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brettgarabedian.bsky.social
Brett Garabedian
@brettgarabedian.bsky.social
340 followers 310 following 78 posts
PhD Candidate with Jim Paulson at Scripps Research | Building immune therapies aimed at cancer’s sweet spot 🍭 #glycotime | Dabbling in protein degraders #TPD 🎯
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brettgarabedian.bsky.social
Brett Garabedian @brettgarabedian.bsky.social · Jul 4
🔥 HOT OFF THE PRESS 🔥

Today in ACS Central Science @pubs.acs.org , we report an anti-PD1 #sialidase conjugate that degrades #SialicAcid on PD1+ T cells, inflaming tumors and controlling their growth beyond SOC PD1 blockade in melanoma models #Glycotime

pubs.acs.org/doi/full/10....
Targeting Sialidase to PD1 Enhances T cell Function and Tumor Control
Immune therapies targeting the PD1 axis have transformed outcomes in cancer treatment by enhancing T cell-mediated immune responses. However, many tumors evade immune clearance through orthogonal esca...
pubs.acs.org
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brettgarabedian.bsky.social
Brett Garabedian @brettgarabedian.bsky.social · 1d
Fake news
erictopol.bsky.social
Eric Topol @erictopol.bsky.social · 2d
Is dark chocolate good for you?
"Sadly for chocoholics, the health claims for dark chocolate come from wishful thinking and sly marketing, not the findings of science."
Sorry
www.economist.com/science-and-...
Is dark chocolate actually healthy?
We assess whether that tempting idea is too good to be true
www.economist.com
Reposted by Brett Garabedian
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 4d
Get your Zoster vaccine! @naturemedicine.bsky.social
A consistent relationship of VZV reactivation with dementia in 100M US adults after controlling for nearly 400 measured characteristics, with zoster vaccines reducing risk of dementia in dose-dependent manner
www.nature.com/articles/s41...
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Reposted by Brett Garabedian
couts.bsky.social
Andrew Couts @couts.bsky.social · 8d
NEW: ICE is planning to hire a team of nearly 30 people to surveil social media 24/7, build dossiers on people, and flag them for arrest and deportation. @dell.bsky.social has the scoop: www.wired.com/story/ice-so...
ICE Wants to Build Out a 24/7 Social Media Surveillance Team
Documents show ICE plans to hire dozens of contractors to scan X, Facebook, TikTok, and other platforms to target people for deportation.
www.wired.com
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Reposted by Brett Garabedian
glycocode.bsky.social
Lara K. Mahal @glycocode.bsky.social · 8d
A real triumph for #glycotime and basic research, thanks to the work of Steve Withers and others.🧪
nature.com
Nature @nature.com · 8d
This first of its kind procedure could improve access to donor organs because the donor blood type would no longer matter

go.nature.com/3IToaM3
First human transplant of kidney modified to have ‘universal’ blood type
Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.
go.nature.com
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brettgarabedian.bsky.social
Brett Garabedian @brettgarabedian.bsky.social · 9d
#badglycans #glycotime
brettgarabedian.bsky.social
Brett Garabedian @brettgarabedian.bsky.social · 14d
www.science.org/doi/10.1126/...
Age-related remodeling of the sialoglycans dampens murine CD8+ T cell function
Age-related changes in glycocalyx are associated with reduced T cell responsiveness.
www.science.org
3
Reposted by Brett Garabedian
barackobama.bsky.social
Barack Obama @barackobama.bsky.social · 16d
We have people in power making broad claims around certain drugs and autism that have been continuously disproven.
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brettgarabedian.bsky.social
Brett Garabedian @brettgarabedian.bsky.social · 17d
“Until we address Trump's corruption as the absolute, primary threat it represents right now, every other national security discussion is pointless, akin to rearranging deck chairs on the Titanic.”
anneapplebaum.bsky.social
Anne Applebaum @anneapplebaum.bsky.social · 17d
Read the Dekleptocracy substack: "When a phantom foundation with no address, no registration and a founder who might not exist, wires $100 million to the president's crypto company, America has a problem"
dekleptocracy.substack.com/p/trumps-she...
Trump's Shell Game Threatens American Security
We're pushing to make anti-corruption a top priority on the political agenda to fight authoritarianism, strengthen the rule of law and protect democracy.
dekleptocracy.substack.com
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brettgarabedian.bsky.social
Brett Garabedian @brettgarabedian.bsky.social · 20d
Reminiscent of work by @wisnovskylab.bsky.social

www.pnas.org/doi/10.1073/...
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7 | PNAS
Glyco-immune checkpoint receptors, molecules that inhibit immune cell activity following binding to glycosylated cell-surface antigens, are emergin...
www.pnas.org
brettgarabedian.bsky.social
Brett Garabedian @brettgarabedian.bsky.social · 20d
CD43 strikes again #glycotime

www.biorxiv.org/content/10.1...
Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing
Natural killer (NK) cell-based immunotherapies represent a promising avenue for cancer treatment due to their ability to eliminate cancer cells independently of antigen presentation and potential for ...
www.biorxiv.org
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brettgarabedian.bsky.social
Brett Garabedian @brettgarabedian.bsky.social · 20d
next level stuff
www.npr.org/2025/09/20/g...
Defense Secretary Hegseth requires new 'pledge' for reporters at the Pentagon
The Pentagon is implementing new guidelines that will require journalists to sign a pledge and agree to report only approved and officially released information.
www.npr.org
Reposted by Brett Garabedian
justinwolfers.bsky.social
Justin Wolfers @justinwolfers.bsky.social · 21d
Critical part of the President's new $100,000 charge for H1-B visas: The Administration can also offer a $100,000 discount to any person, company, or industry that it wants. Replacing rules with arbitrary discretion.

