Lightnews — Scholar-powered news

Sebastián Palacios Martínez @spalaciosm.bsky.social · 3d

Can't wait to try this out!

Joachim Goedhart @joachimgoedhart.bsky.social · 3d

FLIM Playground: An interactive, end-to-end graphical user interface for analyzing single-cell fluorescence lifetime data by Rupsa Datta and team: www.biorxiv.org/content/10.1...

Fig 1. System overview of FLIM Playground.

After (A) loading a saved configuration, (B) Data Extraction collects and validates channel inputs across all fields of views, (C) calibrates for IRF shifts or uses reference standards, and (D) extracts single-cell lifetime (fitting and phasor), morphology, and texture features in one step. (E) To bridge the data extraction with downstream analysis, FLIM Playground combines multiple single-cell datasets and assists users with assigning category labels to each cell. (F) The three feature classes include identifiers (red), numerical features (yellow), and categorical features (blue), are transformed into interactive widgets shared by all analysis methods. (G) Data Analysis includes univariate, bivariate, and multivariate modules. (H) FLIM Playground can either be deployed online in major operating systems or as a data analysis web application. Interactive interfaces are indicated by green backgrounds.

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Reposted by Sebastián Palacios Martínez

Kevin Terretaz @kwolbachia.bsky.social · 8d

I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager!
I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...

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Reposted by Sebastián Palacios Martínez

Nature @nature.com · 10d

Jane Goodall, known for her pioneering work with chimpanzees, has passed away aged 91

go.nature.com/46K10ja

Jane Goodall’s legacy: three ways she changed science

The primatologist challenged what it meant to be a scientist.

go.nature.com

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Reposted by Sebastián Palacios Martínez

Nick Desnoyer @nickdesnoyer.bsky.social · 11d

I find that so many biologists are also talented artists.

@hsuanpai.bsky.social is a skilled technician and apparently good at any artistic media she touches.. even LB.

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Reposted by Sebastián Palacios Martínez

Joachim Goedhart @joachimgoedhart.bsky.social · 12d

My initial assessment of this paper ⬇️ was brief, so let’s have a better look at it:
🧵

Joachim Goedhart @joachimgoedhart.bsky.social · 16d

Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains.
Is it impressive? Yes
Is it new? No
Should you use it? Probably not.
www.cell.com/cell/fulltex...

Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains

A family of rationally designed time-resolved fluorescent proteins with controllable lifetimes across the visible spectrum enables simultaneous multiplexed live imaging, super-resolution microscopy, a...

www.cell.com

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Reposted by Sebastián Palacios Martínez

Tristan Lee @tristanl.ee · Aug 21

Screenshot from Fallout: New Vegas showing someone using the C-Finder weapon to focus the power of the sun
https://fallout.fandom.com/wiki/Euclid%27s_C-Finder?file=Euclid.jpg.jpg

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Sebastián Palacios Martínez @spalaciosm.bsky.social · Aug 22

Another #FluorescenceFriday, another movie of the cytoskeleton.

This time around EB3-mScarlet3 and LifeAct-mStayGold co-expressed in U2Os cells!

LUTs here (Ink collection)--> sites.imagej.net/JDM_LUTs/luts/

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Reposted by Sebastián Palacios Martínez

Michael R Photography 🌿 @msriffle.bsky.social · Aug 7

Today is National Lighthouse Day honoring the historical and cultural significance of lighthouses. I've posted this image before but have reprocessed it. It is the lighthouse at St. Marks Florida. #photography #landscape #EastCoastKin #bnw #blackandwhitephotography #infrared #fullspectrum #clouds

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Reposted by Sebastián Palacios Martínez

New England Society for Microscopy @nesmicroscopy.bsky.social · Jul 21

🐙 This Octopus shifts from deep to active rest while "dreaming" for #MicroscopyMonday. REM‑like sleep (color bursts and twitches) filmed in real time by Horst Obenhaus @octoscience.bsky.social‬, currently a 2025 Whitman Fellow at @mblscience.bsky.social. #NESM

#Octopus #Neuro #SleepScience #MBL

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Reposted by Sebastián Palacios Martínez

eLife @elife.bsky.social · Jul 1

One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics.
buff.ly/pMGXJVM

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Sebastián Palacios Martínez @spalaciosm.bsky.social · Jun 28

Plasmid here 🧬➡️ www.addgene.org/Dorus_Gadella/

Addgene: Dorus Gadella Lab Materials

www.addgene.org

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Sebastián Palacios Martínez @spalaciosm.bsky.social · Jun 28

A very late #FluorescenceFriday.

