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Reposted by Dan Landau

Jay Shendure @jshendure.bsky.social · 18h

Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...

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Reposted by Dan Landau

Oded Rechavi @odedrechavi.bsky.social · 20h

Trying to work from home with my kids around

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ivanraimondi.bsky.social @ivanraimondi.bsky.social · 22h

🚀 Excited to share SMART-PTA (miniaturized Primary Template Amplification) a high-throughput single-cell whole-genome amplification method that preserves clonal lineage information while enabling deep genomic and transcriptomic profiling.

Dan Landau @landau.bsky.social · 22h

Shout out to Tamara Prieto, Dennis Yuan, John Zinno and @ivanraimondi.bsky.social . Thank you to our funders at @themarkfdn.bsky.social

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Dan Landau @landau.bsky.social · 22h

Shout out to Tamara Prieto, Dennis Yuan, John Zinno and @ivanraimondi.bsky.social . Thank you to our funders at @themarkfdn.bsky.social

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Dan Landau @landau.bsky.social · 22h

Highlights:
- Immune cell clonal expansion & migration
- Mutational signatures change through life
- Driver acquisition, growth dynamics and impact on phenotype to enhance fitness
- CNVs in normal esophagus
- Massive selection of chr9q cnLOH with convergent acquisition multiple times through life

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Dan Landau @landau.bsky.social · 22h

Big, beautiful trees!!

SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.

www.biorxiv.org/content/10.1...

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ralucagordan.bsky.social @ralucagordan.bsky.social · 12d

I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...

DNA mutagenesis driven by transcription factor competition with mismatch repair

Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.

www.cell.com

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Reposted by Dan Landau

Wolfgang Huber @wkhuber.bsky.social · 16d

Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems?

Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

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Thiago Carvalho @cyrilpedia.bsky.social · 17d

If you want to deep dive in to immunology you could do worse than Gabriel's evolutionary landscaping

www.biorxiv.org/content/10.1...

Replaying germinal center evolution on a quantified affinity landscape

Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...

www.biorxiv.org

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Reposted by Dan Landau

Oded Rechavi @odedrechavi.bsky.social · 19d

It's probably the deterioration of social media (I hope) but i'm exposed to a lot less cool science. It used to feel like a new cool study is being preprinted/published every week, and lately it's rare (at least so it seems). Share a recent study that's worth knowing!

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Glen @vaguebiscuit.bsky.social · 18d

Well don't I feel stupid

A headline about the James Webb Telescope potentially finding a new stellar object dubbed a black hole star

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John Greally @greally.bsky.social · 19d

Seven years.
Over 400 pages.
About 750 references.
Over 40 figures.
Finally I get to hold the finished book.
It’s a big day.

#EpigeneticsBook
@cshlpress.bsky.social

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Reposted by Dan Landau

Til Steinicke @til-steinicke.bsky.social · 22d

Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀

Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n

Rapid epigenomic classification of acute leukemia - Nature Genetics

The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.

www.nature.com

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Reposted by Dan Landau

Eric Topol @erictopol.bsky.social · 27d

Major advance for refractory lupus by engineering the T cells in the patient's body (in vivo) and achieving success in 5 patients @nejm.org (uses mRNA/nanoparticle package)
www.nejm.org/doi/full/10....

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Itai Yanai @itaiyanai.bsky.social · Sep 12

Interested in cellular plasticity? Come to my live virtual talk at the Night Science Seminar Series! Free register here: cassyni.com/events/ApfsK...

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Anna Obenauf @obenaufa.bsky.social · Sep 12

I feel deeply honored to receive the 2025 Dr. Josef Steiner Cancer Research Award for our work on decoding and rewiring the immune-evasive TME. It truly is a recognition of the entire team past and present as well as our collaborators and mentors.🙌 Thank you for your trust!

IMP @impvienna.bsky.social · Sep 12

Congratulations to our @obenaufa.bsky.social on receiving the highly prestigious Dr. Josef Steiner Cancer Research Award 2025! 🎉

Read more in this interview with Anna: www.imp.ac.at/news/article...

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Barbara Marte @barbmarte.bsky.social · Sep 11

2. www.nature.com/articles/s41...

Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature

Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...

www.nature.com

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Reposted by Dan Landau

dkotliar.bsky.social @dkotliar.bsky.social · Sep 3

Paper from me, Michelle Curtis, @soumya-boston.bsky.social and co out now in @natmethods.nature.com! We now call it starCAT instead of *CAT but the strategy is the same: Build a catalog of ~50 interpretable T cell gene expression programs + use them to interpret new data nature.com/articles/s41...

Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions - Nature Methods

TCAT is a pipeline that can simultaneously capture gene expression programs related to T cell subsets and activation states for accurate T cell characterization.

nature.com

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Reposted by Dan Landau

Itai Yanai @itaiyanai.bsky.social · Sep 6

Microbiomes are interactive, multispecies communities, but bulk analysis obscures functional diversification from environmental and genetic heterogeneity. In our new review we describe how single-bacterium transcriptomics dissects microbiomes at cellular resolution.
www.science.org/doi/10.1126/...

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Irish Literary Times @irishlittimes.bsky.social · Aug 30

Postscript by Seamus Heaney who died twelve years ago today

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Jeff Mold @jeffmold.bsky.social · Aug 27

Looks interesting! www.nature.com/articles/s41...

Maternal stress triggers early-life eczema through fetal mast cell programming - Nature

Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to ...

www.nature.com

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Reposted by Dan Landau

Jeff Mold @jeffmold.bsky.social · Aug 27

www.nature.com/articles/s41...

Haematopoietic stem cell number is not solely defined by niche availability - Nature

Haematopoietic stem cell numbers are restricted at both systemic and local levels.

www.nature.com

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Dan Landau @landau.bsky.social · Aug 14

🧨Exciting new pre-print 🧨 Introducing ppmSeq - cost effective, scalable dual-strand 🧬🧬 sequencing. Scalability & ultra-low error in one! A game changer for somatic genome discovery science and cfDNA clinical apps. Check out thread for deets!

Alex @alexpellancheng.bsky.social · Aug 14

Highly accurate sequencing OR high throughput? We refuse to choose.

Introducing ppmSeq, a method built to deliver both. Our latest from the @landau.bsky.social lab with Ultima Genomics
👀👀👀

See ⬇️ for a primer on the next frontier of genomics
www.biorxiv.org/content/10.1...

Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecules

Distinguishing real biological variation in the form of single-nucleotide variants (SNVs) from errors is a major challenge for genome sequencing technologies. This is particularly true in settings whe...

www.biorxiv.org

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Dan Landau @landau.bsky.social · Aug 11

Donald Judd

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Dan Landau @landau.bsky.social · Jul 20

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