⚡️GREG_CORDER⚡️
@flybottleescape.bsky.social
Associate Professor @ Penn | Dept Psychiatry + Dept Neuroscience + Dept Anesthesiology | Pain • Placebo • Poppies • Psychedelics
https://corderlab.com/
https://corderlab.com/
Pinned
Researchers identify the neurons involved in the emotional distress associated with pain
go.nature.com/4qIKkB8
go.nature.com/4qIKkB8
Chronic pain could be eased by uncoupling the sensory and emotional experiences
Researchers identify the neurons involved in the emotional distress associated with pain, and design a genetic approach that could soothe suffering without opioid drugs.
go.nature.com
🧠⚡️💊New @nature.com publication !
Mimicking opioid analgesia in cortical pain circuits
We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy
nature.com/articles/s41...
@pennmedicine.bsky.social
Mimicking opioid analgesia in cortical pain circuits
We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy
nature.com/articles/s41...
@pennmedicine.bsky.social
Reposted by ⚡️GREG_CORDER⚡️
A consensus spinal cord cell type atlas across mouse, macaque, and human https://www.biorxiv.org/content/10.64898/2026.02.04.703852v1
February 6, 2026 at 8:15 AM
A consensus spinal cord cell type atlas across mouse, macaque, and human https://www.biorxiv.org/content/10.64898/2026.02.04.703852v1
!!!!! TENURE !!!!!
January 29, 2026 at 6:22 PM
!!!!! TENURE !!!!!
Reposted by ⚡️GREG_CORDER⚡️
By splitting #pain into its component parts, researchers provide pain relief in #mice. In PNAS Journal Club: https://ow.ly/eHT750Y1eGh
#ChronicPain #opioid #MachineLearning #AnteriorCingulateCortex
#ChronicPain #opioid #MachineLearning #AnteriorCingulateCortex
January 22, 2026 at 6:02 PM
By splitting #pain into its component parts, researchers provide pain relief in #mice. In PNAS Journal Club: https://ow.ly/eHT750Y1eGh
#ChronicPain #opioid #MachineLearning #AnteriorCingulateCortex
#ChronicPain #opioid #MachineLearning #AnteriorCingulateCortex
🧠⚡️💊New @nature.com publication !
Mimicking opioid analgesia in cortical pain circuits
We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy
nature.com/articles/s41...
@pennmedicine.bsky.social
Mimicking opioid analgesia in cortical pain circuits
We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy
nature.com/articles/s41...
@pennmedicine.bsky.social
Researchers identify the neurons involved in the emotional distress associated with pain
go.nature.com/4qIKkB8
go.nature.com/4qIKkB8
Chronic pain could be eased by uncoupling the sensory and emotional experiences
Researchers identify the neurons involved in the emotional distress associated with pain, and design a genetic approach that could soothe suffering without opioid drugs.
go.nature.com
January 8, 2026 at 6:01 PM
🧠⚡️💊New @nature.com publication !
Mimicking opioid analgesia in cortical pain circuits
We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy
nature.com/articles/s41...
@pennmedicine.bsky.social
Mimicking opioid analgesia in cortical pain circuits
We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy
nature.com/articles/s41...
@pennmedicine.bsky.social
Reposted by ⚡️GREG_CORDER⚡️
Researchers identify the neurons involved in the emotional distress associated with pain
go.nature.com/4qIKkB8
go.nature.com/4qIKkB8
Chronic pain could be eased by uncoupling the sensory and emotional experiences
Researchers identify the neurons involved in the emotional distress associated with pain, and design a genetic approach that could soothe suffering without opioid drugs.
go.nature.com
January 8, 2026 at 9:12 AM
Researchers identify the neurons involved in the emotional distress associated with pain
go.nature.com/4qIKkB8
go.nature.com/4qIKkB8
Reposted by ⚡️GREG_CORDER⚡️
Identity of neurons involved in the emotional distress associated with pain yields genetic approach that could soothe suffering without opioid drugs @nature.com
www.nature.com/articles/s41... @flybottleescape.bsky.social @upenn.edu @cmu.edu
@yttrilab.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41... @flybottleescape.bsky.social @upenn.edu @cmu.edu
@yttrilab.bsky.social
www.nature.com/articles/d41...
January 7, 2026 at 6:51 PM
Identity of neurons involved in the emotional distress associated with pain yields genetic approach that could soothe suffering without opioid drugs @nature.com
www.nature.com/articles/s41... @flybottleescape.bsky.social @upenn.edu @cmu.edu
@yttrilab.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41... @flybottleescape.bsky.social @upenn.edu @cmu.edu
@yttrilab.bsky.social
www.nature.com/articles/d41...
