Lightnews — Scholar-powered news

Mahmoud Pouladi @pouladilab.bsky.social · Aug 8

This special issue brings together expert reviews that explore these important emerging areas of research.

A big thank you to all the contributing authors for their excellent work synthesizing these emerging insights, and to the reviewers for their constructive feedback.

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Mahmoud Pouladi @pouladilab.bsky.social · Aug 8

For decades, Huntington's disease research has focused primarily on neuronal vulnerability. However, mounting evidence reveals that astrocytes, microglia, oligodendrocytes, and other non-neuronal cells play crucial roles as active participants in HD pathogenesis.

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Mahmoud Pouladi @pouladilab.bsky.social · Aug 8

Excited to announce the publication of a special issue on "Glia and non-neuronal cells in Huntington’s disease" that I co-edited with Dr. Asa Petersen in the Journal of Huntington's Disease (Volume 14, Issue 3)!

journals.sagepub.com/toc/huna/14/3

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Daniele Bertoglio @danielebertoglio.bsky.social · Apr 16

Can we identify biomarkers responsive to mHTT lowering?

In this new study, we investigated 💧 #CSF and ☢️ #PET biomarkers that could be used non-invasively to track 📈 the temporal response to #mHTT modulation in mice 🐭.

#openaccess article: 👉 lnkd.in/eqTirauF

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Reposted by Mahmoud Pouladi

Brent Toderian @brenttoderian.bsky.social · Mar 15

A new study has ranked Canada 3rd on a list of the top countries with social purpose, seen as being “the most progressive and inclusive” countries in the world.

Denmark and Sweden occupy the top 2 spots on the list, while Norway and New Zealand round out the top 5.

Via @cultmtl.bsky.social

Canada named among top countries with social purpose

A study by U.S. News & World Report has ranked Canada third on a list of the top countries with social purpose.

cultmtl.com

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Reposted by Mahmoud Pouladi

Frank Beier @beierlab.bsky.social · Mar 14

Changes to MSc, PhD and postdoc funding programs from 🇨🇦 tri councils. Harmonization across councils, more awards, and new eligibility for international PhD and postdoc applicants!

NSERC - Latest News - Launch of the new Harmonized Tri-agency Scholarship and Fellowship programs

As announced in Budget 2024, the scholarship and fellowship programs administered by the three federal research funding agencies – the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council (NSERC), and the Social Sciences and Humanities Research Council (SSHRC) – have been streamlined into a new harmonized talent program called the Canada Research Training Awards Suite (CRTAS) that will open for applications in summer 2025.

www.nserc-crsng.gc.ca

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Reposted by Mahmoud Pouladi

BF Francis Ouellette @bffo.bsky.social · Mar 13

From #OUP 's #DATABASE journal | VarGuideAtlas: a repository of variant interpretation guidelines | #Bioinformatics #Genomics 🧬 🖥️ 🧪 🔓
⬇️
academic.oup.com/database/art...

VarGuideAtlas: a repository of variant interpretation guidelines

Abstract. Variant interpretation guidelines guide the process of determining the role of DNA variants in patients’ health. Currently, hundreds of guideline

academic.oup.com

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Reposted by Mahmoud Pouladi

Ethan Greenblatt @vancityflyguy.bsky.social · Mar 14

Come be my colleague at UBC! A great place to work w/amazing students, a beautiful campus, and…maybe one or two other perks 🇨🇦

Dr Karen Pinder 🇨🇦 🔬 @drkarenpinder.bsky.social · Mar 13

We are hiring our next Department Head. If interested, you will be joining a great team of committed researchers and teachers. 👇

www.med.ubc.ca/careers/admi...

Head, Department of Cellular and Physiological Sciences - UBC Faculty of Medicine

Ranked among the world’s top medical schools with the fifth-largest MD enrollment in North America, the UBC Faculty of Medicine is a leader in both the science and the practice of medicine. Across Bri...

www.med.ubc.ca

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Reposted by Mahmoud Pouladi

Sergiu P. Pasca @sergiuppasca.bsky.social · Dec 5

Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis
Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS

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Mahmoud Pouladi @pouladilab.bsky.social · Mar 7

This study adds a new dimension to our understanding of how aging alters oligodendrocytes and myelin plasticity, and their link to cognitive resilience. A fascinating read!

Mahmoud Pouladi @pouladilab.bsky.social · Mar 7

Why does Plp1 matter? Myelination is crucial for brain function, and its dysregulation is linked to cognitive decline. With age, Plp1 expression rises in the female hippocampus. The authors show that boosting Plp1 in older mice (both male & female) led to improved memory performance.

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Mahmoud Pouladi @pouladilab.bsky.social · Mar 7

Women tend to age better cognitively than men, but why? This cool new study finds aging reactivates genes on the inactive X chromosome in the female hippocampus. This shift could contribute to cognitive resilience, with the myelin gene Plp1 playing a major role.

www.science.org/doi/10.1126/...