Reposting one of my favorite timelapses from the past year: EB3-mScarlet3 in a HeLa cell, look at those microtubules grow!

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Sebastián Palacios Martínez @spalaciosm.bsky.social · Jun 28

News article on the project:

Phage therapy: I found a bacteria-eating virus in my loo

It's hoped phages could give us new ways of treating infections which are immune to antibiotics.

www.bbc.com

Sebastián Palacios Martínez @spalaciosm.bsky.social · Jun 28

Shout-out to The Phage Collection Project run by @fnobrega.bsky.social

You can order your very own samplng kit and help with the discovery of new phages to combat antibiotic resistance!

Check their website for more info ➡️ www.phage-collection.org

ThePhageCollectionProject

www.phage-collection.org

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Sebastián Palacios Martínez @spalaciosm.bsky.social · Jun 25

Proud to work with and learn from an extraordinary biologist 🔬

The Company of Biologists @biologists.bsky.social · Jun 25

This week, we are featuring Joachim Goedhart, one of the most prolific authors on @the-node.bsky.social, as an extraordinary biologist. #100biologists
@joachimgoedhart.bsky.social

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Reposted by Sebastián Palacios Martínez

Christophe 🔬 L @christlet.bsky.social · Jun 22

Great nod to the photography work of Bernd and Hilla Becher

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Reposted by Sebastián Palacios Martínez

Hao Yin @haoyin.bsky.social · Jun 20

Leukocyte #TransEndothelialMigration #TransPericyteMigration hotspots at a glance
😍

Jaap van Buul Lab @jcellsci.bsky.social 2025
journals.biologists.com/jcs/article-...

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Sebastián Palacios Martínez @spalaciosm.bsky.social · Mar 24

Seems like you tagged the wrong Sebastián Palacios, but happy to learn there's many of us doing fun cell bio!

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Reposted by Sebastián Palacios Martínez

Arjun Raj @arjunraj.bsky.social · Mar 20

I miss when the biggest controversy about mRNA was whether it correlated with protein or not.

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Reposted by Sebastián Palacios Martínez

Ankita Jha @ankita13jha.bsky.social · Mar 10

As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration
www.biorxiv.org/content/10.1...

CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration

Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...

www.biorxiv.org

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Reposted by Sebastián Palacios Martínez

Joachim Goedhart @joachimgoedhart.bsky.social · Mar 7

I had to try this (see preprint), so here's a result with milk ± ampyrone and it just works!!

Image showing that text is occluded by milk, but it the milk is transparent when an absorbing dye (ampyrone) is added.

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Sebastián Palacios Martínez @spalaciosm.bsky.social · Feb 12

Does biofluorescence enhance visual signals in birds-of-paradise?: short answer, yes! Birds of paradise show fluorescence in the 520-560nm range.
royalsocietypublishing.org/doi/10.1098/...

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Reposted by Sebastián Palacios Martínez

Journal of Cell Biology @jcb.org · Jan 24

Tubulin arginylation regulates #microtubule dynamics. New study from MacTaggart, @annakashina.bsky.social and colleagues identifies an ATE1-dependent #arginylation site at E77 of α-tubulin and show that this modification regulates the binding of MAP1S to #microtubules. https://buff.ly/4jqLqhT

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Sebastián Palacios Martínez @spalaciosm.bsky.social · Jan 15

Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filaments by Pasolli et al.

Very exciting to see tool development for the less well-studied components of the cytoskeleton.

www.biorxiv.org/content/10.1...

Reposted by Sebastián Palacios Martínez

Stephan Huveneers @huveneerslab.bsky.social · Jan 14

Curvature-sensing BAR proteins control junction turnover to promote collective migration of endothelial cells in angiogenesis. rdcu.be/d6a04

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