Reposted by ⚡️GREG_CORDER⚡️
Hot off the @nature.com press!!
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
Mimicking opioid analgesia in cortical pain circuits - Nature
The anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic effects of mor...
www.nature.com
January 7, 2026 at 5:05 PM
Hot off the @nature.com press!!
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
✨New Corder Lab preprint 🧠⚡️
- from Dr Sophie Rogers !
Differential modulation of aversive signaling by expectation across the cingulate cortex
We image the same ACC + RSC neurons over time during noxious fear learning to ask: who encodes aversion vs who predicts it 🔮
biorxiv.org/content/10.6...
- from Dr Sophie Rogers !
Differential modulation of aversive signaling by expectation across the cingulate cortex
We image the same ACC + RSC neurons over time during noxious fear learning to ask: who encodes aversion vs who predicts it 🔮
biorxiv.org/content/10.6...
January 6, 2026 at 1:21 AM
✨New Corder Lab preprint 🧠⚡️
- from Dr Sophie Rogers !
Differential modulation of aversive signaling by expectation across the cingulate cortex
We image the same ACC + RSC neurons over time during noxious fear learning to ask: who encodes aversion vs who predicts it 🔮
biorxiv.org/content/10.6...
- from Dr Sophie Rogers !
Differential modulation of aversive signaling by expectation across the cingulate cortex
We image the same ACC + RSC neurons over time during noxious fear learning to ask: who encodes aversion vs who predicts it 🔮
biorxiv.org/content/10.6...
Happy yearSEVENversary to our Lab !!!!!!!
(still pre-tenure)
last year was finally our big paper publishing year but we've got a bunch more cool preprints coming soon :)
(still pre-tenure)
last year was finally our big paper publishing year but we've got a bunch more cool preprints coming soon :)
January 2, 2026 at 4:13 PM
Happy yearSEVENversary to our Lab !!!!!!!
(still pre-tenure)
last year was finally our big paper publishing year but we've got a bunch more cool preprints coming soon :)
(still pre-tenure)
last year was finally our big paper publishing year but we've got a bunch more cool preprints coming soon :)
Reposted by ⚡️GREG_CORDER⚡️
"Mason’s criticism of the prosocial behavior field as a whole: It 'has a little bit too much of a pony in the race.' The job of science is to discover, not pick and choose the explanations that are preferred, she adds."
www.thetransmitter.org/empathy/up-a...
www.thetransmitter.org/empathy/up-a...
Up and out with Peggy Mason
Mason helped define the rodent prosocial behavior field, but now she’s changing course.
www.thetransmitter.org
January 2, 2026 at 12:22 AM
"Mason’s criticism of the prosocial behavior field as a whole: It 'has a little bit too much of a pony in the race.' The job of science is to discover, not pick and choose the explanations that are preferred, she adds."
www.thetransmitter.org/empathy/up-a...
www.thetransmitter.org/empathy/up-a...
If you start 'Phantom Thread' at exactly 10:14:47PM on New Year's Eve, you will ring in the New Year with Reynolds Woodcock
🎉🍾🥂🍄🟫
🎉🍾🥂🍄🟫
January 1, 2026 at 2:10 AM
If you start 'Phantom Thread' at exactly 10:14:47PM on New Year's Eve, you will ring in the New Year with Reynolds Woodcock
🎉🍾🥂🍄🟫
🎉🍾🥂🍄🟫
🧠🐭💊 Check out our work on the role of Central Amygdala cell-types in opioid withdrawal ...
Now published in Neuropsychopharmacology
@npp-journal.bsky.social
Open-access link: www.nature.com/articles/s41...
Now published in Neuropsychopharmacology
@npp-journal.bsky.social
Open-access link: www.nature.com/articles/s41...
December 19, 2025 at 3:34 PM
🧠🐭💊 Check out our work on the role of Central Amygdala cell-types in opioid withdrawal ...
Now published in Neuropsychopharmacology
@npp-journal.bsky.social
Open-access link: www.nature.com/articles/s41...
Now published in Neuropsychopharmacology
@npp-journal.bsky.social
Open-access link: www.nature.com/articles/s41...
Reposted by ⚡️GREG_CORDER⚡️
Thrilled this is out, led by former PD Cameron Ogg (now with her own lab at @rhodescollege.bsky.social!). It was a driven by a desire to see, in real-time, how LC activity/NE release influences downstream targets in behaving animals. SO hard to do, but Cameron did it! www.cell.com/cell-reports...
