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Reposted by Oliver Harschnitz

Miki Ebisuya @ebisuyamiki.bsky.social · 1d

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...

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Reposted by Oliver Harschnitz

James Briscoe @jamesbriscoe.bsky.social · 2d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Nicolas Rivron @nicolasrivron.bsky.social · 3d

The ethical framework for embryo models needs clarity and simplicity. The spirit of the integrated/non-integrated distinction was to more prominently regulate models that could potentially develop into a fetus. Hafez Ismaili M’hamdi discusses this. www.progress.org.uk/complexity-w...

Complexity without ethics: Why integration matters for embryo models | PET

Properly understood, the integrated/non-integrated distinction was not just a technical shorthand for the presence or absence of particular tissues.

www.progress.org.uk

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Reposted by Oliver Harschnitz

Human Technopole @humantechnopole.bsky.social · 7d

🏆 Congratulations to the winners of our Best Presentation Award, Eleonora Conti (@harschnitz.bsky.social Group) and Best Poster Award: Alexandra Livanova (Sottoriva Group); Emily Georgiades (Bienko Group); @veronicalarocca.bsky.social (Harschnitz Group)

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Nereo Kalebic @nereokalebic.bsky.social · 8d

My group @humantechnopole.bsky.social is searching for a #postdoc to work at the interface between #neurodevelopment and #cancerbiology focusing on neurofibromatosis type 1: careers.humantechnopole.it/job/Postdoc-...

Postdoc in Neurobiology - Kalebic Group (funded by Gilbert Family Foundation)

careers.humantechnopole.it

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Oliver Harschnitz @harschnitz.bsky.social · 9d

Could not be more proud of Eleonora Conti who won the Best Talk Award and of Veronica La Rocca who won Best Poster Award at today's @humantechnopole.bsky.social PhD & Postdoc Symposium! A real tribute to all their hard work and a sign of exciting things to come. Incredibly well-deserved. #ProudPI

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Oliver Harschnitz @harschnitz.bsky.social · 9d

Huge thanks to the organisers, namely Davide Aprile, Jessica Armida Bertolini, Claudio Del Fatti, Azahara Maria Fuentes Trillo, @alteagj.bsky.social, Katherine Logan, Francesco Maggiore, @giovannimaltinti.bsky.social, @fmarcuccio.bsky.social, & @lindarepetto.bsky.social for all their hard work!

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Oliver Harschnitz @harschnitz.bsky.social · 9d

Big day at @humantechnopole.bsky.social with today's PhD & Postdoc Symposium providing a stellar line up of speakers and poster presenters. This year's theme is 'Research in Motion: Dynamics in Time, Space, and Technology'. So much exciting science to enjoy!

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Oliver Harschnitz @harschnitz.bsky.social · 11d

One can hope! It promises to be an amazing seminar.

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Oliver Harschnitz @harschnitz.bsky.social · 11d

Very excited that Francesca Peri will be our next speaker for the
@humantechnopole.bsky.social External Seminar Series this Thursday, October 2nd. Big thanks to @nereokalebic.bsky.social for hosting! For external people wanting to join, please see: forms.office.com/e/qk5AhGnaVZ.

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Reposted by Oliver Harschnitz

Jop Kind @jopkind.bsky.social · 22d

1/ 🧵 I am excited to share a new preprint from our group:
Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes.
doi.org/10.1101/2025...
#Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social

MeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesis

During corticogenesis, neural gene expression is tightly coordinated by chromatin and epigenetic changes, whose misregulation can lead to neurodevelopmental disorders[1][1]–[4][2]. The role of spatial...

doi.org

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Reposted by Oliver Harschnitz

Nobu Hamazaki @nobuhamazaki.bsky.social · 13d

New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...

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Ha Nguyen @hanguyen07.bsky.social · Sep 10

Excited to share our preprint, now available online on BioRxiv! biorxiv.org/content/10.1.... We uncovered the coupling of translation and secretion machineries at the #axonalER to promote local delivery of axonal transmembrane proteins (TMPs) to the plasma membrane.

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Oliver Harschnitz @harschnitz.bsky.social · 16d

Two fantastic days of science, ideas, and connection at the @humantechnopole.bsky.social faculty retreat. Grateful to everyone for sharing their exciting work and sparking such inspiring discussions. Truly a pleasure to spend time with this amazing community.

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Reposted by Oliver Harschnitz

James Briscoe @jamesbriscoe.bsky.social · 17d

Great to see this from @vmetzis.bsky.social & co published

Dissection of CDX2 regulatory elements identifies a repressive element that converts to an enhancer with a nuclear receptor motif switch

www.cell.com/developmenta...

