Japanese researchers discover #mitochondria #protein linked to #longevity

medicalxpress.com/news/2025-12...

COX7RP:

— mitochondrial protein
— promotes respiratory #supercomplexes
— enhances #energy production
— reduces #oxidative #stress
— increases #mouse #lifespan

#health #science 🧪 #aging

I'd be interested to know if you were able to identify any PSI:NDH supercomplexes. Low in abundance in spinach for sure, but definitely there.

In situ structure determination of Respiratory Supercomplexes and ATP synthase oligomers in mammalian mitochondrial inner membrane. www.biorxiv.org/content/10.1101/2025.09.19.677273v1 #cryoem

In situ structure determination of Respiratory Supercomplexes and ATP synthase oligomers in mammalian mitochondrial inner membrane. https://www.biorxiv.org/content/10.1101/2025.09.19.677273v1

In situ structure determination of Respiratory Supercomplexes and ATP synthase oligomers in mammalian mitochondrial inner membrane. https://www.biorxiv.org/content/10.1101/2025.09.19.677273v1

Purification and pigment analysis of diadinoxanthin-binding PSI-LHCI supercomplexes from Euglena gracilis strain Z https://www.biorxiv.org/content/10.1101/2025.06.29.662240v1

Purification and pigment analysis of diadinoxanthin-binding PSI-LHCI supercomplexes from Euglena gracilis strain Z https://www.biorxiv.org/content/10.1101/2025.06.29.662240v1

Impressive spacer selection mechanism by Cas9-adaptation supercomplexes - all pathway captured by #cryoEM #Cas9 🧬🧩🧵

#MINFLUX highlight:
Sequential replacement of PSD95 subunits in postsynaptic supercomplexes is slowest in the cortex, eLife 2024
PSD95 forms complexes at synapses, copies are sequentially replaced over time. PSD95 within supercomplexes have average spacing of 12.7nm.
elifesciences.org/articles/99303

Wonderful educational talk by Hans-Peter Braun @unihannover.bsky.social on mitochondrial supercomplexes. With an insightful historical perspective illustrating the remarkable advances our field has seen in recent years.

Structural Insights and Challenges in the Supercomplexes Formed by Photosystem I in Phototrophs onlinelibrary.wiley.com/doi/full/10....

Structural Insights and Challenges in the Supercomplexes Formed by Photosystem I in Phototrophs onlinelibrary.wiley.com/doi/10.1111/...

Je découvre le mot respirasome 🤩
J'aurais pensé que les complexes étaient davantage enchassés dans la couche lipidique.
Ce qui m'épate aussi c'est leur position par paquets sur la crête : les ATP synthases aux extrémités et les supercomplexes au centre.

Et pourtant c'est bien ça ! Plus précisément, il s'agit de respirasomes : des supercomplexes qui réunissent les complexes I, III et IV (et parfois II) de la chaîne respiratoire !

[Phys.Org]High-resolution images capture intricate structure of mitochondrial supercomplexes - Phys.org Mitochondria are the powerhouses in our cells, producing the energy for all vital processes. Using cryo-electron tomography, researchers at the University of Basel, Switzerland, have now gained...

We added a nice comparison of the different supercomplexes observed to date in different organisms

Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...

#Mitochondria power our cells, but how? Using cryo-electron tomography, @cellarchlab.com and <a href="https://bsky.app/profile/did:plc:mhpz7gfc4j2xb525uro3udnj" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@florentwaltz.bsky.social report in <a href="https://bsky.app/profile/did:plc:vqgovau5gkirnk3ss5qwjdmz" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@science.org that energy-producing proteins form supercomplexes, optimizing ATP production.

High-resolution cryo-electron tomography has unveiled the intricate architecture of mitochondrial supercomplexes, revealing their role in efficient ATP production and potential implications for health and biotechnology. doi.org/g887f6

Architectures of photosynthetic RC-LH1 supercomplexes from Rhodobacter blasticus. @ScienceAdvances Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8ygl

Our latest cryo-EM study reveals the architecture of the KOGG complex, a key player in collagen lysine O-link glycosylation. This LH3/ColGalT1 enzyme machinery ensures proper collagen maturation and may even form fiber-like supercomplexes! #Glycosylation #Collagen
doi.org/10.1038/s41467-025-57768-9

Sad news about Karen Davies' passing.
Karen was an inspiration in bioenergetics and cryoET. Her pioneering postdoctoral work on ATP synthase and respiratory supercomplexes marked turning points in the field. I created Scholar profile to acknowledge her contribution
scholar.google.com/citations?hl...

Detection of Iron Protein Supercomplexes in Pseudomonas aeruginosa by Native Metalloproteomics https://www.biorxiv.org/content/10.1101/2025.01.15.633287v1

Detection of Iron Protein Supercomplexes in Pseudomonas aeruginosa by Native Metalloproteomics https://www.biorxiv.org/content/10.1101/2025.01.15.633287v1

Bioengineered yeast tethered respiratory supercomplexes reveal mechanisms governing efficient substrate utilization www.biorxiv.org/content/10.1...