Formation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells!
Read our paper @cp-cell.bsky.social!
❕Publication: doi.org/10.1016/j.ce...
❕Press Release: www.biochem.mpg.de/en/pressroom
@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet
Read our paper @cp-cell.bsky.social!
❕Publication: doi.org/10.1016/j.ce...
❕Press Release: www.biochem.mpg.de/en/pressroom
@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet
January 28, 2026 at 4:39 PM
Formation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells!
Read our paper @cp-cell.bsky.social!
❕Publication: doi.org/10.1016/j.ce...
❕Press Release: www.biochem.mpg.de/en/pressroom
@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet
Read our paper @cp-cell.bsky.social!
❕Publication: doi.org/10.1016/j.ce...
❕Press Release: www.biochem.mpg.de/en/pressroom
@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet
A paper on this is to follow, a variation was described here: www.nature.com/articles/s41...
An abridged version of the method can also be found directly on the cryoET portal. Click "View All Info" on the page of one of the datasets contained in this deposition.
An abridged version of the method can also be found directly on the cryoET portal. Click "View All Info" on the page of one of the datasets contained in this deposition.
January 28, 2026 at 3:53 PM
A paper on this is to follow, a variation was described here: www.nature.com/articles/s41...
An abridged version of the method can also be found directly on the cryoET portal. Click "View All Info" on the page of one of the datasets contained in this deposition.
An abridged version of the method can also be found directly on the cryoET portal. Click "View All Info" on the page of one of the datasets contained in this deposition.
Research Fellow role at the University of Leeds applying cryoEM and cryoET to understand amyloid polymorphism in Parkinsons and metabolic disease. Closing date: 8th March
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Research Fellow: Structural Biology - DEMENTIA RESEARCHER
University of Leeds is seeking a Research Fellow using cryoEM and cryoET to study amyloid fibril structures in Parkinsons and type 2 diabetes.
www.dementiaresearcher.nihr.ac.uk
January 28, 2026 at 12:42 PM
Research Fellow role at the University of Leeds applying cryoEM and cryoET to understand amyloid polymorphism in Parkinsons and metabolic disease. Closing date: 8th March
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
New on the CryoET Data Portal: ~27,000 tomograms of affinity-captured lysosomes from HEK293T cells across 4 physiological states. Includes raw data, AreTomo3 reconstructions & Membrain-Seg annotations. Openly available for reuse!
cryoetdataportal.czscience.com/depositions/...
cryoetdataportal.czscience.com/depositions/...
January 27, 2026 at 7:59 PM
New on the CryoET Data Portal: ~27,000 tomograms of affinity-captured lysosomes from HEK293T cells across 4 physiological states. Includes raw data, AreTomo3 reconstructions & Membrain-Seg annotations. Openly available for reuse!
cryoetdataportal.czscience.com/depositions/...
cryoetdataportal.czscience.com/depositions/...
Our paper is finally out!
I’m proud to share this collaborative work using FIB milling and cryo-electron tomography to study tick-borne flavivirus replication. Thanks to all co-authors and collaborators — great teamwork #CryoET #ElectronTomography #Virology #Flavivirus #Microscopy #StructuralBiology
I’m proud to share this collaborative work using FIB milling and cryo-electron tomography to study tick-borne flavivirus replication. Thanks to all co-authors and collaborators — great teamwork #CryoET #ElectronTomography #Virology #Flavivirus #Microscopy #StructuralBiology
I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology #teamtomo
www.nature.com/articles/s41...
#virology #teamtomo
www.nature.com/articles/s41...
Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications
In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.
www.nature.com
January 23, 2026 at 9:28 PM
Our paper is finally out!
