Carlos Guardia
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charlyguardia.bsky.social
Carlos Guardia
@charlyguardia.bsky.social
310 followers 790 following 26 posts
NewPI@NIEHS | Stadtman TTI | NIH DSP #2021 | Cell Biology - Autophagy - Intracellular Traffic - Placenta | My opinions are my own | 🇦🇷🏳️‍🌈🇺🇸
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charlyguardia.bsky.social
Thanksgiving edition of the publications in the #PlacentalCellBio section of @biomednews.bsky.social

biomed.news/bims-placeb/...

Cheers!
November 25, 2025 at 1:26 PM
Reposted by Carlos Guardia
dnatarheel.bsky.social
Multiple tenure-track faculty positions at the UNC Lineberger Comprehensive Cancer Center in Chapel Hill!
We seek creative scientists working in fundamental molecular, cellular, and computational areas. Basic and translational cancer research, all ranks.
unc.peopleadmin.com/postings/309...
Open Rank
The UNC Lineberger Comprehensive Cancer Center, in collaboration with departments in the School of Medicine and across the entire University of North Carolina at Chapel Hill, is seeking outstanding ca...
unc.peopleadmin.com
November 14, 2025 at 1:05 PM
Reposted by Carlos Guardia
preeclampsia.org
Today is #WorldPrematurityDay. We are sharing Missy Ellison's story with #prematurity with her daughter due to #preeclampsia

"I nearly lost my life to preeclampsia in 2019. My daughter was born at 30 weeks 3 days"

Give: www.preeclampsia.org/givetoday
November 17, 2025 at 5:47 PM
Reposted by Carlos Guardia
mblscience.bsky.social
We are hiring!

Interested? Apply here: go.mbl.edu/AS1887
November 16, 2025 at 10:15 PM
charlyguardia.bsky.social
Sorry for the silence (Government shutdown!) but I'm back with the latest pubs in the #PlacentalCellBio @biomednews.bsky.social

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November 16, 2025 at 9:51 PM
Reposted by Carlos Guardia
embarbosa.bsky.social
Excited to share our new paper! 🧬

Exploring how redox-modulating compounds can protect mothers and babies in diabetic pregnancies — a step toward new gestational therapies and long-term health.

Honored to be part of the amazing team behind this work! 💫

www.sciencedirect.com/science/arti...
Manganese porphyrin [MnTE-2-PyP]5+ improves maternal and offspring glycemic homeostasis, placental morphology, and redox balance in diabetic pregnant rats
Gestational Diabetes Mellitus (GDM) is a prevalent metabolic disorder during pregnancy, associated with oxidative stress and inflammation at systemic …
www.sciencedirect.com
October 28, 2025 at 6:17 PM
charlyguardia.bsky.social
A new week, a new selection of papers in #PlacentalCellBio
@biomednews.bsky.social

biomed.news/bims-placeb/...

Take a look at this pick from the Jawerbaum's lab in Argentina: pubmed.ncbi.nlm.nih.gov/40976335/

Enjoy!
bims: Biomed News
biomed.news
September 28, 2025 at 7:30 PM
Reposted by Carlos Guardia
deniswirtz.bsky.social
Check this out: This is what the human fallopian tube looks like as one travels through its different sections.

We have developed a new 3D single-cell tissue mapping workflow to automatically/accurately detect ovarian cancer precancerous lesions (STICs).

More here: www.biorxiv.org/content/10.1...
September 25, 2025 at 3:20 PM
Reposted by Carlos Guardia
cellclub.bsky.social
Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling | Science Advances www.science.org/doi/10.1126/...
Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling
Senescent OPCs, caused by a declined autophagy, suppress neuronal firing and excitatory transmission via CCL3/5-CCR5 signaling.
www.science.org
September 25, 2025 at 3:20 PM
Reposted by Carlos Guardia
cellclub.bsky.social
Steric repulsion counteracts ER–to–lipid droplet protein movement | Science Advances www.science.org/doi/10.1126/...
Steric repulsion counteracts ER–to–lipid droplet protein movement
Steric hindrance affects the relocation of ER-to-LD proteins and primarily regulates the LD proteome.
www.science.org
September 25, 2025 at 3:21 PM
Reposted by Carlos Guardia
cp-cellreports.bsky.social
AVID mouse: A versatile platform for real-time, multiscale ATP imaging and spatial systems metabolism analysis in living mice
AVID mouse: A versatile platform for real-time, multiscale ATP imaging and spatial systems metabolism analysis in living mice
Ohnishi et al. present the AVID mouse, which enables real-time, multiscale imaging of ATP dynamics in vivo across organs and cell types. This platform reveals spatially heterogeneous changes in energy metabolism during both physiological conditions and pathological states such as myocardial infarction, enabling systems-level analysis of metabolic regulation.
dlvr.it
September 22, 2025 at 7:50 PM
charlyguardia.bsky.social
New week, new summary of pubs in the #PlacentalCellBio
@biomednews.bsky.social

