Maria Barna
@mbarnalab.bsky.social
Reposted by Maria Barna
Ribosomal RNA (rRNA) genes are found in hundreds of copies in the human genome.
Do sequence variations in these paralogs change the ribosome function? Yes!
I am excited to share our new preprint @mbarnalab @jkpritch in collaboration with Calico:
www.medrxiv.org/content/10.1...
1/8
Do sequence variations in these paralogs change the ribosome function? Yes!
I am excited to share our new preprint @mbarnalab @jkpritch in collaboration with Calico:
www.medrxiv.org/content/10.1...
1/8
November 19, 2025 at 11:00 PM
Ribosomal RNA (rRNA) genes are found in hundreds of copies in the human genome.
Do sequence variations in these paralogs change the ribosome function? Yes!
I am excited to share our new preprint @mbarnalab @jkpritch in collaboration with Calico:
www.medrxiv.org/content/10.1...
1/8
Do sequence variations in these paralogs change the ribosome function? Yes!
I am excited to share our new preprint @mbarnalab @jkpritch in collaboration with Calico:
www.medrxiv.org/content/10.1...
1/8
Reposted by Maria Barna
Mutations in mitochondrial rRNA are recurrently observed in cancers! 😳🤯
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
November 6, 2025 at 11:53 AM
Mutations in mitochondrial rRNA are recurrently observed in cancers! 😳🤯
Reposted by Maria Barna
First ad for a position in my new lab at the University of Bristol! If you are looking for a fully funded PhD in cutting edge science that will be based in a supportive environment, and in a great city, check out the link below!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol on FindAPhD.com
PhD Project - Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol, listed on FindAPhD.com
www.findaphd.com
October 13, 2025 at 2:32 PM
First ad for a position in my new lab at the University of Bristol! If you are looking for a fully funded PhD in cutting edge science that will be based in a supportive environment, and in a great city, check out the link below!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Maria Barna
An epic story and a must read. This is really beautiful work to understand the most amazing monthly regeneration event - menstruation. The authors reconstitute this process in mice (which don’t normally menstruate) allowing important new insights. Will also be a powerful model for future work.
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
October 10, 2025 at 11:41 PM
An epic story and a must read. This is really beautiful work to understand the most amazing monthly regeneration event - menstruation. The authors reconstitute this process in mice (which don’t normally menstruate) allowing important new insights. Will also be a powerful model for future work.
Reposted by Maria Barna
Congratulations to Dan Jarosz on being named the first associate dean for basic science in the Stanford School of Medicine!
news.stanford.edu/stories/2025...
news.stanford.edu/stories/2025...
Dan Jarosz becomes first senior associate dean for basic science
Jarosz is the inaugural appointment to the newly created position, which will support basic science faculty throughout the Stanford School of Medicine.
news.stanford.edu
October 8, 2025 at 4:23 PM
Congratulations to Dan Jarosz on being named the first associate dean for basic science in the Stanford School of Medicine!
news.stanford.edu/stories/2025...
news.stanford.edu/stories/2025...
Reposted by Maria Barna
Reminder to register for “Cracking the Code: Nucleic Acid Medicines Coming of Age” a Nature Conferences here in Boston, December 8th - 10th! natureconferences.streamgo.live/cracking-the...
Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes
Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes
Cracking the Code: Nucleic Acid Medicines Coming of Age
The 2025 conference brings together leading academics and industry professionals to explore developments and challenges in the rapidly evolving field of nucleic acid medicines. By uniting researchers ...
natureconferences.streamgo.live
September 30, 2025 at 7:45 PM
Reminder to register for “Cracking the Code: Nucleic Acid Medicines Coming of Age” a Nature Conferences here in Boston, December 8th - 10th! natureconferences.streamgo.live/cracking-the...
Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes
Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes
Reposted by Maria Barna
Mouse studies show that depriving neuroblastoma of polyamine causes a switch in protein synthesis to suppress tumor growth and promote cell differentiation @nature.com @childrensphila.bsky.social @princetonupress.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
September 25, 2025 at 2:42 AM
Mouse studies show that depriving neuroblastoma of polyamine causes a switch in protein synthesis to suppress tumor growth and promote cell differentiation @nature.com @childrensphila.bsky.social @princetonupress.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Kathrin is definitely larger than life! Best recruit ever!!
This massive poster of the ad campaign for the new recruits at the @unibonn.bsky.social is the nerdiest version and the closest I’ll ever get to a superhero movie poster. #Bauzaun
September 25, 2025 at 2:42 AM
Kathrin is definitely larger than life! Best recruit ever!!
Reposted by Maria Barna
Reposted by Maria Barna
90% of doing science is being open to new ideas.
May 31, 2025 at 6:14 PM
90% of doing science is being open to new ideas.
Reposted by Maria Barna
Quality over quantity: Small RNA pauses translation elongation to lift protein activity: Molecular Cell www.cell.com/molecular-ce...
Quality over quantity: Small RNA pauses translation elongation to lift protein activity
Small noncoding RNAs typically regulate the translation initiation of target mRNAs
and thereby protein production. In this issue of Molecular Cell, Thongdee et al. discovered
a novel regulatory mechan...
www.cell.com
May 8, 2025 at 11:01 AM
Quality over quantity: Small RNA pauses translation elongation to lift protein activity: Molecular Cell www.cell.com/molecular-ce...
Reposted by Maria Barna
Dr. Davide Ruggero of UCSF has received a rare renewal of his prestigious ACS Professorship, recognizing his groundbreaking cancer research on protein synthesis. ✨
@ruggerolab.bsky.social @ucsfcancer.bsky.social
urology.ucsf.edu/news/all/202...
@ruggerolab.bsky.social @ucsfcancer.bsky.social
urology.ucsf.edu/news/all/202...
