Lightnews — Scholar-powered news

Alex Toker @alextoker.bsky.social · Sep 8

Congratulations to the wonderfully-talented @adrijanavarro.bsky.social on her #JBC paper out today! We took a dive into the wonderful world of glycobiology, linking it to AKT and oncogene signaling in cancer. Brought to you by Toker Lab productions. @asbmbjournals.bsky.social

The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation

AKT phosphorylates the glycosyltransferase ALG3. The PI3K/AKT signaling pathway is frequently dysregulated in cancer and controls key cellular processes such as survival, proliferation, metabolism, an...

www.jbc.org

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Alex Toker @alextoker.bsky.social · May 28

congrats to you and everyone and thank you for including us in this exciting work!!

Tigist Tamir @phosphotig.bsky.social · May 28

Extra! Extra! Read all about it!Our study from the White Lab is online today! Thank you to all that made the story & my postdoc time phenomenal
Forest White
Roger Davis
Jess Spinelli
@mvhlab.bsky.social @alextoker.bsky.social
@mitkochinstitute.bsky.social
www.sciencedirect.com/science/arti...

a man holding a piece of paper in front of a sign that says extra extra read all about it

Alt: a man holding a piece of paper in front of a sign that says extra extra read all about it

media.tenor.com

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Reposted by Alex Toker

Rushika M. Perera @rushika-perera.bsky.social · Mar 28

An incredible tour de force in biochemistry and cell biology by superstar @robzonculab.bsky.social lab postdoc @aakritijain.bsky.social
LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells.
www.science.org/doi/10.1126/...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

www.science.org

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Alex Toker @alextoker.bsky.social · Mar 7

We stood up for science and will continue to stand up and fight, for our right, to…. do science!!
@tarumur.bsky.social @dibblelab.bsky.social @piskounovalab.bsky.social @bdmanning.bsky.social

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American Association for Cancer Research (AACR) @theaacr.bsky.social · Feb 18

The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. Read our statement: https://buff.ly/4gRXNB8

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🌊🏄BlueWaveSurfer🏄🌊 @bluewavesurfer.bsky.social · Jan 12

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Alex Toker @alextoker.bsky.social · Dec 20

Outstanding new study from @ralitsamadsen.bsky.social. This is a must read for everyone in the field of cancer and PI3K! Congrats to all involved!

Ralitsa Madsen @ralitsamadsen.bsky.social · Dec 20

Wow, what a fantastic Christmas present to get - the main output of my @wellcometrust.bsky.social Henry Wellcome Fellowship is now out @molsystbiol.bsky.social and should be of interest to anybody who loves (PI3K) signalling and quantitative biology! www.embopress.org/doi/full/10....

Oncogenic PIK3CA corrupts growth factor signaling specificity | Molecular Systems Biology

imageimageA single-cell signaling framework is developed for quantitative measurements of information flow within the phosphoinositide 3-kinase (PI3K) pathway, enabling high-resolution studies of grow...

www.embopress.org

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Alex Toker @alextoker.bsky.social · Dec 17

Interesting article and viewpoints. Hopefully these new models of research and training will work, as the current model is just unsustainable.

Harvard Professors Leaving for Private Sector Research | Harvard Magazine

Three distinguished scientists on leaving academia to advance biomedical research

www.harvardmagazine.com

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Reposted by Alex Toker

Lemmon and Ferguson Labs at Yale @lemmonferguson.bsky.social · Dec 1

If you are in London and are interested in the EGF receptor, come to this meeting at the Royal Society Dec 9/10 (online attendance also available). 40 years since the EGFR was sequenced (in London).

royalsociety.org/science-even...

Epidermal growth factor receptor after 40 Years | Royal Society

Discussion meeting organised by Professor Mark A Lemmon FRS.

royalsociety.org

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Alex Toker @alextoker.bsky.social · Nov 26

Great news for AKT inhibitors! Capivasertib in combo with abiraterone and ADT improves progression free survival in PTEN deficient prostate cancer! Anticipating approval for this combo, coming off the approval of capi in ER+be breast cancer. Good work AZ!

www.onclive.com/view/capivas...

Capivasertib Plus Abiraterone/ADT Improves rPFS in PTEN-Deficient mHSPC

Capivasertib plus abiraterone and ADT improved rPFS in PTEN-deficient metastatic hormone-sensitive prostate cancer.

www.onclive.com

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Reposted by Alex Toker

Johanna Joyce @johannajoyce.bsky.social · Nov 25

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
🧵 1/

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Thomas Arnesen @natmachinery.bsky.social · Nov 21

go.bsky.app/HqEcaCw

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Evangelia Petsalaki @epetsalaki.bsky.social · Nov 21

PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!

