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Reposted by Julie Miesch

Juanma García-Arcos @juanmagararc.bsky.social · 6d

🚨 New preprint out!
“Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social
We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies.

www.biorxiv.org/content/10.1...

Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM

Flipper-TR is a membrane dye sensitive to lipid packing widely used to probe membrane tension in live cells via fluorescence lifetime imaging microscopy (FLIM). However, no consensus currently exists ...

www.biorxiv.org

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Reposted by Julie Miesch

Buzz Baum @buzzbaum.bsky.social · 9d

LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…

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Reposted by Julie Miesch

Emmanuel Levy's lab @elevylab.bsky.social · 25d

Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...

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James Manton @jamesdmanton.bsky.social · 25d

The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...

The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.

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Reposted by Julie Miesch

Akaash Kumar @akaashkumar.bsky.social · 25d

🚨Publication alert🚨
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...

Multispectral live-cell imaging with uncompromised spatiotemporal resolution - Nature Photonics

A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with...

www.nature.com

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Reposted by Julie Miesch

James Manton @jamesdmanton.bsky.social · 26d

We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:

A comparison of imaging an expansion microscopy hydrogel with a water dipping objective lens, using either eye gel as an immersion medium or a combination of Immersol W, water and a thin FEP film. In both cases, the sample is supported by a thin FEP film rather than a coverglass.

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Sep 10

Microtubule lattice conformation and integrity regulate α-tubulin acetylation https://www.biorxiv.org/content/10.1101/2025.09.09.675099v1

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Tim Petzold @timpetzold.bsky.social · Sep 3

Our humble gata2b in situ hybridization image made it onto the cover of @biologyopen.bsky.social!

If you'd like to check out the story behind the image, the link to our new paper is:

journals.biologists.com/bio/article/...

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Julie Miesch @juliemiesch.bsky.social · Aug 14

Oh looks like my microtubules 😉

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Reposted by Julie Miesch

Journal of Cell Biology @jcb.org · Aug 11

Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...

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Simon Bullock @simonbullock11.bsky.social · Aug 5

Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Aug 2

Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization https://www.biorxiv.org/content/10.1101/2025.08.02.668268v1

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Reposted by Julie Miesch

Ana Almeida @ac-almeida.bsky.social · Jul 30

🔎New preprint!
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...

Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability

Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free tubul...

www.biorxiv.org

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Reposted by Julie Miesch

Life Sciences Switzerland (LS2) @lifesciswitzerland.bsky.social · Jul 30

📢 Deadline extended to Join Arolla 2025!
📅 Aug 25–29, Grand Hotel, Arolla
🌍 For junior & senior scientists in cutting-edge bio research
🧬 Abstracts + reg close August 11
💸 Discounts for LS2 members!
👉 Info & reg: meetings.ls2.ch/arolla2025

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Reposted by Julie Miesch

Waggoner Lab @labwaggoner.bsky.social · Jul 17

Designed protein pockets recognize intrinsically disordered protein regions @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.statnews.com/2025/07/17/n...

Disorder meets its match

Designed protein pockets recognize intrinsically disordered protein regions

www.science.org

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Marko Kaksonen @kaksonen.bsky.social · Jul 10

How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi!

www.cell.com/current-biol...

Mosaic evolution of clathrin-mediated endocytosis in fungi

Picco et al. take an evolutionary approach to study clathrin-mediated endocytosis in a fungal clade and discover that the process is evolving in a mosaic fashion. The early phase of endocytosis has sh...

www.cell.com

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Reposted by Julie Miesch

Pau Guillamat @pauguillamat.bsky.social · Jun 30

New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations.

The tissue morphogenesis logic, now engineered into living, programmable materials.

www.biorxiv.org/content/10.1...

#ActiveMatter #TissueEngineering

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Sjors Scheres @sjorsscheres.bsky.social · Jun 25

We have a 3-year funded postdoc position to work on structures of #amyloid filaments. If you are an expert in protein biochemistry, structural biology or #cryoEM / #cryoET, this could be for you! Feel free to email me with any questions. Come join us! 🤩

www.nature.com/naturecareer...

Postdoctoral Scientist - Structural Studies - Dr Sjors Scheres - LMB 2640 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12840844

Postdoctoral Scientist Starting Salary: £41,344 Fixed term: 3 years MRC Laboratory of Molecular Biology, Cambridge, UK We are looking for a postdoc...

www.nature.com

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Marko Kaksonen @kaksonen.bsky.social · Jun 24

How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...

Localization of WDS proteins and fimbrin in three fungal species.

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Derivery Lab - MRC LMB @deriverylab.bsky.social · Jun 23

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

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MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Jun 23

Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes.
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs

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Reposted by Julie Miesch

Angélique Perret @angieprrt.bsky.social · Jun 17

🤩 Last week I successfully defended my PhD!
It was such a special day, made even better by having friends, family, and colleagues there with me. Thanks for all the support and kind words!
Huge thanks to my jury members for the thoughtful feedback and conversations.

@soldatilab.bsky.social

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Paul & Virginie - Centriole Lab @centriolelab.bsky.social · Jun 19

🚨 New preprint!
Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM
www.biorxiv.org/content/10.1...

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Julie Miesch @juliemiesch.bsky.social · Jun 19

Congrats Dr Perret 🥳🥳

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Reposted by Julie Miesch

Joe Parham @joeparham19.bsky.social · May 29

We are excited to share our preprint describing how Sulfolobus cells coordinate DNA segregation with cell division! In eukaryotes this type of regulation involves checkpoints and CDK-cyclins. But how does this work in archaea? This is the question we ask in our paper: www.biorxiv.org/content/10.1...

Temporal and spatial coordination of DNA segregation and cell division in an archaeon.

Cells must coordinate DNA segregation with cytokinesis to ensure that each daughter cell inherits a complete genome. Here, we explore how DNA segregation and division are mechanistically coupled in ar...

www.biorxiv.org

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Reposted by Julie Miesch

Paul & Virginie - Centriole Lab @centriolelab.bsky.social · Apr 23

New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...

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