banner
mbarnalab.bsky.social
Maria Barna
@mbarnalab.bsky.social
140 followers 120 following 360 posts
Posts Media Videos Starter Packs
Reposted by Maria Barna
DevBioStanford @devbiostanford.bsky.social · 17h
Congratulations to Dan Jarosz on being named the first associate dean for basic science in the Stanford School of Medicine!

news.stanford.edu/stories/2025...
Dan Jarosz becomes first senior associate dean for basic science
Jarosz is the inaugural appointment to the newly created position, which will support basic science faculty throughout the Stanford School of Medicine.
news.stanford.edu
1
Reposted by Maria Barna
raflynn5.bsky.social
Ryan Flynn @raflynn5.bsky.social · 8d
Reminder to register for “Cracking the Code: Nucleic Acid Medicines Coming of Age” a Nature Conferences here in Boston, December 8th - 10th! natureconferences.streamgo.live/cracking-the...

Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes
Cracking the Code: Nucleic Acid Medicines Coming of Age
The 2025 conference brings together leading academics and industry professionals to explore developments and challenges in the rapidly evolving field of nucleic acid medicines. By uniting researchers ...
natureconferences.streamgo.live
7 23
Reposted by Maria Barna
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 14d
Mouse studies show that depriving neuroblastoma of polyamine causes a switch in protein synthesis to suppress tumor growth and promote cell differentiation @nature.com @childrensphila.bsky.social @princetonupress.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...
1 3
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · 14d
Kathrin is definitely larger than life! Best recruit ever!!
katleppek.bsky.social
Kathrin Leppek @katleppek.bsky.social · 14d
This massive poster of the ad campaign for the new recruits at the @unibonn.bsky.social is the nerdiest version and the closest I’ll ever get to a superhero movie poster. #Bauzaun
1 6
Reposted by Maria Barna
kurianlab.bsky.social
Kurianlab @kurianlab.bsky.social · Sep 6
www.sciencedirect.com/science/arti...
Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
RNA-binding proteins (RBPs) are best known as effectors along the entire gene expression pathway and as constituents of RNA-protein machines such as t…
www.sciencedirect.com
11 20
Reposted by Maria Barna
itaiyanai.bsky.social
Itai Yanai @itaiyanai.bsky.social · May 31
90% of doing science is being open to new ideas.
2 66 260
Reposted by Maria Barna
yjchao.bsky.social
Yanjie Chao @yjchao.bsky.social · May 8
Quality over quantity: Small RNA pauses translation elongation to lift protein activity: Molecular Cell www.cell.com/molecular-ce...
Quality over quantity: Small RNA pauses translation elongation to lift protein activity
Small noncoding RNAs typically regulate the translation initiation of target mRNAs and thereby protein production. In this issue of Molecular Cell, Thongdee et al. discovered a novel regulatory mechan...
www.cell.com
8 19
Reposted by Maria Barna
ucsfurology.bsky.social
UCSF Department of Urology @ucsfurology.bsky.social · Apr 24
Dr. Davide Ruggero of UCSF has received a rare renewal of his prestigious ACS Professorship, recognizing his groundbreaking cancer research on protein synthesis. ✨
@ruggerolab.bsky.social @ucsfcancer.bsky.social

urology.ucsf.edu/news/all/202...
2 8
Reposted by Maria Barna
andershlund.bsky.social
Anders H. Lund @andershlund.bsky.social · Apr 16
I am happy to share the latest paper from the lab. We detail a tripartite cell-free translation system based on the separation of mRNAs, ribosomes and ribosome-depleted cytoplasmic lysate from human cells, allowing for flexible reconstitution of translation reaction.
#RNA #Ribosome
natprot.nature.com
Nature Protocols @natprot.nature.com · Apr 16
New Article! A tripartite cell-free translation system to study mammalian translation
A tripartite cell-free translation system to study mammalian translation
Nature Protocols, Published online: 16 April 2025; doi:10.1038/s41596-025-01155-7This protocol presents a tripartite mammalian cell-free translation system, comprising cytoplasmic and ribosome fractions combined with endogenous or synthetic mRNAs, permitting flexible reconstitution and careful dissection of the mechanisms of translation.
bit.ly
2 28 49
Reposted by Maria Barna
shadys11.bsky.social
Shady Saad @shadys11.bsky.social · Apr 21
I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social

