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Ana Janeva

@anajaneva.bsky.social

210 followers 480 following 59 posts

PhD in Eva Hörmanseder's Lab at IES, Helmholtz Munich. Epigenetic memory and Reprogramming. CRC 1064 Chromatin Dynamics PhD rep. UniHeidelberg, EMBL & DAAD alumna. 🇲🇰🇩🇪

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Ana Janeva @anajaneva.bsky.social · Jan 26

I am thrilled to share that our latest pre-print from the @evahoermanseder.bsky.social lab 🐸🧬, is now online! Check it out here:
www.biorxiv.org/content/10.1...

Highlights and key findings from our study in the thread below 👇

Digital Reprogramming Decodes Epigenetic Barriers of Cell Fate Changes

Fates of differentiated cells in our body can be induced to change by nuclear reprogramming. In this way, cells valuable for therapeutic purposes and disease modeling can be produced. However, the eff...

www.biorxiv.org

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Reposted by Ana Janeva

University of Cambridge @cam.ac.uk · 1d

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social

Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 1d

A good day to remember John Gurdon’s school report from his biology master at Eton

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The New York Times @nytimes.com · 1d

Dr. John Gurdon, a British biologist and Nobel laureate who in the early 1960s introduced a paradigm-shifting method of cell manipulation that led to the world’s first cloning of a large mammal, a sheep named Dolly, died on Tuesday at 92.

John B. Gurdon, 92, Dies; Nobelist Paved Way for Cloning of Animals

His work in the manipulation of cells laid the foundation for stem cell biology and regenerative medicine and led to the first cloned large mammal, a sheep named Dolly.

nyti.ms

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Helmholtz Munich @helmholtzmunich.bsky.social · 16d

🚀 #NAKO Launches the Pilot Phase of Its Trusted Research Environment

📝 Health-focused companies can now apply for secure, GDPR-compliant access to Germany’s largest long-term population health data.

👉 Read more: t1p.de/q0i64

@nako.de
#HelmholtzMunich #DataProtection #HealthResearch

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Reposted by Ana Janeva

Maxim Greenberg @maxvcg.bsky.social · 23d

Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...

Epigenetic relay: Polycomb-directed DNA methylation in mammalian development

In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...

journals.plos.org

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Reposted by Ana Janeva

László Tora @tlaszlo.bsky.social · 28d

Do not forget to apply to the FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics (19–22 October 2026, Budapest, Hungary. Will be a great meeting as always. Check out the site: network.febs.org/posts/febs-a...

FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics

The FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics will take place 19–22 October 2026 in Budapest, Hungary. Here we give a taste of the scientific content, flag some of the speaker...

network.febs.org

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Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Sep 4

🎊 Congratulations to Juliane Glaser (@julianeg.bsky.social) and Valentin Flury (@flurylab.bsky.social) on being awarded each an @erc.europa.eu Starting Grant! – #ERCStG

www.ie-freiburg.mpg.de/6057908/2025...

Two ERC Starting Grants for Max Planck in Freiburg

Two young scientists from the Max Planck Institute in Freiburg, Juliane Glaser and Valentin Flury, have each received €1.5 million in ERC Starting Grants to conduct research into epigenetic mechanisms...

www.ie-freiburg.mpg.de

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Oded Rechavi @odedrechavi.bsky.social · Aug 31

Post doc: "this is the worst rejection I ever got"
PI:

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Ana Janeva @anajaneva.bsky.social · Aug 20

I'm just here to say this is an absolutely beautiful cover, but independently of that sounds like a book I'd love to read!!!

