Last post before taking off for a 2-week vacation!
I am thrilled to share that my lab has joined the @geneontology.bsky.social consortium as curator of all things #ECM and has contributed to the latest GO paper, now published in @narjournal.bsky.social: doi.org/10.1093/nar/...!
#Matrisome #MatriGO
I am thrilled to share that my lab has joined the @geneontology.bsky.social consortium as curator of all things #ECM and has contributed to the latest GO paper, now published in @narjournal.bsky.social: doi.org/10.1093/nar/...!
#Matrisome #MatriGO
December 19, 2025 at 10:53 PM
Last post before taking off for a 2-week vacation!
I am thrilled to share that my lab has joined the @geneontology.bsky.social consortium as curator of all things #ECM and has contributed to the latest GO paper, now published in @narjournal.bsky.social: doi.org/10.1093/nar/...!
#Matrisome #MatriGO
I am thrilled to share that my lab has joined the @geneontology.bsky.social consortium as curator of all things #ECM and has contributed to the latest GO paper, now published in @narjournal.bsky.social: doi.org/10.1093/nar/...!
#Matrisome #MatriGO
Alcohol-related Hepatitis
Hepatocyte YAP ⏫Myofibroblast prolif/inflamm
Pro-fibrotic GDF15 paracrine
Human hepatocyte organoids in type 2 BME
AH vs Cirrhosis
⬇️Hepatocyte marker ALB CYP3A4 ALDOB
⬆️Cholangiocyte marker KRT19
+Spatial Matrisome
#JHEPRep 2025
www.sciencedirect.com/science/arti...
Hepatocyte YAP ⏫Myofibroblast prolif/inflamm
Pro-fibrotic GDF15 paracrine
Human hepatocyte organoids in type 2 BME
AH vs Cirrhosis
⬇️Hepatocyte marker ALB CYP3A4 ALDOB
⬆️Cholangiocyte marker KRT19
+Spatial Matrisome
#JHEPRep 2025
www.sciencedirect.com/science/arti...
November 27, 2025 at 12:40 PM
Alcohol-related Hepatitis
Hepatocyte YAP ⏫Myofibroblast prolif/inflamm
Pro-fibrotic GDF15 paracrine
Human hepatocyte organoids in type 2 BME
AH vs Cirrhosis
⬇️Hepatocyte marker ALB CYP3A4 ALDOB
⬆️Cholangiocyte marker KRT19
+Spatial Matrisome
#JHEPRep 2025
www.sciencedirect.com/science/arti...
Hepatocyte YAP ⏫Myofibroblast prolif/inflamm
Pro-fibrotic GDF15 paracrine
Human hepatocyte organoids in type 2 BME
AH vs Cirrhosis
⬇️Hepatocyte marker ALB CYP3A4 ALDOB
⬆️Cholangiocyte marker KRT19
+Spatial Matrisome
#JHEPRep 2025
www.sciencedirect.com/science/arti...
📣 Publication alert: Our paper, “A guide to building the matrisome interactome: from computational predictions to experimental validation” is now published in @febsj.bsky.social!
📄 The paper is available in #OpenAccess at: doi.org/10.1111/febs...
#ECM #Matrisome #Interactome #SystemsBiology
📄 The paper is available in #OpenAccess at: doi.org/10.1111/febs...
#ECM #Matrisome #Interactome #SystemsBiology
November 25, 2025 at 2:10 AM
📣 Publication alert: Our paper, “A guide to building the matrisome interactome: from computational predictions to experimental validation” is now published in @febsj.bsky.social!
📄 The paper is available in #OpenAccess at: doi.org/10.1111/febs...
#ECM #Matrisome #Interactome #SystemsBiology
📄 The paper is available in #OpenAccess at: doi.org/10.1111/febs...
#ECM #Matrisome #Interactome #SystemsBiology
Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis - Nature Communications
Human cortical development involves dynamic changes in matrisome gene expression across cell types and developmental stages. Here, authors show that these changes reveal links to neurodevelopmental di...
www.nature.com
November 22, 2025 at 6:22 PM
Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
It was pleasure to host my former lab mate Noor Jailkhani from Matrisome Bio yesterday at The University of Connecticut School of Medicine. Not many can say that they both developed a new technology hands on, and then led this into the market as the CEO of a successful company.
