Oliver Harschnitz
@harschnitz.bsky.social
Stem cell biologist passionate about developmental biology, regenerative medicine, and virology | Group leader at Human Technopole in Milan
Reposted by Oliver Harschnitz
PhD position in my lab in #AI #RNA, in co-supervision with superstar @florianjug.bsky.social
www.polimi.it/dottorato/fu...
www.polimi.it/dottorato/fu...
November 24, 2025 at 11:05 AM
PhD position in my lab in #AI #RNA, in co-supervision with superstar @florianjug.bsky.social
www.polimi.it/dottorato/fu...
www.polimi.it/dottorato/fu...
Reposted by Oliver Harschnitz
This week we introduced an #assembloid-based platform to begin studying how #enteroviruses affect human neuromuscular systems.
This is a collaboration with Jan Carette here at Stanford.
Work led by Christine Peters, Jimena Andersen and Min-Yin Li.
This is a collaboration with Jan Carette here at Stanford.
Work led by Christine Peters, Jimena Andersen and Min-Yin Li.
November 20, 2025 at 4:44 PM
This week we introduced an #assembloid-based platform to begin studying how #enteroviruses affect human neuromuscular systems.
This is a collaboration with Jan Carette here at Stanford.
Work led by Christine Peters, Jimena Andersen and Min-Yin Li.
This is a collaboration with Jan Carette here at Stanford.
Work led by Christine Peters, Jimena Andersen and Min-Yin Li.
Incredibly proud of Greta Galeotti for passing her first year Thesis Committee Meeting today after presenting her work on HSV-1 latency in human trigeminal neurons. A huge thanks to Greg Smith and @ilegnini.bsky.social for their input and the productive discussion. #ProudPI
November 10, 2025 at 4:52 PM
Incredibly proud of Greta Galeotti for passing her first year Thesis Committee Meeting today after presenting her work on HSV-1 latency in human trigeminal neurons. A huge thanks to Greg Smith and @ilegnini.bsky.social for their input and the productive discussion. #ProudPI
Reposted by Oliver Harschnitz
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports www.embopress.org/doi/full/10....
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports
imageimageHuman progenitors are programmed into ependymal cells in brain organoids via GEMC1
and MCIDAS expression. This strategy recapitulates hallmarks of the adult human V-SVZ
niche, providing a pl...
www.embopress.org
November 10, 2025 at 12:22 PM
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports www.embopress.org/doi/full/10....
Huge congratulations to @nicolapalazzi.bsky.social for successfully passing his PhD viva. It has been an amazing journey and a privilege to work with you over the past years! Can't wait to share the exciting discoveries you made. Thanks also to the examiners Mirko Cortese and Ilija Brizic. #ProudPI
November 7, 2025 at 7:41 PM
Huge congratulations to @nicolapalazzi.bsky.social for successfully passing his PhD viva. It has been an amazing journey and a privilege to work with you over the past years! Can't wait to share the exciting discoveries you made. Thanks also to the examiners Mirko Cortese and Ilija Brizic. #ProudPI
Reposted by Oliver Harschnitz
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
www.nature.com
November 5, 2025 at 4:03 PM
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Oliver Harschnitz
Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
journals.biologists.com/dev/issue/15...
journals.biologists.com/dev/issue/15...
Volume 152 Issue 20 | Development | The Company of Biologists
journals.biologists.com
November 5, 2025 at 8:54 AM
Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
journals.biologists.com/dev/issue/15...
journals.biologists.com/dev/issue/15...
Reposted by Oliver Harschnitz
New work by @gleesonlab.bsky.social & colleagues in @cp-cellstemcell.bsky.social
“A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders” 🧪🧠🧫🧬
www.cell.com/cell-stem-ce...
“A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders” 🧪🧠🧫🧬
www.cell.com/cell-stem-ce...
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders
Wang and colleagues present a phenotypic brain organoid atlas for neurodevelopmental
disorders, revealing disease-specific cellular and molecular alterations that illuminate
NDD pathogenesis. Integrat...
www.cell.com
November 3, 2025 at 8:26 PM
New work by @gleesonlab.bsky.social & colleagues in @cp-cellstemcell.bsky.social
“A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders” 🧪🧠🧫🧬
www.cell.com/cell-stem-ce...
