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Reposted by Nathanael Caveney

Vuk Stambolic @vukstambolic.bsky.social · 2d

Launch your independent research career in beautiful Toronto!

Princess Margaret Cancer Centre is recruiting an ECR in cancer biology with appointment to University of Toronto and a generous startup package. Vibrant research community.
Apply now!

www.nature.com/naturecareer...

Principal Investigator - Early Career in Cancer Biology - Toronto (City), Ontario (CA) job with Princess Margaret Cancer Centre | 12845320

We are seeking an early-career faculty Scientist at Assistant Professor level to establish an independent research program in Cancer Biology.

www.nature.com

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Filip Van Petegem @filipvanpetegem.bsky.social · 9d

Our cryo-EM structure of the intermediate state of the KCNQ1 potassium channel is out. Collaborative effort with the David Fedida and Luca Maragliano labs. Cryo-EM work spearheaded by Efthimios Kyriakis, PhD

www.nature.com/articles/s41...

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Ben Engel @cellarchlab.com · 12d

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

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Sjors Scheres @sjorsscheres.bsky.social · 16d

I feel some responsibility, as we develop the software. But helical reconstruction is prone to getting stuck in local minima, and unfortunately still requires a lot of self-criticism. The most important one: if you don't see expected features in the map, don't trust it!

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Nathanael Caveney @ncaveney.bsky.social · 23d

Another wild paper from Jan Burian et al! Modern day gold mining w/ cutting edge sequencing tech! ⛏️
@rockefelleruniv.bsky.social

www.nature.com/articles/s41...

Bioactive molecules unearthed by terabase-scale long-read sequencing of a soil metagenome - Nature Biotechnology

Optimized long-read sequencing constructs megabase-scale genome assemblies from complex soil samples.

www.nature.com

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Dr. Deanna Santer @drdeannasanter.bsky.social · 23d

📢🥳 The #SanterLab is recruiting to have new people join the #IFN fun!

With #CIHR & other 💰:
1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169
2) #Immunology PhD student
3) Postdoctoral fellow

Please see our Google lab website + dept website 😀

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CAUT/ACPPU @caut.bsky.social · 24d

In Canada, proposed cuts of 15% across the federal government would have a dramatic effect on already globally decimated research & science.

Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024.

Send a letter: win.newmode.net/canadianasso...

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Dimitry Tegunov @dtegunov.bsky.social · 29d

Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.

Harry Low’s Lab @lowlab.bsky.social · 29d

‘We expect that this approach may be useful for cryo-EM analysis of other small particles near or below the theoretical size limit.’ 🤯

Oli Clarke @olibclarke.bsky.social · Sep 13

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Oli Clarke @olibclarke.bsky.social · Sep 13

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Charu Kaushic @ckaushic.bsky.social · Aug 27

‼️ Notice of upcoming funding opportunity!

Co-led by CIHR-III and CIHR-IIPH, the CIHR Research Excellence, Diversity, and Independence (REDI) Early Career Transition Award (2025) competition will launch in October.

Learn more: cihr-irsc.gc.ca/e/54442.html

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Prof. Stefan Rahmstorf @rahmstorf.bsky.social · Aug 30

Wow. Check this out.
Politicians actually trying to solve problems can achieve a lot!
www.washingtonpost.com/climate-solu...

Paris said au revoir to cars. Air pollution maps reveal a dramatic change.

Air pollution fell substantially as the city restricted car traffic and made way for parks and bike lanes.

www.washingtonpost.com

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Waggoner Lab @labwaggoner.bsky.social · Aug 13

Expanding the cytokine receptor alphabet reprograms T cells into diverse states @natmicrobiol.nature.com #GarciaLab @xrtcell.bsky.social
www.nature.com/articles/s41...

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John Rubinstein @johnrubinstein.bsky.social · Jul 25

🇨🇦🚨Job alert🚨🇨🇦
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children

Amy Wong 🇨🇦 @dramywong.bsky.social · Jul 25

We are hiring 📣 Join our mighty team! See posting below 👇

www.sickkids.ca/en/research/...

www.sickkids.ca

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Nathanael Caveney @ncaveney.bsky.social · Jul 21

🚨 Two weeks left to apply! 🚨 #facultyjobs

Ali Salahpour @salahpourali.bsky.social · Jul 21

Reminder we have a Faculty position opening in our Dept in Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology. Closing date, August 5 (two weeks from now). Please RT/Repost. jobs.utoronto.ca/job/Toronto-...