November 14, 2025 at 12:14 AM
It was pleasure to host my former lab mate Noor Jailkhani from Matrisome Bio yesterday at The University of Connecticut School of Medicine. Not many can say that they both developed a new technology hands on, and then led this into the market as the CEO of a successful company.
🎉 A big milestone for the #MatrisomeProject!
Congratulations to the Özbek group at @embl.org for the release of the matrisome of the sea anemone in @elife.bsky.social, the 10th dataset powered by the @matrisome.bsky.social pipeline!
Here’s to the power of #OpenScience 🚀 🔬
matrisome.org
Congratulations to the Özbek group at @embl.org for the release of the matrisome of the sea anemone in @elife.bsky.social, the 10th dataset powered by the @matrisome.bsky.social pipeline!
Here’s to the power of #OpenScience 🚀 🔬
matrisome.org
matrisome.org
November 11, 2025 at 9:51 PM
🎉 A big milestone for the #MatrisomeProject!
Congratulations to the Özbek group at @embl.org for the release of the matrisome of the sea anemone in @elife.bsky.social, the 10th dataset powered by the @matrisome.bsky.social pipeline!
Here’s to the power of #OpenScience 🚀 🔬
matrisome.org
Congratulations to the Özbek group at @embl.org for the release of the matrisome of the sea anemone in @elife.bsky.social, the 10th dataset powered by the @matrisome.bsky.social pipeline!
Here’s to the power of #OpenScience 🚀 🔬
matrisome.org
New research from University of Aberdeen neuroscientists shows how matrisome genes guide brain development and relate to neurodevelopmental disorders. @eunchaikang.bsky.social @uniofaberdeen.bsky.social
Read more: www.nature.com/articles/s41...
Read more: www.nature.com/articles/s41...
Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis - Nature Communications
Human cortical development involves dynamic changes in matrisome gene expression across cell types and developmental stages. Here, authors show that these changes reveal links to neurodevelopmental di...
www.nature.com
November 11, 2025 at 4:38 PM
New research from University of Aberdeen neuroscientists shows how matrisome genes guide brain development and relate to neurodevelopmental disorders. @eunchaikang.bsky.social @uniofaberdeen.bsky.social
Read more: www.nature.com/articles/s41...
Read more: www.nature.com/articles/s41...
This study maps the Nematostella matrisome, the genes that build and maintain its structural support system, showing how these components change across life stages.
buff.ly/pioKnKZ
buff.ly/pioKnKZ
November 2, 2025 at 9:21 AM
This study maps the Nematostella matrisome, the genes that build and maintain its structural support system, showing how these components change across life stages.
buff.ly/pioKnKZ
buff.ly/pioKnKZ
Curious about the matrisome of Nematostella vectensis? Check the new paper of the Özbek group now published in eLife. doi.org/10.7554/eLif...
@elife.bsky.social
@elife.bsky.social
Molecular dynamics of the matrisome across sea anemone life history
Integrated proteomic and single-cell transcriptomic analyses define the Nematostella vectensis matrisome and reveal conserved extracellular matrix functions driving life cycle transitions in this non-...
doi.org
October 24, 2025 at 6:15 AM
Curious about the matrisome of Nematostella vectensis? Check the new paper of the Özbek group now published in eLife. doi.org/10.7554/eLif...
@elife.bsky.social
@elife.bsky.social
📘 New #publication. The group of Veronika Lukacs-Kornek recently published a research article titled "Global matrisome changes in obese lung are linked to fibroblastic stroma and premature aging" in Cell Reports.
Read more on our website: www.immunosensation.de/news/obesity...
Read more on our website: www.immunosensation.de/news/obesity...
Obesity causes lungs to age prematurely
What effects does severe obesity have on the lungs? A research team led by Prof. Dr. Veronika Lukacs-Kornek from the ‘ImmunoSensation2’ Cluster of Excellence…
www.immunosensation.de
October 6, 2025 at 9:08 AM
📘 New #publication. The group of Veronika Lukacs-Kornek recently published a research article titled "Global matrisome changes in obese lung are linked to fibroblastic stroma and premature aging" in Cell Reports.