Locus coeruleus norepinephrine neurons facilitate orbitofrontal cortex remapping and behavioral flexibility
Ogg et al. use in vivo imaging techniques to record activity in the locus coeruleus
(LC) and the orbitofrontal cortex (OFC) during a reversal learning task in freely
moving rodents. They show that man...
www.cell.com
December 15, 2025 at 2:47 PM
Thrilled this is out, led by former PD Cameron Ogg (now with her own lab at @rhodescollege.bsky.social!). It was a driven by a desire to see, in real-time, how LC activity/NE release influences downstream targets in behaving animals. SO hard to do, but Cameron did it! www.cell.com/cell-reports...
Now officially: Dr Rogers🎓✨
Unofficially: still the same Sophie.. with more letters + even more legend 🧠🍄💥
You crushed your thesis defense with equal parts science and soul. From psilocybin/psychedelics to pain + aversive processing in cortex you brought rigor, clarity and creative
Congrats 🍾
Unofficially: still the same Sophie.. with more letters + even more legend 🧠🍄💥
You crushed your thesis defense with equal parts science and soul. From psilocybin/psychedelics to pain + aversive processing in cortex you brought rigor, clarity and creative
Congrats 🍾
December 12, 2025 at 9:34 PM
Now officially: Dr Rogers🎓✨
Unofficially: still the same Sophie.. with more letters + even more legend 🧠🍄💥
You crushed your thesis defense with equal parts science and soul. From psilocybin/psychedelics to pain + aversive processing in cortex you brought rigor, clarity and creative
Congrats 🍾
Unofficially: still the same Sophie.. with more letters + even more legend 🧠🍄💥
You crushed your thesis defense with equal parts science and soul. From psilocybin/psychedelics to pain + aversive processing in cortex you brought rigor, clarity and creative
Congrats 🍾
Check out this amazing recognition for all of Lindsay’s amazing efforts in scicom!!!
🙌🏼🔥🎉🤘🏽🫡🍾
🙌🏼🔥🎉🤘🏽🫡🍾
BEST DAY EVER!!! The award is called the Eric & Wendy Schmidt Award for Excellence in Science Communications & is run by @nationalacademies.org & @schmidtsciences.bsky.social #scicomm #phdstudent
November 18, 2025 at 2:08 PM
Check out this amazing recognition for all of Lindsay’s amazing efforts in scicom!!!
🙌🏼🔥🎉🤘🏽🫡🍾
🙌🏼🔥🎉🤘🏽🫡🍾
@sfn.org Come say hi to postdoc Blake Kimmey Tues, Nov. 18, 8:00 AM - 12:00 PM
PSTR278.07 - Convergent state-control of endogenous opioid analgesia
He's got new behavior/DREADD/Xenium data on PAG-to-thalamic circuits in pain/placebo/fear, building from his preprint: biorxiv.org/content/10.1...
PSTR278.07 - Convergent state-control of endogenous opioid analgesia
He's got new behavior/DREADD/Xenium data on PAG-to-thalamic circuits in pain/placebo/fear, building from his preprint: biorxiv.org/content/10.1...
November 17, 2025 at 5:47 PM
@sfn.org Come say hi to postdoc Blake Kimmey Tues, Nov. 18, 8:00 AM - 12:00 PM
PSTR278.07 - Convergent state-control of endogenous opioid analgesia
He's got new behavior/DREADD/Xenium data on PAG-to-thalamic circuits in pain/placebo/fear, building from his preprint: biorxiv.org/content/10.1...
PSTR278.07 - Convergent state-control of endogenous opioid analgesia
He's got new behavior/DREADD/Xenium data on PAG-to-thalamic circuits in pain/placebo/fear, building from his preprint: biorxiv.org/content/10.1...
Reposted by ⚡️GREG_CORDER⚡️
Sophie Rogers of the Corder @flybottleescape.bsky.social lab studies how a psychedelic drug with growing therapeutic promise can alter the brain in ways that help overcome traumatic fear memories. Read more in this brief by fellow NGG student Jafar Bhatti! www.upennglia.com/briefs/bib-p...
How psychedelics remap the brain to help overcome traumatic fear — GLIA
or technically, Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles [See original abstract on Pubmed]
www.upennglia.com
November 7, 2025 at 5:17 PM
Sophie Rogers of the Corder @flybottleescape.bsky.social lab studies how a psychedelic drug with growing therapeutic promise can alter the brain in ways that help overcome traumatic fear memories. Read more in this brief by fellow NGG student Jafar Bhatti! www.upennglia.com/briefs/bib-p...
