Daniel Goldhill
@influenzal.bsky.social
Scientist. Lecturer in Virology at RVC. Likes experimental evolution, influenza, coronaviruses, desserts. Main life goal: never running a western blot.
Finished a virology PhD or finishing soon? Check out this job - www.healthjobsuk.com/job/UK/Londo...
Job vacancy: Healthcare Scientist, UK Health Security Agency, London | trac.jobs
www.healthjobsuk.com
November 14, 2025 at 12:16 PM
Finished a virology PhD or finishing soon? Check out this job - www.healthjobsuk.com/job/UK/Londo...
Reposted by Daniel Goldhill
Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...
Ecology and spread of the North American H5N1 epizootic - Nature
The panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primaril...
www.nature.com
November 12, 2025 at 7:33 PM
Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...
Reposted by Daniel Goldhill
My 1st first-author paper is out as a preprint! Excited to share the fascinating story of marine-feeding vampire bats 🌊🦇 We found that marine-diet bats were exposed to #H5#AvianFlu 🦠 from marine wildlife and could potentially spread it to livestock via blood feed🩸
doi.org/10.1101/2025.11.09.686930
doi.org/10.1101/2025.11.09.686930
November 11, 2025 at 8:38 PM
My 1st first-author paper is out as a preprint! Excited to share the fascinating story of marine-feeding vampire bats 🌊🦇 We found that marine-diet bats were exposed to #H5#AvianFlu 🦠 from marine wildlife and could potentially spread it to livestock via blood feed🩸
doi.org/10.1101/2025.11.09.686930
doi.org/10.1101/2025.11.09.686930
Reposted by Daniel Goldhill
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference
The substantial genetic diversity generated during influenza A virus replication facilitates both evasion of pre-existing host immunity and cross-species emergence. A major contributor to this diversi...
www.biorxiv.org
November 4, 2025 at 3:17 AM
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
If you are looking for a PhD in the UK, please check out the LIDo program - www.lido-dtp.ac.uk/apply.
If you are interested in viruses and making genetically edited salmon, please look up my icase project.
International students are welcome to apply!
Please reach out if you have questions.
If you are interested in viruses and making genetically edited salmon, please look up my icase project.
International students are welcome to apply!
Please reach out if you have questions.
November 4, 2025 at 11:14 AM
If you are looking for a PhD in the UK, please check out the LIDo program - www.lido-dtp.ac.uk/apply.
If you are interested in viruses and making genetically edited salmon, please look up my icase project.
International students are welcome to apply!
Please reach out if you have questions.
If you are interested in viruses and making genetically edited salmon, please look up my icase project.
International students are welcome to apply!
Please reach out if you have questions.
Reposted by Daniel Goldhill
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
November 3, 2025 at 12:26 PM
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Guys- new spillover route just dropped.
Talk about an in-flight meal.
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
October 27, 2025 at 11:17 PM
Guys- new spillover route just dropped.
Reposted by Daniel Goldhill
warwick.ac.uk/fac/cross_fa...
I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.
If you're interested reach out and I'd be happy to have a chat.
I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.
If you're interested reach out and I'd be happy to have a chat.
Dr Jeremy Keown
Dr Jeremy Keown
warwick.ac.uk
October 24, 2025 at 7:58 AM
warwick.ac.uk/fac/cross_fa...
I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.
If you're interested reach out and I'd be happy to have a chat.
I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.
If you're interested reach out and I'd be happy to have a chat.
Reposted by Daniel Goldhill
🧵🚨
The UK’s independent scientific bodies are highly vulnerable to politicisation - over the past 5 months I've been working with @martinmckee.bsky.social to map out their vulnerabilities and it's not good news.
Today our report is published!
www.ucl.ac.uk/policy-lab/n...
1/11
The UK’s independent scientific bodies are highly vulnerable to politicisation - over the past 5 months I've been working with @martinmckee.bsky.social to map out their vulnerabilities and it's not good news.
Today our report is published!
www.ucl.ac.uk/policy-lab/n...
1/11
UK’s arm’s length public bodies are highly vulnerable to politicisation
Seven in ten Britons say it is important for top scientific institutions to be independent in exclusive new polling.
www.ucl.ac.uk
October 9, 2025 at 3:47 PM
🧵🚨
The UK’s independent scientific bodies are highly vulnerable to politicisation - over the past 5 months I've been working with @martinmckee.bsky.social to map out their vulnerabilities and it's not good news.
Today our report is published!
www.ucl.ac.uk/policy-lab/n...
1/11
The UK’s independent scientific bodies are highly vulnerable to politicisation - over the past 5 months I've been working with @martinmckee.bsky.social to map out their vulnerabilities and it's not good news.
Today our report is published!
www.ucl.ac.uk/policy-lab/n...
1/11
Reposted by Daniel Goldhill
Excited to share that our paper on the relationship between viral load and metagenomic outputs in wildlife samples is now published in Microbial Genomics @microbiologysociety! 🎉 Fantastic collaboration with a brilliant team.
