Hesso Farhan
@hessofarhan.bsky.social
Professor at the Medical University of Innsbruck, Austria. Interested in Endoplasmic Reticulum, Mechanobiology, Proteostasis, Organelles, Cell migration, Pseudoenzymes
Reposted by Hesso Farhan
Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional.
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
November 25, 2025 at 4:22 PM
Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional.
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
Reposted by Hesso Farhan
Delayed weekly selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...
Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...
bims-proteo 2025-11-16 papers
biomed.news
November 21, 2025 at 7:46 PM
Delayed weekly selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...
Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...
Reposted by Hesso Farhan
or just q.e.d. it www.qedscience.com
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
www.qedscience.com
November 23, 2025 at 5:14 PM
or just q.e.d. it www.qedscience.com
Reposted by Hesso Farhan
Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
November 6, 2025 at 5:00 PM
Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
Reposted by Hesso Farhan
What do ER exit sites really look like? Using large-scale volume FIB-SEM and a custom 3D-Unet pipeline (ASEM), Nahir et al @kirchhausenlab.bsky.social reveal that ERES are vesicular, abundant & diverse, resolving long-standing morphological discrepancies rupress.org/jcb/article/...
#ER_literature
#ER_literature
October 31, 2025 at 5:15 PM
What do ER exit sites really look like? Using large-scale volume FIB-SEM and a custom 3D-Unet pipeline (ASEM), Nahir et al @kirchhausenlab.bsky.social reveal that ERES are vesicular, abundant & diverse, resolving long-standing morphological discrepancies rupress.org/jcb/article/...
#ER_literature
#ER_literature
Reposted by Hesso Farhan
Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy | Science Translational Medicine www.science.org/doi/10.1126/...
Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy
Depletion of the ER stress sensor IRE1α can reduce paclitaxel-induced peripheral neuropathy in mice.
www.science.org
October 30, 2025 at 12:35 PM
Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy | Science Translational Medicine www.science.org/doi/10.1126/...
Reposted by Hesso Farhan
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com/4hj9NNV
go.nature.com/4hj9NNV
Economics Nobel prize won by researchers who showed how science boosts growth
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com
October 13, 2025 at 8:37 PM
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com/4hj9NNV
go.nature.com/4hj9NNV
Reposted by Hesso Farhan
Bei #Grundlagenforschung kürzen? Keine gute Idee! so die Philosophin @asmeincke.bsky.social in ihrem Gastkommentar in @diepressecom.bsky.social. Denn Österreich brauche eine starke und vielfältige Wissenschaft.
@fwf-at.bsky.social @oeaw.bsky.social
Bessere Ideen 👉
www.diepresse.com/20152064/bei...
@fwf-at.bsky.social @oeaw.bsky.social
Bessere Ideen 👉
www.diepresse.com/20152064/bei...
Bei Grundlagenforschung kürzen? Keine gute Idee!
Kein Geist, kein Sinn. Österreich braucht keine männliche MINT-Monokultur, sondern eine starke und vielfältige Wissenschaft.
www.diepresse.com
September 30, 2025 at 1:26 PM
Bei #Grundlagenforschung kürzen? Keine gute Idee! so die Philosophin @asmeincke.bsky.social in ihrem Gastkommentar in @diepressecom.bsky.social. Denn Österreich brauche eine starke und vielfältige Wissenschaft.
@fwf-at.bsky.social @oeaw.bsky.social
Bessere Ideen 👉
www.diepresse.com/20152064/bei...
@fwf-at.bsky.social @oeaw.bsky.social
Bessere Ideen 👉
www.diepresse.com/20152064/bei...
Reposted by Hesso Farhan
Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
September 30, 2025 at 7:35 AM
Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:
It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
September 30, 2025 at 7:36 AM
It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.
The microbial metabolite preQ1 modifies tRNA, reduces cell proliferation, and decreases protein translation. This is mediated by IRE1-dependent cleavage of preQ1-modified tRNAs.
rdcu.be/eHw46
rdcu.be/eHw46
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control
Nature Cell Biology - Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth,...
rdcu.be
September 22, 2025 at 8:49 AM
The microbial metabolite preQ1 modifies tRNA, reduces cell proliferation, and decreases protein translation. This is mediated by IRE1-dependent cleavage of preQ1-modified tRNAs.
rdcu.be/eHw46
rdcu.be/eHw46
Beautiful work which supports a role for the ER in mechanobiology.
💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration.
bit.ly/3HFAQ8S
bit.ly/3HFAQ8S
Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode - Nature Cell Biology
Rawal et al. combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization ...
bit.ly
August 25, 2025 at 3:47 PM
Beautiful work which supports a role for the ER in mechanobiology.