Reposted by ⚡️GREG_CORDER⚡️
become my colleague at penn bioengineering: apply.interfolio.com/173716
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 19, 2025 at 2:29 AM
become my colleague at penn bioengineering: apply.interfolio.com/173716
Reposted by ⚡️GREG_CORDER⚡️
We could always get some re-interpretation language from NIH but at present the "council in a calendar year" is pretty dang clear. For 2026 Councils, we can submit six apps between May 2025 and March 2026.
September 18, 2025 at 7:20 PM
We could always get some re-interpretation language from NIH but at present the "council in a calendar year" is pretty dang clear. For 2026 Councils, we can submit six apps between May 2025 and March 2026.
🙏 Please help!
ad nauseam topic but for new NIH n=6 submission policy is it:
a. 6 subs in 2025 calendar year = we can sub 6 R01s for Oct '25 + another 6 for Jan-Dec '26?
b. subs in Oct '25 w/ May '26 Council = we can sub 6 R01s Oct '25 to June '26; count resets Oct '26?
ad nauseam topic but for new NIH n=6 submission policy is it:
a. 6 subs in 2025 calendar year = we can sub 6 R01s for Oct '25 + another 6 for Jan-Dec '26?
b. subs in Oct '25 w/ May '26 Council = we can sub 6 R01s Oct '25 to June '26; count resets Oct '26?
September 18, 2025 at 6:20 PM
🙏 Please help!
ad nauseam topic but for new NIH n=6 submission policy is it:
a. 6 subs in 2025 calendar year = we can sub 6 R01s for Oct '25 + another 6 for Jan-Dec '26?
b. subs in Oct '25 w/ May '26 Council = we can sub 6 R01s Oct '25 to June '26; count resets Oct '26?
ad nauseam topic but for new NIH n=6 submission policy is it:
a. 6 subs in 2025 calendar year = we can sub 6 R01s for Oct '25 + another 6 for Jan-Dec '26?
b. subs in Oct '25 w/ May '26 Council = we can sub 6 R01s Oct '25 to June '26; count resets Oct '26?
Reposted by ⚡️GREG_CORDER⚡️
(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium
September 15, 2025 at 5:06 PM
(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium
Reposted by ⚡️GREG_CORDER⚡️
Have you ever wondered how some of the leaders in the pain field got their start? Check out this essay from @painthejournal.bsky.social about PRF editorial board member, Allan Basbaum, to learn how he became the journal’s 3rd Editor-in-Chief bit.ly/3JIJTXf #PRF #PainAwarenessMonth
September 9, 2025 at 7:00 PM
Have you ever wondered how some of the leaders in the pain field got their start? Check out this essay from @painthejournal.bsky.social about PRF editorial board member, Allan Basbaum, to learn how he became the journal’s 3rd Editor-in-Chief bit.ly/3JIJTXf #PRF #PainAwarenessMonth
Reposted by ⚡️GREG_CORDER⚡️
My new essay for @thetransmitter.bsky.social. Why is understanding emotion so challenging? The debates around what counts as an "emotion" shed insight.
These disputes are multidimensional, principled and fascinating. Here, I unpack them.
www.thetransmitter.org/the-big-pict...
These disputes are multidimensional, principled and fascinating. Here, I unpack them.
www.thetransmitter.org/the-big-pict...
Emotion research has a communication conundrum
In 2025, the words we use to describe emotions matter, but their definitions are controversial. Here, I unpack the different positions in this space and the rationales behind them—and I invite 13…
www.thetransmitter.org
September 5, 2025 at 11:15 AM
My new essay for @thetransmitter.bsky.social. Why is understanding emotion so challenging? The debates around what counts as an "emotion" shed insight.
These disputes are multidimensional, principled and fascinating. Here, I unpack them.
www.thetransmitter.org/the-big-pict...
These disputes are multidimensional, principled and fascinating. Here, I unpack them.
www.thetransmitter.org/the-big-pict...
Reposted by ⚡️GREG_CORDER⚡️
What can *genetic insensitivity to opioids* teach us about endogenous opioid function in humans?
Fully funded position in Oslo (PhD student or postdoc)
Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Recrui...
Please RT for reach
Fully funded position in Oslo (PhD student or postdoc)
Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Recrui...
Please RT for reach
Phd candidate or postdoc– Genetic determinants of opioid responsiveness
The Department of Research and Development at the Division of Emergencies and Critical Care, Oslo University Hospital in collaboration with Leknes Affective Brain lab (www.affectivebrains.com) and the...
2411.webcruiter.no
August 29, 2025 at 2:20 PM
What can *genetic insensitivity to opioids* teach us about endogenous opioid function in humans?
Fully funded position in Oslo (PhD student or postdoc)
Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Recrui...
Please RT for reach
Fully funded position in Oslo (PhD student or postdoc)
Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Recrui...
Please RT for reach