Scholar

José R. Penadés

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H-index: 58
Biology 59%
Environmental science 21%
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Reposted by: José R. Penadés

brockhurstlab.bsky.social
PS Simon’s tail fibre protein structure models showing the variants causing altered surface receptor binding specificity are Lovell-y
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Reposted by: José R. Penadés

brockhurstlab.bsky.social
5-years in the making this paper has been a real journey!

Also, a fun collaboration with @frimanscience.bsky.social @jofoth.bsky.social Edze Westra, Simon Lovell, Aras Kadioglu

#mevosky #phagesky
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Reposted by: José R. Penadés, Jesse M. Shapiro, Simon Roux , and 1 more

brockhurstlab.bsky.social
New preprint!

Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠

Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!

An epic effort by Rosanna Wright

www.biorxiv.org/content/10.1...
Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages
Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...
www.biorxiv.org
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Reposted by: José R. Penadés

biorxiv-microbiol.bsky.social
The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model https://www.biorxiv.org/content/10.1101/2025.10.04.680436v1
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Reposted by: José R. Penadés

cnb-csic.bsky.social
El proyecto "Descubrir actividades de resistencia antimicrobiana más allá de la resistencia" de
@sanmillan.bsky.social (#CNB, @csic.es) y @jaescudero.bsky.social (@ucm.es) recibe una ayuda del Programa #Fundamentos de Fundación BBVA.

ℹ️Lee la noticia aquí👇

bit.ly/48cvkp1
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Reposted by: José R. Penadés

Reposted by: José R. Penadés

Reposted by: José R. Penadés

craigmaclean.bsky.social
Builds on pre-print posted earlier this week and gratuitously reposted here

www.biorxiv.org/content/10.1...
#Phagesky
Evolutionary rescue accelerates competitive exclusion in a parasite community
Environmental stress drives biodiversity loss by altering competitive hierarchies and pushing taxa towards extinction. Parasites and their communities are particularly vulnerable to stress due to envi...
www.biorxiv.org
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Reposted by: José R. Penadés, Jesse M. Shapiro

craigmaclean.bsky.social
New pre-print
Competition between phage constrains adaptation to thermal fluctuating temperatures.
More work led by Sam Greenrod in collaboration with @kayla-king.bsky.social lab.
#Phagesky#Microsky

www.biorxiv.org/content/10.1...
www.biorxiv.org
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Reposted by: José R. Penadés, Alan McNally

bugsinblood.bsky.social
Now published! www.nature.com/articles/s41...

Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
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Reposted by: José R. Penadés

craigmaclean.bsky.social
New pre-print: Eco-evolutionary responses of phage to different thermal regimes.

Great work led by Sam Greenrod and fun collaboration with Kayla King's lab.
1/2

www.biorxiv.org/content/10.1...
Evolutionary rescue accelerates competitive exclusion in a parasite community
Environmental stress drives biodiversity loss by altering competitive hierarchies and pushing taxa towards extinction. Parasites and their communities are particularly vulnerable to stress due to envi...
www.biorxiv.org
1 15 20

Reposted by: José R. Penadés, Alan McNally

brockhurstlab.bsky.social
Now peer-reviewed, improved and published in @microbiologysociety.org Microbiology - thanks to editor and reviewers!

www.microbiologyresearch.org/content/jour...
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Reposted by: José R. Penadés, Jesse M. Shapiro, Simon Roux

zaminiqbal.bsky.social
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
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Reposted by: José R. Penadés, Alan McNally

jwanford.bsky.social
🎉 Delighted to share the first pre-print from my lab where we demonstrate that intergenic DNA repeats mediate phase variation of the mucoid phenotype in hypervirulent Klebsiella pneumoniae: www.biorxiv.org/content/10.1... #klebclub
Simple Sequence Repeats Mediate Phase Variation of the Mucoid Phenotype in Hypervirulent Klebsiella pneumoniae
Hypervirulent Klebsiella pneumoniae (HVKp) express a thick mucoid capsular polysaccharide which is essential for virulence and survival in the bloodstream but inhibits epithelial adhesion and invasion...
www.biorxiv.org
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Reposted by: José R. Penadés

alicemaestri.bsky.social
We're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded.

Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!
INSTITUT PASTEUR - Technicien de recherche Microbiologie H/F
emploi.pasteur.fr
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Reposted by: José R. Penadés

Reposted by: José R. Penadés

Reposted by: José R. Penadés, Simon Roux, Nicole Dubilier , and 1 more

jorg-vogel-lab.bsky.social
Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…
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Reposted by: José R. Penadés

Reposted by: José R. Penadés

Reposted by: José R. Penadés, Demis Hassabis

Reposted by: José R. Penadés

Reposted by: José R. Penadés

Reposted by: José R. Penadés

by José R. Penadés

jrpenades.bsky.social
Our second paper with @tcostalab.bsky.social and GoogleDeepMind
reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.
www.cell.com/cell/fulltex...
AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution
By solving a previously unsolved biological question, the AI co-scientist predicted a complex mechanism of gene transfer and generated hypotheses that opened new research directions, illustrating AI's...
www.cell.com
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by José R. Penadés — Reposted by: José R. Penadés

jrpenades.bsky.social
Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...
www.cell.com
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by José R. Penadés

by José R. Penadés

Reposted by: José R. Penadés

tcostalab.bsky.social
Thrilled to share that two of our papers with @jrpenades.bsky.social & GoogleDeepMind
are now out in @cellpress.bsky.social

1️⃣Microbial piracy: tinyurl.com/yvf6t3b3
2️⃣AI co-scientist mirrors experimental science: tinyurl.com/2dym92kj

@imperialcollegeldn.bsky.social
@imperiallifesci.bsky.social
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Reposted by: José R. Penadés, Alan McNally

epcrocha.bsky.social
Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...
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