Ryan Boileau
@bffswithbiology.bsky.social
NIH-F32 Postdoctoral Fellow @ChoryLab
@DukeU @DukeCAGT | PhD @UCSF
Chromatin, SynBio, Automation
#FirstGen | Nice to meet you friend☀️🌲😊
@DukeU @DukeCAGT | PhD @UCSF
Chromatin, SynBio, Automation
#FirstGen | Nice to meet you friend☀️🌲😊
Reposted by Ryan Boileau
Same as it ever was.
September 29, 2025 at 9:23 PM
Same as it ever was.
Reposted by Ryan Boileau
HHMI adopts Plan U journals.plos.org/plosbiology/...
September 24, 2025 at 6:08 PM
HHMI adopts Plan U journals.plos.org/plosbiology/...
It's 2025 and excel still cant open two different worksheets with the same file name. Thank you for your attention to this matter
September 9, 2025 at 6:55 PM
It's 2025 and excel still cant open two different worksheets with the same file name. Thank you for your attention to this matter
Reposted by Ryan Boileau
New preprint from the lab just dropped! Our continued partnership with Irfan Kathiriya from @ucsanfrancisco.bsky.social on gene regulatory networks in atrial disease modeling using iPS cells
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease
There is evidence for a shared genetic basis of atrial septal defects (ASDs) and atrial fibrillation (AF), but it remains unclear how genetic susceptibility leads to these distinct human atrial diseas...
www.biorxiv.org
August 20, 2025 at 8:14 PM
New preprint from the lab just dropped! Our continued partnership with Irfan Kathiriya from @ucsanfrancisco.bsky.social on gene regulatory networks in atrial disease modeling using iPS cells
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
IDT prices seem to inflate like groceries these days. Highly recommend 10nm scale for >60nt oligos from GeneWiz, best deal on the market I've seen-- even if you have to wait a few days. Cheapest gene block synthesis now from Twist also.
August 15, 2025 at 8:48 PM
IDT prices seem to inflate like groceries these days. Highly recommend 10nm scale for >60nt oligos from GeneWiz, best deal on the market I've seen-- even if you have to wait a few days. Cheapest gene block synthesis now from Twist also.
Reposted by Ryan Boileau
Our work on rationally engineering allosteric protein switches is now out in Nature Methods: www.nature.com/articles/s41... Thanks a lot to @grunewald.bsky.social and @noahholzleitner.bsky.social for the comprehensive news and views: www.nature.com/articles/s41...
Rational engineering of allosteric protein switches by in silico prediction of domain insertion sites - Nature Methods
ProDomino is a machine leaning-based method, trained on a semisynthetic domain insertion dataset, to guide the engineering of protein domain recombination.
www.nature.com
August 4, 2025 at 11:41 AM
Our work on rationally engineering allosteric protein switches is now out in Nature Methods: www.nature.com/articles/s41... Thanks a lot to @grunewald.bsky.social and @noahholzleitner.bsky.social for the comprehensive news and views: www.nature.com/articles/s41...
Reposted by Ryan Boileau
To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪
July 26, 2025 at 2:11 PM
To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪
Reposted by Ryan Boileau
Noncanonical amino acids are efficiently incorporated into proteins by optimizing mRNA codon usage go.nature.com/3MDSSXQ
rdcu.be/exfiH
rdcu.be/exfiH
Efficient genetic code expansion without host genome modifications - Nature Biotechnology
Noncanonical amino acids are efficiently incorporated into proteins by optimizing mRNA codon usage.
go.nature.com
July 25, 2025 at 3:40 AM
Noncanonical amino acids are efficiently incorporated into proteins by optimizing mRNA codon usage go.nature.com/3MDSSXQ
rdcu.be/exfiH
rdcu.be/exfiH
Reposted by Ryan Boileau
Cachexia (which I now know how to pronounce) is an awful and overlooked part of cancer. At least reducing this indignity would be great
Excited to share that our study on the role of the liver in #CancerCachexia is out in Cell! 😀 🧬
We found that the liver plays an active role in driving weight loss in cancer through disruption of the circadian regulator REV-ERBα and secretion of catabolic hepatokines
www.cell.com/cell/fulltex...
We found that the liver plays an active role in driving weight loss in cancer through disruption of the circadian regulator REV-ERBα and secretion of catabolic hepatokines
www.cell.com/cell/fulltex...
July 23, 2025 at 5:37 PM
Cachexia (which I now know how to pronounce) is an awful and overlooked part of cancer. At least reducing this indignity would be great
Reposted by Ryan Boileau
amazing new discovery by my @gladstoneinst.bsky.social and @ucsanfrancisco.bsky.social colleagues, on cell-directed combination therapy for Alzheimer's disease. Although having seen first-hand what irinotecan does, I wouldn't recommend it. Proof of principle impressive. www.cell.com/cell/fulltex...
Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
A multi-cell-type drug discovery strategy targeting dysregulated gene networks in
neurons and glia identified letrozole and irinotecan as a combination therapy that
significantly improved memory and r...
www.cell.com
July 21, 2025 at 8:16 PM
amazing new discovery by my @gladstoneinst.bsky.social and @ucsanfrancisco.bsky.social colleagues, on cell-directed combination therapy for Alzheimer's disease. Although having seen first-hand what irinotecan does, I wouldn't recommend it. Proof of principle impressive. www.cell.com/cell/fulltex...
Reposted by Ryan Boileau
Fabulous post by @randomwalker.bsky.social & Sayash raising the same concern many of us have about whether we're on the right track with how we're using AI for science. Everyone should read it, take a deep breath & think through the implications.
www.aisnakeoil.com/p/could-ai-s...
www.aisnakeoil.com/p/could-ai-s...
Could AI slow science?
Confronting the production-progress paradox
www.aisnakeoil.com
July 17, 2025 at 4:05 PM
Fabulous post by @randomwalker.bsky.social & Sayash raising the same concern many of us have about whether we're on the right track with how we're using AI for science. Everyone should read it, take a deep breath & think through the implications.
www.aisnakeoil.com/p/could-ai-s...
www.aisnakeoil.com/p/could-ai-s...
Reposted by Ryan Boileau
long-time coming, multi-lab paper on the evolution of gene regulation in the tetrapod heart. I actually did the mouse and chick embryo heart dissections for this one! onlinelibrary.wiley.com/doi/epdf/10....
The Interplay of Ontogeny and Phylogeny at the Transcriptome Level of the Tetrapod Heart
You have to enable JavaScript in your browser's settings in order to use the eReader.
onlinelibrary.wiley.com
July 3, 2025 at 8:32 PM
long-time coming, multi-lab paper on the evolution of gene regulation in the tetrapod heart. I actually did the mouse and chick embryo heart dissections for this one! onlinelibrary.wiley.com/doi/epdf/10....
Reposted by Ryan Boileau
Biomedical research is facing a funding crisis.
Cuts to federal funding will mean fewer medical breakthroughs, less economic growth, and loss of opportunities for early-career scientists, and loss of our country's leadership in life science.
Here's what you should know about the proposed cuts. 🧵
Cuts to federal funding will mean fewer medical breakthroughs, less economic growth, and loss of opportunities for early-career scientists, and loss of our country's leadership in life science.
Here's what you should know about the proposed cuts. 🧵
July 3, 2025 at 3:19 PM
Biomedical research is facing a funding crisis.
Cuts to federal funding will mean fewer medical breakthroughs, less economic growth, and loss of opportunities for early-career scientists, and loss of our country's leadership in life science.
Here's what you should know about the proposed cuts. 🧵
Cuts to federal funding will mean fewer medical breakthroughs, less economic growth, and loss of opportunities for early-career scientists, and loss of our country's leadership in life science.
Here's what you should know about the proposed cuts. 🧵
Just reminded of the new NIH public access policy in effect today-- researchers now required to deposit new publications resulting from NIH-funding into PubMed Central immediately upon publication independent of open access status. No need to pay extra for open access anymore? Smells like progress
July 1, 2025 at 8:51 PM
Just reminded of the new NIH public access policy in effect today-- researchers now required to deposit new publications resulting from NIH-funding into PubMed Central immediately upon publication independent of open access status. No need to pay extra for open access anymore? Smells like progress
Reposted by Ryan Boileau
Marjorie Taylor Greene doesn't want you to know the name of her opponent but will try every desperate attempt to save her seat.
My name is Shawn Harris. I am a Democrat, husband, father, Retired Brigadier General, farmer, and I'm running against MTG. Can you spread the word?
My name is Shawn Harris. I am a Democrat, husband, father, Retired Brigadier General, farmer, and I'm running against MTG. Can you spread the word?
June 30, 2025 at 11:24 PM
Marjorie Taylor Greene doesn't want you to know the name of her opponent but will try every desperate attempt to save her seat.
My name is Shawn Harris. I am a Democrat, husband, father, Retired Brigadier General, farmer, and I'm running against MTG. Can you spread the word?
My name is Shawn Harris. I am a Democrat, husband, father, Retired Brigadier General, farmer, and I'm running against MTG. Can you spread the word?
Reposted by Ryan Boileau
Duke appears to have lost NIH grants because they used the prefix "trans" in reference to disease transmission, transgenic genetic material, translational studies, or signal transduction www.dukechronicle.com/article/2025...
June 27, 2025 at 2:03 PM
Duke appears to have lost NIH grants because they used the prefix "trans" in reference to disease transmission, transgenic genetic material, translational studies, or signal transduction www.dukechronicle.com/article/2025...
