🔍Problems with synthetic C1 metabolism? The @pabnik.bsky.social group identifies seven major barriers limiting its deployment in microorganisms and proposes specific strategies to overcome each of them. Check out their paper 👉https://doi.org/10.1093/femsre/fuaf011
July 16, 2025 at 11:03 AM
🔍Problems with synthetic C1 metabolism? The @pabnik.bsky.social group identifies seven major barriers limiting its deployment in microorganisms and proposes specific strategies to overcome each of them. Check out their paper 👉https://doi.org/10.1093/femsre/fuaf011
❌ The problem: Metabolic engineering heavily relies on adaptive laboratory evolution to functionalize synthetic metabolism, for example for more efficient C1 assimilation, in vivo. However, desired phenotypes often emerge only after years - thus, metabolic engineering turnover times aren’t great.
January 21, 2026 at 7:52 PM
❌ The problem: Metabolic engineering heavily relies on adaptive laboratory evolution to functionalize synthetic metabolism, for example for more efficient C1 assimilation, in vivo. However, desired phenotypes often emerge only after years - thus, metabolic engineering turnover times aren’t great.
We were thrilled to welcome @cuwelte.bsky.social as our second keynote speaker at the Euro C1 Conference. Her talk “Challenging Methanotrophy: Carbon Monoxide Metabolism in Anaerobic Methanotrophic Archaea” shed light on surprising new aspects of archaeal carbon cycling.
#EuroC1 #MPI #Keynote
#EuroC1 #MPI #Keynote
May 12, 2025 at 12:18 PM
We were thrilled to welcome @cuwelte.bsky.social as our second keynote speaker at the Euro C1 Conference. Her talk “Challenging Methanotrophy: Carbon Monoxide Metabolism in Anaerobic Methanotrophic Archaea” shed light on surprising new aspects of archaeal carbon cycling.
#EuroC1 #MPI #Keynote
#EuroC1 #MPI #Keynote
The enzyme PLA2G15 breaks down BMP, and inhibiting PLA2G15 extends lifespan in a mouse model of Niemann–Pick type C1, a neurodegenerative disorder marked by impaired lysosomal lipid metabolism
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
May 8, 2025 at 7:18 PM
The enzyme PLA2G15 breaks down BMP, and inhibiting PLA2G15 extends lifespan in a mouse model of Niemann–Pick type C1, a neurodegenerative disorder marked by impaired lysosomal lipid metabolism
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
@nicoc-micsynmet.bsky.social ramps up synthetic C1 metabolism, pushing C1 biotech from the lab close to the launchpad at #MPA2025 @univie.ac.at
July 29, 2025 at 9:57 AM
@nicoc-micsynmet.bsky.social ramps up synthetic C1 metabolism, pushing C1 biotech from the lab close to the launchpad at #MPA2025 @univie.ac.at
Congratulations!
Our group leader Tristan Wagner wins an
@ERC_Research #ConsolidatorGrant!
His project #EnLightEn targets the #C1-metabolism and will shed light on the #metabolism of #microbes in #anaerobic environments.
mpi-bremen.de/en/ERC-Conso...
Our group leader Tristan Wagner wins an
@ERC_Research #ConsolidatorGrant!
His project #EnLightEn targets the #C1-metabolism and will shed light on the #metabolism of #microbes in #anaerobic environments.
mpi-bremen.de/en/ERC-Conso...
November 24, 2023 at 7:40 AM
Congratulations!
Our group leader Tristan Wagner wins an
@ERC_Research #ConsolidatorGrant!
His project #EnLightEn targets the #C1-metabolism and will shed light on the #metabolism of #microbes in #anaerobic environments.
mpi-bremen.de/en/ERC-Conso...
Our group leader Tristan Wagner wins an
@ERC_Research #ConsolidatorGrant!
His project #EnLightEn targets the #C1-metabolism and will shed light on the #metabolism of #microbes in #anaerobic environments.
mpi-bremen.de/en/ERC-Conso...