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Simon Fisher @profsimonfisher.bsky.social · Aug 7

If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇

Notes from Beethoven’s genome

Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven with population-based datasets used to quantify musical achievement.

www.cell.com

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Reposted by Ana Janeva

Nature @nature.com · Aug 19

An infant with an inherited life-threatening metabolic condition has responded to a tailored therapy that uses CRISPR to correct a specific mutation

go.nature.com/3Jmdbuy

A baby benefits from personalized gene editing in the clinic

An infant with an inherited life-threatening metabolic condition has responded to a tailored therapy that uses the gene-editing tool CRISPR to correct a specific mutation.

go.nature.com

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Reposted by Ana Janeva

Bluma Lesch @ambystoma22.bsky.social · Aug 20

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

H3K4me3 amplifies transcription at intergenic active regulatory elements

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

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GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · Aug 20

We are excited to announce the Otto Meyerhof Prize, awarded by #Boehringer Ingelheim and the #GBM for e𝐚𝐫𝐥𝐲-𝐜𝐚𝐫𝐞𝐞𝐫 scientists conducting research in Germany:
- PhD no more than 8 years ago
- Nominations and self-applications
💶 €5000 prize money
📅 Deadline 30.11.25
📩 Submit to: [email protected]

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Reposted by Ana Janeva

Itai Yanai @itaiyanai.bsky.social · Aug 19

A great thing about working in a lab is being involved in lab meetings and witnessing everyone's projects take shape. A single project may seem to go slow but all projects together is impressive. Caroline Bartman discussed this on the podcast:
podcasts.apple.com/us/podcast/2... @cbartman.bsky.social

28 | Caroline Bartman and the flash(cards) of inspiration

Podcast Episode · Night Science · 02/13/2023 · 28m

podcasts.apple.com

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Arnaud Krebs @arnaudkr.bsky.social · Aug 18

This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇

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Nature @nature.com · Aug 18

Nature research paper: Establishment of chromatin architecture interplays with embryo hypertranscription

go.nature.com/3UumSJJ

Establishment of chromatin architecture interplays with embryo hypertranscription - Nature

A study reveals progressive cohesin loading and a hypertranscription state responsible for the formation of genic cohesin islands at active regulatory genes in mouse embryos, highlighting an interplay between chromatin architecture and transcription as they are established for the first time.

go.nature.com

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Nature Cell Biology @natcellbio.nature.com · Aug 13

🍹Kefalopoulou, Rullens et al. develop Dam&ChIC to assay #chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division and X chromosome inactivation.
bit.ly/4fGJFMi

Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation - Nature Cell Biology

Kefalopoulou, Rullens et al. develop Dam&ChIC to assay chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division a...

bit.ly

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 7

1/n Fun journey continues: Our new @cp-cellstemcell.bsky.social paper out on how the Inherent & Dormant Plasticity of Mouse Naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells".

www.cell.com/cell-stem-ce...

Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs

Hanna and colleagues show that signaling pathway modulation amplifies the inherent flexibility of genetically unmodified mouse naive PSCs to adopt extra-embryonic cell fate potential. This endows them...

www.cell.com

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Oded Rechavi @odedrechavi.bsky.social · Aug 6

With constantly changing norms around work-life balance I no longer know if "Working 9 to 5" is a song about a difficult situation or an ideal situation

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Thomas Norman @normanlab.bsky.social · Aug 6

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

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Hamperl Lab @hamperllab.bsky.social · Aug 4

Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉

🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.

www.biorxiv.org/cgi/content/...

Replisome progression regulates R-loop mediated transcriptional repression

Maintaining cellular proliferation necessitates the synchronized activity of diverse molecular machineries operating in parallel on the genome. Wide-spread transcription and R-loop formation can inter...

www.biorxiv.org

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European Research Council (ERC) @erc.europa.eu · Jul 29

🔬 Stephan Hamperl ‪uncovered how clashes between #gene reading & #DNA copying inside cells drive disease. Their tools reveal new insights into #cancer, ageing & development.

Read more 👉 europa.eu/!H7RtjQ

#FrontierResearch #GeneEditing #Genetics #Oncology @www.helmholtz-munich.de

Revealing cellular conflict role in disease and development

Understanding the conflicts that happen within our cells could shed new light not only on disease progression, but also on how our bodies...

europa.eu

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MwahahahahahadScientist @mads100tist.bsky.social · Aug 5

In case you've ever wondered, I talked with @amjeve.bsky.social about science, myself, and the future of #DevBio as part of the Pathway to Independence Fellowship @biologists.bsky.social 🧪 journals.biologists.com/dev/article/...