Alejandro De Los Angeles, DPhil MPH
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adelosangeles520.bsky.social
Alejandro De Los Angeles, DPhil MPH
@adelosangeles520.bsky.social
Stem Cell Biologist and Embryologist by way of Oxford and Harvard. Neurology, Psychiatry, Epidemiology, Ethics. Aspiring Physician Scientist.
Reposted by Alejandro De Los Angeles, DPhil MPH
A one-time gene therapy can markedly slow the progression of Huntington’s disease, potentially paving the way for the first ever treatment to alter the course of this rare, inherited brain disorder.

go.nature.com/4gLO6Wz
Huntington’s disease treated for first time using gene therapy
Nature - Preliminary results from a small trial offer the clearest evidence yet that the brain disease’s progression can be slowed.
go.nature.com
September 27, 2025 at 3:23 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
New paper out from @zernickagoetz.bsky.social lab led by Dong-Yuan Chen.

We show how the extracellular matrix guides body axis formation in mouse—and possibly human—embryos. Dong did some very challenging experiments - glad to have played a part in seeing it complete.

doi.org/10.1038/s414...
July 24, 2025 at 3:10 AM
Reposted by Alejandro De Los Angeles, DPhil MPH
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social@jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
July 11, 2025 at 8:59 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...
July 12, 2025 at 10:11 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
ICYMI: New online! Challenges of combining multimodal data in assessment of people with traumatic brain injury
Challenges of combining multimodal data in assessment of people with traumatic brain injury
Nature Reviews Neurology, Published online: 11 July 2025; doi:10.1038/s41582-025-01121-7Brennan and Teasdale compare a newly proposed classification system for traumatic brain injury with the gold-standard Glasgow Coma Scale.
bit.ly
July 13, 2025 at 4:02 AM
Reposted by Alejandro De Los Angeles, DPhil MPH
Ventral telencephalic progenitor maturation is gated by developmental timing, revealing a distinct regulatory logic underlying the development of inhibitory neurons

@annrosebright.bsky.social @flo-neuhaus.bsky.social aus.bsky.social, @chr-mayer.bsky.social

www.nature.com/articles/s41...
Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience
Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...
www.nature.com
July 8, 2025 at 7:11 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
Reposted by Alejandro De Los Angeles, DPhil MPH
Our July issue is now live!

www.nature.com/neuro/volume...
July 7, 2025 at 6:17 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
Large-scale research resource models #Alzheimers disease with high and low polygenic risk in human iPSCs. 100+ lines from patients & controls, a powerful tool to study complex AD biology. ow.ly/TeMO50WlGMv

@ukdri.ac.uk @ox.ac.uk @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social
July 7, 2025 at 8:52 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
Molecular and functional diversity of the autonomic nervous system — a Review by Tongtong Wang, Avedis Tufenkjian, Olujimi A. Ajijola & Yuki Oka

#neuroscience #neuroskyence

www.nature.com/articles/s41...
Molecular and functional diversity of the autonomic nervous system - Nature Reviews Neuroscience
The autonomic nervous system has long been viewed as a simple motor system in brain-to-body signalling. In this review, Wang and colleagues highlight diversity within autonomic neurons and their dynam...
www.nature.com
July 7, 2025 at 8:30 AM
Reposted by Alejandro De Los Angeles, DPhil MPH
We keep learning new ways to block autoimmunity and potentially cure autoimmune diseases. Beyond engineered T cells, now natural killer (NK) cells
www.nature.com/articles/d41...
Turbocharged ‘killer’ cells show promise for autoimmune disease
Experimental treatment could offer a safer, cheaper alternative to CAR T cell therapies for disorders such as lupus.
www.nature.com
July 7, 2025 at 1:09 PM
Excited to share our new paper in @Nature! 🎉 As leader of an international consortium, we're proposing a #roadmap to extend human embryo research beyond the 14-day limit to 28 days. Unlocking immense promise for science & medicine! 🔬💡

Read more: rdcu.be/eufLy
Human embryo research: how to move towards a 28-day limit | Nature
The decades-old limit on how long human embryos can be grown in culture is under debate. A new road map outlines how to extend the length of culture responsibly. The decades-old limit on how long human embryos can be grown in culture is under debate. A new road map outlines how to extend the length of culture responsibly.
rdcu.be
July 1, 2025 at 10:05 AM
Reposted by Alejandro De Los Angeles, DPhil MPH
Amyloid-beta(Aβ) accumulation is not common in centenarians, but, when present, is linked to reduced cognitive performance jamanetwork.com/journals/jam...
June 30, 2025 at 5:57 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
NEW: A Parkinson’s drug has been found to reduce symptoms of treatment-resistant depression.