Assistant Professor - Pharmacology and Toxicology

jobs.utoronto.ca

Reposted by Nathanael Caveney

Ali Salahpour @salahpourali.bsky.social · Jul 21

Reminder we have a Faculty position opening in our Dept in Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology. Closing date, August 5 (two weeks from now). Please RT/Repost. jobs.utoronto.ca/job/Toronto-...

Assistant Professor - Pharmacology and Toxicology

jobs.utoronto.ca

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Reposted by Nathanael Caveney

Yousuf A. Khan @yousufakhan.bsky.social · Jul 2

Sharing some of my PhD work that just came out today.

TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)

www.nature.com/articles/s41...

(1/5)

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Acceleration Consortium @accelerationc.bsky.social · Jun 19

Our friends in Pharmacology + Toxicology at the @uoftmedicine.bsky.social @uoft.bsky.social are looking for an assistant professor! The successful candidate will also become a member of the Acceleration Consortium. Apply now: jobs.utoronto.ca/job/Toronto-...

Assistant Professor - Pharmacology and Toxicology

jobs.utoronto.ca

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Nathanael Caveney @ncaveney.bsky.social · Jun 18

An updated link due to some technical issues w/ the HR portal: jobs.utoronto.ca/job/Toronto-...

Assistant Professor - Pharmacology and Toxicology

jobs.utoronto.ca

Nathanael Caveney @ncaveney.bsky.social · Jun 14

As you might infer from that mouthful, we are trying to keep an open mind with this search, so please share broadly!

And, as one of the most recent recruits to the department, I can honestly say it has been a great place to set up shop!

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Nathanael Caveney @ncaveney.bsky.social · Jun 14

Excited to share that our department at UofT is hiring! We are looking for someone working on "Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology". jobs.utoronto.ca/job/Toronto-...

Assistant Professor - Pharmacology & Toxicology

jobs.utoronto.ca

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John Janetzko @jjanetzko.bsky.social · Jun 10

Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild.
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.

www.biorxiv.org/content/10.1...

Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement

Arrestin proteins bind active G protein-coupled receptors (GPCRs) through coordinated protein-protein, protein-phosphate, and protein-lipid interactions to attenuate G protein signaling and promote GP...

www.biorxiv.org

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John Rubinstein @johnrubinstein.bsky.social · May 31

🇨🇦🚨Job Alert🚨🇨🇦
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...

2026 Canada Excellence Research Chair Opportunities | Research & Innovation

research.utoronto.ca

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Roger Castells @rcastellsg.bsky.social · May 28

Very excited for the “Machines acting on DNA and RNA, a molecular mechanistic perspective” - CNIO-CaixaResearch Frontiers Meeting!

Getting started with the introduction by @oscarllorca.bsky.social

@cniostopcancer.bsky.social

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Ian Yen @ianyyen.bsky.social · Apr 24

Thrilled to announce my first PhD publication in Nature Comms! We determined structures of the Tad pilus ATPase CpaF from Caulobacter. We use these structures to propose how CpaF employs a rotary mechanism of catalysis to drive Tad pilus assembly.
www.nature.com/articles/s41...

Conformational changes in the motor ATPase CpaF facilitate a rotary mechanism of Tad pilus assembly - Nature Communications

The bacterial Tad pilus extends and retracts using a single bifunctional ATPase CpaF. Here, the authors employ cryo-EM, fluorescent microscopy, and AlphaFold modelling to propose how a rotary mechanis...

www.nature.com

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Angelo Iulianella @aineurolab.bsky.social · Apr 19

Recruiting scientists from the US has to be coupled with increases to tricouncil funding, else we will fail both the recruits, & of course Canadian scientists, who are struggling with insufficient funds. Discovery & biomedical research funding (NSERC, CIHR) in Canada is among the lowest in the G7.

Patrick MacDonald🇨🇦 @bcellorg.bsky.social · Apr 19

“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is”

https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y

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