biomed.news/bims-placeb/...

My personal fav: this study about placental plasticity to hypoxia pubmed.ncbi.nlm.nih.gov/40961454/

Enjoy!
September 22, 2025 at 2:37 PM
Reposted by Carlos Guardia
science.org
NIH says it will not renew a handful of research grants that an advocacy group identified as involving human fetal tissue—a decision that is setting off alarm bells for some in the scientific community. https://scim.ag/3VOoJJY
Scientists decry NIH pledge to end some human fetal tissue research
Move could signal return to ban on such studies imposed by first Trump administration
scim.ag
September 16, 2025 at 3:12 PM
Reposted by Carlos Guardia
ibudin.bsky.social
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 15, 2025 at 6:03 PM
charlyguardia.bsky.social
Here are the curated lists of pubs in the #PlacentalCellBio
@biomednews.bsky.social report from the last two weeks!

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My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/

Enjoy!
Efficient stem cell-derived mouse embryo models for environmental studies - PubMed
Blastoids are stem cell-derived structures that mimic natural blastocysts by incorporating all three lineages: trophectoderm, epiblast, and primitive endoderm. However, current methods often yield inc...
pubmed.ncbi.nlm.nih.gov
September 14, 2025 at 3:23 PM
Reposted by Carlos Guardia
loke-ctr.bsky.social
🚀 We’re all set!
This Sunday marks the return of the Placental Biology Course – our first in-person for six years. 25 participants joining for lectures and practical sessions delivered by experts in the field of placental biology!
September 5, 2025 at 1:43 PM
charlyguardia.bsky.social
Here are my pre-selected papers in @biomednews.bsky.social 's #PlacentalCellBio of the week 🧐

biomed.news/bims-placeb/...

Having participated in this call as a member of the Fetal Membrane Society Consortium, my selfish pick for the week is: pubmed.ncbi.nlm.nih.gov/40840313.

Cheers!
bims: Biomed News
biomed.news
September 4, 2025 at 10:43 PM
charlyguardia.bsky.social
Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!
Liver-specific loss of Atg9a perturbs lipid metabolism and hepatocyte integrity
The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional At...
doi.org
September 3, 2025 at 4:56 PM
Reposted by Carlos Guardia
natmethods.nature.com
A laser flash melting procedure, followed by rapid revitrification, provides a simple approach to help mitigate the preferred orientation problem that plagues cryo-EM analysis.

www.nature.com/articles/s41...
Laser flash melting cryo-EM samples to overcome preferred orientation - Nature Methods
Individual proteins tend to adopt preferred orientations when subjected to vitrification for cryo-electron microscopy analysis. A laser flash melting procedure followed by rapid revitrification provid...
www.nature.com
August 29, 2025 at 6:44 PM
Reposted by Carlos Guardia
jcb.org
Identification of organelle-specific #autophagy regulators from tandem #CRISPR screens. New study from Truc Losier, Karyn King, Maxime Rousseaux, and Ryan Russell (@russellbiolab.bsky.social) @uottawa.ca: rupress.org/jcb/article/...

#Biochemistry #CellSignaling
August 28, 2025 at 1:45 PM
charlyguardia.bsky.social
Here are the curated lists of pubs in the #PlacentalCellBio
@biomednews.bsky.social report from the last two weeks!

biomed.news/bims-placeb/...
biomed.news/bims-placeb/...

Lots of goodies but my personal choice: mTSCs from 32-cell morulae! www.nature.com/articles/s41...