A dual enhancer-attenuator element ensures transient Cdx2 expression during mouse posterior body formation

Amblard et al. dissect the function of cis-regulatory elements regulating transient Cdx2 expression during mouse caudal body formation. They highlight the requirement of an attenuator, a transiently r...

www.cell.com

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Reposted by Oliver Harschnitz

Denis Jabaudon @djabaudon.bsky.social · 21d

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Cell-extrinsic controls over neocortical neuron fate and diversity

Cell-extrinsic cues are key for neocortical cell identity and diversity.

www.science.org

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Reposted by Oliver Harschnitz

Nereo Kalebic @nereokalebic.bsky.social · 24d

Check out our new paper linking morphoregulatory adducins with neural progenitor proliferation and neurogenesis:

Human Technopole @humantechnopole.bsky.social · 24d

🧠 New study from our @nereokalebic.bsky.social Group reveals how adducins shape neural progenitors, fuelling #neocortex expansion and brain evolution. Insights with implications for neurodevelopmental disorders, published in @cp-cellreports.bsky.social

humantechnopole.it/en/news/the-...

The role of adducins in the development of the cerebral cortex - Human Technopole

Human Technopole researchers show that adducin proteins regulate morphology, proliferation, and fate of neural progenitor cells, sustaining the expansion of the mammalian neocortex. The findings, whic...

humantechnopole.it

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Oliver Harschnitz @harschnitz.bsky.social · 25d

Exciting new study by Polina Oberst and @studerl.bsky.social in @cp-devcell.bsky.social identifies cholesterol imbalance as a convergent mechanism across multiple genetic and environmental factors of major depressive disorder.

www.cell.com/developmenta...

Environmental and genetic risk factors of depression converge on neuronal dysfunction driven by changes in cholesterol homeostasis

Oberst and Xu et al. identify cholesterol imbalance as a shared driver of neuronal dysfunction across genetic and environmental risk factors for depression. Their findings suggest that diverse causes ...

www.cell.com

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Carmelo Ferrai @carmeloferrai.bsky.social · May 13

EpiSci - Hi there! Our review “Mechanotransduction in stem cells” is finally published. With @carstenschulte4.bsky.social we provided a comprehensive picture, that aims to cover the whole mechanotransductive pathway from the cell microenvironment to the nucleus. 1/3 pubmed.ncbi.nlm.nih.gov/38729084/

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Ina Sonnen @sonnenlab.bsky.social · Sep 9

Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.

doi.org/10.1101/2025...

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Reposted by Oliver Harschnitz

Ollie Inge @oliveringe.bsky.social · Sep 9

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation

Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

www.cell.com

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Oliver Harschnitz @harschnitz.bsky.social · Sep 9

I am absolutely thrilled to be hosting @nicolasrivron.bsky.social as a speaker for the External Seminar Series on October 13th. Come and learn all about early human pregnancy using stem cell-based models.

For external people who would like to join, please see: forms.office.com/e/Zra4b4H4xx

Human Technopole @humantechnopole.bsky.social · Sep 9

🌱 How can stem cells model the earliest stages of human pregnancy? Join Nicolas Rivron at HT to explore embryo models called #blastoids and what they reveal about human development and fertility.

Register by 10 Oct 👉 humantechnopole.it/en/training/...

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Oliver Harschnitz @harschnitz.bsky.social · Sep 3

Beautiful work from Nan Xu and the @studerl.bsky.social lab in @natcellbio.nature.com combining directed differentiation of hPSCs and genome-wide CRISPR screens to identify the epigenetic factors Menin and SUZ12 as regulators of developmental pace across germ layers.
www.nature.com/articles/s41...

Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing - Nature Cell Biology

Xu et al. perform a whole-genome CRISPR-Cas9 knockout screen using directed differentiation systems. They find that MEN1 and SUZ12 modulate human developmental timing by epigenetically controlling biv...

www.nature.com

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Reposted by Oliver Harschnitz

The Hassan Brain Development Team @hassanbraindevlab.bsky.social · Sep 1

Latest from the lab, the beautiful work of Iryna Mohylyak and colleagues describing a temporal developmental transcriptional program for mitochondrial quality control and synaptic connectivity, with @jdejuan-sanz.bsky.social, Olga Corti and @steinaerts.bsky.social
labs
www.nature.com/articles/s41...

Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity - Nature Communications

This study investigates the developmental transcriptional regulation of mitochondrial quality control. Authors identify the Drosophila factor Mirana, homologous to mammalian TZAP, as a key temporal re...

www.nature.com

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Reposted by Oliver Harschnitz

Björn Meyer @bmeyer.bsky.social · Sep 2

EBV induces CNS homing of B cells attracting inflammatory T cells. www.nature.com/articles/s41...

EBV induces CNS homing of B cells attracting inflammatory T cells - Nature

Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.

www.nature.com

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