Read more on our website: www.immunosensation.de/news/obesity...
Read more on our website: www.immunosensation.de/news/obesity...
Global matrisome changes in obese lung are linked to fibroblastic stroma and premature aging
Global matrisome changes in obese lung are linked to fibroblastic stroma and premature aging
Rottmann et al. use multi-omics and functional assays to show that obesity remodels the lung matrisome and enhances fibroblast contractility, exhibiting hallmarks of aging. These changes mirror premature aging signatures in the lung, linking overnutrition to impaired pulmonary function.
dlvr.it
September 22, 2025 at 2:38 PM
Global matrisome changes in obese lung are linked to fibroblastic stroma and premature aging
New #stemcellreports paper: Unraveling the matrisome signatures of quiescent and activated muscle stem cells. #Myoblue tinyurl.com/ycyy3nw5
Unraveling the matrisome signatures of quiescent and activated muscle stem cells
The extracellular matrix (ECM) niche regulates skeletal muscle stem cell (MuSC) behavior.
Using transcriptomic data and 3D imaging, they show that quiescent MuSCs express unique
ECM markers, including...
tinyurl.com
September 11, 2025 at 6:02 PM
New #stemcellreports paper: Unraveling the matrisome signatures of quiescent and activated muscle stem cells. #Myoblue tinyurl.com/ycyy3nw5
New study profiles the matrisome of skeletal muscle-resident cells and identified quiescent muscle #stemcells as key #ECM producers. Injury shifts muscle stem cells from ECM production to remodeling and motility. ow.ly/2GZB50WVfNt
@isscr.org
@gairdnerawards.bsky.social
@sickkidsvs.bsky.social
@isscr.org
@gairdnerawards.bsky.social
@sickkidsvs.bsky.social
September 11, 2025 at 3:21 PM
New study profiles the matrisome of skeletal muscle-resident cells and identified quiescent muscle #stemcells as key #ECM producers. Injury shifts muscle stem cells from ECM production to remodeling and motility. ow.ly/2GZB50WVfNt
@isscr.org
@gairdnerawards.bsky.social
@sickkidsvs.bsky.social
@isscr.org
@gairdnerawards.bsky.social
@sickkidsvs.bsky.social
@nabalabuic.bsky.social opening up the Uncovering the Matrisome BSMB conference at Surrey.
September 2, 2025 at 12:19 PM
@nabalabuic.bsky.social opening up the Uncovering the Matrisome BSMB conference at Surrey.
In collaboration with Pam Kreeger's lab, we asked whether differences in the #ECM of the omentum and mesentery could explain the difference in prevalence of ovarian cancer metastasis to these sites. Read our preprint to learn what we found! #HGSOC #Matrisome www.biorxiv.org/content/10.1...
Comparative proteomic analysis of the ECM composition of the human omentum and mesentery, the main sites of ovarian cancer metastasis
Due to its limited symptoms, high-grade serous ovarian cancer (HGSOC) has frequently metastasized extensively throughout the peritoneal cavity prior to its diagnosis, resulting in an overall five-year...
www.biorxiv.org
August 1, 2025 at 2:10 AM
In collaboration with Pam Kreeger's lab, we asked whether differences in the #ECM of the omentum and mesentery could explain the difference in prevalence of ovarian cancer metastasis to these sites. Read our preprint to learn what we found! #HGSOC #Matrisome www.biorxiv.org/content/10.1...
Rijuta Lamba, Alexandra Naba @nabalabuic.bsky.social, @valerioizzi.bsky.social and team present MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–ECM interactions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
July 16, 2025 at 8:59 AM
Rijuta Lamba, Alexandra Naba @nabalabuic.bsky.social, @valerioizzi.bsky.social and team present MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–ECM interactions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Fantastic start to the day here at the 3rd "Human Proteome and Health" Symposium at Rhodes House where Dr Katerina Gospodinova from the ARUK-ODDI and @cmd.ox.ac.uk discussed proteomic profiling of the #matrisome for use a novel therapeutic modality in #Alzheimers Disease 🧠 @arukthamesv.bsky.social
June 25, 2025 at 8:36 AM
Fantastic start to the day here at the 3rd "Human Proteome and Health" Symposium at Rhodes House where Dr Katerina Gospodinova from the ARUK-ODDI and @cmd.ox.ac.uk discussed proteomic profiling of the #matrisome for use a novel therapeutic modality in #Alzheimers Disease 🧠 @arukthamesv.bsky.social
🎓 Congratulations to Dr Do Hyeon Gim on a brilliant PhD defense! His thesis uncovers cell-type and temporal-specific matrisome expression signatures in human cortical development and neurodevelopmental disorders. Read it here: doi.org/10.1101/2025...