Enjoy!
bims: Biomed News
biomed.news
August 24, 2025 at 5:01 PM
Reposted by Carlos Guardia
peiferlabunc.bsky.social
The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share
Dear Fly Community, In May 2025, the NIH terminated all grant funding to Harvard University, including the NHGRI grant that supported FlyBase. This grant also funded FlyBase teams at Indiana University (IU) and the University of Cambridge (UK), and as a result, their subawards were also canceled. The Cambridge team has secured support for one to two years through generous donations from the European fly community, emergency funding from the Wellcome Trust, and support from the University of Cambridge. At IU, funding has been secured for one year thanks to reserve funds from Thom Kaufman and a supplement from ORIP/NIH to the Bloomington Drosophila Stock Center (BDSC). Unfortunately, the situation at Harvard is far more critical. Harvard University had supported FlyBase staff since May but recently denied a request for extended bridge funding. As a result, all eight employees (four full-time and four part-time) were abruptly laid off, with termination dates ranging from August to mid-October depending on their positions. In addition, our curator at the University of New Mexico will leave her position at the end of August. This decision came as a shock, and we are urgently pursuing all possible funding options. To put the need into perspective: although FlyBase is free to use, it is not free to make. It takes large teams of people and millions of dollars a year to create FlyBase to support fly research (the last NHGRI grant supported us with more than 2 million USD per annum). To help sustain FlyBase operations, we have been reaching out to you to ask for your support. We have set up a donation site in Cambridge, UK, to which European labs have and can continue to contribute, and a new donation site at IU to which labs in the US and the rest of the world can contribute. We urge researchers to work with their grant administrators to contribute to FlyBase via these sites if at all possible, as more of the money will go to FlyBase. However, we appreciate that some fu… https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase Our immediate goals are: 1. To maintain core curation activities and keep the FlyBase website online 2. To complete integration with the Alliance of Genome Resources (The Alliance). Integration with the Alliance is essential for FlyBase’s long-term sustainability. For nearly a decade, NHGRI/NIH has supported the unification of Model Organism Databases (MODs) into the Alliance, which we aim to achieve by 2028. Therefore, securing bridge funding to sustain FlyBase over the next three years is crucial for successful integration and the long-term access to FlyBase data. At present, our remaining funds will allow us to keep the FlyBase website online for approximately one more year. Beyond that, its future is uncertain unless new funding is secured. We will, of course, continue pursuing additional grant opportunities as they arise. Given the uncertainty of future NIH or alternative funding sources, we are relying on the Fly community for support. Your contributions will directly help us retain the staff needed to complete this transition and to secure ongoing fly data curation into the Alliance beyond 2028. We at FlyBase are incredibly grateful for the outpouring of support from the community during this challenging time. Your encouragement has strengthened our resolve and underscores how vital this resource remains to Drosophila research worldwide. Sincerely, The FlyBase Team
August 23, 2025 at 12:18 PM
Reposted by Carlos Guardia
cellclub.bsky.social
Identification of organelle-specific autophagy regulators from tandem CRISPR screens url: rupress.org/jcb/article-...
Identification of organelle-specific autophagy regulators from tandem CRISPR screens
Losier et al. identify distinct kinase signaling pathways that differentially regulate bulk and selective autophagy. Using kinome-wide CRISPR screening, th
rupress.org
August 21, 2025 at 5:36 PM
Reposted by Carlos Guardia
cp-cellreports.bsky.social
Dissection of surface area-dependent lipolysis at a single organelle level
Dissection of surface area-dependent lipolysis at a single organelle level
Ma et al. reveal that lipolysis is controlled by both lipase activity (biochemistry) and lipase-accessible lipid droplet surface area (biophysics). The derivative of the linear relationship between lipolytic flux and lipid droplet surface area is called lipolytic efficiency, which is equivalent to the lipase activity.
dlvr.it
August 18, 2025 at 2:38 PM
Reposted by Carlos Guardia
slefkopoulos.bsky.social
🥂Congrats to Gao, Li & co for their new @natcellbio.nature.com study: they derive #trophectoderm stem cells from 32-cell mouse #embryos. These cells represent an early trophectoderm state, develop into #placenta cells and organoids and contribute to blastoid generation.
rdcu.be/eAKzp

bit.ly/4fyZ9Sg
Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state - Nature Cell Biology
Gao, Li and colleagues derive trophectoderm stem cells from 32-cell mouse embryos. These cells represent an early trophectoderm state and are capable of developing into placenta cells, forming placent...
bit.ly
August 14, 2025 at 8:42 PM