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CellComM Lab

@cellcommlab.bsky.social

460 followers 300 following 14 posts

𝗖𝗲𝗹𝗹 𝗖𝗼𝗺𝘮𝘶𝘯𝘪𝘤𝘢𝘵𝘪𝘰𝘯 & 𝗠𝘪𝘨𝘳𝘢𝘵𝘪𝘰𝘯 Lab, headed by @pjsaez.bsky.social #UKE_HH We ❤ #CellComm #CellMigration 🧪🔬

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CellComM Lab @cellcommlab.bsky.social · Jan 24

#CellMigration for #FluorescenceFriday 🧪🔬

If a metastatic #cancer cell is offered 2 paths it decides very fast, bc it does matter where it goes...

OTOH, if a non-cancer #cell is offered 2 options it takes some time to explore and decide.

More in the paper: www.nature.com/articles/s41...

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Jean-Yves Tinevez @jytinevez.bsky.social · 2d

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA

Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

forum.image.sc

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Nat Clarke @natclarke.bsky.social · 1d

🚨 My lab is hiring at all levels!

Interested in animal origins & evolutionary cell biology?

I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.

🔗: clarkelab.com/join/

Please repost!

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Thomas Worzfeld @worzfeld.bsky.social · Sep 9

Interested in doing exciting research on #epithelial #plasticity in the #kidney or #intestine?

Then please check out our recent job ads for #PhD and #Postdoc positions!

www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...

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Javier Boix @jboixcampos.bsky.social · Jul 18

I can't imagine a better day of the week to publish this than #FluorescenceFriday: PathoPlex is finally published! 🎉

This presents a revolutionary jump from 4-6 to 100+ markers per sample! 🤯

Read the full story here:
www.nature.com/articles/s41...

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Reposted by CellComM Lab

Pablo J. Sáez @pjsaez.bsky.social · Jul 18

#HotFromThePress !!

What if instead of analyzing 4-6 pathology markers you could check >100 in the *same* sample?

@maltekuehl.com & co @puellesv.bsky.social lab introduce #PathoPlex, method that could even predict disease

Full www.nature.com/articles/s41...
@focalplane.bsky.social @nature.com 🧪🔬

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Shailaja Seetharaman @sseethar.bsky.social · Jul 9

Excited to be starting my research group as a tenure track Presidential Young Professor at the Mechanobiology Institute @mbisg.bsky.social, and the Dept of Physiology at @nusingapore.bsky.social in the fall! More about our work on vascular mechanobiology in health & disease mechano-medicine-lab.com

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Pablo J. Sáez @pjsaez.bsky.social · Jul 8

This is why we love #cellmigration

#Leukocytes: #Neutrophils (cyan) #Macrophages (orange) chemotaxis.

I couldn't share it before the retirement of @zebrafishrock.bsky.social, but cool #microscopy in #zebrafish continue to rock !

#scicomm #scisky @cellcommlab.bsky.social @focalplane.bsky.social 🧪🔬

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Javier Boix @jboixcampos.bsky.social · Jul 1

🧵 Neural networks meet cell migration in Valencia!

Hi Bluesky! 👋 I'm Javier, computational biologist @cellcommlab.bsky.social l working at the intersection of AI and cell biology 🖥️🧫

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Sebastián Palacios Martínez @spalaciosm.bsky.social · Jun 28

A very late #FluorescenceFriday.

Reposting one of my favorite timelapses from the past year: EB3-mScarlet3 in a HeLa cell, look at those microtubules grow!

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Waggoner Lab @labwaggoner.bsky.social · Jun 29

Immune cell profiling reveals diverse niches of immune residents of the enteric nervous system and potential neuroimmune interactions
www.pnas.org/doi/10.1073/...

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Reposted by CellComM Lab

Manuela Casasoli @manuelacasasoli.bsky.social · Jun 29

Read and enjoy this short article about interesting mathematical shapes (plus.maths.org/content/rand...) to learn about random surfaces and the secrets of the Universe!