May 19, 2025 at 9:23 AM
🎓 Congratulations to Dr Do Hyeon Gim on a brilliant PhD defense! His thesis uncovers cell-type and temporal-specific matrisome expression signatures in human cortical development and neurodevelopmental disorders. Read it here: doi.org/10.1101/2025...
Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-Analysis #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
February 25, 2025 at 10:23 AM
Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-Analysis #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-Analysis https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
February 25, 2025 at 10:17 AM
Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-Analysis https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-Analysis https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
February 25, 2025 at 10:17 AM
Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-Analysis https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
🧠❤️🧠
“We now know that up to 20 percent of the brain is extracellular space, filled with hundreds of ECM proteins—a “matrisome” that plays multiple roles, including modulating synaptic function and myelin formation.”
#speirgorm #Neuroplasticity #BainHealth
Despite evidence for a role in plasticity, many neuroscientists still view the extracellular matrix as “brain goop.” @annamolofskylab.bsky.social explains why the field needs a shift in scientific thinking to move beyond this outdated perspective.
www.thetransmitter.org/extracellula...
#neuroskyence
www.thetransmitter.org/extracellula...
#neuroskyence
Cracking the code of the extracellular matrix
Despite evidence for a role in plasticity and other crucial functions, many neuroscientists still view these proteins as “brain goop.” The field needs technical advances and a shift in scientific…
www.thetransmitter.org
January 17, 2025 at 1:20 PM
🧠❤️🧠
“We now know that up to 20 percent of the brain is extracellular space, filled with hundreds of ECM proteins—a “matrisome” that plays multiple roles, including modulating synaptic function and myelin formation.”
#speirgorm #Neuroplasticity #BainHealth
What a way to wrap up 2024!!! A top notch webinar from
@nabalabuic.bsky.social chaired by @collagenyoshi.bsky.social on The Matrisome project, all the tools available to #ECMatrix researchers and how to use them!!! Bright things up ahead for the matrix field!!! Can't wait for what's next.
@nabalabuic.bsky.social chaired by @collagenyoshi.bsky.social on The Matrisome project, all the tools available to #ECMatrix researchers and how to use them!!! Bright things up ahead for the matrix field!!! Can't wait for what's next.
December 13, 2024 at 9:57 AM
What a way to wrap up 2024!!! A top notch webinar from
@nabalabuic.bsky.social chaired by @collagenyoshi.bsky.social on The Matrisome project, all the tools available to #ECMatrix researchers and how to use them!!! Bright things up ahead for the matrix field!!! Can't wait for what's next.
@nabalabuic.bsky.social chaired by @collagenyoshi.bsky.social on The Matrisome project, all the tools available to #ECMatrix researchers and how to use them!!! Bright things up ahead for the matrix field!!! Can't wait for what's next.
Back from vacation full of energy for the week ahead 😀
Looking forward to presenting the latest developments of the #Matrisome at @themeshwork.bsky.social seminar on Thursday and to providing an update on the work from my lab on Friday at the UIC Department of Physiology and Biophysics seminar!
Looking forward to presenting the latest developments of the #Matrisome at @themeshwork.bsky.social seminar on Thursday and to providing an update on the work from my lab on Friday at the UIC Department of Physiology and Biophysics seminar!
December 9, 2024 at 6:59 PM
Back from vacation full of energy for the week ahead 😀
Looking forward to presenting the latest developments of the #Matrisome at @themeshwork.bsky.social seminar on Thursday and to providing an update on the work from my lab on Friday at the UIC Department of Physiology and Biophysics seminar!
Looking forward to presenting the latest developments of the #Matrisome at @themeshwork.bsky.social seminar on Thursday and to providing an update on the work from my lab on Friday at the UIC Department of Physiology and Biophysics seminar!