New(ish) paper to share with all the new & familiar folks on Bluesky (I'm glad you're all here!):
Iannucci et al. #Temperature and #Flow Control Organic #Carbon #Metabolism in #Boreal Headwater #Streams agupubs.onlinelibrary.wiley.com/doi/10.1029/...
💧🌎🧪👩🔬 #JGRB #AGU #MacroCO2 #BonanzaCreek #LTER
Iannucci et al. #Temperature and #Flow Control Organic #Carbon #Metabolism in #Boreal Headwater #Streams agupubs.onlinelibrary.wiley.com/doi/10.1029/...
💧🌎🧪👩🔬 #JGRB #AGU #MacroCO2 #BonanzaCreek #LTER
November 11, 2024 at 7:30 PM
New(ish) paper to share with all the new & familiar folks on Bluesky (I'm glad you're all here!):
Iannucci et al. #Temperature and #Flow Control Organic #Carbon #Metabolism in #Boreal Headwater #Streams agupubs.onlinelibrary.wiley.com/doi/10.1029/...
💧🌎🧪👩🔬 #JGRB #AGU #MacroCO2 #BonanzaCreek #LTER
Iannucci et al. #Temperature and #Flow Control Organic #Carbon #Metabolism in #Boreal Headwater #Streams agupubs.onlinelibrary.wiley.com/doi/10.1029/...
💧🌎🧪👩🔬 #JGRB #AGU #MacroCO2 #BonanzaCreek #LTER
Formate from THF-C1 metabolism induces the AOX1 promoter in formate dehydrogenase-deficient Pichia pastoris https://www.biorxiv.org/content/10.1101/2024.05.29.596193v1
Formate from THF-C1 metabolism induces the AOX1 promoter in formate dehydrogenase-deficient Pichia pastoris https://www.biorxiv.org/content/10.1101/2024.05.29.596193v1
In Pichia pastoris (Komagataella phaffii), formate is a recognized alternative inducer to methanol f
www.biorxiv.org
May 30, 2024 at 6:18 AM
Formate from THF-C1 metabolism induces the AOX1 promoter in formate dehydrogenase-deficient Pichia pastoris https://www.biorxiv.org/content/10.1101/2024.05.29.596193v1
Here we further characterize methylolanthanin (MLL), a chelator that is involved in Ln metabolism in bacteria (see www.pnas.org/doi/10.1073/...) Yes, methylotrophic bacteria use La, Nd... in their C1 metabolism! #fblockrocks They use them in the active site of methanol dehydrogenase enzymes. Anyway…
December 3, 2024 at 3:54 PM
Here we further characterize methylolanthanin (MLL), a chelator that is involved in Ln metabolism in bacteria (see www.pnas.org/doi/10.1073/...) Yes, methylotrophic bacteria use La, Nd... in their C1 metabolism! #fblockrocks They use them in the active site of methanol dehydrogenase enzymes. Anyway…
These are the *minimal* fluxes if flux distributions would be optimal. In reality, flux through BKACE might be higher, e.g. due to losses/inefficiencies/imbalances down the line. Also worth noting: It's "only" 8% because formate supplies "only" C1-metabolism and serine. Happy to discuss more.
April 4, 2025 at 1:37 PM
These are the *minimal* fluxes if flux distributions would be optimal. In reality, flux through BKACE might be higher, e.g. due to losses/inefficiencies/imbalances down the line. Also worth noting: It's "only" 8% because formate supplies "only" C1-metabolism and serine. Happy to discuss more.
(🧵 2/7) This Tansley review by Jardine et al. explores how plants and microbes use one-carbon (C₁) metabolism to grow, adapt to stress, and interact with their environment.
August 12, 2025 at 10:01 AM
(🧵 2/7) This Tansley review by Jardine et al. explores how plants and microbes use one-carbon (C₁) metabolism to grow, adapt to stress, and interact with their environment.
Register now for the EuroC1 Meeting 2025, taking place on from May 7 to 8 in #Bremen.
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
Register by March 31
mpi-bremen.de/EuroC1-Sympo...
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
Register by March 31
mpi-bremen.de/EuroC1-Sympo...
January 22, 2025 at 1:29 PM
Register now for the EuroC1 Meeting 2025, taking place on from May 7 to 8 in #Bremen.