“A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders” 🧪🧠🧫🧬
www.cell.com/cell-stem-ce...
Reposted by Oliver Harschnitz
Already 53 phenomenal papers published in the @jhumimmunity.org ! Look it up and submit your best papers to the only journal focused on human inborn errors of immunity, their phenocopies, and related topics in human immunology:
rupress.org/jhi
rupress.org/jhi
Journal of Human Immunity | Rockefeller University Press
Journal of Human Immunity (JHI) publishes papers that provide novel insights into the physiology and pathology of human immunity through the study of genetic defects and their phenocopies, including t...
rupress.org
October 31, 2025 at 2:58 PM
Already 53 phenomenal papers published in the @jhumimmunity.org ! Look it up and submit your best papers to the only journal focused on human inborn errors of immunity, their phenocopies, and related topics in human immunology:
rupress.org/jhi
rupress.org/jhi
Reposted by Oliver Harschnitz
Really excited to see this out in the open: www.life-science-alliance.org/content/9/1/...! @isabellavoelkl.bsky.social explored and compared different in vitro developmental model systems to study ciliogenesis.
In vitro approaches to study centriole and cilium function in early mouse embryogenesis
Although centrioles and primary cilia play an essential role in early mammalian development, their specific function during the interval between their initial formation and the subsequent arrest of em...
www.life-science-alliance.org
October 30, 2025 at 9:17 AM
Really excited to see this out in the open: www.life-science-alliance.org/content/9/1/...! @isabellavoelkl.bsky.social explored and compared different in vitro developmental model systems to study ciliogenesis.
Reposted by Oliver Harschnitz
How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...
Epigenetic lockdown of type I interferon sensing and signalling in human pluripotent cells.
The Human Silencing Hub (HUSH) complex safeguards genome integrity in human somatic cells by repressing transposable elements and regulating type I interferon (IFN-I) induction. In early development, ...
www.biorxiv.org
October 29, 2025 at 6:03 PM
How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...
An amazing day as Eleonora Conti successfully defended her PhD, a first for the lab. It is difficult to put into words how proud I am of Eleonora and the stellar work she has done. Truly a star in the making! Big thanks to the examiners @antoinezalc.bsky.social and @ilegnini.bsky.social. #ProudPI
October 24, 2025 at 8:51 PM
An amazing day as Eleonora Conti successfully defended her PhD, a first for the lab. It is difficult to put into words how proud I am of Eleonora and the stellar work she has done. Truly a star in the making! Big thanks to the examiners @antoinezalc.bsky.social and @ilegnini.bsky.social. #ProudPI
Reposted by Oliver Harschnitz
Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...
October 18, 2025 at 6:55 AM
Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...
Reposted by Oliver Harschnitz
'This multicellular system with induced pluripotent stem cell-derived neurons, microglia, oligodendroglia, astrocytes, pericytes, and brain microvascular endothelial cells has potential for opening possibilities for disease modeling, drug discovery and development'
#Immunology #Neuroimmunology
#Immunology #Neuroimmunology
Engineered 3D immuno-glial-neurovascular human miBrain model | PNAS
Patient-specific, human-based cellular models integrating a biomimetic blood–brain
barrier, immune, and myelinated neuron components are critically...
www.pnas.org
October 18, 2025 at 5:04 PM
'This multicellular system with induced pluripotent stem cell-derived neurons, microglia, oligodendroglia, astrocytes, pericytes, and brain microvascular endothelial cells has potential for opening possibilities for disease modeling, drug discovery and development'
#Immunology #Neuroimmunology
#Immunology #Neuroimmunology
Reposted by Oliver Harschnitz
Excited to be co-organizing this @embo.org Workshop on #Pathogen #Immunity and #Signalling next June 8-12 2026 in Leiden! 🥳🥳🥳 #Savethedate
Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...