I’m proud to share this collaborative work using FIB milling and cryo-electron tomography to study tick-borne flavivirus replication. Thanks to all co-authors and collaborators — great teamwork #CryoET #ElectronTomography #Virology #Flavivirus #Microscopy #StructuralBiology
I’m proud to share this collaborative work using FIB milling and cryo-electron tomography to study tick-borne flavivirus replication. Thanks to all co-authors and collaborators — great teamwork #CryoET #ElectronTomography #Virology #Flavivirus #Microscopy #StructuralBiology
WEBINAR: Dr. Danielle Grotjahn, Scripps Research discusses how #cryoET shapes our understanding of cellular architecture, and analyzing data to extract quantitative insights: 10 Feb, 5 PM CET | 11 Feb, 5 AM CET
Register here: ter.li/zfiv48
#CellBiology #StructuralBiology #ElectronMicroscopy
Register here: ter.li/zfiv48
#CellBiology #StructuralBiology #ElectronMicroscopy
January 23, 2026 at 11:21 AM
WEBINAR: Dr. Danielle Grotjahn, Scripps Research discusses how #cryoET shapes our understanding of cellular architecture, and analyzing data to extract quantitative insights: 10 Feb, 5 PM CET | 11 Feb, 5 AM CET
Register here: ter.li/zfiv48
#CellBiology #StructuralBiology #ElectronMicroscopy
Register here: ter.li/zfiv48
#CellBiology #StructuralBiology #ElectronMicroscopy
While everything feels flash-frozen in Michigan, it's a great time to plan for U-M's 2026 #CryoET Data Processing Workshop!
This hands-on workshop will introduce participants to standard image processing packages used to analyze cryo-ET data.
Apply by March 20: myumi.ch/lsi-cryo-wor...
This hands-on workshop will introduce participants to standard image processing packages used to analyze cryo-ET data.
Apply by March 20: myumi.ch/lsi-cryo-wor...
January 20, 2026 at 1:59 PM
While everything feels flash-frozen in Michigan, it's a great time to plan for U-M's 2026 #CryoET Data Processing Workshop!
This hands-on workshop will introduce participants to standard image processing packages used to analyze cryo-ET data.
Apply by March 20: myumi.ch/lsi-cryo-wor...
This hands-on workshop will introduce participants to standard image processing packages used to analyze cryo-ET data.
Apply by March 20: myumi.ch/lsi-cryo-wor...
Gradient based refinement of CryoET tilt series alignment improves tomogram contrast and structure resolution www.biorxiv.org/content/10.64898/2026.01.16.699989v1 #cryoem
January 20, 2026 at 10:44 AM
Gradient based refinement of CryoET tilt series alignment improves tomogram contrast and structure resolution www.biorxiv.org/content/10.64898/2026.01.16.699989v1 #cryoem
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
January 20, 2026 at 10:01 AM
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Gradient based refinement of CryoET tilt series alignment improves tomogram contrast and structure resolution https://www.biorxiv.org/content/10.64898/2026.01.16.699989v1
January 20, 2026 at 2:17 AM
Gradient based refinement of CryoET tilt series alignment improves tomogram contrast and structure resolution https://www.biorxiv.org/content/10.64898/2026.01.16.699989v1
Gradient based refinement of CryoET tilt series alignment improves tomogram contrast and structure resolution https://www.biorxiv.org/content/10.64898/2026.01.16.699989v1
January 20, 2026 at 2:17 AM
Gradient based refinement of CryoET tilt series alignment improves tomogram contrast and structure resolution https://www.biorxiv.org/content/10.64898/2026.01.16.699989v1
Excited to finally share this work also in written form! 🎉 Huge thanks to all co-authors and collaborators — this really was a team effort, and I’m very grateful for all the ideas, discussions, and hard work that went into it. Thanks everyone! #TeamTomo #cryoET #autophagy
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
January 18, 2026 at 5:37 PM
Excited to finally share this work also in written form! 🎉 Huge thanks to all co-authors and collaborators — this really was a team effort, and I’m very grateful for all the ideas, discussions, and hard work that went into it. Thanks everyone! #TeamTomo #cryoET #autophagy
✨Peeking inside cells with frozen beams!🔬 CryoET builds 3D maps of life’s tiny architecture, revealing details at the atomic level.🤯 #science
Source: https://phys.org/news/2026-01-tightening-focus-subcellular-snapshots-combined.html
Source: https://phys.org/news/2026-01-tightening-focus-subcellular-snapshots-combined.html
