM
Allodynia is pain with light touch. Something I assumed was normal my entire life until recently 🧍
I told my rheumatologist about one of my symptoms and she goes “ oh, that’s allodynia” and I’m like “ actually I did know the name because i googled it once 👉👈”
She said it was good I had done research. Most doctors hate that.
She said it was good I had done research. Most doctors hate that.
January 23, 2026 at 7:02 AM
I told my rheumatologist about one of my symptoms and she goes “ oh, that’s allodynia” and I’m like “ actually I did know the name because i googled it once 👉👈”
She said it was good I had done research. Most doctors hate that.
She said it was good I had done research. Most doctors hate that.
Light-aversion and cephalic allodynia in an intravenous CGRP model of migraine-like behaviour …
▶️ Read Full Paper
📚 Source: The journal of headache and pain
👤 Creator: Veronika K Andersen et al.
📅 Date: 2026-01-22
🆔 PMID: 41572144
🔗 DOI: 10.1186/s10194-026-02278-2
#MigrainePaper #Migraine #PubMed
▶️ Read Full Paper
📚 Source: The journal of headache and pain
👤 Creator: Veronika K Andersen et al.
📅 Date: 2026-01-22
🆔 PMID: 41572144
🔗 DOI: 10.1186/s10194-026-02278-2
#MigrainePaper #Migraine #PubMed
Light-aversion and cephalic allodynia in an intravenous CGRP model of migraine-like behaviour in male and female rats
No abstract...
pubmed.ncbi.nlm.nih.gov
January 23, 2026 at 5:51 AM
Light-aversion and cephalic allodynia in an intravenous CGRP model of migraine-like behaviour …
▶️ Read Full Paper
📚 Source: The journal of headache and pain
👤 Creator: Veronika K Andersen et al.
📅 Date: 2026-01-22
🆔 PMID: 41572144
🔗 DOI: 10.1186/s10194-026-02278-2
#MigrainePaper #Migraine #PubMed
▶️ Read Full Paper
📚 Source: The journal of headache and pain
👤 Creator: Veronika K Andersen et al.
📅 Date: 2026-01-22
🆔 PMID: 41572144
🔗 DOI: 10.1186/s10194-026-02278-2
#MigrainePaper #Migraine #PubMed
Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia
Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia
Peripheral mechanisms of mechanical allodynia after nerve injury remain unclear. Li et al. identify a subset of trigeminal afferents in mice activated by facial brushing after nerve injury. Targeted manipulations reveal these neurons’ causal role in pain-like behaviors and heightened sensitivity, providing new insights into primary afferents underlying mechanical allodynia.
dlvr.it
January 21, 2026 at 8:51 PM
Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia
Oh, that makes sense. I'd say I haven't had a migraine this week, but maybe one's coming? I have a lot of nerve problems, and this could be anything from aura to allodynia due to fibro/small fiber neuropathy.
It's happened before, but I never thought to track it. I should do that.
It's happened before, but I never thought to track it. I should do that.
January 21, 2026 at 5:44 PM
Oh, that makes sense. I'd say I haven't had a migraine this week, but maybe one's coming? I have a lot of nerve problems, and this could be anything from aura to allodynia due to fibro/small fiber neuropathy.
It's happened before, but I never thought to track it. I should do that.
It's happened before, but I never thought to track it. I should do that.
Daily migraines also hurt me. And so do my other major joint pains from my lupus and rheumatoid arthritis and fibromyalgia (allodynia is part of that).
I just do not want even more pain.
Ibuprofen helps some, but it can also cause high blood pressure.
Fucked if I do, fucked if I don’t.
I just do not want even more pain.
Ibuprofen helps some, but it can also cause high blood pressure.
Fucked if I do, fucked if I don’t.
January 20, 2026 at 8:11 PM
Daily migraines also hurt me. And so do my other major joint pains from my lupus and rheumatoid arthritis and fibromyalgia (allodynia is part of that).
I just do not want even more pain.
Ibuprofen helps some, but it can also cause high blood pressure.
Fucked if I do, fucked if I don’t.
I just do not want even more pain.
Ibuprofen helps some, but it can also cause high blood pressure.