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Reposted by Alex Toker

Brendan Manning @bdmanning.bsky.social · Nov 21

Join us in Boston! The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health has just opened a Jr. Faculty search. Apply by January 15, 2025 at academicpositions.harvard.edu/postings/14371

Assistant Professor, Department of Molecular Metabolism

The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health invites applications for the level of assistant professor. The shared interest of MET faculty is to explor...

academicpositions.harvard.edu

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Alex Toker @alextoker.bsky.social · Nov 20

Published a few weeks ago in Cancer Research, we show benefit of targeting HMCR with pitavastatin in combo with AKT inhibitors in TNBC. Many amazing people contributed, led by the magnificently talented @alissandra-hillis.bsky.social! Looking to initiate new clinical trials based on this combo. 🧪

Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer

Two FDA-approved compounds, AKT inhibitors and pitavastatin, synergize to induce cell death in triple-negative breast cancer, motivating evaluation of the efficacy of this combination in clinical tria...

aacrjournals.org

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Reposted by Alex Toker

Dani cRabaiotti 🦀 @danirabaiotti.bsky.social · Feb 10

Welcome to the Science feed!

Please read our FAQs for instructions for how to be added as a contributor: bossett.io/science-feed/

Mod introductory posts linked below⬇️

Use the test tube emoji on posts you want to appear in the feed🧪

Please like the feed and make sure you follow our feed rules:

Science Feed Rules:
🧪 No misinformation
🧪 Keep posts relevant to science
🧪 Use alt text
🧪 Credit images
🧪 Give context to links to external sites
🧪 Have fun!

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Reposted by Alex Toker

Jason Moore @moorejh.bsky.social · Nov 16

NIH research funding supported 412,000 jobs in 2023 & doubled economic returns www.fiercebiotech.com/research/rep... #NIH #research #funding

Report: Every dollar of NIH research funding doubles in economic returns

Research funded by the National Institutes of Health (NIH) generated $2.46 in economic activity for every $1 of funding in 2023, a total of $92.9 billion, according to an

www.fiercebiotech.com

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Reposted by Alex Toker

Louisa @louisathelast.bsky.social · Nov 16

Good morning, Bluesky. Today’s #GoodMorningNews: a trial at Washington University’s school of medicine has shown great results for a vaccine that would prevent recurrence for a particularly aggressive form of breast cancer. It’s a small trial, but 3 years later 16/18 participants remain cancer free

Vaccine shows promise against aggressive breast cancer | WashU Medicine

Clinical trial targeted recurrence of hard-to-treat triple-negative breast cancer

medicine.washu.edu

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Alex Toker @alextoker.bsky.social · Nov 17

Great to be posting science again!!
Very proud of this work, thanks to a wonderful collaboration with Forest White lab at MIT, Cantley lab at DFCI, and leb by the amazingly talented @alissandra-hillis.bsky.social! Published as fully @openaccess.bsky.social in PNAS.
www.pnas.org/doi/10.1073/...

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Alex Toker @alextoker.bsky.social · Nov 16

The honor was all mine. Thank you for being such gracious and generous hosts, it was a true privilege to give the lecture and also hear all the amazing science at the University of Dundee and the PPU.

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Alex Toker @alextoker.bsky.social · Nov 16

Thank you for doing this! Many people to nominate here. Let's grow this community!

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Reposted by Alex Toker

Krishna Mudumbi @krishnamudumbi.bsky.social · Nov 16

I made a starter pack for people interested in signal transduction! Please include yourself or others!

Tagging a few people to spread the word: @drstarbird.bsky.social @fantauzzolab.bsky.social @alextoker.bsky.social

go.bsky.app/MVvjypg

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Johanna Joyce @johannajoyce.bsky.social · Nov 14

Inspired by the other amazing starter packs - here's one for cancer researchers!

I tried to make this broad - from immunology to genomics to cell biology and so much more..

This list also includes organizations & institutes supporting cancer researchers 🧪🔬⚕️🩺

Hope its useful!

go.bsky.app/FEoaJMc

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Alex Toker @alextoker.bsky.social · Nov 16

I have said goodbye to the once great platform that was Twitter, and hope to find many of my science friends and stories here on BlueSky! Is there anybody out there...?

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