Security Verification
Read the full article
phys.org
January 17, 2026 at 9:38 PM
✨Peeking inside cells with frozen beams!🔬 CryoET builds 3D maps of life’s tiny architecture, revealing details at the atomic level.🤯 #science
Source: https://phys.org/news/2026-01-tightening-focus-subcellular-snapshots-combined.html
Source: https://phys.org/news/2026-01-tightening-focus-subcellular-snapshots-combined.html
A combined approach using light microscopy and ion beam milling enhances the precision of cryoET sample preparation, enabling more accurate targeting of small, rare structures within cells. doi.org/hbkb94
Tightening the focus of subcellular snapshots: Combined approach yields better cell slices for cryoET imaging
Taking images of tiny structures within cells is tricky business. One technique, cryogenic electron tomography (cryoET), shoots electrons through a frozen sample.
phys.org
January 17, 2026 at 8:20 PM
A combined approach using light microscopy and ion beam milling enhances the precision of cryoET sample preparation, enabling more accurate targeting of small, rare structures within cells. doi.org/hbkb94
Ais-cryoET 1.0.47
Segmentation of cryo-electron tomography data - https://ais-cryoet.readthedocs.org/ https://aiscryoet.org/
Author: mgflast
🏠Homepage
Segmentation of cryo-electron tomography data - https://ais-cryoet.readthedocs.org/ https://aiscryoet.org/
Author: mgflast
🏠Homepage
January 16, 2026 at 9:00 PM
Ais-cryoET 1.0.47
Segmentation of cryo-electron tomography data - https://ais-cryoet.readthedocs.org/ https://aiscryoet.org/
Author: mgflast
🏠Homepage
Segmentation of cryo-electron tomography data - https://ais-cryoet.readthedocs.org/ https://aiscryoet.org/
Author: mgflast
🏠Homepage
Excited to see this work on the cover of #MolecularCell. A massive, open #cryoEM #cryoET dataset capturing molecular organization inside intact cells, pushing what’s possible for #visualproteomics, method development, and computational reuse. Congratulations to the authors.
ter.li/of4cgh
ter.li/of4cgh
January 16, 2026 at 10:03 AM
Excited to see this work on the cover of #MolecularCell. A massive, open #cryoEM #cryoET dataset capturing molecular organization inside intact cells, pushing what’s possible for #visualproteomics, method development, and computational reuse. Congratulations to the authors.
ter.li/of4cgh
ter.li/of4cgh
Congratulations to the team and their work that made the cover of Molecular Cell. A massive, open #cryoET dataset that captures molecular organization inside intact cells and pushes what’s possible for visual proteomics, method development, and computational reuse. 👉 ter.li/of4cgh
January 15, 2026 at 7:41 PM
Congratulations to the team and their work that made the cover of Molecular Cell. A massive, open #cryoET dataset that captures molecular organization inside intact cells and pushes what’s possible for visual proteomics, method development, and computational reuse. 👉 ter.li/of4cgh
[2026-01-14] 📚 Updates in #3DPC
(1) PI3DETR: Parametric Instance Detection of 3D Point Cloud Edges With a Geometry-Aware 3DETR
(2) SemiETPicker: Fast and Label-Efficient Particle Picking for CryoET Tomography Using Semi-Supervised Learning
🔍 More at researchtrend.ai/communities/3DPC
(1) PI3DETR: Parametric Instance Detection of 3D Point Cloud Edges With a Geometry-Aware 3DETR
(2) SemiETPicker: Fast and Label-Efficient Particle Picking for CryoET Tomography Using Semi-Supervised Learning
🔍 More at researchtrend.ai/communities/3DPC
January 14, 2026 at 3:09 AM
We resolved the molecular architecture of a condensate—inside cells. 🤯 By combining in situ cryoET with multiscale simulations, we show how a single point mutation modifies molecular interactions, shifts the condensate’s material properties, and alters its biological function. Preprint 👇
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
January 13, 2026 at 6:33 PM
We resolved the molecular architecture of a condensate—inside cells. 🤯 By combining in situ cryoET with multiscale simulations, we show how a single point mutation modifies molecular interactions, shifts the condensate’s material properties, and alters its biological function. Preprint 👇
Surface morphometrics reveals local #membrane thickness variation in organellar subcompartments. New study from Michaela Medina, Ya-Ting Chang, Danielle A. Grotjahn @nanigrotjahn.bsky.social and colleagues @scripps.edu: rupress.org/jcb/article/...