April 24, 2025 at 6:38 PM
Dr. Davide Ruggero of UCSF has received a rare renewal of his prestigious ACS Professorship, recognizing his groundbreaking cancer research on protein synthesis. ✨
@ruggerolab.bsky.social @ucsfcancer.bsky.social
urology.ucsf.edu/news/all/202...
@ruggerolab.bsky.social @ucsfcancer.bsky.social
urology.ucsf.edu/news/all/202...
Reposted by Maria Barna
I am happy to share the latest paper from the lab. We detail a tripartite cell-free translation system based on the separation of mRNAs, ribosomes and ribosome-depleted cytoplasmic lysate from human cells, allowing for flexible reconstitution of translation reaction.
#RNA #Ribosome
#RNA #Ribosome
New Article! A tripartite cell-free translation system to study mammalian translation
A tripartite cell-free translation system to study mammalian translation
Nature Protocols, Published online: 16 April 2025; doi:10.1038/s41596-025-01155-7This protocol presents a tripartite mammalian cell-free translation system, comprising cytoplasmic and ribosome fractions combined with endogenous or synthetic mRNAs, permitting flexible reconstitution and careful dissection of the mechanisms of translation.
bit.ly
April 16, 2025 at 10:47 AM
Reposted by Maria Barna
I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social
www.cell.com/cell/fulltex...
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social
www.cell.com/cell/fulltex...
DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation
DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest
polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing
these native solubility-p...
www.cell.com
April 21, 2025 at 12:01 PM
I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social
www.cell.com/cell/fulltex...
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social
www.cell.com/cell/fulltex...
Reposted by Maria Barna
Reposted by Maria Barna
This started out as two separate projects, actually! 🤝 @mbarnalab.bsky.social has long been interested in comparing the composition of ribosomes in different parts of a cell, since localized mRNA translation is such an important aspect of gene regulation and protein homeostasis. (2/18)
March 31, 2025 at 6:45 AM
This started out as two separate projects, actually! 🤝 @mbarnalab.bsky.social has long been interested in comparing the composition of ribosomes in different parts of a cell, since localized mRNA translation is such an important aspect of gene regulation and protein homeostasis. (2/18)
Reposted by Maria Barna
Reposted by Maria Barna
The crux of rigorously characterizing #IRES:
Kathrin Leppek @katleppek.bsky.social, Maria Barna and colleagues compile a toolbox of approaches to study internal #ribosome entry sites in mammalian cells and embryonic tissues
www.embopress.org/doi/full/10....
Kathrin Leppek @katleppek.bsky.social, Maria Barna and colleagues compile a toolbox of approaches to study internal #ribosome entry sites in mammalian cells and embryonic tissues
www.embopress.org/doi/full/10....
March 13, 2025 at 2:03 PM
The crux of rigorously characterizing #IRES:
Kathrin Leppek @katleppek.bsky.social, Maria Barna and colleagues compile a toolbox of approaches to study internal #ribosome entry sites in mammalian cells and embryonic tissues
www.embopress.org/doi/full/10....
Kathrin Leppek @katleppek.bsky.social, Maria Barna and colleagues compile a toolbox of approaches to study internal #ribosome entry sites in mammalian cells and embryonic tissues
www.embopress.org/doi/full/10....
Very proud of my graduate students @adelefrancisxu and Zijian Zhang & key members of our lab and collaborators @GarryPNolan & Sharon Pitteri lfor the incredibly hard work to characterize subcellular ribosomes.
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
A subcellular map of translational machinery composition and regulation at the single-molecule level
Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion microscopy (RiboExM) to visualize individual ribosomes and ...
www.science.org
March 24, 2025 at 1:19 AM
Very proud of my graduate students @adelefrancisxu and Zijian Zhang & key members of our lab and collaborators @GarryPNolan & Sharon Pitteri lfor the incredibly hard work to characterize subcellular ribosomes.
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
Amazing and inspiring story on RNA binding proteins and translation specificity! Congrats to all!
x.com/RuggeroDavide/…
x.com/RuggeroDavide/…
March 24, 2025 at 1:19 AM
Amazing and inspiring story on RNA binding proteins and translation specificity! Congrats to all!
x.com/RuggeroDavide/…
x.com/RuggeroDavide/…
Very grateful for the support from @pewhealth for this project and @travisclantz who is an amazing graduate student who is taking the lead on getting this project off the ground!
x.com/pewhealth/stat…
x.com/pewhealth/stat…
March 24, 2025 at 1:19 AM
Very grateful for the support from @pewhealth for this project and @travisclantz who is an amazing graduate student who is taking the lead on getting this project off the ground!
x.com/pewhealth/stat…
x.com/pewhealth/stat…
So happy to be with amazing former postdocs at the RNA Canada 2024 meeting!! I’m so happy that @OZhulyn is dressed in pink!!
March 24, 2025 at 1:19 AM
So happy to be with amazing former postdocs at the RNA Canada 2024 meeting!! I’m so happy that @OZhulyn is dressed in pink!!
Great Highlight of the @RuggeroDavide and colleagues latest paper. A really unexpected and hidden role for eIF4E phosphorylation!
x.com/NatureRevCance…
x.com/NatureRevCance…
March 24, 2025 at 1:19 AM
Great Highlight of the @RuggeroDavide and colleagues latest paper. A really unexpected and hidden role for eIF4E phosphorylation!
x.com/NatureRevCance…
x.com/NatureRevCance…
1/9
We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer.
doi.org/10.1016/j.xgen…
We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer.
doi.org/10.1016/j.xgen…
March 24, 2025 at 1:18 AM
1/9
We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer.
doi.org/10.1016/j.xgen…
We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer.
doi.org/10.1016/j.xgen…
March 24, 2025 at 1:18 AM