More info: 📖 tinyurl.com/ywb7tvjm
More info: 📖 tinyurl.com/ywb7tvjm
Quantifying viral load and characterizing virus diversity in wildlife samples with target enrichment sequencing
Metagenomics is a powerful tool for characterizing viruses, with broad applications across diverse disciplines, from understanding the ecology and evolutionary history of viruses to identifying causat...
tinyurl.com
September 29, 2025 at 11:23 AM
Excited to share that our paper on the relationship between viral load and metagenomic outputs in wildlife samples is now published in Microbial Genomics @microbiologysociety! 🎉 Fantastic collaboration with a brilliant team.
More info: 📖 tinyurl.com/ywb7tvjm
More info: 📖 tinyurl.com/ywb7tvjm
Reposted by Daniel Goldhill
In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025
The hemagglutinin of human influenza virus evolves rapidly to erode neutralizing antibody immunity. Twice per year, new vaccine strains are selected with the goal of providing maximum protection again...
www.biorxiv.org
September 8, 2025 at 9:48 PM
In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Reposted by Daniel Goldhill
In under 24h following the newly identified outbreak of #Ebola in the DRC, the virus has been isolated, sequenced and the virus sequence data made publicly available.
virological.org/t/the-16th-e...
virological.org/t/the-16th-e...
The 16th Ebola Virus Disease Outbreak in Bulape Health Zone, Kasai, Democratic Republic of the Congo: A new spillover event from an unknown reservoir host
Background The Democratic Republic of the Congo (DRC) is currently facing concurrent outbreaks including mpox, cholera and malaria (1-4). The Ministry of Public Health, DRC has declared the 16th Ebola...
virological.org
September 5, 2025 at 12:09 AM
In under 24h following the newly identified outbreak of #Ebola in the DRC, the virus has been isolated, sequenced and the virus sequence data made publicly available.
virological.org/t/the-16th-e...
virological.org/t/the-16th-e...
About time!
BBC News - Children to be offered chickenpox vaccine on NHS
www.bbc.com/news/article...
www.bbc.com/news/article...
Children offered chickenpox vaccine on NHS
All young children in England and Wales will be offered a free chickenpox vaccine by the NHS from January 2026.
www.bbc.com
August 29, 2025 at 7:00 AM
About time!
Reposted by Daniel Goldhill
Really excited to have been a part of this study, lead by @willharv.bsky.social on how reassortment of H5N1 in birds has lead to a 'specialist' genotype that thrives in seabirds and drives summer/spring (rather than winter) waves of poultry outbreaks www.biorxiv.org/content/10.1...
Genetic reassortment and diversification of host specificity have driven evolutionary trajectories of lineages of panzootic H5N1 influenza
Since 2021, subclade 2.3.4.4b A(H5N1) high pathogenicity avian influenza (HPAI) viruses have undergone changes in ecology and epidemiology, causing a panzootic of unprecedented scale in wild and domes...
www.biorxiv.org
August 21, 2025 at 8:00 AM
Really excited to have been a part of this study, lead by @willharv.bsky.social on how reassortment of H5N1 in birds has lead to a 'specialist' genotype that thrives in seabirds and drives summer/spring (rather than winter) waves of poultry outbreaks www.biorxiv.org/content/10.1...
Reposted by Daniel Goldhill
We have a new research assistant role co-supervised with @cjohansson-lab.bsky.social
Working on #vaccines and #immunology
www.jobs.ac.uk/job/DOH045/r...
@imperialmed.bsky.social
Working on #vaccines and #immunology
www.jobs.ac.uk/job/DOH045/r...
@imperialmed.bsky.social
Research Assistant in Vaccine Immunology at Imperial College London
Discover Research Assistant in Vaccine Immunology jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.
www.jobs.ac.uk
August 14, 2025 at 6:56 AM
We have a new research assistant role co-supervised with @cjohansson-lab.bsky.social
Working on #vaccines and #immunology
www.jobs.ac.uk/job/DOH045/r...
@imperialmed.bsky.social
Working on #vaccines and #immunology
www.jobs.ac.uk/job/DOH045/r...
@imperialmed.bsky.social
Reposted by Daniel Goldhill
Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.
August 12, 2025 at 12:47 PM
Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.
Reposted by Daniel Goldhill
Want to move to Switzerland? We are looking for a postdoc to study airborne viruses:
careers.epfl.ch/job/Lausanne...
@linseymarr.bsky.social @lakdawalalab.bsky.social @corsiaq.bsky.social @influenzal.bsky.social @chuckhaas.bsky.social
careers.epfl.ch/job/Lausanne...
@linseymarr.bsky.social @lakdawalalab.bsky.social @corsiaq.bsky.social @influenzal.bsky.social @chuckhaas.bsky.social
August 11, 2025 at 4:06 PM
Want to move to Switzerland? We are looking for a postdoc to study airborne viruses:
careers.epfl.ch/job/Lausanne...
@linseymarr.bsky.social @lakdawalalab.bsky.social @corsiaq.bsky.social @influenzal.bsky.social @chuckhaas.bsky.social
careers.epfl.ch/job/Lausanne...
