Jatin Nagpal
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jatinnagpal.bsky.social
Jatin Nagpal
@jatinnagpal.bsky.social
1.8K followers 990 following 65 posts
💭 Neuroscience. Microbiome. Optogenetics.
📍APC Microbiome Ireland. University College Cork.
👤 Lecturer. Co-chair, UCC Race Equality Network. Director, ALBA Network. SciComm Coord., EU COST AFFECT-EVO.
📜 https://research.ucc.ie/profiles/[email protected]
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jatinnagpal.bsky.social
Jatin Nagpal @jatinnagpal.bsky.social · Oct 16
Had a great time discussing ‘What brain is the best to study disorders of behaviour’. Thanks to my fellow panelists and the audience for an enagaging session at European College of Neuropsychopharmacology (ECNP) 2025 meeting in Amsterdam.

#ECNP2025
jatinnagpal.bsky.social
www.science.org/doi/10.1126/...
Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer’s disease
Intermittent fasting enhances cognition in Alzheimer’s disease via gut microbial indole-3-propionic acid activating neuronal PXR.
www.science.org
November 30, 2025 at 1:50 PM
Reposted by Jatin Nagpal
cp-cellhostmicrobe.bsky.social
Gut bacterial metabolism of steroid hormones

Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including anti-inflammatory prednisolone. This microbial activity is enriched in Crohn’s disease patients & diminishes drug bioavailability
www.cell.com/cell-host-mi...
Gut bacteria metabolize natural and synthetic steroid hormones via the reductive OsrABC pathway
Jacoby et al. identify a gut bacterial pathway that reduces natural and synthetic steroid hormones, including the anti-inflammatory drug prednisolone. This microbial activity is enriched in Crohn’s di...
www.cell.com
October 22, 2025 at 5:46 PM
Reposted by Jatin Nagpal
network-alba.bsky.social
🚀 #ALBADiversityWeek 2025 starts today! We celebrate diversity & intersectionality by highlighting key activities and sharing valuable resources.
👀 Stay tuned all week as we revisit achievements and launch new initiatives. Share our posts to join the #GlobalDiversityAwarenessMonth celebration. 🧵
October 27, 2025 at 11:33 AM
Reposted by Jatin Nagpal
ribeirocarlitos.bsky.social
New essay in @currentbiology.bsky.social special brain-body issue! Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino Oliveira-Maia showing @champalimaudf.bsky.social discovery ↔️ clinic at its best. www.cell.com/current-biol...
From cognition in the body to the body in cognition
Carlos Ribeiro and Albino Oliveira-Maia propose how brain–body interactions may inform the study of ‘higher’ cognitive functions such as learning and memory across model systems.
www.cell.com
October 20, 2025 at 4:40 PM
jatinnagpal.bsky.social
Had a great time discussing ‘What brain is the best to study disorders of behaviour’. Thanks to my fellow panelists and the audience for an enagaging session at European College of Neuropsychopharmacology (ECNP) 2025 meeting in Amsterdam.

#ECNP2025
October 16, 2025 at 8:56 AM
jatinnagpal.bsky.social
Reaffirming the value of model organisms in training scientific minds | @natcellbio.nature.com

www.nature.com/articles/s41...
October 15, 2025 at 7:39 PM
Reposted by Jatin Nagpal
jfcryan.bsky.social
What is the best brain to study disorders of behavior? Great discussion at @ecnp.eu moderated by @jatinnagpal.bsky.social with inputs from @ribeirocarlitos.bsky.social @emreyaksi.bsky.social @eknapska.bsky.social & Hannah Clarke #ecnp2025
October 12, 2025 at 1:51 PM
Reposted by Jatin Nagpal
surojitsural.bsky.social
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.

www.science.org/doi/10.1126/...

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Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
www.science.org
September 24, 2025 at 8:17 PM
jatinnagpal.bsky.social
Great to see our review on microbiome, exposome and cognitive development out in @annualreviews.bsky.social.

@apcmicrobiomeirel.bsky.social
@uccresearch.bsky.social

#MicrobiomeSky #Gut-Brain
September 17, 2025 at 7:37 AM
Reposted by Jatin Nagpal
atinsharma.bsky.social
Did I just read the best abstract ever? 😁

www.biorxiv.org/content/10.1...
Blood, sweat, and beers: investigating mosquito biting preferences amidst noise and intoxication in a cross-sectional cohort study at a large music festival
Introduction We live in a world split between mosquito magnets and those lucky enough to remain (nearly) untouched. The reasons why some people attract more mosquito bites than others remain largely m...
www.biorxiv.org
August 27, 2025 at 7:03 PM
jatinnagpal.bsky.social
Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits.

www.biorxiv.org/content/10.1...
Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits
All cells in an animal collectively ensure, moment-to-moment, the survival of the whole organism in the face of environmental stressors. Physiology seeks to elucidate the intricate network of interact...
www.biorxiv.org
August 21, 2025 at 1:56 PM
jatinnagpal.bsky.social
“Recognising the “New Ireland” means embracing its diversity, not as a problem to manage, but as a strength to celebrate.”
Well articulated by Prof. Lokesh Joshi.
www.thejournal.ie/readme/racis...
Professor: 'It's hard to reassure international researchers about their safety in Ireland'
Professor Lokesh Joshi of University of Galway says recent racist attacks will affect Ireland’s ability to attract world-class researchers.
www.thejournal.ie
August 17, 2025 at 5:53 PM
Reposted by Jatin Nagpal
sancholab.bsky.social
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
nature.com
July 16, 2025 at 5:37 PM
Reposted by Jatin Nagpal
natmicrobiol.nature.com
New RESOURCE!

Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria

@arzamasovalex.bsky.social @drlarsbode.bsky.social Andrei Osterman, Jeff Gordon & co

#microbiomesky #microsky

www.nature.com/articles/s41...
Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria - Nature Microbiology
A comprehensive genomic analysis reveals species- and strain-level heterogeneity in carbohydrate utilization potential across bifidobacteria of human origin.
www.nature.com
July 16, 2025 at 11:31 AM
Reposted by Jatin Nagpal
lisamaierlab.bsky.social
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
rdcu.be
July 16, 2025 at 9:20 PM
Reposted by Jatin Nagpal
jfcryan.bsky.social
Exciting Senior Scientist 👩‍🔬 👨‍🔬 role available in my research group 🧠 🦠 - Closing date Tuesday 5th August 2025.

Please Share

@apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social
Full details here
my.corehr.com/pls/uccrecru...
July 7, 2025 at 11:20 AM
Reposted by Jatin Nagpal
scienhub-org.bsky.social
🧠 How does your gut talk to your brain? We’re diving into the Gut-Brain Axis at #BCNMicrobiome with two leading voices: Jane Foster from #UTSWMedCenter on Microbiome & Depression and @maburto.bsky.social on Microbiota-Brain Communication
June 26, 2025 at 8:12 AM
jatinnagpal.bsky.social
Honoured and delighted to join the board of directors at ALBA Network. I look forward to contributing to the ALBA mission to promote equity and inclusion in neuroscience.
@ucc.ie @apcmicrobiomeirel.bsky.social @uccresearch.bsky.social
network-alba.bsky.social ALBA Network @network-alba.bsky.social · Jun 26
Congratulations to our newly elected Board members:
🎉 Sandhya Koushika, Jatin Nagpal, and Ibukun Akinrinade
🎉 Chair-Elect: Bita Moghaddam
Thank you to everyone who joined the ALBA General Assembly 2025! 💙
We’re grateful for your energy and insights.
@fens.org
June 26, 2025 at 7:59 PM
Reposted by Jatin Nagpal
pamferretti.bsky.social
Interested in microbiome GWAS and heritability studies? Check out our new Review in Nature Reviews Genetics! We explore key findings, challenges, and future directions of the field.
rdcu.be/epoRR

@blekhman.bsky.social @sambhawa.bsky.social and Dr. Kelsey Johnson.
Genomics of host–microbiome interactions in humans
Nature Reviews Genetics - In this Review, Ferretti et al. discuss advances in our understanding of interactions between the human genome and the microbiome, including the effects of the microbiome...
rdcu.be
June 4, 2025 at 4:52 PM
Reposted by Jatin Nagpal
claesengroup.bsky.social
When all this pollution is causing you headaches...

💪🦠
June 24, 2025 at 11:26 AM
Reposted by Jatin Nagpal
nizet.bsky.social
Exciting fundamental discovery!

Early embryos fight bacteria WITHOUT immune cells

Zebrafish, mouse, and human embryos use epithelial cells (trophoectoderm)—not immune cells—to engulf and destroy 𝘌. 𝘤𝘰𝘭𝘪 and 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴

Hoijman Lab Barcelona 🇪🇸
𝘊𝘦𝘭𝘭 𝘏𝘰𝘴𝘵 𝘔𝘪𝘤𝘳𝘰𝘣𝘦

www.sciencedirect.com/science/arti...
June 21, 2025 at 5:06 AM
Reposted by Jatin Nagpal
jenbiddle.bsky.social
This is so cool - octopus can sense microbiomes: sending a gift link www.nytimes.com/2025/06/17/s...
Eight Arms to Taste Your Microbiome
www.nytimes.com
June 19, 2025 at 5:45 PM
Reposted by Jatin Nagpal
biorxiv-neursci.bsky.social
A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain https://www.biorxiv.org/content/10.1101/2025.06.10.658982v1
June 15, 2025 at 10:15 PM
Reposted by Jatin Nagpal
natrevimmunol.nature.com
A Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social @apcmicrobiomeirel.bsky.social proposes that microbiota–microglia cross-talk may have major implications for our understanding of neurological disorders and neuropsychiatric disease
#immunosky #microsky #microbiome
A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology
This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...
www.nature.com
June 12, 2025 at 3:41 PM
jatinnagpal.bsky.social
Microbiome for the clinicians | Cell

www.cell.com/cell/fulltex...
The microbiome for clinicians
Preclinical studies suggest a rapidly growing potential for the application of microbiome research in improving patient outcomes. This perspective lays out the potential steps that can be taken toward...
www.cell.com
June 4, 2025 at 8:23 AM