www.cell.com/cell/fulltex...
DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation
DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-p...
www.cell.com
3 23 100
Reposted by Maria Barna
kurianlab.bsky.social
Kurianlab @kurianlab.bsky.social · Apr 16
www.cell.com/cancer-cell/...
Small-molecule RNA therapeutics to target prostate cancer
Kuzuoglu-Ozturk et al. showcase a therapeutic approach, “translatome therapy,” to combat lethal prostate cancer. Zotatifin, a clinical molecule, targets the RNA-helicase eIF4A. Zotatifin decreases the...
www.cell.com
2 7
Reposted by Maria Barna
adelexu.bsky.social
adelexu.bsky.social @adelexu.bsky.social · Mar 31
This started out as two separate projects, actually! 🤝 @mbarnalab.bsky.social has long been interested in comparing the composition of ribosomes in different parts of a cell, since localized mRNA translation is such an important aspect of gene regulation and protein homeostasis. (2/18)
1 1
Reposted by Maria Barna
carolynbertozzi.bskyverified.social
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Mar 8
Exciting new work from Barna Lab @stanfordmedicine.bsky.social

www.science.org/doi/10.1126/...
A subcellular map of translational machinery composition and regulation at the single-molecule level
Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...
www.science.org
3 58 220
Reposted by Maria Barna
embojournal.org
The EMBO Journal @embojournal.org · Mar 13
The crux of rigorously characterizing #IRES:
Kathrin Leppek @katleppek.bsky.social, Maria Barna and colleagues compile a toolbox of approaches to study internal #ribosome entry sites in mammalian cells and embryonic tissues
www.embopress.org/doi/full/10....
7 15
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · Mar 22
Thanks so much Liam! I’m just setting up my BlueSky account right now.
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · Mar 22
Thanks so much Carolyn! I’m just setting up my BlueSky account right now.
1 4
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · Mar 24
A terrific collaboration between my lab and the lab of @KatLeppek.
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · Mar 24
Very proud of my graduate students ⁦@adelefrancisxu⁩ and Zijian Zhang & key members of our lab and collaborators ⁦⁦@GarryPNolan⁩ & Sharon Pitteri lfor the incredibly hard work to characterize subcellular ribosomes.

science.org/doi/10.1126/sc…
A subcellular map of translational machinery composition and regulation at the single-molecule level
Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion microscopy (RiboExM) to visualize individual ribosomes and ...
www.science.org
1
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · Mar 24
Amazing and inspiring story on RNA binding proteins and translation specificity! Congrats to all!

x.com/RuggeroDavide/…
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · Mar 24
Very grateful for the support from @pewhealth for this project and @travisclantz who is an amazing graduate student who is taking the lead on getting this project off the ground!

x.com/pewhealth/stat…
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · Mar 24
So happy to be with amazing former postdocs at the RNA Canada 2024 meeting!! I’m so happy that @OZhulyn is dressed in pink!!
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · Mar 24
Great Highlight of the @RuggeroDavide and colleagues latest paper. A really unexpected and hidden role for eIF4E phosphorylation!

x.com/NatureRevCance…
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · Mar 24
9/9
This major effort was led by @D_Rothschild_, Theo Susanto, @xsui98, @spence_jeffrey_, @WangXiaoLab, and others and co-supervised by @jkpritch. Congratulations!
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · Mar 24
8/9
Cancer-specific rRNA variant expression is found in the TCGA dataset. By comparing cancer and control biopsies, we find cancer-specific rRNA variant expression in different cancer types, including an increase in lowly abundant rRNA variants.
1 1
mbarnalab.bsky.social
Maria Barna @mbarnalab.bsky.social · Mar 24
7/9
We discover in the GTEx dataset tissue specific rRNA variant expression levels, including rRNA variant expression level differences between brain tissues (derived from the ectoderm lineage) and digestive system tissues (derived from the endoderm lineage).
1 1