Will Shoemaker
@shoestrapped.bsky.social
1K followers 400 following 220 posts
Biologist applying principles from physics at ICTP in Trieste, Italy 🇮🇹 Postdoc researching microbial ecology and evolution in Jacopo Grilli’s research group. PhD w/ @jaytlennon.bsky.social. https://wrshoemaker.github.io
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Reposted by Will Shoemaker
karalmckinley.bsky.social
Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!
Reposted by Will Shoemaker
kevinjkircher.com
Sometimes I think about how from 1935-1975ish, Bell Labs produced an insane amount of revolutionary science and technology, including 11 Nobel Prizes, the transistor, UNIX, C, the laser, the solar cell, information theory, etc. The secret? Provide scientists with ample, steady, no-strings funding.
sites.stat.columbia.edu
Reposted by Will Shoemaker
mobydickatsea.bsky.social
There is no steady unretracing progress in this life; we do not advance through fixed gradations, and at the last one pause
Reposted by Will Shoemaker
gibbological.bsky.social
The landscape of microbial associations in human cancer www.science.org/doi/10.1126/...

TLDR -- most cancers do not have microbiomes...but a few do have consistent microbe associations (i.e., colorectal and oral cancers). Make sense!
The landscape of microbial associations in human cancer
Differences between cancer types, infectious disease, and potential prognostic markers are uncovered by studying microbes within cancer DNA.
www.science.org
Reposted by Will Shoemaker
dijiang319.bsky.social
@science.org ⤵️challenges prevailing notion—repressor and activator act by distinct mechanisms: repressors block via steric hindrance/activators enable Pol II binding to promoter🧬

E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science bit.ly/adv2064
Reposted by Will Shoemaker
physicsbioph-bot.bsky.social
Ilya Nemenman, Pankaj Mehta: Randomness with constraints: constructing minimal models for high-dimensional biology https://arxiv.org/abs/2509.03765 https://arxiv.org/pdf/2509.03765 https://arxiv.org/html/2509.03765
Reposted by Will Shoemaker
mikeblazanin.bsky.social
Happy to see this paper finally out in @pnas.org!

#phage #microbiology #MicroSky #VirEvol 🦠 🧫 🔬

Gift link: www.pnas.org/eprint/YYDZ9...
Reposted by Will Shoemaker
atwilliams.bsky.social
faust everywhere for anyone with the eyes to see
parismarx.com
Geoffrey Hinton’s ex-girlfriend used ChatGPT to tell him “what a rat [he] was.” Now if only the media could wake up to how untrustworthy and self-serving his doomsayer assessment of AI is.
Godfather of AI Says His Girlfriend Broke Up With Him Using ChatGPT
Geoffrey Hinton, long considered a "godfather of AI," revealed that his ex-girlfriend had broken up with him — by using ChatGPT.
futurism.com
shoestrapped.bsky.social
Rarefaction curves of richness as a function of # paintings! A good pedagogical example of the many ways one can sample biodiversity.
Reposted by Will Shoemaker
surtlab.bsky.social
Common grant reviews I got multiple times from 2 very different NSF panels when I proposed things like this (full acknowledgement it’s on me to write and justify better)

“But Lenski already did this, evolution is gonna happen”

“There are no alternatives proposed in case the bacteria do not adapt”
relenski.bsky.social
Should more microbiologists be running long-term evolution experiments? It isn't just me who thinks so :>)

dynamicecology.wordpress.com/2025/09/02/b...
Reposted by Will Shoemaker
relenski.bsky.social
Should more microbiologists be running long-term evolution experiments? It isn't just me who thinks so :>)

dynamicecology.wordpress.com/2025/09/02/b...
Reposted by Will Shoemaker
clsong.com
www.journals.uchicago.edu/doi/10.1086/...

A truly delightful read by Judith Bronstein reflecting on the state of mutualism studies. It's a thoughtful look at where the field has been and where it's going—and such beautiful writing as well!
The Study of Mutualism, Past, Present, and Future | The American Naturalist: Vol 0, No ja
www.journals.uchicago.edu
Reposted by Will Shoemaker
janrosenow.bsky.social
There’s a persistent myth that new solar farms don’t really help tackle climate change because panels are “made with coal” and “never pay back” their carbon debt.

This is simply false.

- UN: solar ~8x cleaner than gas, ~19x than coal per kWh
- panels repay CO2 in 4 months; save 57x over life
shoestrapped.bsky.social
Completely shameful. USian tenured professors, especially at high-profile institutions, need to be making more noise and causing much, much more trouble to roadblock ongoing republican attempts to dismantle science.
crampell.bsky.social
Trump admin planning to change student visas from lasting for duration of academic program to fixed 4-yr term, and then much harder to renew
Could destroy US ability to attract global talent, particularly those seeking advanced degrees in STEM. The median time to complete a PhD is 5.7 yrs per NSF.
Trump Deals A New Immigration Blow To International Students
Trump officials have proposed a new rule limiting international students to fixed periods of entry, making a U.S. education more precarious.
www.forbes.com
Reposted by Will Shoemaker
jwmason.bsky.social
The IRA was surprisingly effective at spurring investment in green energy. Where it failed was making it *politically* sustainable by delivering immediate tangible benefits to the public. In that sense, the Green New Deal was, in retrospect, the more prudent and realistic approach. on.ft.com/4n4Ayra
Reposted by Will Shoemaker
martinadalbello.bsky.social
Check out our new paper led by brilliant @jhuisman.bsky.social about how microbial communities cope with stress due to increasing salinity in their environment. We have all your favorites: isolate phenotyping, pairwise competitions, community propagations, and theory. #microsky #mevosky #ecosky
Reposted by Will Shoemaker
climateofgavin.bsky.social
The tendency to credit GenAI efforts with the success of ML in much more specific (and appropriate) contexts to justify increasing emissions for AI slop generation is something to behold.