♾️ #iTeachMath #Science‪ #Maths
Do not miss @plusmaths.bsky.social
Image by Thomas Budzinski (perso.ens-lyon.fr/thomas.budzi...)

Image Source:
https://perso.ens-lyon.fr/thomas.budzinski/pictures.html
and
https://plus.maths.org/content/random-surfaces-universe#maths

"This picture represents a uniform triangulation of the sphere with over 30,000 vertices. Image by Thomas Budzinski, used by permission."

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Reposted by CellComM Lab

FocalPlane @focalplane.bsky.social · Jun 27

📢Our latest preprint list is now up on FocalPlane.
This week’s list focusses on research using microscopy tools to answer questions in biology. As always, please let us know if there are other preprints that you’d like to see included.
focalplane.biologists.com/2025/06/27/m...

Microscopy preprints - applications in biology - FocalPlane

Microscopy preprints - applications in biology - News

focalplane.biologists.com

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AI4Life @ai4life.bsky.social · Jun 27

The 2nd AI4Life Challenge is live!
Calling the AI & bioimaging community to tackle a key microscopy challenge: removing noise while preserving detail.

📦 Paired noisy/clean datasets
📈 Ground-truth evaluation
🧠 DL focus

Build, test, compete 👉 ai4life.eurobioimaging.eu/challenge-2/

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Reposted by CellComM Lab

Joachim Goedhart @joachimgoedhart.bsky.social · Jun 26

De novo designed bright, hyperstable rhodamine binders for fluorescence microscopy by Bo Huang and team: www.biorxiv.org/content/10.1...

$Fig. 4 Super-resolution microscopy in live and fixed cells with Rhobin. (A) Rhobin transiently binds rhodamine molecules and thereby constantly replenishes signal lost through photobleaching of dyes. (B-D) No-wash STED microscopy of live U2OS cells transiently expressing LifeAct-Rhobin2 labeled with 100 nM JFX650. (C, D) Zoom-ins of regions highlighted in (B) imaged either with confocal or STED microscopy. Scale bar: 20 μm (B) and 10 μm (C, D). (E-H) Rhobin enables timelapse STED microscopy of fast ER dynamics with minimal signal loss. U2OS stably expressing N-terminal tag fusions of SEC61B were stained with 1 μM Halo-JFX650 (HaloTag7, reHaloF) or 2 μM SiRhP (Rhobin2) and imaged at a frame rate of 0.387 fps for at least 100 time points. (F, G) Selected frames from timelapse acquisitions of Rhobin2:SEC61B labeled with SiRhP (F) or HaloTag7:SEC61B labeled with Halo-JFX650 (G). Scale bar: 2 μm. (H) Signal .CC-BY-NC 4.0 International licenseavailable under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprintthis version posted June 25, 2025.;https://doi.org/10.1101/2025.06.24.661379doi:bioRxiv preprint 22 loss during timelapse imaging. Mean ± SD signal inside cells over time for indicated constructs. (I-K) PAINT-type super-resolution microscopy with Rhobin. Rhobin2-SEC61B was transiently expressed in U2OS cells and labeled with 5 nM SiRhP after chemical fixation. Imaging under no- wash conditions and near-TIRF illumination. (I) Repeated, but transient binding of SiRhP molecules to Rhobin2 at low nanomolar concentrations can be observed as intensity bursts in intensity time traces extracted from a diffraction-limited area. See movie S3 for raw data of binding-induced blinking. (J) Sum image across 10,000 frames of an image stack, simulating a diffraction-limited image. (K). Reconstructed image from localized molecules in the full stack.$

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Pablo J. Sáez @pjsaez.bsky.social · Jun 20

#FluorescenceFriday

#Mitochondria, powerhouse of the #cell were labeled (cyan) and it's possible to visualize how they reach *every* corner to provide energy.