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
Register by March 31
mpi-bremen.de/EuroC1-Sympo...
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
Register by March 31
mpi-bremen.de/EuroC1-Sympo...
Just 2 days to go until we can welcome the participants of the EuroC1 Meeting 2025 here in #Bremen.
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
mpi-bremen.de/EuroC1-Sympo...
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
mpi-bremen.de/EuroC1-Sympo...
May 5, 2025 at 6:59 AM
Just 2 days to go until we can welcome the participants of the EuroC1 Meeting 2025 here in #Bremen.
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
mpi-bremen.de/EuroC1-Sympo...
Young and established researchers will present findings & engage in insightful discussions on #C1 #metabolism and volatile #organic compound-related topics.
mpi-bremen.de/EuroC1-Sympo...
New Article: "Metabolic flux analysis in leaf metabolism quantifies the link between photorespiration and one carbon metabolism" rdcu.be/eDWLH
C flux quantification between two major plant metabolisms—photorespiration and C1 metabolism—using 13CO2 labelling and...
C flux quantification between two major plant metabolisms—photorespiration and C1 metabolism—using 13CO2 labelling and...
September 3, 2025 at 3:54 PM
New Article: "Metabolic flux analysis in leaf metabolism quantifies the link between photorespiration and one carbon metabolism" rdcu.be/eDWLH
C flux quantification between two major plant metabolisms—photorespiration and C1 metabolism—using 13CO2 labelling and...
C flux quantification between two major plant metabolisms—photorespiration and C1 metabolism—using 13CO2 labelling and...
This research explores the evolutionary and functional relationships between plant and microbial one-carbon (C1) metabolism in terrestrial ecosystems.
November 7, 2025 at 5:41 PM
This research explores the evolutionary and functional relationships between plant and microbial one-carbon (C1) metabolism in terrestrial ecosystems.
C1 photochemotrophy – rethinking one-carbon metabolism in phototrophs www.sciencedirect.com/science/arti...
C1 photochemotrophy – rethinking one-carbon metabolism in phototrophs
Excessive CO2 emissions, caused by an imbalance between carbon oxidation and reduction, drive climate change. To address this, we propose photochemotr…
www.sciencedirect.com
February 9, 2025 at 8:28 AM
C1 photochemotrophy – rethinking one-carbon metabolism in phototrophs www.sciencedirect.com/science/arti...
(🧵 3/7) It highlights a recently discovered photosynthetic C₁ pathway and proposes that this ancient, overlooked system could be key to understanding how ecosystems respond to rising carbon dioxide and environmental change.
August 12, 2025 at 10:01 AM
(🧵 3/7) It highlights a recently discovered photosynthetic C₁ pathway and proposes that this ancient, overlooked system could be key to understanding how ecosystems respond to rising carbon dioxide and environmental change.
Obituary: Prof. Donovan P Kelly (1940-2024), with a review of his life's work in microbial sulfur metabolism, autotrophy and C1 metabolism academic.oup.com/femsle/advan...
June 27, 2024 at 1:38 PM
Obituary: Prof. Donovan P Kelly (1940-2024), with a review of his life's work in microbial sulfur metabolism, autotrophy and C1 metabolism academic.oup.com/femsle/advan...
Eventually, we assembled the complete CORE cycle, successfully supplying E.coli's C1-metabolism (nucleotides etc.) and serine biosynthesis from CO2. It ain't a new autotrophic E.coli just yet, but we'll get there...⏳📆
April 4, 2025 at 10:03 AM
Eventually, we assembled the complete CORE cycle, successfully supplying E.coli's C1-metabolism (nucleotides etc.) and serine biosynthesis from CO2. It ain't a new autotrophic E.coli just yet, but we'll get there...⏳📆
Metagenomic reconstruction of microbial genomes and biogeochemical pathways: insights into carbon and nitrogen dynamics in the Arabian Sea
Marinobacter showed increased gene abundance for C1 metabolism, nitrogen cycling, sulfur oxidation, nitrous oxide (N2O)
www.sciencedirect.com/science/arti...