October 18, 2025 at 5:05 PM
Excited to be co-organizing this @embo.org Workshop on #Pathogen #Immunity and #Signalling next June 8-12 2026 in Leiden! 🥳🥳🥳 #Savethedate
Could not be prouder of @analaura-duarte.bsky.social who passed her first year Thesis Committee Meeting today discussing her project on the neuropathology induced by inborn errors of immunity. Very exciting times ahead! Big thanks to Aleksandra Badura and Alice Giustacchini for their input. #ProudPI
October 17, 2025 at 3:51 PM
Could not be prouder of @analaura-duarte.bsky.social who passed her first year Thesis Committee Meeting today discussing her project on the neuropathology induced by inborn errors of immunity. Very exciting times ahead! Big thanks to Aleksandra Badura and Alice Giustacchini for their input. #ProudPI
Reposted by Oliver Harschnitz
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Many thanks to @nicolasrivron.bsky.social for today’s External Seminar Series at @humantechnopole.bsky.social. It was amazing to learn all about early human pregnancy using stem cell-based models, species-specific differences and the role of evolution on early development.
October 13, 2025 at 8:44 PM
Many thanks to @nicolasrivron.bsky.social for today’s External Seminar Series at @humantechnopole.bsky.social. It was amazing to learn all about early human pregnancy using stem cell-based models, species-specific differences and the role of evolution on early development.
A wonderful autumn hike.
October 12, 2025 at 5:52 PM
A wonderful autumn hike.
Reposted by Oliver Harschnitz
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
1/
doi.org/10.1101/2025...
October 8, 2025 at 1:05 PM
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
1/
doi.org/10.1101/2025...
Reposted by Oliver Harschnitz
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College
Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.
www.magd.cam.ac.uk
October 7, 2025 at 4:02 PM
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Reposted by Oliver Harschnitz
The ethical framework for embryo models needs clarity and simplicity. The spirit of the integrated/non-integrated distinction was to more prominently regulate models that could potentially develop into a fetus. Hafez Ismaili M’hamdi discusses this. www.progress.org.uk/complexity-w...
Complexity without ethics: Why integration matters for embryo models | PET
Properly understood, the integrated/non-integrated distinction was not just a technical shorthand for the presence or absence of particular tissues.
www.progress.org.uk
October 6, 2025 at 7:03 PM
The ethical framework for embryo models needs clarity and simplicity. The spirit of the integrated/non-integrated distinction was to more prominently regulate models that could potentially develop into a fetus. Hafez Ismaili M’hamdi discusses this. www.progress.org.uk/complexity-w...
Reposted by Oliver Harschnitz
🏆 Congratulations to the winners of our Best Presentation Award, Eleonora Conti (@harschnitz.bsky.social Group) and Best Poster Award: Alexandra Livanova (Sottoriva Group); Emily Georgiades (Bienko Group); @veronicalarocca.bsky.social (Harschnitz Group)
October 2, 2025 at 1:56 PM
🏆 Congratulations to the winners of our Best Presentation Award, Eleonora Conti (@harschnitz.bsky.social Group) and Best Poster Award: Alexandra Livanova (Sottoriva Group); Emily Georgiades (Bienko Group); @veronicalarocca.bsky.social (Harschnitz Group)
Reposted by Oliver Harschnitz
My group @humantechnopole.bsky.social is searching for a #postdoc to work at the interface between #neurodevelopment and #cancerbiology focusing on neurofibromatosis type 1: careers.humantechnopole.it/job/Postdoc-...
Postdoc in Neurobiology - Kalebic Group (funded by Gilbert Family Foundation)
Postdoc in Neurobiology - Kalebic Group (funded by Gilbert Family Foundation)
careers.humantechnopole.it
October 2, 2025 at 5:31 AM
My group @humantechnopole.bsky.social is searching for a #postdoc to work at the interface between #neurodevelopment and #cancerbiology focusing on neurofibromatosis type 1: careers.humantechnopole.it/job/Postdoc-...
Could not be more proud of Eleonora Conti who won the Best Talk Award and of Veronica La Rocca who won Best Poster Award at today's @humantechnopole.bsky.social PhD & Postdoc Symposium! A real tribute to all their hard work and a sign of exciting things to come. Incredibly well-deserved. #ProudPI
September 30, 2025 at 5:11 PM
Could not be more proud of Eleonora Conti who won the Best Talk Award and of Veronica La Rocca who won Best Poster Award at today's @humantechnopole.bsky.social PhD & Postdoc Symposium! A real tribute to all their hard work and a sign of exciting things to come. Incredibly well-deserved. #ProudPI