Reposted by Ryan Boileau
🚨 NEW PUBLICATION 🚨 "An experimental census of retrons for DNA production and genome editing"
@natbiotech.nature.com
@seth-shipman.bsky.social
@natbiotech.nature.com
@seth-shipman.bsky.social
An experimental census of retrons for DNA production and genome editing - Nature Biotechnology
Genome editing tools are developed through large-scale characterization of bacterial retrons.
go.nature.com
June 30, 2025 at 1:23 PM
🚨 NEW PUBLICATION 🚨 "An experimental census of retrons for DNA production and genome editing"
@natbiotech.nature.com
@seth-shipman.bsky.social
@natbiotech.nature.com
@seth-shipman.bsky.social
Reposted by Ryan Boileau
I am very proud that the public, through NIH, has built such a powerful and successful enterprise to understand and treat diseases like cancer.
I am very sad that this research enterprise at NIH is suffering such damage. That’s bad for patients, bad for the economy, bad for all of us.
🧪
I am very sad that this research enterprise at NIH is suffering such damage. That’s bad for patients, bad for the economy, bad for all of us.
🧪
June 30, 2025 at 12:45 AM
I am very proud that the public, through NIH, has built such a powerful and successful enterprise to understand and treat diseases like cancer.
I am very sad that this research enterprise at NIH is suffering such damage. That’s bad for patients, bad for the economy, bad for all of us.
🧪
I am very sad that this research enterprise at NIH is suffering such damage. That’s bad for patients, bad for the economy, bad for all of us.
🧪
Reposted by Ryan Boileau
Happy to share a new publication: an introduction to comparative oncology in @natrevcancer.nature.com. Thanks to the leaders in the field for welcoming me as an invertebrate researcher.
rdcu.be/etKdN
rdcu.be/etKdN
Advancing cancer research via comparative oncology
Nature Reviews Cancer - Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular...
rdcu.be
June 30, 2025 at 4:27 PM
Happy to share a new publication: an introduction to comparative oncology in @natrevcancer.nature.com. Thanks to the leaders in the field for welcoming me as an invertebrate researcher.
rdcu.be/etKdN
rdcu.be/etKdN
Reposted by Ryan Boileau
Warnock: A budget is not just a fiscal document. A budget is a moral document. Show me your budget and I'll show you who you think matters and who doesn't. And if this awful budget were an EKG, it would suggest that our nation has a heart problem and is in need of moral surgery
June 30, 2025 at 3:29 AM
Warnock: A budget is not just a fiscal document. A budget is a moral document. Show me your budget and I'll show you who you think matters and who doesn't. And if this awful budget were an EKG, it would suggest that our nation has a heart problem and is in need of moral surgery
Reposted by Ryan Boileau
So unless something changes the NIH budget for FY26 remains at the FY25 levels (which is really the FY24 levels) ~48 billion. Not great in absolute terms but a hella lot better than what the white house and house wanted. Same with NSF - stays at ~9
June 28, 2025 at 6:43 PM
So unless something changes the NIH budget for FY26 remains at the FY25 levels (which is really the FY24 levels) ~48 billion. Not great in absolute terms but a hella lot better than what the white house and house wanted. Same with NSF - stays at ~9
Reposted by Ryan Boileau
Thanks to WRAL for documenting the tremendous impact of the Trump administration efforts to end important research grants
www.wral.com/news/local/u...
www.wral.com/news/local/u...
100+ UNC research projects lose federal funding
UNC-Chapel Hill is navigating a significant $126 million reduction in federal grant funding compared to last fiscal year.
www.wral.com
June 27, 2025 at 2:34 PM
Thanks to WRAL for documenting the tremendous impact of the Trump administration efforts to end important research grants
www.wral.com/news/local/u...
www.wral.com/news/local/u...
Reposted by Ryan Boileau
MassLive.com recently interviewed several Harvard FlyBase people and wrote this news article about the importance of FlyBase: tinyurl.com/4chpts9f
Why a database of bug genes could be one of Trump’s most devastating cuts at Harvard
FlyBase, the world's only fruit fly database, is in the crosshairs of Trump's attack on Harvard. Here's why it could matter for your health.
tinyurl.com
June 25, 2025 at 8:31 PM
MassLive.com recently interviewed several Harvard FlyBase people and wrote this news article about the importance of FlyBase: tinyurl.com/4chpts9f
Reposted by Ryan Boileau
Breaking news: The National Institutes of Health has ceased terminating grants on politically sensitive topics after a federal judge ruled last week that the cancellations were illegal.
scim.ag/4l9MO8Y
scim.ag/4l9MO8Y
Following court order, NIH ceases new terminations of politically sensitive grants
After a judge told agency to restore hundreds of killed grants, NIH backs off plans to cancel more existing projects
scim.ag
June 25, 2025 at 5:36 PM
Breaking news: The National Institutes of Health has ceased terminating grants on politically sensitive topics after a federal judge ruled last week that the cancellations were illegal.
scim.ag/4l9MO8Y
scim.ag/4l9MO8Y
Reposted by Ryan Boileau
Demand an affidavit ballot and submit it. Your vote will count.
If this has happened to you today, get in touch with us at [email protected].
Read more on our live blog: hellgatenyc.com/hell-gate-ny...
Read more on our live blog: hellgatenyc.com/hell-gate-ny...
June 24, 2025 at 9:09 PM
Demand an affidavit ballot and submit it. Your vote will count.