Want visas? You know who to call and who to flatter.
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Reposted by Brett Garabedian
jayapal.house.gov
Congresswoman Pramila Jayapal @jayapal.house.gov · 21d
These are visas for skilled workers — doctors, scientists, and engineers.

This move will hurt US innovation and exacerbate an already serious shortage of medical professionals. In what world does this make sense?? www.bloomberg.com/news/article...
Trump to Add New $100,000 Fee For H-1B Visas In Latest Crackdown
President Donald Trump is expected to sign a proclamation as soon as Friday that would move to extensively overhaul the H-1B visa program, requiring a $100,000 fee for applications in a bid to curb ov...
www.bloomberg.com
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Reposted by Brett Garabedian
harmitmalik.bsky.social
Harmit Singh Malik @harmitmalik.bsky.social · 21d
Any academic folks on H1B visas (even with stamps in passports) please get legal advice from your University attorneys before leaving the US.
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brettgarabedian.bsky.social
Brett Garabedian @brettgarabedian.bsky.social · 22d
New work from Dr. Kikuchi et al. in the Paulson lab @scripps.edu showing H3N2 #influenza tropism for #sialicacid on tracheal ciliated cells #glycotime

www.biorxiv.org/content/10.1...
H3N2 influenza virus tropism shifts to glycan receptors on tracheal ciliated cells
Human H3N2 influenza viruses, introduced during the 1968 pandemic, have evolved to recognize human-type sialic acid-containing receptors (Neu5Acα2-6Gal) extended with at least three LacNAc (Galβ1-4Glc...
www.biorxiv.org
1
Reposted by Brett Garabedian
barackobama.bsky.social
Barack Obama @barackobama.bsky.social · 23d
After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.
Let’s be clear about what happened to Jimmy Kimmel
Trump’s most brazen attack on free speech yet.
www.yahoo.com
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brettgarabedian.bsky.social
Brett Garabedian @brettgarabedian.bsky.social · 22d
Great study by Landon J. Edgar and team demonstrating #sialicacid attentuates T cell death via Fas #glycotime

www.biorxiv.org/content/10.1...
www.biorxiv.org
Reposted by Brett Garabedian
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23d
Human intratumoral T cells treated with PD1-IL2v up-regulate chemotactic and effector molecules, leading to a potent antitumor response
www.science.org/doi/10.1126/...
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Reposted by Brett Garabedian
christhechang.bsky.social
Chris Chang @christhechang.bsky.social · 24d
Happy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...
An Alkyne-Directed Cleavage Approach for Activity-Based Cu(I) Sensing Reveals Manganese-Promoted Sensitization of Cuproptosis
Copper is an essential element for sustaining life. However, disruptions in copper homeostasis underpin disease, as illustrated by cuproptosis, an emerging form of cell death resulting from aberrant a...
pubs.acs.org
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Reposted by Brett Garabedian
ibudin.bsky.social
Itay Budin @ibudin.bsky.social · 25d
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
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Reposted by Brett Garabedian
carolynbertozzi.bskyverified.social
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Sep 9
Great perspective by @dereklowe.bsky.social on recent advances in cell surface #glycoRNA biology, including new work from @raflynn5.bsky.social and collaborators identifying an immune silencing effect of N-glycans on activation of TLRs by Acp3U-RNA (www.nature.com/articles/s41...)
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brettgarabedian.bsky.social
Brett Garabedian @brettgarabedian.bsky.social · Sep 8
#Siglec #SialicAcid #Glycotime

www.tandfonline.com/doi/full/10....
Disrupting Siglec-mediated interactions to develop immunotherapies for cancer treatment
Recent advances in cancer immunotherapy have improved patient outcomes, even in advanced stages of the disease. However, the effectiveness of current cancer immunotherapies remains limited to a sma...
www.tandfonline.com
Reposted by Brett Garabedian
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · Sep 7
Genetic manipulation of OGT enhances NK cell-mediated cytotoxicity in tumor immunity
www.sciencedirect.com/science/arti...
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Reposted by Brett Garabedian
neildegrassetyson.com
Neil deGrasse Tyson @neildegrassetyson.com · Sep 7
Notice to flat-Earthers in Earth's Eastern Hemisphere witnessing a Total Lunar Eclipse right now

Once again, please alert the authorities if your eclipse tonight looks like this:
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Reposted by Brett Garabedian
thegodpodcast.com
God @thegodpodcast.com · Sep 5
Bless all the people who ripped RFK Jr. a new asshole today.
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