All recorded under the microscope @cellcommlab.bsky.social

#scicomm #sciencesky #microscopy #organelles @focalplane.bsky.social 🧪🔬

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Pablo J. Sáez @pjsaez.bsky.social · Jun 7

This is why we love #cell dynamics !

Look at this #macrophage branching exploring the surroundings videoed under the microscope

This what immune cells do in our body in search of bacteria, viruses and death cells

#microscopy #cellbio #sciencesky @focalplane.bsky.social @cellcommlab.bsky.social 🧪🔬

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Reposted by CellComM Lab

Elena Scarpa & The Squeezable Cells Lab @squeezycellslab.bsky.social · Jun 6

Very excited to share the first preprint from the lab:
www.biorxiv.org/cgi/content/...
We investigated neural crest migration all the way from head to tail of the Zebrafish embryo and we found their nuclei suffer dramatic deformations.
Want to know of they cope with feeling squeezed? 🐟🐠🐟

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Reposted by CellComM Lab

Pablo J. Sáez @pjsaez.bsky.social · Apr 29

#CellMigration
Join us today @dgz.bsky.social !!
See you in 1 h (zoom id and password in the pic below)

DGZ.bsky.social @dgz.bsky.social · Apr 11

The next #DGZ Focus Workshop on #CellBiology of the #ImmuneSystem will take place on April 29, organized by @pjsaez.bsky.social & Evi Kiermaier – join us! 🧑‍🔬🧑‍🔬🧬

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CellComM Lab @cellcommlab.bsky.social · Apr 25

Yes ! Thanks for the poke @fadelvalle.bsky.social
You can check some of Julie Theriot's paper on membrane protrusions ;)
I'll try to find the ref to put them in the thread for you, @anhhle2702.bsky.social

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Reposted by CellComM Lab

Pablo J. Sáez @pjsaez.bsky.social · Apr 11

Join us for this @dgz.bsky.social seminar online with very cool talks about the Cell biology of the immune system

There will be of course some #CellMigration of leukocytes ;)

Speakers: @liz-kurtz.bsky.social, #ZahraaA, @labliston.bsky.social and #StefanU

DGZ.bsky.social @dgz.bsky.social · Apr 11

The next #DGZ Focus Workshop on #CellBiology of the #ImmuneSystem will take place on April 29, organized by @pjsaez.bsky.social & Evi Kiermaier – join us! 🧑‍🔬🧑‍🔬🧬

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DGZ.bsky.social @dgz.bsky.social · Apr 11

The next #DGZ Focus Workshop on #CellBiology of the #ImmuneSystem will take place on April 29, organized by @pjsaez.bsky.social & Evi Kiermaier – join us! 🧑‍🔬🧑‍🔬🧬

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Pablo J. Sáez @pjsaez.bsky.social · Feb 18

An oldie (10 y!) but goodie: cellular interaction at the top! #cellcomm

Video of a T cell (orange) interacting with a target cell (blue)

From Chen et al. @ Betzig lab (@hhmijanelia.bsky.social) game changing paper !!

Full science.org/doi/10.1126/... @focalplane.bsky.social #scicomm #microscopy 🧪🔬

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CellComM Lab @cellcommlab.bsky.social · Feb 14

Mysterious increase in the motility of these #lysosomes

After adding a non-stimuli treatment the lysosomes (cyan) got crazy (see color coded tracks)
Maybe #mechanosignaling triggered by shear stress?

#Microscopy + #Cells for #FluorescenceFriday 🧪🔬
#SciSky #scicomm #CellBio

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Reposted by CellComM Lab

@tim_stasevich @tim-stasevich.bsky.social · Feb 12

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...

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Christophe 🔬 L @christlet.bsky.social · Feb 9

And finally a funny trick for actin aficionados: label actin with different probes and use their differential staining properties to identify actin structures within cells: www.biorxiv.org/content/10.1...

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