Reposted by Hesso Farhan
Nature research paper: Quantitative imaging of lipid transport in mammalian cells
go.nature.com/4mmSygd
go.nature.com/4mmSygd
Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
go.nature.com
August 21, 2025 at 12:58 PM
Nature research paper: Quantitative imaging of lipid transport in mammalian cells
go.nature.com/4mmSygd
go.nature.com/4mmSygd
New paper by the Reggiori and Ungermann Labs showing using a yeast model that contact sites between the phagophore and ERES are important for phagophore elongation.
rdcu.be/ezUeZ
rdcu.be/ezUeZ
Establishment of the phagophore–ERES membrane contact site initiates phagophore elongation
Nature Structural & Molecular Biology - Gómez-Sánchez et al. show that generation of phagophore–endoplasmic reticulum exit sites (ERES) membrane contact sites, mediated by Atg2...
rdcu.be
August 8, 2025 at 2:23 PM
New paper by the Reggiori and Ungermann Labs showing using a yeast model that contact sites between the phagophore and ERES are important for phagophore elongation.
rdcu.be/ezUeZ
rdcu.be/ezUeZ
Great preprint showing that COPII vesicles do exist in vicinity of ERES. Very interesting.
Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multi-scale Molecular Imaging of Human Cells reveals COPI and COPII Vesicles at ER Exit Sites
Trafficking from the endoplasmic reticulum to the Golgi apparatus comprises the first steps toward the correct localization of 30% of eukaryotic proteins. Coat protein complexes COPII and COPI are inv...
www.biorxiv.org
August 4, 2025 at 2:39 PM
Great preprint showing that COPII vesicles do exist in vicinity of ERES. Very interesting.
Reposted by Hesso Farhan
Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL
rdcu.be/ey8iL
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux
Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...
rdcu.be
August 4, 2025 at 11:41 AM
Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL
rdcu.be/ey8iL
Reposted by Hesso Farhan
Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
New online: Conformational plasticity of a BiP–GRP94 chaperone complex
Conformational plasticity of a BiP–GRP94 chaperone complex
Nature Structural & Molecular Biology, Published online: 14 July 2025; doi:10.1038/s41594-025-01619-0BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.
go.nature.com
July 15, 2025 at 6:06 AM
Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine www.cell.com/trends/molec...
The endoplasmic reticulum proteostasis network and bone disease
Bone homeostasis relies on the coordinated activity of osteoblasts and osteoclasts
that balances bone formation and resorption, and of osteocytes for biomechanical sensing
and hormone secretion. A key...
www.cell.com
July 11, 2025 at 9:22 AM
Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine www.cell.com/trends/molec...
Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX
rdcu.be/evyfX
Targeting proteostasis in multiple myeloma through inhibition of LTK
Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK
rdcu.be
July 9, 2025 at 5:55 PM
Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX
rdcu.be/evyfX
Reposted by Hesso Farhan
External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics | Science Advances www.science.org/doi/10.1126/...
External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics
Plasma membrane–endoplasmic reticulum physical tethering is a mechanotransduction pathway.
www.science.org
June 26, 2025 at 1:16 PM
External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics | Science Advances www.science.org/doi/10.1126/...
Reposted by Hesso Farhan
🚨 Where does #lipid peroxidation kick off in #ferroptosis? 🔥Excited to reveal #ER- #mitochondria #contactsites as the ignition point of the lipid peroxidation cascade! Huge kudos to our Maria Livia Sassano @mariamls.bsky.social & our amazing collaborators who made this breakthrough possible!
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
doi.org
June 13, 2025 at 10:31 AM
🚨 Where does #lipid peroxidation kick off in #ferroptosis? 🔥Excited to reveal #ER- #mitochondria #contactsites as the ignition point of the lipid peroxidation cascade! Huge kudos to our Maria Livia Sassano @mariamls.bsky.social & our amazing collaborators who made this breakthrough possible!
Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass: Developmental Cell www.cell.com/developmenta...
Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass
Song et al. demonstrate that an ER tubulovesicular structure (ER tubular body [ER-TB]),
shaped by the tubular ER-phagy receptors ATL3 and RTN3L, plays an important role in
stress-induced Golgi bypass ...
www.cell.com
June 12, 2025 at 6:41 AM
Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass: Developmental Cell www.cell.com/developmenta...
Reposted by Hesso Farhan
ER needs ATP for processes like protein quality control, but can't make its own. Here, how ATP is imported into the ER lumen and exchanged for ADP.
Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1 - Nature
SLC35B1, initially thought to be a nucleotide sugar transporter, is an essential ATP/ADP exchanger that imports ATP into the endoplasmic reticulum through a unique stepwise translocation mechanism.
www.nature.com
May 24, 2025 at 4:56 AM
ER needs ATP for processes like protein quality control, but can't make its own. Here, how ATP is imported into the ER lumen and exchanged for ADP.
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell www.cell.com/cell/fulltex...
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage
Lysosomes are damaged in quiescent cells, and UPR regulators, IRE-1/XBP-1, promote
lysosome repair for cell-cycle re-entry. Lysosome damage in quiescent cells is caused
in part by macroautophagy and i...
www.cell.com
May 15, 2025 at 9:04 PM
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell www.cell.com/cell/fulltex...
Genetically encoded reporters of actin filament organization in living cells and tissues: Cell www.cell.com/cell/fulltex...
Genetically encoded reporters of actin filament organization in living cells and tissues
Tailoring genetic fusions of widely used actin localization reporters by constraining
the mobility of the fluorescent proteins allows measurements of actin filament organization
in living cells and ti...
www.cell.com
May 2, 2025 at 11:41 AM
Genetically encoded reporters of actin filament organization in living cells and tissues: Cell www.cell.com/cell/fulltex...