In the largest trial to date, pramipexole significantly outperformed placebo over nearly a year when added to antidepressants.

Read more ⬇️
Parkinson’s drug effective in treating persistent depression |
A drug used for Parkinson’s disease has been shown to be effective in reducing the symptoms of difficult to treat depression, in a study led by the University of Oxford.
www.ox.ac.uk
June 30, 2025 at 1:28 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
A new Medical Research Council Centre of Research Excellence (MRC CoRE) aims to develop brain stimulation devices to treat conditions such as Parkinson’s, dementia, stroke and childhood epilepsy.

More info ⬇️
Oxford to lead new £50m MRC Centre to develop brain stimulation
A new Medical Research Council Centre of Research Excellence (MRC CoRE) aims to develop brain stimulation devices to treat conditions such as Parkinson’s, dementia, stroke and childhood epilepsy.
www.ox.ac.uk
June 30, 2025 at 2:06 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
Book review 📚 What do dolphins talk about? One biologist is trying to listen in

https://go.nature.com/44pnG71
What do dolphins talk about? One biologist is trying to listen in
A marine ecologist’s 40-year struggle to understand how animals signal to one another.
go.nature.com
June 30, 2025 at 2:14 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
Beautiful!
How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...
June 19, 2025 at 8:01 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
This is why I am very excited to be part of a group that will oversee a public dialogue about rewriting the day 14 rule, organised by the ‪@nuffieldbioethics.bsky.social‬. You can read more about it here: www.nuffieldbioethics.org/project/revi...
Reviewing the 14-day rule for human embryo research - Nuffield Council on Bioethics
Exploring arguments for and against extending the 14-day time limit for human embryo research.
www.nuffieldbioethics.org
June 27, 2025 at 9:56 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
Cancer cells turbocharge themselves by stealing the energy-producing units from neurons in tumours

https://go.nature.com/4nnVyda
Cancer cells get power boost by stealing mitochondria from nerves
Nature - The theft probably helps the cells to spread around the body, and preventing it could provide a path to treatment, researchers say.
go.nature.com
June 29, 2025 at 5:38 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
Scientists in China have presented the most complete attempt yet at making healthy, fertile mice from two sperm cells. Bipaternal human children, though, are still far away
Scientists have created healthy, fertile mice with two fathers
Bipaternal human children, though, are still far away
econ.trib.al
June 28, 2025 at 7:24 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
Legal experts argue that Harvard is ultimately likely to prevail in its challenges to the Trump administration’s latest attacks, but how and when remains unclear

https://go.nature.com/3I2R4bR
Harvard vs Trump: what this epic battle means for science
Nature - Research across science and medicine will probably shrink at one of the world’s most elite universities amid a new political reality.
go.nature.com
June 29, 2025 at 3:37 PM
Reposted by Alejandro De Los Angeles, DPhil MPH
Excited to share I’m starting my group in Dublin this September, supported by a Research Ireland Pathway award. We will work on neurulation mechanics using chicken embryos and human iPSCs. Looking forward to this new adventure! #newPI #womeninSTEM
Minister for Further and Higher Education, Research, Innovation and Science, James Lawless, has today announced €23 million in funding to support early-career researchers through the Research Ireland Pathway Programme. Read more: www.researchireland.ie/news/pathways/ #ResearchIreland
June 26, 2025 at 7:56 AM
Reposted by Alejandro De Los Angeles, DPhil MPH
Nature research paper: RNA codon expansion via programmable pseudouridine editing and decoding

https://go.nature.com/3G8f3G4
RNA codon expansion via programmable pseudouridine editing and decoding - Nature
An RNA codon-expansion strategy enables incorporation of non-canonical amino acids into proteins of interest orthogonally to existing methods by inserting pseudouridine codons into specific mRNA transcripts and using an engineered decoder tRNA.
go.nature.com
June 28, 2025 at 11:13 AM