Marinobacter showed increased gene abundance for C1 metabolism, nitrogen cycling, sulfur oxidation, nitrous oxide (N2O)
www.sciencedirect.com/science/arti...
Metagenomic reconstruction of microbial genomes and biogeochemical pathways: insights into carbon and nitrogen flux dynamics in the eastern Arabian Sea
The eastern Arabian Sea (EAS) experiences seasonal nutrient availability and productivity shifts driven by the Indian monsoon, influencing microbial c…
www.sciencedirect.com
June 17, 2025 at 5:59 AM
Metagenomic reconstruction of microbial genomes and biogeochemical pathways: insights into carbon and nitrogen dynamics in the Arabian Sea
Marinobacter showed increased gene abundance for C1 metabolism, nitrogen cycling, sulfur oxidation, nitrous oxide (N2O)
www.sciencedirect.com/science/arti...
Marinobacter showed increased gene abundance for C1 metabolism, nitrogen cycling, sulfur oxidation, nitrous oxide (N2O)
www.sciencedirect.com/science/arti...
🧪Researching microbial C1 metabolism? #FEMSMicrobiolEcol invites submissions for our thematic issue exploring the latest advances in C1 compound transformations and its role in global biogeochemical cycles. One month left to submit: buff.ly/aVfZJoR
#CallForPapers #MicrobiologyResearch #Ecology
#CallForPapers #MicrobiologyResearch #Ecology
August 30, 2025 at 10:01 AM
🧪Researching microbial C1 metabolism? #FEMSMicrobiolEcol invites submissions for our thematic issue exploring the latest advances in C1 compound transformations and its role in global biogeochemical cycles. One month left to submit: buff.ly/aVfZJoR
#CallForPapers #MicrobiologyResearch #Ecology
#CallForPapers #MicrobiologyResearch #Ecology
#Synthetic C1 #metabolism in #Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway—led by J. Turlin, M. G. Alván, @oscarpuiggene.bsky.social w/@stefanodonati.bsky.social & @sebwenk.bsky.social @mbio.bsky.social #SynBio
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Synthetic C1 metabolism in Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway | mBio
Soluble C1 feedstocks, such as formate and methanol, have gained attention as sustainable substrates for biotechnology, with the potential to reduce greenhouse gas emissions and reliance on sugar-based resources. Despite their promise, the metabolic ...
journals.asm.org
August 21, 2025 at 3:45 PM
#Synthetic C1 #metabolism in #Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway—led by J. Turlin, M. G. Alván, @oscarpuiggene.bsky.social w/@stefanodonati.bsky.social & @sebwenk.bsky.social @mbio.bsky.social #SynBio
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
The utilization of #C1-feedstocks, such as methanol, by non-model bacteria demands an in-depth analysis of design alternatives, a modular strategy to identify bottlenecks and efficient solutions within the host #metabolism of the chosen host...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Systematic engineering of synthetic serine cycles in Pseudomonas putida uncovers emergent topologies for methanol assimilation
The urgent need for a circular carbon economy has driven research into sustainable substrates, including one-carbon (C1) compounds. The non-pathogenic soil bacterium Pseudomonas putida is a promising ...
www.biorxiv.org
March 9, 2025 at 10:51 AM
The utilization of #C1-feedstocks, such as methanol, by non-model bacteria demands an in-depth analysis of design alternatives, a modular strategy to identify bottlenecks and efficient solutions within the host #metabolism of the chosen host...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
5. Poor metabolic integration of synthetic pathway(s) and regulation of the host metabolism -> 🧬Bacteria have already native systems to cope with C1 feedstocks, so equip them with specific inducible systems or manipulate the copy number of regulatory regions to ease synthetic pathway adoption. 6/n
April 4, 2025 at 11:29 AM
5. Poor metabolic integration of synthetic pathway(s) and regulation of the host metabolism -> 🧬Bacteria have already native systems to cope with C1 feedstocks, so equip them with specific inducible systems or manipulate the copy number of regulatory regions to ease synthetic pathway adoption. 6/n
Please repost!
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
efzu.fa.em2.oraclecloud.com
September 12, 2025 at 11:43 AM
Please repost!
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...