#Biophysics #StructuralBiology #Organelles #CryoET
#Biophysics #StructuralBiology #Organelles #CryoET
January 12, 2026 at 7:15 PM
Surface morphometrics reveals local #membrane thickness variation in organellar subcompartments. New study from Michaela Medina, Ya-Ting Chang, Danielle A. Grotjahn @nanigrotjahn.bsky.social and colleagues @scripps.edu: rupress.org/jcb/article/...
#Biophysics #StructuralBiology #Organelles #CryoET
#Biophysics #StructuralBiology #Organelles #CryoET
Our January software webinar will feature Sliz Lab postdoc Alice-Roza Eruera on Building CryoET Training Workflows Using the SBGrid Ecosystem. Be sure to join us on January 13th!
Register here: buff.ly/wwNF6Zh
#SBGrid #StructuralBiology #Webinars
Register here: buff.ly/wwNF6Zh
#SBGrid #StructuralBiology #Webinars
Webinars
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
buff.ly
January 12, 2026 at 5:04 PM
Our January software webinar will feature Sliz Lab postdoc Alice-Roza Eruera on Building CryoET Training Workflows Using the SBGrid Ecosystem. Be sure to join us on January 13th!
Register here: buff.ly/wwNF6Zh
#SBGrid #StructuralBiology #Webinars
Register here: buff.ly/wwNF6Zh
#SBGrid #StructuralBiology #Webinars
For a starter, #MemBrain-seg from @lorenzlamm.bsky.social would not have been possible without the #ChlamyDataset and lots of other kind contributions from the #CryoET community 🙏🏽
#TeamTomo
#TeamTomo
🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
January 9, 2026 at 7:15 PM
For a starter, #MemBrain-seg from @lorenzlamm.bsky.social would not have been possible without the #ChlamyDataset and lots of other kind contributions from the #CryoET community 🙏🏽
#TeamTomo
#TeamTomo
The #ChlamyDataset is intended to be a public resource for methods development and scientific discovery, and I'm happy to say it has been adopted very early by the #CryoET community, even before the preprint was out. So below I’ll highlight some of the cool stuff that have been done with it 🤗
January 9, 2026 at 7:15 PM
The #ChlamyDataset is intended to be a public resource for methods development and scientific discovery, and I'm happy to say it has been adopted very early by the #CryoET community, even before the preprint was out. So below I’ll highlight some of the cool stuff that have been done with it 🤗
Two people highlighted a recently updated preprint doing cryoEM and cryoET on Flotillin complex structure and organization from Qiang Guo and Ning Gao labs. www.biorxiv.org/content/10.1.... Related work from the MacKinnon lab: www.pnas.org/doi/10.1073/...
January 8, 2026 at 8:00 PM
Two people highlighted a recently updated preprint doing cryoEM and cryoET on Flotillin complex structure and organization from Qiang Guo and Ning Gao labs. www.biorxiv.org/content/10.1.... Related work from the MacKinnon lab: www.pnas.org/doi/10.1073/...