Fucked if I do, fucked if I don’t.
I wish healthcare people understood that some of their requirements hurt me too much as a person with allodynia and chronic pain.
Blood pressure cuffs are incredibly painful for me. I ask for wrist cuffs, which they never have. Of course my BP spikes? The cuff is fucking hurting me.
Blood pressure cuffs are incredibly painful for me. I ask for wrist cuffs, which they never have. Of course my BP spikes? The cuff is fucking hurting me.
January 20, 2026 at 8:08 PM
I wish healthcare people understood that some of their requirements hurt me too much as a person with allodynia and chronic pain.
Blood pressure cuffs are incredibly painful for me. I ask for wrist cuffs, which they never have. Of course my BP spikes? The cuff is fucking hurting me.
Blood pressure cuffs are incredibly painful for me. I ask for wrist cuffs, which they never have. Of course my BP spikes? The cuff is fucking hurting me.
I 'only' have right face, shoulder, and neck allodynia, and that's enough of a bitch. I can't imagine full body. I'm sorry you have to deal with that.
Even a q-tip brushed across my right cheek causes severe pain. No sleeping on that side. Have to be careful how I fix my hair. No makeup.
Even a q-tip brushed across my right cheek causes severe pain. No sleeping on that side. Have to be careful how I fix my hair. No makeup.
January 19, 2026 at 5:50 PM
I 'only' have right face, shoulder, and neck allodynia, and that's enough of a bitch. I can't imagine full body. I'm sorry you have to deal with that.
Even a q-tip brushed across my right cheek causes severe pain. No sleeping on that side. Have to be careful how I fix my hair. No makeup.
Even a q-tip brushed across my right cheek causes severe pain. No sleeping on that side. Have to be careful how I fix my hair. No makeup.
I kind of can. Full body allodynia, bad enough that air pressure is a factor.
January 19, 2026 at 9:54 AM
I kind of can. Full body allodynia, bad enough that air pressure is a factor.
I'd choose a chair without headrest and arms due to allodynia (pain caused by stimulus that wouldn't normally elicit pain, such as from the slightest touch or pressure) caused by the severe stress caused by assessments. According to this non-scientific, judgmental b*stard I’d be judged as ‘OK’.
January 18, 2026 at 12:49 PM
I'd choose a chair without headrest and arms due to allodynia (pain caused by stimulus that wouldn't normally elicit pain, such as from the slightest touch or pressure) caused by the severe stress caused by assessments. According to this non-scientific, judgmental b*stard I’d be judged as ‘OK’.
Could be allodynia (nerve sensitivity especially in the scalp/face, sx of migraines) causing the pillow touching to cause lots of pain? If you have a neuro definitely mention the sudden changes!!! And keep a log if you can since things are different!
Highly recommend Ubrelvy if you can get it!
Highly recommend Ubrelvy if you can get it!
January 18, 2026 at 2:13 AM
Could be allodynia (nerve sensitivity especially in the scalp/face, sx of migraines) causing the pillow touching to cause lots of pain? If you have a neuro definitely mention the sudden changes!!! And keep a log if you can since things are different!
Highly recommend Ubrelvy if you can get it!
Highly recommend Ubrelvy if you can get it!
My body revolted against me today, likely finally caving into the last week of stress. Started in the middle of the night with the worst pain flare, with allodynia as a bonus, but just one of the worst fibro flares I've had in a long time. Meds not managing well but trying to power through.
Sad I Hate Everything GIF by La Guarimba Film Festival
Sad I Hate Everything GIF by La Guarimba Film Festival
giphy.com
January 11, 2026 at 1:04 AM
My body revolted against me today, likely finally caving into the last week of stress. Started in the middle of the night with the worst pain flare, with allodynia as a bonus, but just one of the worst fibro flares I've had in a long time. Meds not managing well but trying to power through.
Risk of Allodynia with GLP-1 Agonists https://www.medrxiv.org/content/10.64898/2026.01.07.26343603v1
January 8, 2026 at 8:10 PM
Risk of Allodynia with GLP-1 Agonists https://www.medrxiv.org/content/10.64898/2026.01.07.26343603v1