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Basavraj Khanppnavar

@basurajsk.bsky.social

37 followers 66 following 12 posts

Scientist @Paul Scherrer Institute. Interested in #membrane-associated #signalling complexes and #host-pathogen interactions #Structural Biology

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Basavraj Khanppnavar @basurajsk.bsky.social · Feb 11

Want to know “How does #Botox enter cells at the right time & place to exert its #therapeutic effect?” Check out our latest paper @naturecomms.bsky.social @psich_en @KorkhovLab @ethzurich.bsky.social
www.nature.com/articles/s41...

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Basavraj Khanppnavar @basurajsk.bsky.social · Aug 30

Wonderful stuff. Congratulations 🎊

Reposted by Basavraj Khanppnavar

Chao Qi @qcxy8886.bsky.social · Jul 17

The best cover🥰, paired cats & paired helical filaments.

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Reposted by Basavraj Khanppnavar

Juha Huiskonen @juhahuiskonen.bsky.social · Jul 8

In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.

The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.

CryoET tomogram with the gap junction (green), ribosomes (cyan) and microtubules (pink)

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Reposted by Basavraj Khanppnavar

Dina Schuster @dina-sch.bsky.social · May 23

Ever wondered how stable your ADCs are and how their stability is influenced by their drug-load?

Variable-temperature electrospray ionization can help with that!

Jan Fiala’s and my postdoc work in the lab of @hecklab.bsky.social was just published! 🥳🥳🥳

pubs.acs.org/doi/10.1021/...

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Antibody–Drug Conjugate Stability Probed by Variable-Temperature Electrospray Ionization Mass Spectrometry

Antibody–drug conjugates (ADCs) are effective anticancer biotherapeutics, often referred to as “magic bullets” due to their high specificity and cytotoxicity. This unique drug class consists of cytoto...

pubs.acs.org

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Reposted by Basavraj Khanppnavar

Janine Brunner @janinebrunner.bsky.social · May 5

I am delighted to share our findings on the binding mode of tetanus neurotoxin and the anti-epileptic drug Levetiracetam to SV2A, an essential synaptic vesicle membrane protein of unknown function, now online in @NatComms.bsky.social

www.nature.com/articles/s41...

Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams - Nature Communications

SV2A, an essential membrane protein in neurotransmission, is known as the receptor of clostridial neurotoxins and target of anti-epileptic drugs. Here the authors show details of the binding site for ...

www.nature.com

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Reposted by Basavraj Khanppnavar

UniTmp @unitmporg.bsky.social · Mar 24

#CryoEM #structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation. @NatureComms Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9f1r

www.nature.com

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Reposted by Basavraj Khanppnavar

Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · Mar 21

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)

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Basavraj Khanppnavar @basurajsk.bsky.social · Mar 20

Delighted to share #AuthorInterview with @biopatrika.bsky.social were we discuss on recent findings on Botox.
biopatrika.com/academia/res...

Molecular Snapshots Unravel Botox’s Secrets of Nerve Cell Entry - BioPatrika

Researcher Spotlight - In our study, we demonstrate for the first time the existence of large conformational changes in Botox and explain their purpose.

biopatrika.com

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Reposted by Basavraj Khanppnavar

Cooty McCootFace @cootymccootface.bsky.social · Mar 17

Coot 1.1.14 has been released!

Coming to homebrew and flatpak soon!

- Clark & Labute comes to Coot 1, Moorhen & chapi!
(svg, 2D ligand environment view)
- Solid Symmetry (symmetry that you can see!)
- PAE plot for AlphaFold models
#coot
#molmatinf

Screenshot of 2d ligand environment view, 1x8b 4dfr, 2vtq, 2p4y

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Basavraj Khanppnavar @basurajsk.bsky.social · Mar 13

Awesome stuff 👏

Reposted by Basavraj Khanppnavar

Chao Qi @qcxy8886.bsky.social · Mar 13

Happy to share our latest publication on
@naturesmb.bsky.social Natural Structure & Molecular Biology, we show tau filaments show Alzheimer fold in mutants V337M and R406W.
thanks @sjorsscheres.bsky.social and Michel Goedert's support. 🥳
rdcu.be/edqzW
rdcu.be/edoGv

Mutant tau filaments from some inherited frontotemporal dementias show the Alzheimer fold

Nature Structural & Molecular Biology - Frontotemporal dementias can be caused by mutations in MAPT, which encodes the protein tau; the mutant protein forms harmful aggregates in the brain....

rdcu.be

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Reposted by Basavraj Khanppnavar

Prof. F.L. Gervasio Research Group @gervasiolab.bsky.social · Mar 12

Very proud of our new review article on the Beta 1-Adrenergic GPCR now available on bioRxiv: www.biorxiv.org/content/10.1....
With @saureli.bsky.social @valeriorizzi.bsky.social and Nicola we used OneOPES to fully converge the free energy landscapes associated with B1AR apo/holo activation.