@linseymarr.bsky.social @lakdawalalab.bsky.social @corsiaq.bsky.social @influenzal.bsky.social @chuckhaas.bsky.social
Reposted by Daniel Goldhill
This is quite late but our lab has a preprint out about a SARS-CoV-2 situation we had in mink in Lithuania back in 2021. It's a doozy with re-emergence of extinct lineages, a country-wide test of all mink farms in Lithuania & some interesting dynamics in mink. www.medrxiv.org/content/10.1... 1/5🧵
July 17, 2025 at 8:44 AM
This is quite late but our lab has a preprint out about a SARS-CoV-2 situation we had in mink in Lithuania back in 2021. It's a doozy with re-emergence of extinct lineages, a country-wide test of all mink farms in Lithuania & some interesting dynamics in mink. www.medrxiv.org/content/10.1... 1/5🧵
Something a little different.
If you're looking for interesting science to engage with older school children, I would like to plug my students' work on cow flu - where it came from and what risk it might pose.
doi.org/10.1042/bio_...
PS> Not peer reviewed but was fun to help write!
If you're looking for interesting science to engage with older school children, I would like to plug my students' work on cow flu - where it came from and what risk it might pose.
doi.org/10.1042/bio_...
PS> Not peer reviewed but was fun to help write!
Cross-species concerns: how worried should you be about cow flu?
In 2024, H5N1 avian flu jumped from birds into cows for the first time. Replicating in cow udders and spreading via milk, the virus rapidly infected dairy cows across the USA. The flu virus also manag...
doi.org
July 8, 2025 at 10:34 AM
Something a little different.
If you're looking for interesting science to engage with older school children, I would like to plug my students' work on cow flu - where it came from and what risk it might pose.
doi.org/10.1042/bio_...
PS> Not peer reviewed but was fun to help write!
If you're looking for interesting science to engage with older school children, I would like to plug my students' work on cow flu - where it came from and what risk it might pose.
doi.org/10.1042/bio_...
PS> Not peer reviewed but was fun to help write!
Reposted by Daniel Goldhill
David R. Hagen just solved a small mystery that I mentioned 13 years ago in the mouseover text of a comic drhagen.com/blog/the-mis...
The Missing 11th of the Month - David R Hagen
Personal website of David R Hagen, scientific software engineer
drhagen.com
June 19, 2025 at 11:40 AM
David R. Hagen just solved a small mystery that I mentioned 13 years ago in the mouseover text of a comic drhagen.com/blog/the-mis...
Reposted by Daniel Goldhill
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
June 18, 2025 at 6:32 AM
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
Excited to present the first review from my lab!
Which mutations allow H5 influenza to jump into humans or other mammals? How close is H5 to a pandemic? This review has the answers and explains the molecular mechanism behind the mutations.
Led by @fcapelastegui.bsky.social.
doi.org/10.1099/jgv....
Which mutations allow H5 influenza to jump into humans or other mammals? How close is H5 to a pandemic? This review has the answers and explains the molecular mechanism behind the mutations.
Led by @fcapelastegui.bsky.social.
doi.org/10.1099/jgv....
June 10, 2025 at 12:44 PM
Excited to present the first review from my lab!
Which mutations allow H5 influenza to jump into humans or other mammals? How close is H5 to a pandemic? This review has the answers and explains the molecular mechanism behind the mutations.
Led by @fcapelastegui.bsky.social.
doi.org/10.1099/jgv....
Which mutations allow H5 influenza to jump into humans or other mammals? How close is H5 to a pandemic? This review has the answers and explains the molecular mechanism behind the mutations.
Led by @fcapelastegui.bsky.social.
doi.org/10.1099/jgv....
This is a really friendly meeting for influenza virologists. Great for PhD students and anyone else working on flu.
SAVE THE DATE!
The 2025 Influenza Update Meeting will be held @uni-of-warwick.bsky.social on the 15th and 16th December - @nicolerobb.bsky.social is leading the organisation for this year's event.
We hope you'll join us there - please repost!
www.gla.ac.uk/research/az/...
The 2025 Influenza Update Meeting will be held @uni-of-warwick.bsky.social on the 15th and 16th December - @nicolerobb.bsky.social is leading the organisation for this year's event.
We hope you'll join us there - please repost!
www.gla.ac.uk/research/az/...
June 9, 2025 at 9:48 AM
This is a really friendly meeting for influenza virologists. Great for PhD students and anyone else working on flu.
Should you drink flu-infected raw milk? Obviously no but now you can put numbers on how bad an idea this is.
If you don't pasteurise it, how long can H5N1 influenza viruses stay infectious for in milk?
We had a look at this in a new preprint with @cvrinfo.bsky.social, @roslininstitute.bsky.social, @pirbrightinst.bsky.social & the APHA (1/N)
www.medrxiv.org/content/10.1...
We had a look at this in a new preprint with @cvrinfo.bsky.social, @roslininstitute.bsky.social, @pirbrightinst.bsky.social & the APHA (1/N)
www.medrxiv.org/content/10.1...
May 29, 2025 at 6:12 PM
Should you drink flu-infected raw milk? Obviously no but now you can put numbers on how bad an idea this is.