Aging activates escape of the silent X chromosome in the female mouse hippocampus

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

www.science.org

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Reposted by Mahmoud Pouladi

Wyeth Wasserman @wywywa.bsky.social · Feb 27

Bioinformatics Job Opportunity
Research Associate / Staff Scientist
Vancouver Canada

Join the Silent Genomes Project to provide an outstanding genetic variation database for Indigenous peoples of Canada to improve rare disease diagnosis

tinyurl.com/bm4ptux3

Priority to Canadians

Please repost

Research Associate

Academic Job Category Faculty Non Bargaining Job Title Research Associate Department Wasserman Laboratory | Department of Medical Genetics | Faculty of Medicine (Wyeth Wasserman) Posting End Date Febr...

tinyurl.com

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Amanda Moehring @flybehaviour.bsky.social · Mar 6

Looking for a postdoc with expertise in genetics and neuroscience. Experience in Drosophila a plus. Get in touch!

www.uwo.ca/research/fun...

Western Postdoctoral Fellowship Program

Western University, in vibrant London, Ontario, delivers an academic and student experience second to none.

www.uwo.ca

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Mahmoud Pouladi @pouladilab.bsky.social · Mar 6

This large multi-omic study links tandem repeat (TR) variations to gene regulation in the human brain. We’ve know for sometime that TRs are not just genomic noise (TRs cause HD, FXS, SCAs, ALS/FTD to name a few), but ~18k TRs as potential causal variants is still a shock. doi.org/10.1038/s415...

Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain - Nature Genetics

Mapping of multi-omic molecular quantitative trait loci associated with tandem repeat size variation in up to 4,412 human brain samples from 1,597 donors offers insights into how these variants affect...

doi.org

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Mahmoud Pouladi @pouladilab.bsky.social · Mar 4

UBC’s Dept of Medical Genetics is hiring a tenure-track Assistant Professor at the Life Sciences Institute.

If you’re interested in joining a strong research community in Vancouver, check out the job posting: medgen.med.ubc.ca/assistant-pr...

Please share with anyone who might be a great fit!

Assistant Professor (Tenure-Track) | Department of Medical Genetics | Life Sciences Institute (LSI) - Department of Medical Genetics

The Department of Medical Genetics, in collaboration with the Life Sciences Institute (LSI), invites applications for a full-time faculty position at the rank of Assistant Professor, tenure track with...

medgen.med.ubc.ca

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Reposted by Mahmoud Pouladi

HDBuzz @hdbuzzfeed.bsky.social · Feb 25

Good morning! Day 1 of #CHDI2025 is kicking of NOW! Get ready to follow along for some exciting Huntington’s disease research over the next 3 days.

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Reposted by Mahmoud Pouladi

Pablo Nepomnaschy @pablonep.bsky.social · Feb 22

Job available for Full Professor Tier 1 Canada Research Chair (CRC) - Indigenous Health and Well-Being at the Faculty of Health Science, Simon Fraser University (RT 🙏🏼 please):

www.sfu.ca/vpacademic/a...

Canada Research Chair - Indigenous Health and Well-Being

www.sfu.ca

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Reposted by Mahmoud Pouladi

Marco A. Maximo Prado @maximoprado.bsky.social · Feb 15

My group would take at least 2 people interested in neurodegeneration as post docs bsky.app/profile/maxi...

Marco A. Maximo Prado @maximoprado.bsky.social · Feb 5

We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.

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Reposted by Mahmoud Pouladi

Katherine McDonell @kemcdonell.bsky.social · Feb 8

The HD community has come to Bluesky!

Mahmoud Pouladi @pouladilab.bsky.social · Jan 26

Made a starter pack of the Huntington disease researchers/orgs I can find on Bluesky.

If you’re an HD researcher and want to be added, reply or DM.

go.bsky.app/UM9WCpA

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Mahmoud Pouladi @pouladilab.bsky.social · Feb 7

Added to the HD starter pack! :)

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Reposted by Mahmoud Pouladi

Alan Richardson @alanrichardson.bsky.social · Feb 3

www.ubc.ca/campus-notif... in-person classes at ubc Vancouver are cancelled tomorrow. I only found out due to a message from a colleague in another department forwarded to me. You can cancel outright or move to online.

UBC Campus Notifications | The University of British Columbia

Campus notification for The University of British Columbia.

www.ubc.ca

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Canadian Association for Neuroscience @canacn.bsky.social · Jan 27

New opportunity posted: Principal Investigator in neurodevelopment/Assistant Professor – CHU Sainte-Justine Azrieli Research Centre, Université de Montréal
can-acn.org/principal-in... #neurojobs
@CRA_CHUSJ

Principal Investigator in neurodevelopment/Assistant Professor – CHU Sainte-Justine Azrieli Research Centre, Université de Montréal – Canadian Association for Neuroscience

can-acn.org

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Mahmoud Pouladi @pouladilab.bsky.social · Jan 26

Made a starter pack of the Huntington disease researchers/orgs I can find on Bluesky.

If you’re an HD researcher and want to be added, reply or DM.

go.bsky.app/UM9WCpA

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Reposted by Mahmoud Pouladi

John Rubinstein @johnrubinstein.bsky.social · Jan 24

Come be my boss!
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...

Program Head - Molecular Medicine, The Hospital for Sick Children Research Institute - Toronto (City), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 667223

Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute

jobs.sciencecareers.org

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