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Reposted by Basavraj Khanppnavar

Nature @nature.com · Mar 12

Nature research paper: Natural behaviour is learned through dopamine-mediated reinforcement

https://go.nature.com/3XMKATn

Natural behaviour is learned through dopamine-mediated reinforcement - Nature

Studies in zebra finches show that dopamine has a key role as a reinforcement signal in the trial-and-error process of learning that underlies complex natural behaviours.

go.nature.com

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Reposted by Basavraj Khanppnavar

Nature @nature.com · Mar 12

Male blue-lined octopuses inject females with venom during mating to avoid being eaten by their partners

https://go.nature.com/3FqtOU4

Bad romance: male octopuses inject deadly venom into their mates

The paralysing toxin deployed by the male blue-lined octopus might help to protect him from being eaten.

go.nature.com

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Reposted by Basavraj Khanppnavar

Stephan Gruber @gruberlab.bsky.social · Mar 11

Happy to share the beautiful structure of a Wadjet SMC complex by @roisnehamelinf.bsky.social, with support from the DCI and @drhonsworth.bsky.social ! This is a type II Wadjet with unique characteristics including a tandem KITE subunit, distinct coiled coil architecture and a deviant hinge.

Side view of the structure of a monomer of type II Wadjet.

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Basavraj Khanppnavar @basurajsk.bsky.social · Mar 10

Well said!!. I totally support this. As a collaborator or teamate and co coauthor, it's also our responsibility to ensure quality of Science in every publication we publish as coauthor. #SaveScienceFromJunk

Sjors Scheres @sjorsscheres.bsky.social · Mar 9

If you do an experiment for someone else's paper and you become a co-author, this means that you agree with *everything* in that paper! It takes time and effort to reach consensus, but this ensures better science. That's why I cannot understand how some people publish so many papers each year.

Reposted by Basavraj Khanppnavar

Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡 @klausenhauser.bsky.social · Mar 5

Hey kiddos. Don’t forget to filter your buffers and samples (any cut off is better than no cutoff) or use an inline filter on your systems!

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Reposted by Basavraj Khanppnavar

Bryan Roth @zenbrainest.bsky.social · Feb 26

We have deposited the following mice (all B6/J backcrossed) to @mmrrc.bsky.social
Adgrf5-EGFP-CT-IRES-CRE
GPR123- EGFP-CT-IRES-CRE
GPR124- EGFP-CT-IRES-CRE
GPR125- EGFP-CT-IRES-CRE
Gpr133-EGFP-CT-IRES-CRE
GPR156-IRES-Cre
GPR156-mGL-IRES-Cre
GPR75-IRES-Cre

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Reposted by Basavraj Khanppnavar

Department of Biology, ETH Zurich @eth-dbiol.bsky.social · Feb 18

The paper by @BasurajSK, Oneda Leka, Pal Sushant, @KorkhovLab, and Richard Kammerer (@psich_en), published in @NatureComms provides molecular insights in botulinum neurotoxin recognition and pH-dependent conformational transitions relevant to its mechanism of action. biol.ethz.ch/en/news-and-...

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Reposted by Basavraj Khanppnavar

Lukas VF Novak @animalculum.bsky.social · Feb 13

Symbiotic #bacteria ride along with single-celled #protists in ocean's upper layer phys.org/news/2025-02...

#Symbionts of predatory protists are widespread in the oceans and related to animal pathogens www.cell.com/cell-host-mi...

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Reposted by Basavraj Khanppnavar

cryoEM papers @cryoempapers.bsky.social · Feb 12

Cryo-EM structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation pubmed.ncbi.nlm.nih.gov/39934119/ #cryoem

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Basavraj Khanppnavar @basurajsk.bsky.social · Feb 11

These mechanisms explain why one of the deadliest toxins is also a highly successful therapeutic protein.

Basavraj Khanppnavar @basurajsk.bsky.social · Feb 11

After endocytosis, the acidification of the vesicle lumen acts as a signal for Botox to adopt It only adopt translocation-competent state and to enter the host cytosol.

Basavraj Khanppnavar @basurajsk.bsky.social · Feb 11

The Botox in free state is highly dynamic, but upon binding to SV2B receptor, it attains an open conformation, preventing premature entry into the host cell.

Basavraj Khanppnavar @basurajsk.bsky.social · Feb 11

This work highlights how biological toxins—one of nature’s most finely evolved molecules—function with sophistication and accuracy. They can inspire the development of new innovative tools & therapeutics. #Science #Evolution #Technology